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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2009, Volume 52, Issue 21, pp. 6768 - 6781
Journal Article
Neurology, ISSN 0028-3878, 04/2012, Volume 78, Issue 16, pp. 1229 - 1236
Objective: To evaluate the efficacy and safety of a selective serotonin reuptake inhibitor (SSRI) and a serotonin and norepinephrine reuptake inhibitor (SNRI)... 
NORTRIPTYLINE | AMITRIPTYLINE | CLINICAL-TRIAL | OUTPATIENTS | GERIATRIC DEPRESSION | PAROXETINE | ISCHEMIC-HEART-DISEASE | MAJOR DEPRESSION | SCALE | FLUOXETINE | CLINICAL NEUROLOGY | Psychiatric Status Rating Scales - statistics & numerical data | Humans | Depressive Disorder - drug therapy | Male | Parkinson Disease - drug therapy | Paroxetine - therapeutic use | Paroxetine - adverse effects | Paroxetine - administration & dosage | Adult | Female | Severity of Illness Index | Adrenergic Uptake Inhibitors - adverse effects | Parkinson Disease - complications | Adrenergic Uptake Inhibitors - therapeutic use | Double-Blind Method | Drug Administration Schedule | Depressive Disorder - diagnosis | Serotonin Uptake Inhibitors - therapeutic use | Serotonin Uptake Inhibitors - adverse effects | Antidepressive Agents - therapeutic use | Venlafaxine Hydrochloride | Delayed-Action Preparations - adverse effects | Depressive Disorder - complications | Serotonin Uptake Inhibitors - administration & dosage | Adrenergic Uptake Inhibitors - administration & dosage | Cyclohexanols - therapeutic use | Delayed-Action Preparations - therapeutic use | Antidepressive Agents - administration & dosage | Antidepressive Agents - adverse effects | Cyclohexanols - administration & dosage | Parkinson's disease | paroxetine | Neurodegenerative diseases | Antidepressants | Classification | Clinical trials | Depression | Serotonin uptake inhibitors | Venlafaxine | Norepinephrine | Movement disorders | Index Medicus | Abridged Index Medicus | 165 | 239 | 321
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2010, Volume 53, Issue 12, pp. 4731 - 4748
To create potentially superior aids to smoking cessation and/or antidepressants and to elucidate bupropion's possible mechanisms of action(s), 23 analogues... 
SYSTEM | NICOTINIC RECEPTORS | METABOLITES | CHEMISTRY, MEDICINAL | DRUG-INTERACTIONS | TRANSPORTERS | NEURONS | TARGETS | ALPHA 6 | BRAIN | BUPROPION HYDROXYLATION | Analgesics - pharmacology | Body Temperature - drug effects | Stereoisomerism | Humans | Bupropion - analogs & derivatives | Motor Activity - drug effects | Male | Nicotinic Antagonists - pharmacology | Structure-Activity Relationship | Serotonin Uptake Inhibitors - chemical synthesis | Nicotine - pharmacology | Adrenergic Uptake Inhibitors - chemistry | Nicotinic Antagonists - chemical synthesis | Analgesics - chemical synthesis | Dopamine Uptake Inhibitors - chemical synthesis | Adrenergic Uptake Inhibitors - chemical synthesis | Nicotinic Agonists - pharmacology | Cell Line | Dopamine Uptake Inhibitors - pharmacology | Bupropion - chemical synthesis | Serotonin Uptake Inhibitors - chemistry | Mice, Inbred ICR | Animals | Bupropion - chemistry | Nicotinic Antagonists - chemistry | Receptors, Nicotinic - physiology | Analgesics - chemistry | Dopamine Uptake Inhibitors - chemistry | Adrenergic Uptake Inhibitors - pharmacology | Bupropion - pharmacology | Mice | Serotonin Uptake Inhibitors - pharmacology | Smoking Cessation | Index Medicus | hydroxybupropion | antinociception | hypothermia | nAChR antagonism | norepinephrine uptake | locomotor activity | structure activity relationship | dopamine uptake | bupropion | Nicotine
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 18, pp. 5559 - 5566
Two new series of monoamine triple reuptake inhibitors (TRIs) have been discovered through scaffold homologation of our recently reported series of... 
Triple reuptake inhibitor | Dopamine | Serotonin | Monoamine reuptake inhibitors | Depression | Norepinephrine | Noradrenalin | Major depressive disorder | CHEMISTRY, MEDICINAL | SSRIS | CHEMISTRY, ORGANIC | NEXT-GENERATION | Serotonin Uptake Inhibitors - pharmacokinetics | Neurotransmitter Uptake Inhibitors - pharmacokinetics | Antidepressive Agents, Tricyclic - pharmacokinetics | Humans | Neurotransmitter Uptake Inhibitors - pharmacology | Dopamine Uptake Inhibitors - pharmacokinetics | Serotonin Uptake Inhibitors - chemical synthesis | Antidepressive Agents, Tricyclic - chemistry | Pyrrolidines - pharmacology | Depression - drug therapy | Pain - drug therapy | Drug Design | Dopamine Uptake Inhibitors - chemical synthesis | Dopamine - metabolism | Caco-2 Cells | Neurotransmitter Uptake Inhibitors - chemical synthesis | Dopamine Uptake Inhibitors - pharmacology | Pyrrolidines - pharmacokinetics | Rats | Serotonin Uptake Inhibitors - chemistry | Pyrrolidines - chemistry | Animals | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - chemical synthesis | Pyrrolidines - chemical synthesis | Antidepressive Agents, Tricyclic - pharmacology | Neurotransmitter Uptake Inhibitors - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Serotonin Uptake Inhibitors - pharmacology | Analysis | Depression, Mental | Electric utilities | Health aspects | Noradrenaline | Atmospheric carbon dioxide | Index Medicus | Brain
Journal Article
2009, ISBN 9780195368741, xvi, 304
Book
The New England Journal of Medicine, ISSN 0028-4793, 03/2006, Volume 354, Issue 12, pp. 1243 - 1252
Journal Article
Journal Article
2001, 2nd ed., Perspectives in psychiatry, ISBN 9780470841365, Volume 8, viii, 216
SSRIs have been used as an effective treatment for depression for many years, but have recently become more widely used in the treatment of many other... 
Chemotherapy | Anxiety Disorders | drug therapy | Depression, Mental | Serotonin uptake inhibitors | Anxiety | Depressive Disorder | therapeutic use | Depression, Mental - Chemotherapy
Book
Neurology, ISSN 0028-3878, 10/2006, Volume 67, Issue 8, pp. 1411 - 1420
Background: Serotonin (5-HT) and norepinephrine (NE) are involved in pain modulation via descending inhibitory pathways in the brain and spinal cord.... 
NOREPINEPHRINE REUPTAKE INHIBITOR | EFFICACY | PERSISTENT PAIN | DOUBLE-BLIND | MAJOR DEPRESSIVE DISORDER | PLACEBO-CONTROLLED TRIAL | EXTENDED-RELEASE | CLINICAL NEUROLOGY | IMIPRAMINE TREATMENT | DUAL-SEROTONIN | VENLAFAXINE | Diabetic Neuropathies - blood | Thiophenes - therapeutic use | Humans | Middle Aged | Acetaminophen - administration & dosage | Male | Palliative Care | Peripheral Nervous System Diseases - physiopathology | Thiophenes - administration & dosage | Thiophenes - blood | Peripheral Nervous System Diseases - blood | Female | Serotonin Uptake Inhibitors - blood | Adrenergic Uptake Inhibitors - blood | Acetaminophen - therapeutic use | Neuralgia - physiopathology | Drug Therapy, Combination | Diabetic Neuropathies - physiopathology | Severity of Illness Index | Adrenergic Uptake Inhibitors - therapeutic use | Double-Blind Method | Drug Administration Schedule | Serotonin Uptake Inhibitors - therapeutic use | Treatment Outcome | Analgesics, Non-Narcotic - administration & dosage | Diabetic Neuropathies - drug therapy | Analgesics, Non-Narcotic - therapeutic use | Neuralgia - drug therapy | Norepinephrine - metabolism | Neuralgia - blood | Serotonin Uptake Inhibitors - administration & dosage | Pain - physiopathology | Adrenergic Uptake Inhibitors - administration & dosage | Duloxetine Hydrochloride | Aged | Peripheral Nervous System Diseases - drug therapy | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article