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Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 10/2017, Volume 12, Issue 10, pp. 1595 - 1600
Background and objectives: RRT and doubling of serum creatinine are considered the objective hard end points in nephrology intervention trials. Because both... 
Creatinine | Nephrology | Diabetes mellitus, type 2 | Humans | Diabetic nephropathies | Tetrazoles | Linear models | Kidney | Glomerular filtration rate | Irbesartan | Losartan | Renal dialysis | Renal replacement therapy | Angiotensin II | Biphenyl compounds | SERUM CREATININE | CHOICE | DECISION | DISEASE | NEPHROLOGISTS | UROLOGY & NEPHROLOGY | DIABETIC-NEPHROPATHY | OUTCOMES | IRBESARTAN | PROGRESSION | DECLINE | Up-Regulation | Angiotensin II Type 1 Receptor Blockers - adverse effects | Renal Insufficiency, Chronic - etiology | Diabetic Nephropathies - etiology | Health Status Indicators | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Biphenyl Compounds - adverse effects | Diabetic Nephropathies - drug therapy | Biphenyl Compounds - therapeutic use | Glomerular Filtration Rate - drug effects | Diabetic Nephropathies - physiopathology | Time Factors | Clinical Decision-Making | Endpoint Determination | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology | Kidney - drug effects | Risk Factors | Proportional Hazards Models | Linear Models | Treatment Outcome | Biomarkers - blood | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Renal Insufficiency, Chronic - prevention & control | Diabetes Mellitus, Type 2 - physiopathology | Losartan - therapeutic use | Creatinine - blood | Losartan - adverse effects | Tetrazoles - therapeutic use | Clinical Trials as Topic - methods | Tetrazoles - adverse effects | Diabetes Mellitus, Type 2 - drug therapy | Health Status | Research Design | Renal Dialysis | Index Medicus | irbesartan | Diabetic Nephropathies | glomerular filtration rate | Renal Replacement Therapy | Biphenyl Compounds | nephrology | kidney | creatinine | Diabetes Mellitus, Type 2 | Original | renal dialysis
Journal Article
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 482 - 485
Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to curing the infection(1).... 
CELLS | ACTIVATION | SUBEROYLANILIDE HYDROXAMIC ACID | MULTIDISCIPLINARY SCIENCES | IN-VIVO | VALPROIC ACID | INFECTION | HISTONE DEACETYLASE INHIBITORS | TYPE-1 | EXPRESSION | PCR | Gene Expression Regulation, Viral - drug effects | Humans | Hydroxamic Acids - adverse effects | Histone Deacetylase Inhibitors - administration & dosage | RNA, Viral - blood | Virus Latency - drug effects | Proviruses - drug effects | HIV-1 - growth & development | Proviruses - genetics | Hydroxamic Acids - administration & dosage | Anti-HIV Agents - therapeutic use | CD4-Positive T-Lymphocytes - virology | Hydroxamic Acids - pharmacology | Biomarkers - metabolism | HIV Infections - blood | Risk Assessment | HIV-1 - drug effects | CD4-Positive T-Lymphocytes - cytology | HIV Infections - virology | RNA, Viral - biosynthesis | CD4-Positive T-Lymphocytes - metabolism | Viremia - drug therapy | HIV-1 - genetics | Proviruses - growth & development | Histones - drug effects | Up-Regulation - drug effects | Acetylation - drug effects | Viremia - virology | HIV Infections - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Histone Deacetylase Inhibitors - adverse effects | Physiological aspects | Antiviral agents | HIV patients | Health aspects | Vorinostat | Antiretroviral drugs | Plasma | Cell culture | Lymphocytes | Human immunodeficiency virus--HIV | Genomes | Drug therapy | Drug dosages | Index Medicus
Journal Article
Annals of Neurology, ISSN 0364-5134, 2009, Volume 66, Issue 3, pp. 378 - 389
Journal Article
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7584, pp. 110 - 114
Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas(1,2). Mutant IDH protein produces a new... 
MAINTENANCE | METHYLATION | LANDSCAPE | DEMETHYLATION | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | ARCHITECTURE | PHENOTYPE | EXPRESSION | 2-HYDROXYGLUTARATE | PRINCIPLES | Chromatin - metabolism | Up-Regulation | Humans | Glioma - genetics | Base Sequence | Glioma - pathology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Chromatin - drug effects | Repressor Proteins - metabolism | Oncogenes - genetics | Insulator Elements - genetics | Glioma - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Isocitrate Dehydrogenase - genetics | DNA Methylation - genetics | Down-Regulation - drug effects | Mutation - genetics | CRISPR-Cas Systems - genetics | Insulator Elements - drug effects | Phenotype | Isocitrate Dehydrogenase - chemistry | Receptor, Platelet-Derived Growth Factor alpha - genetics | CCCTC-Binding Factor | CpG Islands - genetics | Protein Binding | Isocitrate Dehydrogenase - metabolism | Cell Proliferation - drug effects | Enhancer Elements, Genetic - genetics | Glutarates - metabolism | Cell Transformation, Neoplastic - drug effects | Chromatin - genetics | DNA Methylation - drug effects | Glioma - drug therapy | Complications and side effects | Care and treatment | Platelet-derived growth factor | Gliomas | Analysis | Influence | Genetic aspects | Research | Methylation | Oncogenes | DNA methylation | Epigenetics | Genomes | Mutation | Gene expression | Binding sites | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
Stem Cells, ISSN 1066-5099, 03/2010, Volume 28, Issue 3, pp. 564 - 572
Human mesenchymal stem cells (hMSCs) are multipotent cells that can differentiate into many cell types. Chondrogenesis is induced in hMSCs cultured as a... 
Cell shape | Rac1 | Chondrogenesis | Smooth muscle cells | N-cadherin | Mesenchymal stem cells | MYOBLAST FUSION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ADHESION | ONCOLOGY | MESENCHYMAL PROGENITOR CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENE-EXPRESSION | CYTOSKELETAL TENSION | DIFFERENTIATION | RHO-GTPASES | PROTEINS | HEMATOLOGY | MODULATION | MAMMARY EPITHELIAL-CELLS | Chondrocytes - cytology | Chondrogenesis - drug effects | Cadherins - metabolism | Humans | Extracellular Matrix - metabolism | Antigens, CD - genetics | Cell Lineage - drug effects | Transforming Growth Factor beta3 - metabolism | Antigens, CD - metabolism | Cell Differentiation - genetics | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Cadherins - genetics | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Chondrocytes - metabolism | Transforming Growth Factor beta3 - pharmacology | Mesenchymal Stromal Cells - drug effects | Cell Adhesion - genetics | Muscle Development - physiology | Cells, Cultured | Gene Expression Regulation - physiology | Mesenchymal Stromal Cells - metabolism | Up-Regulation - genetics | Antigens, CD - drug effects | Cadherins - drug effects | Cell Adhesion - drug effects | Cell Lineage - physiology | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Chondrogenesis - physiology | Muscle Development - drug effects | rac1 GTP-Binding Protein - drug effects | Cell Differentiation - drug effects | Cell Shape - physiology | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2016, Volume 311, Issue 4, pp. H871 - H880
We previously reported that endoplasmic reticulum (ER) stress is induced in the subfornical organ (SFO) and the hypothalamic paraventricular nucleus (PVN) of... 
Heart failure | Brain | Sympathetic activity | Hypothalamic paraventricular nucleus | Mitogen-activated protein kinase | Subfornical organ | Endoplasmic reticulum stress | heart failure | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | INDUCED PHOSPHORYLATION | MYOCARDIAL-INFARCTION | ER STRESS | subfornical organ | KINASE | RATS | sympathetic activity | KAPPA-B | brain | endoplasmic reticulum stress | hypothalamic paraventricular nucleus | mitogen-activated protein kinase | UNFOLDED PROTEIN RESPONSE | PERIPHERAL VASCULAR DISEASE | UP-REGULATION | Cholagogues and Choleretics - pharmacology | Tumor Necrosis Factor-alpha - genetics | Heart Failure - physiopathology | Male | NF-KappaB Inhibitor alpha - genetics | Peptidyl-Dipeptidase A - drug effects | Interleukin-1beta - genetics | Sympathetic Nervous System - physiopathology | RNA, Messenger - metabolism | Activating Transcription Factor 6 - genetics | Subfornical Organ - drug effects | Brain - metabolism | Heat-Shock Proteins - genetics | Inflammation - metabolism | Receptor, Angiotensin, Type 1 - genetics | Cyclooxygenase 2 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Real-Time Polymerase Chain Reaction | Echocardiography | Signal Transduction | Rats | Cyclooxygenase 2 - drug effects | Heart Failure - metabolism | Rats, Sprague-Dawley | Blotting, Western | Brain - drug effects | Tumor Necrosis Factor-alpha - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Endoplasmic Reticulum Stress | Paraventricular Hypothalamic Nucleus - metabolism | Infusions, Intraventricular | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Interleukin-1beta - drug effects | Sympathetic Nervous System - drug effects | Mitogen-Activated Protein Kinase 1 - drug effects | X-Box Binding Protein 1 - drug effects | Sympathetic Nervous System - metabolism | Transcription Factor RelA - genetics | Activating Transcription Factor 6 - drug effects | Mitogen-Activated Protein Kinase 3 - drug effects | Taurochenodeoxycholic Acid - pharmacology | Peptidyl-Dipeptidase A - genetics | Renin-Angiotensin System | Receptor, Angiotensin, Type 1 - drug effects | RNA, Messenger - drug effects | Subfornical Organ - metabolism | Heat-Shock Proteins - drug effects | Activating Transcription Factor 4 - genetics | Activating Transcription Factor 4 - drug effects | NF-KappaB Inhibitor alpha - drug effects | Paraventricular Hypothalamic Nucleus - drug effects | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Transcription Factor RelA - drug effects | X-Box Binding Protein 1 - genetics | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Cellular signal transduction | Endoplasmic reticulum | Health aspects | Mitogen-activated protein kinases | Signal transduction | Inflammation | Kinases | Index Medicus | Cardiovascular Neurohormonal Regulation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2015, Volume 112, Issue 32, pp. 10038 - 10043
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits... 
Mucolysis | (Tri)sulfides | Red meat | Mucus barrier | Colorectal cancer | colorectal cancer | MUCIN | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | red meat | mucus barrier | (tri)sulfides | mucolysis | COLORECTAL-CANCER | CALCIUM | FAT | MICE | INHIBITOR | CYTOTOXICITY | EXPRESSION | Immunohistochemistry | Cell Cycle - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Colon - drug effects | Microbiota - drug effects | Body Weight - drug effects | Ki-67 Antigen - metabolism | Male | Mucus - drug effects | Colony Count, Microbial | Intestinal Mucosa - drug effects | Feces - microbiology | Heme - pharmacology | Mucus - metabolism | Sulfides - metabolism | Cell Death - drug effects | Biomarkers - metabolism | Colon - pathology | Mice, Inbred C57BL | Epithelial Cells - pathology | Up-Regulation - genetics | Antioxidants - pharmacology | Intestinal Mucosa - microbiology | Down-Regulation - drug effects | Down-Regulation - genetics | Up-Regulation - drug effects | Animals | Diet | Models, Biological | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Colon - microbiology | Cell Cycle - drug effects | Intestinal Mucosa - pathology | Cell proliferation | Colon cancer | Epithelial cells | Heme | Physiological aspects | Observations | Health aspects | Bacteria | Microorganisms | Colon | Rodents | Genes | Index Medicus | Biological Sciences | susceptibility | expression | bacterial | inhibitor | mucin | fat | colorectal-cancer | mice | cytotoxicity
Journal Article
Nature, ISSN 0028-0836, 04/2013, Volume 496, Issue 7444, pp. 238 - 242
Journal Article
Autophagy, ISSN 1554-8627, 05/2012, Volume 8, Issue 5, pp. 812 - 825
Our study first proposed that curcumin could protect human endothelial cells from the damage caused by oxidative stress via autophagy. Furthermore, our results... 
autophagy | endothelial cell | FOXO1 | oxidative stress | curcumin | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Oxidative stress | Endothelial cell | Curcumin | Autophagy | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Protein Transport - drug effects | Autophagy - drug effects | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Nucleus - metabolism | Forkhead Transcription Factors - metabolism | Protective Agents - pharmacology | Protein Binding - drug effects | Cytoprotection - drug effects | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Beclin-1 | Hydrogen Peroxide - toxicity | rab GTP-Binding Proteins - metabolism | Cell Survival - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Curcumin - pharmacology | Down-Regulation - drug effects | Ubiquitin-Activating Enzymes - metabolism | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Acetylation - drug effects | Autophagy-Related Protein 7 | Human Umbilical Vein Endothelial Cells - enzymology | Signal Transduction - drug effects | Models, Biological | Human Umbilical Vein Endothelial Cells - pathology | Forkhead Box Protein O1 | Oxidative Stress - drug effects | Cell Nucleus - drug effects | CELL BIOLOGY | Index Medicus
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 04/2012, Volume 8, Issue 4, pp. 1440 - 1449
The importance of mesenchymal stem cells (MSC) in vascular regeneration is becoming increasingly recognized. However, few in vitro studies have been performed... 
Mesenchymal stem cell | Elasticity | Vascular differentiation | Nanofiber | 3-D matrix | HYDROGELS | MATERIALS SCIENCE, BIOMATERIALS | STIFFNESS | ENGINEERING, BIOMEDICAL | EXTRACELLULAR-MATRIX | SCAFFOLDS | Cross-Linking Reagents - pharmacology | Up-Regulation - radiation effects | Tensile Strength - drug effects | Elastic Modulus - drug effects | Polyethylene Glycols - chemistry | Methacrylates - chemistry | Spectroscopy, Fourier Transform Infrared | Tissue Scaffolds - chemistry | Polymerization - drug effects | Mesenchymal Stromal Cells - cytology | Ultraviolet Rays | Time Factors | Polymerase Chain Reaction | Compressive Strength - drug effects | Compressive Strength - radiation effects | Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology | Porosity - drug effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Biomarkers - metabolism | Cell Differentiation - radiation effects | Nanofibers - chemistry | Mesenchymal Stromal Cells - drug effects | Nanofibers - ultrastructure | Polymerization - radiation effects | Endothelial Cells - metabolism | Mesenchymal Stromal Cells - metabolism | Rats | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Elasticity - drug effects | Endothelial Cells - radiation effects | Materials Testing | Elasticity - radiation effects | Muscle, Smooth, Vascular - cytology | Tensile Strength - radiation effects | Porosity - radiation effects | Elastic Modulus - radiation effects | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Animals | Cell Differentiation - drug effects | Endothelial Cells - cytology | Gene Expression Regulation - radiation effects | Endothelial Cells - drug effects | Actin | Polyethylene glycol | Stem cells | Smooth muscle | Muscle proteins | Polyols | Nanotechnology | Endothelium | Index Medicus | mesenchymal stem cell | vascular differentiation | 3D matrix | nanofiber
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 05/2005, Volume 203, Issue 2, pp. 398 - 409
Human mesenchymal stem cells (hMSCs) expanded with and without fibroblast growth factor (FGF) supplementation were compared with respect to their proliferation... 
PROGENITOR CELLS | CROSS-TALK | PROTEIN-KINASE-C | IN-VITRO | PHYSIOLOGY | ATDC5 CELLS | DEFICIENT MDX MICE | STROMAL CELLS | GENE-EXPRESSION SIGNATURES | CHONDROCYTE DIFFERENTIATION | N-CADHERIN | CELL BIOLOGY | Chondrocytes - cytology | Chondrogenesis - drug effects | Age Factors | Oligonucleotide Array Sequence Analysis | Humans | Fibroblast Growth Factor 2 - pharmacology | Bone Marrow Cells - physiology | Gene Expression Profiling | Cell Culture Techniques - methods | Proteoglycans - drug effects | Cell Differentiation - genetics | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Chondrocytes - physiology | Collagen - drug effects | Up-Regulation - physiology | Bone Marrow Cells - drug effects | Mesenchymal Stromal Cells - physiology | Mesenchymal Stromal Cells - drug effects | Tissue Engineering - methods | Bone Marrow Cells - cytology | Gene Expression Regulation - genetics | Extracellular Matrix Proteins - genetics | Cells, Cultured | Proteoglycans - metabolism | Down-Regulation - drug effects | Extracellular Matrix Proteins - drug effects | Down-Regulation - physiology | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Chondrogenesis - physiology | Collagen - metabolism | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Cell Differentiation - drug effects | Signal Transduction - physiology | Cell Proliferation - drug effects | Index Medicus
Journal Article