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1. Full Text Uracil‐DNA glycosylases—Structural and functional perspectives on an essential family of DNA repair enzymes
by Schormann, N and Ricciardi, R and Chattopadhyay, D
Protein science, ISSN 0961-8368, 12/2014, Volume 23, Issue 12, pp. 1667 - 1685
base excision repair | DNA mimicry | DNA repair | uracil‐DNA glycosylase | uracil-DNA glycosylase | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Uracil-DNA Glycosidase - metabolism | Molecular Mimicry | DNA Repair | Humans | Uracil-DNA Glycosidase - chemistry | Substrate Specificity | Protein Conformation | DNA - metabolism | DNA - drug effects | Uracil-DNA Glycosidase - antagonists & inhibitors | Genetic research | Enzymes | Hydrolases | Pyrimidines | DNA | Bacteriology | Deoxyribonucleic acid--DNA | Substrate specificity | DNA glycosylase | Catalysis | Repair | Uracil | Base excision repair | Substrates | Mimicry | Structure-function relationships | Index Medicus | Reviews
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2. Full Text Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision
by Ahn, Woo-Chan and Aroli, Shashanka and Kim, Jin-Hahn and Moon, Jeong Hee and Lee, Ga Seal and Lee, Min-Ho and Sang, Pau Biak and Oh, Byung-Ha and Varshney, Umesh and Woo, Eui-Jeon
Nature chemical biology, ISSN 1552-4450, 06/2019, Volume 15, Issue 6, pp. 607 - 614
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Uracil-DNA Glycosidase - metabolism | Biocatalysis | DNA, Bacterial - metabolism | Uracil-DNA Glycosidase - chemistry | Models, Molecular | Protein Conformation | Uracil - metabolism | DNA Damage | Binding Sites | Mycobacterium smegmatis - enzymology | Uracil-DNA Glycosidase - genetics | Binding | Water chemistry | Histidine | Uracil-DNA glycosidase | Cytotoxicity | DNA glycosylase | Catalysis | Uracil | DNA repair | Deoxyribonucleic acid--DNA | Covalent bonds
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3. Full Text In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications
by Pałasz, Aleksandra and Cież, Dariusz
European journal of medicinal chemistry, ISSN 0223-5234, 06/2015, Volume 97, Issue 1, pp. 582 - 611
Antiviral | Antibacterial | 5-Fluorouracil | Anticancer | Fused uracils | Uracils | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Uracil - pharmacology | Animals | Humans | Uracil - chemical synthesis | Drug Discovery - methods | Uracil - chemistry | Chemistry Techniques, Synthetic - methods | Antiviral agents | Nitriles | Drug discovery | Health aspects | Gastrointestinal system | Fluorouracil | Index Medicus
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4. Full Text Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
by Zannad, Faiez, Prof and Cannon, Christopher P, Prof and Cushman, William C, Prof and Bakris, George L, Prof and Menon, Venu, MD and Perez, Alfonso T, MD and Fleck, Penny R, MBA and Mehta, Cyrus R, PhD and Kupfer, Stuart, MD and Wilson, Craig, PhD and Lam, Hung, PhD and White, William B, Prof and EXAMINE Investigators
The Lancet (British edition), ISSN 0140-6736, 2015, Volume 385, Issue 9982, pp. 2067 - 2076
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Myocardial Infarction - chemically induced | Peptide Fragments - metabolism | Double-Blind Method | Humans | Middle Aged | Natriuretic Peptide, Brain - metabolism | Risk Factors | Diabetes Mellitus, Type 2 - prevention & control | Hospitalization - statistics & numerical data | Male | Stroke - chemically induced | Uracil - adverse effects | Piperidines - adverse effects | Diabetic Cardiomyopathies - prevention & control | Female | Aged | Hypoglycemic Agents - adverse effects | Heart Failure - chemically induced | Acute Coronary Syndrome - prevention & control | Angina, Unstable - etiology | Uracil - analogs & derivatives | Heart failure | Type 2 diabetes | Clinical trials | Coronary heart disease | Patient outcomes | Mortality | Heart attacks | Biomarkers | Diabetes | Acute coronary syndromes | Drug therapy | Index Medicus | Abridged Index Medicus
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5. Full Text T-cell activation by transitory neo-antigens derived from distinct microbial pathways
by Corbett, Alexandra J and Eckle, Sidonia B. G and Birkinshaw, Richard W and Liu, Ligong and Patel, Onisha and Mahony, Jennifer and Chen, Zhenjun and Reantragoon, Rangsima and Meehan, Bronwyn and Cao, Hanwei and Williamson, Nicholas A and Strugnell, Richard A and Van Sinderen, Douwe and Mak, Jeffrey Y. W and Fairlie, David P and Kjer-Nielsen, Lars and Rossjohn, Jamie and McCluskey, James
Nature (London), ISSN 0028-0836, 2014, Volume 509, Issue 7500, pp. 361 - 365
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | T-Lymphocyte Subsets - immunology | Immunity, Mucosal - immunology | Pyrimidines - immunology | Vitamin B Complex - immunology | Glyoxal - metabolism | T-Lymphocyte Subsets - cytology | Minor Histocompatibility Antigens | Humans | Molecular Conformation | Antigens, Bacterial - immunology | Amino Sugars - immunology | Pyrimidines - chemistry | Pyrimidines - metabolism | Histocompatibility Antigens Class I - metabolism | Pyruvaldehyde - metabolism | Lymphocyte Activation - immunology | Riboflavin - metabolism | Uracil - immunology | Uracil - chemistry | Riboflavin - biosynthesis | Antigens, Bacterial - chemistry | Glyoxal - chemistry | Histocompatibility Antigens Class I - immunology | Models, Molecular | Riboflavin - immunology | Antigen Presentation - immunology | Histocompatibility Antigens Class I - chemistry | Immunity, Innate - immunology | Metabolic Networks and Pathways | Mucous Membrane - immunology | Amino Sugars - metabolism | Schiff Bases - chemistry | Ligands | Uracil - metabolism | Amino Sugars - chemistry | Pyruvaldehyde - chemistry | Vitamin B Complex - metabolism | Antigens, Bacterial - metabolism | Uracil - analogs & derivatives | Antigens | Immune response | Physiological aspects | Physiological research | Research | T cells | Properties | T cell receptors | Mutation | Metabolites | Bacteriology | Index Medicus
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6. Full Text Self-primer and self-template recycle rolling circle amplification strategy for sensitive detection of uracil-DNA glycosylase activity
by Zhang, Pingping and Wang, Lei and Zhao, Haiyan and Xu, Xiaowen and Jiang, Wei
Analytica chimica acta, ISSN 0003-2670, 02/2018, Volume 1001, pp. 119 - 124
Self-primer and self-template | Uracil-DNA glycosylase | Pre-amplicon probe | Recycle rolling circle amplification | Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Uracil-DNA Glycosidase - metabolism | Limit of Detection | Nucleic Acid Amplification Techniques - methods | Humans | Uracil-DNA Glycosidase - analysis | Enzyme Inhibitors - pharmacology | Enzyme Assays - methods | Biosensing Techniques - methods | HeLa Cells | Uracil-DNA Glycosidase - antagonists & inhibitors | Studies | Analytical chemistry | Amplification | Nicking endonuclease | Uracil-DNA glycosidase | DNA glycosylase | Diagnosis | Hybridization | Endonuclease | Uracil | Deoxyribonucleic acid--DNA | Index Medicus
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7. Full Text A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported
by Galashevskaya, Anastasia and Sarno, Antonio and Vågbø, Cathrine B and Aas, Per A and Hagen, Lars and Slupphaug, Geir and Krokan, Hans E
DNA repair, ISSN 1568-7864, 09/2013, Volume 12, Issue 9, pp. 699 - 706
Activation-induced cytidine deaminase | Adaptive immunity | Uracil DNA glycosylase | Base excision repair | DNA damage | Uracil in DNA | Toxicology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Uracil-DNA Glycosidase - metabolism | Cell Line | Limit of Detection | Tandem Mass Spectrometry - standards | Uracil Nucleotides - genetics | Humans | Chromatography, High Pressure Liquid | Mice, Knockout | DNA - genetics | Hydrolysis | Uracil Nucleotides - chemistry | Chromatography, Reverse-Phase | DNA - isolation & purification | DNA - chemistry | Reference Standards | Animals | DNA Contamination | Mice | Genome, Human | Uracil-DNA Glycosidase - genetics | Uracil Nucleotides - isolation & purification | Genetic research | Pyrimidines | Analysis | Genomics | Index Medicus
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8. Full Text On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin
by Pearson, Leanne and Mihali, Troco and Moffitt, Michelle and Kellmann, Ralf and Neilan, Brett
Marine drugs, ISSN 1660-3397, 2010, Volume 8, Issue 5, pp. 1650 - 1680
Polyketide | Alkaloid | Toxicology | Non-ribosomal peptide | Cyanotoxin | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Cyanobacteria - genetics | Uracil - isolation & purification | Marine Toxins - toxicity | Peptides, Cyclic - isolation & purification | Cyanobacteria - metabolism | Bacterial Toxins - toxicity | Marine Toxins - biosynthesis | Peptides, Cyclic - toxicity | Uracil - biosynthesis | Bacterial Toxins - isolation & purification | Peptides, Cyclic - chemistry | Uracil - toxicity | Saxitoxin - biosynthesis | Peptides, Cyclic - genetics | Marine Toxins - genetics | Saxitoxin - toxicity | Bacterial Toxins - genetics | Saxitoxin - chemistry | Saxitoxin - genetics | Microcystins - biosynthesis | Uracil - chemistry | Genes, Bacterial | Marine Toxins - isolation & purification | Microcystins - toxicity | Peptides, Cyclic - biosynthesis | Bacterial Toxins - chemistry | Bacterial Toxins - biosynthesis | Animals | Marine Toxins - chemistry | Microcystins - chemistry | Microcystins - genetics | Microcystins - isolation & purification | Saxitoxin - isolation & purification | Uracil - analogs & derivatives | Index Medicus | toxicology | non-ribosomal peptide | cyanotoxin | alkaloid | polyketide
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