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Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2010, Volume 53, Issue 12, pp. 4731 - 4748
To create potentially superior aids to smoking cessation and/or antidepressants and to elucidate bupropion’s possible mechanisms of action(s), 23 analogues... 
NICOTINIC RECEPTORS | CHEMISTRY, MEDICINAL | DRUG-INTERACTIONS | TRANSPORTERS | TARGETS | ALPHA 6 | BRAIN | BUPROPION HYDROXYLATION | Analgesics - pharmacology | Body Temperature - drug effects | Stereoisomerism | Humans | Bupropion - analogs & derivatives | Motor Activity - drug effects | Male | Nicotinic Antagonists - pharmacology | Structure-Activity Relationship | Serotonin Uptake Inhibitors - chemical synthesis | Nicotine - pharmacology | Adrenergic Uptake Inhibitors - chemistry | Nicotinic Antagonists - chemical synthesis | Analgesics - chemical synthesis | Dopamine Uptake Inhibitors - chemical synthesis | Adrenergic Uptake Inhibitors - chemical synthesis | Nicotinic Agonists - pharmacology | Cell Line | Dopamine Uptake Inhibitors - pharmacology | Bupropion - chemical synthesis | Serotonin Uptake Inhibitors - chemistry | Mice, Inbred ICR | Animals | Bupropion - chemistry | Nicotinic Antagonists - chemistry | Receptors, Nicotinic - physiology | Analgesics - chemistry | Dopamine Uptake Inhibitors - chemistry | Adrenergic Uptake Inhibitors - pharmacology | Bupropion - pharmacology | Mice | Serotonin Uptake Inhibitors - pharmacology | Smoking Cessation | hydroxybupropion | antinociception | hypothermia | nAChR antagonism | norepinephrine uptake | locomotor activity | structure activity relationship | dopamine uptake | bupropion | Nicotine
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2006, Volume 354, Issue 12, pp. 1243 - 1252
Journal Article
Neurology, ISSN 1526-632X, 2012, Volume 78, Issue 16, pp. 1229 - 1236
Journal Article
Journal Article
Neurology, ISSN 1526-632X, 2006, Volume 67, Issue 8, pp. 1411 - 1420
Background: Serotonin (5-HT) and norepinephrine (NE) are involved in pain modulation via descending inhibitory pathways in the brain and spinal cord.... 
NOREPINEPHRINE REUPTAKE INHIBITOR | EFFICACY | PERSISTENT PAIN | DOUBLE-BLIND | MAJOR DEPRESSIVE DISORDER | PLACEBO-CONTROLLED TRIAL | EXTENDED-RELEASE | CLINICAL NEUROLOGY | IMIPRAMINE TREATMENT | DUAL-SEROTONIN | VENLAFAXINE | Diabetic Neuropathies - blood | Thiophenes - therapeutic use | Humans | Middle Aged | Acetaminophen - administration & dosage | Male | Palliative Care | Peripheral Nervous System Diseases - physiopathology | Thiophenes - administration & dosage | Thiophenes - blood | Peripheral Nervous System Diseases - blood | Female | Serotonin Uptake Inhibitors - blood | Adrenergic Uptake Inhibitors - blood | Acetaminophen - therapeutic use | Neuralgia - physiopathology | Drug Therapy, Combination | Diabetic Neuropathies - physiopathology | Severity of Illness Index | Adrenergic Uptake Inhibitors - therapeutic use | Double-Blind Method | Drug Administration Schedule | Serotonin Uptake Inhibitors - therapeutic use | Treatment Outcome | Analgesics, Non-Narcotic - administration & dosage | Diabetic Neuropathies - drug therapy | Analgesics, Non-Narcotic - therapeutic use | Neuralgia - drug therapy | Norepinephrine - metabolism | Neuralgia - blood | Serotonin Uptake Inhibitors - administration & dosage | Pain - physiopathology | Adrenergic Uptake Inhibitors - administration & dosage | Duloxetine Hydrochloride | Aged | Peripheral Nervous System Diseases - drug therapy
Journal Article
Journal Article
Psychopharmacology, ISSN 1432-2072, 2011, Volume 219, Issue 2, pp. 313 - 326
High levels of impulsivity are a core symptom of psychiatric disorders such as ADHD, mania, personality disorders and drug addiction. The effectiveness of... 
Econometric and Statistical Methods: General | Geneeskunde (GENK) | Bescherming en bevordering van de menselijke gezondheid | Medical sciences | Geneeskunde(GENK) | Neurosciences | Impulsivity | Biomedicine | Dopamine | Serotonin | Delayed reward | Pharmacology/Toxicology | Psychiatry | Noradrenaline | Five-choice serial reaction time task | PSYCHIATRY | GLOBAL 5-HT DEPLETION | DEFICIT-HYPERACTIVITY DISORDER | TERM ATOMOXETINE TREATMENT | NEUROSCIENCES | REACTION-TIME-TASK | PREFRONTAL CORTEX | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | RESPONSE-INHIBITION | NUCLEUS-ACCUMBENS CORE | NOREPINEPHRINE TRANSPORTER | PHARMACOLOGY & PHARMACY | D-AMPHETAMINE | Citalopram - pharmacology | Dopamine Uptake Inhibitors - therapeutic use | Male | Dose-Response Relationship, Drug | Time Factors | Reaction Time - drug effects | Atomoxetine Hydrochloride | Serial Learning - drug effects | Animals, Outbred Strains | Choice Behavior - drug effects | Adrenergic Uptake Inhibitors - therapeutic use | Dopamine Uptake Inhibitors - pharmacology | Amphetamine - therapeutic use | Amphetamine - pharmacology | Serotonin Uptake Inhibitors - therapeutic use | Rats | Piperazines - therapeutic use | Piperazines - pharmacology | Animals | Propylamines - therapeutic use | Adrenergic Uptake Inhibitors - pharmacology | Citalopram - therapeutic use | Impulsive Behavior - drug therapy | Propylamines - pharmacology | Serotonin Uptake Inhibitors - pharmacology | Antidepressants | Mental illness | Neurotransmitters | Inhibitor drugs | Response time | Animal behavior | Rodents | Psychopharmacology | Drug abuse | Drug addiction | Mental disorders | Attention deficit hyperactivity disorder | impulsive behavior | Drug delivery | Personality | Reaction time task | Intertrial interval | Amphetamine | Affective disorders | Reinforcement | Norepinephrine | citalopram | Neurotransmission | monoamines | Original Investigation
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article