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Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 206, pp. 206ra138 - 206ra138
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7504, pp. 268 - 272
Journal Article
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6239
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 43, pp. 29751 - 29765
Background: Although both are involved in metabolic homeostasis, the interconnection between ER stress and FGF21 remains incompletely understood. Results:... 
BETA-KLOTHO | PPAR-ALPHA | Fibroblast Growth Factor (FGF) | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN SENSITIVITY | Unfolded Protein Response (UPR) | Liver Metabolism | ENERGY-EXPENDITURE | ER Stress | Hepatocyte | METABOLIC REGULATOR | MESSENGER-RNA | TRANSCRIPTION FACTOR | FGF21 | Organ Specificity - drug effects | Non-alcoholic Fatty Liver Disease - pathology | Transcription, Genetic - drug effects | Transcriptional Activation - genetics | Fatty Liver - pathology | Humans | Transcriptional Activation - drug effects | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Fibroblast Growth Factors - genetics | Molecular Sequence Data | Hepatocytes - pathology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Hepatocytes - metabolism | Endoplasmic Reticulum Stress - genetics | Promoter Regions, Genetic - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Fibroblast Growth Factors - metabolism | Organ Specificity - genetics | Base Sequence | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Fatty Liver - genetics | Unfolded Protein Response - drug effects | Endoribonucleases - metabolism | Unfolded Protein Response - genetics | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - metabolism | Signal Transduction - genetics | Recombinant Proteins - pharmacology | Enzyme Activation - drug effects | Regulatory Factor X Transcription Factors | Hep G2 Cells | Transcription Factors - metabolism | Animals | Diet | Signal Transduction - drug effects | Mice, Obese | Molecular Biophysics
Journal Article
Hepatology, ISSN 0270-9139, 04/2016, Volume 63, Issue 4, pp. 1190 - 1204
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25269
Background: Nonalcoholic fatty liver disease (NAFLD) is a known outcome of hepatosteatosis. Free fatty acids (FFA) induce the unfolded protein response (UPR)... 
LIPOTOXICITY | APOPTOSIS | ACTIVATION | GLUCAGON-LIKE PEPTIDE-1 | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | INDUCED AUTOPHAGY | PANCREATIC BETA-CELLS | MECHANISMS | ENDOPLASMIC-RETICULUM STRESS | RECEPTOR DOWN-REGULATION | Life Style | Obesity - drug therapy | Apoptosis - drug effects | Fatty Liver - pathology | Humans | Diet, High-Fat - adverse effects | Hepatocytes - pathology | Male | Adipocytes - drug effects | Hepatocytes - metabolism | Autophagy - drug effects | Obesity - etiology | Hepatocytes - drug effects | Unfolded Protein Response - drug effects | Fatty Liver - metabolism | Fructose - adverse effects | Endoplasmic Reticulum Stress - drug effects | Peptides - chemistry | Glucagon-Like Peptide 1 - analogs & derivatives | Mice, Inbred C57BL | Adipocytes - pathology | Fatty Liver - drug therapy | Obesity - metabolism | Obesity - pathology | Peptides - pharmacology | Animals | Survival Analysis | Venoms - therapeutic use | Mice | Venoms - pharmacology | Dietary Carbohydrates - adverse effects | Venoms - chemistry | Peptides - therapeutic use | Fatty Liver - etiology | Type 2 diabetes | Proteins | Unsaturated fatty acids | Liver diseases | Genes | Stress management | Saturated fatty acids | Fructose | Apoptosis | Liver | Homology | Lipids | CCAAT/enhancer-binding protein | Kinases | Autophagy | Trans fats | Prohibition | Lysates | Fatty liver | Protein folding | Rodents | Lesions | Stresses | Cytokines | Mortality | Electron microscopy | Fatty acids | Survival | Stress | Steatosis | Medicine | Studies | Transmission electron microscopy | Microscopy | Hepatocytes | Cell death | Oils & fats | Insulin resistance | Growth hormones | Diabetes | Endoplasmic reticulum | Phagocytosis
Journal Article
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5772 - 5781
Multiple myeloma (MM) cells are characterized by high protein synthesis resulting in chronic endoplasmic reticulum (ER) stress, which is adaptively managed by... 
SURVIVAL | CELLS | IN-VITRO | UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | BONE-MARROW | ENDOPLASMIC-RETICULUM STRESS | IDENTIFICATION | HEMATOLOGY | TRANSCRIPTION FACTOR | eIF-2 Kinase - metabolism | Humans | Pyrazines - therapeutic use | Endoribonucleases - antagonists & inhibitors | Boronic Acids - therapeutic use | RNA, Messenger - metabolism | X-Box Binding Protein 1 | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Multiple Myeloma - drug therapy | Enzyme Inhibitors - chemistry | RNA Splicing - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Stromal Cells - drug effects | Bone Marrow Cells - drug effects | Cell Death - drug effects | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Unfolded Protein Response - drug effects | Bortezomib | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Bone Marrow Cells - cytology | RNA, Messenger - genetics | Stromal Cells - metabolism | Enzyme Inhibitors - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Enzyme Activation - drug effects | Lactams, Macrocyclic - pharmacology | Enzyme Inhibitors - therapeutic use | Regulatory Factor X Transcription Factors | Benzoquinones - pharmacology | Multiple Myeloma - pathology | Animals | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Pyrazines - pharmacology | Bone Marrow Cells - metabolism | Multiple Myeloma - genetics | Stromal Cells - cytology | Boronic Acids - pharmacology | Lymphoid Neoplasia
Journal Article
Oncogene, ISSN 0950-9232, 07/2015, Volume 34, Issue 29, pp. 3760 - 3769
Journal Article