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by Zhao, S and Xu, W and Jiang, W and Yu, W and Lin, Y and Zhang, T and Yao, J and Zhou, L and Zeng, Y and Li, H and Li, Y and Shi, J and An, W and Hancock, S. M and He, F and Qin, L and Chin, J and Yang, P and Chen, X and Lei, Q and Xiong, Y and Guan, K.-L
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 327, Issue 5968, pp. 1000 - 1004
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 1440-1681, 09/2007, Volume 34, Issue 9, pp. 906 - 911
SUMMARY • Arginase is the focal enzyme of the urea cycle hydrolysingl-arginine to urea andl-ornithine. Emerging studies have identified arginase in the... 
smooth muscle cell proliferation | arginine | nitric oxide synthase | diabetes | endothelial dysfunction | hypertension | arginase | Hypertension | Arginine | Endothelial dysfunction | Smooth muscle cell proliferation | Arginase | Nitric oxide synthase | Diabetes | PHYSIOLOGY | MEDIATED DILATION | I EXPRESSION | TRANSLATIONAL CONTROL | AMINO-ACID TRANSPORTER | INTIMAL HYPERPLASIA | SYNTHASE ACTIVITY | MOUSE MODEL | L-ARGININE TRANSPORT | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | Cardiovascular Diseases - physiopathology | Cell Proliferation | Reactive Oxygen Species - metabolism | Cardiovascular Diseases - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Arginase - metabolism | Endothelium, Vascular - physiopathology | Homeostasis | Cardiovascular Diseases - enzymology | Endothelium, Vascular - enzymology | Muscle, Smooth, Vascular - physiopathology | Arginine - analogs & derivatives | Collagen - metabolism | Animals | Endothelium, Vascular - metabolism | Urea - metabolism | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | Muscle, Smooth, Vascular - enzymology | Arginine - metabolism | Muscle, Smooth, Vascular, metabolism | Collagen, metabolism | Endothelium, Vascular, physiopathology | Arginine, analogs and derivatives | Nitric Oxide, metabolism | Endothelium, Vascular, metabolism | Urea, metabolism | Nitric Oxide Synthase Type III, metabolism | Arginine, metabolism | Cardiovascular Diseases, enzymology | Endothelium, Vascular, enzymology | Muscle, Smooth, Vascular, physiopathology | Cardiovascular Diseases, physiopathology | Cardiovascular Diseases, metabolism | Arginase, metabolism | Muscle, Smooth, Vascular, enzymology | Reactive Oxygen Species, metabolism | Deicing chemicals | Physiological aspects | Endothelium-derived relaxing factors | Nitric oxide
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 7, p. e0200847
.... They remain viable and functional for 4 weeks expressing typical markers of liver function such as synthesis of albumin, urea, and alpha-1 p450 drug metabolism... 
OVEREXPRESSION | HOMEOSTASIS | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | DISEASE | SENSITIVITY | SYSTEMS | LIPOPROTEIN-LIPASE | Glucose Transporter Type 4 - metabolism | Signal Transduction | Humans | Liver - metabolism | Organoids - cytology | MicroRNAs - metabolism | Necrosis - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Hepatocytes - metabolism | Insulin Receptor Substrate Proteins - metabolism | Inflammation - metabolism | Insulin - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 8 - metabolism | Organoids - metabolism | Chemokine CCL3 - metabolism | Chemokine CCL2 - metabolism | Kupffer Cells - metabolism | Liver - cytology | Interleukin-6 - metabolism | Care and treatment | MicroRNA | Liver diseases | Development and progression | Insulin resistance | Inflammation | Research | Laboratories | Liver | Kupffer cells | Fluorescence | Lipids | Interleukin 6 | Liver cancer | Fatty liver | Organoids | Rodents | Gastroenterology | Drug metabolism | Lipoprotein (low density) receptors | Inhibition | Lipid metabolism | Stellate cells | Cytokines | Incubation | Internal medicine | CCL3 protein | Regression analysis | Gene expression | Metabolism | Ribonucleic acid--RNA | Insulin | Patients | Fatty acids | Endothelial cells | Gelatinase B | Steatosis | Medicine | Urea | Signaling | Hepatocytes | Tumor necrosis factor | Pharmacy | Fibrosis | Neutrophil collagenase | Diabetes | Chemokines | Monocyte chemoattractant protein 1 | Metabolic disorders | RNA | Ribonucleic acid
Journal Article
International journal of legal medicine, ISSN 1437-1596, 2012, Volume 127, Issue 2, pp. 267 - 276
Journal Article
Amino acids, ISSN 1438-2199, 2016, Volume 49, Issue 1, pp. 129 - 138
.... Oxidative stress is involved in the pathophysiology of many inborn errors of metabolism. However, little is known about the role of oxidative damage in hepatic and renal changes in hypermethioninemia... 
Life Sciences | Biochemistry, general | Oxidative stress | Analytical Chemistry | Life Sciences, general | Methionine sulfoxide | Biochemical Engineering | Proteomics | Neurobiology | Methionine | Delta aminolevulinic dehydratase | LIPID-PEROXIDATION | ANTIOXIDANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DELTA-AMINOLEVULINATE DEHYDRATASE | DAMAGE | HYPERMETHIONINEMIA | METABOLISM | FAT | ADENOSYLTRANSFERASE I/III DEFICIENCY | PROTEINS | RESIDUES | Glycine N-Methyltransferase - metabolism | Liver - pathology | Reactive Oxygen Species - metabolism | Kidney - pathology | Rats, Wistar | Glycine N-Methyltransferase - deficiency | Male | Methionine - pharmacology | Porphobilinogen Synthase - metabolism | Amino Acid Metabolism, Inborn Errors - metabolism | Kidney - metabolism | Sulfhydryl Compounds - metabolism | Liver - drug effects | Methionine - analogs & derivatives | Injections, Subcutaneous | Female | Urea - metabolism | Amino Acid Metabolism, Inborn Errors - pathology | Superoxide Dismutase - metabolism | Glutathione Peroxidase - metabolism | Amino Acid Metabolism, Inborn Errors - chemically induced | Kidney - drug effects | Methionine - metabolism | Liver - metabolism | Rats | Thiobarbituric Acid Reactive Substances - metabolism | Cholesterol - metabolism | Enzyme Activation - drug effects | Triglycerides - metabolism | Catalase - metabolism | Animals | Glucose - metabolism | Oxidative Stress - drug effects | Lipid Peroxidation | Enzymes | Urea | Liver | Physiological aspects | Amino acids | Triglycerides | Superoxide | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 2015, Volume 239, Issue 2, pp. 393 - 400
Abstract Objective The pathogenic events responsible for accelerated atherosclerosis in patients with chronic renal failure (CRF) are poorly understood. Here... 
Cardiovascular | MnTBAP | chronic renal failure | UCP-1 | Endothelial cells | uncoupling protein 1 | Urea | O-linked-N-acetylglucosamine | manganese tetrakis (4-benzoic acid) porphyrin | CRF | ROS | reactive oxygen species | GlcNAc | Prostacyclin synthase | Reactive oxygen species | Chronic renal failure | Manganese tetrakis (4-benzoic acid) porphyrin | Uncoupling protein 1 | OXIDATIVE STRESS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PREDICTOR | ATHEROSCLEROSIS | INSULIN-RESISTANCE | CARDIOVASCULAR-DISEASE | GENE-EXPRESSION | HIGH GLUCOSE | PERIPHERAL VASCULAR DISEASE | CHRONIC KIDNEY-DISEASE | Tumor Necrosis Factor-alpha - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Cytochrome P-450 Enzyme System - metabolism | Endothelium, Vascular - drug effects | Aorta - metabolism | Urea - chemistry | Antigens, CD - metabolism | Endoglin | Atherosclerosis - enzymology | Kidney Failure, Chronic - chemically induced | Chemokine CCL2 - metabolism | Endothelium - enzymology | Intramolecular Oxidoreductases - metabolism | Interleukin-6 - metabolism | Superoxide Dismutase - metabolism | Atherosclerosis - physiopathology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Random Allocation | Atherosclerosis - metabolism | Kidney Failure, Chronic - metabolism | Catalase - metabolism | Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - metabolism | Animals | Endothelium, Vascular - pathology | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Chronic kidney failure | Atherosclerosis | Endothelium
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7656, pp. 168 - 172
.... The oncogene KRAS and tumour suppressor STK11, which encodes the kinase LKB1, regulate metabolism and are frequently mutated in non-small-cell lung cancer (NSCLC... 
REPLICATION | METABOLISM | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | AMPK | LKB1 | Carbamyl Phosphate - metabolism | Metabolomics | AMP-Activated Protein Kinases - metabolism | Cell Proliferation | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Pyrimidines - metabolism | S Phase | Cell Death | DNA - biosynthesis | Female | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Carbamoyl-Phosphate Synthase (Ammonia) - genetics | Carcinoma, Non-Small-Cell Lung - pathology | DNA Damage - drug effects | Lung Neoplasms - genetics | Nitrogen - metabolism | Lung Neoplasms - enzymology | Ammonia - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Purines - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | DNA Replication | Mitochondria - metabolism | Pyrimidines - pharmacology | Xenograft Model Antitumor Assays | Animals | Carbamoyl-Phosphate Synthase (Ammonia) - metabolism | Bicarbonates - metabolism | Mice | Carcinoma, Non-Small-Cell Lung - enzymology | DNA-Directed DNA Polymerase - metabolism | Carbamoyl-Phosphate Synthase (Ammonia) - deficiency | Pyrimidines | Gene mutations | Lung cancer | Cancer cells | Genetic aspects | Nucleotide sequencing | Health aspects | Methods | DNA sequencing | Correlation | Transcription | DNA polymerase | Toxicity | DNA damage | Oncology | K-Ras protein | LKB1 protein | Bicarbonate | Mitochondria | Phosphate | Carbonates | Signatures | Damage | Stalling | Deoxyribonucleic acid--DNA | Enzymes | Mortality | Non-small cell lung carcinoma | Nitrogen | Pools | Metabolism | Gene expression | Flow | DNA biosynthesis | Ammonia | Urea | Depletion | Lungs | Carbamoyl phosphate | Cell death | Human behavior | Tumors | Cancer | Index Medicus
Journal Article
Biochimie, ISSN 0300-9084, 2015, Volume 119, pp. 146 - 165
Creatine is physiologically provided equally by diet and by endogenous synthesis from arginine and glycine with successive involvements of arginine glycine... 
GAMT | CRTR | SLC6A8 | AGAT | AMP activated protein kinase | Creatine | Secondary creatine disorders | GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXYGEN SPECIES GENERATION | UREA CYCLE DISORDERS | MAGNETIC-RESONANCE-SPECTROSCOPY | RAT-KIDNEY TRANSAMIDINASE | LINKED MENTAL-RETARDATION | ACUTE MYOCARDIAL-INFARCTION | TERM-FOLLOW-UP | ARGININE-GLYCINE AMIDINOTRANSFERASE | Amino Acid Transport Systems, Basic - genetics | Humans | Nerve Tissue Proteins - deficiency | Movement Disorders - diagnosis | Amidinotransferases - genetics | Intellectual Disability - metabolism | Biological Transport, Active | Gyrate Atrophy - enzymology | Amino Acid Metabolism, Inborn Errors - genetics | Intellectual Disability - enzymology | Brain Diseases, Metabolic, Inborn - genetics | Hyperammonemia - diagnosis | Hyperammonemia - genetics | Creatine - genetics | Urea Cycle Disorders, Inborn - metabolism | Creatine - biosynthesis | Gyrate Atrophy - genetics | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Guanidinoacetate N-Methyltransferase - metabolism | Amidinotransferases - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Language Development Disorders - enzymology | Urea Cycle Disorders, Inborn - diagnosis | Energy Metabolism | Urea Cycle Disorders, Inborn - enzymology | Movement Disorders - genetics | Mutation | Ornithine - deficiency | Amino Acid Transport Systems, Basic - metabolism | Amino Acid Metabolism, Inborn Errors - enzymology | S-Adenosylmethionine - metabolism | AMP-Activated Protein Kinases - metabolism | Hyperammonemia - metabolism | Developmental Disabilities - metabolism | Guanidinoacetate N-Methyltransferase - genetics | Ornithine - genetics | Developmental Disabilities - genetics | Language Development Disorders - metabolism | Brain Diseases, Metabolic, Inborn - enzymology | Brain Diseases, Metabolic, Inborn - diagnosis | Intellectual Disability - genetics | Amino Acid Metabolism, Inborn Errors - diagnosis | Amino Acid Metabolism, Inborn Errors - metabolism | Mental Retardation, X-Linked - genetics | Mental Retardation, X-Linked - enzymology | Developmental Disabilities - enzymology | Language Development Disorders - diagnosis | Mental Retardation, X-Linked - diagnosis | Movement Disorders - enzymology | Creatine - metabolism | Hyperammonemia - enzymology | Creatine - deficiency | Gyrate Atrophy - diagnosis | Developmental Disabilities - diagnosis | Speech Disorders - diagnosis | Plasma Membrane Neurotransmitter Transport Proteins - deficiency | Speech Disorders - metabolism | Amidinotransferases - deficiency | Brain Diseases, Metabolic, Inborn - metabolism | Language Development Disorders - genetics | Ornithine - metabolism | Gyrate Atrophy - metabolism | Prenatal Diagnosis | Speech Disorders - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Amino Acid Transport Systems, Basic - deficiency | Movement Disorders - metabolism | Animals | Urea Cycle Disorders, Inborn - genetics | Guanidinoacetate N-Methyltransferase - deficiency | Intellectual Disability - diagnosis | Movement Disorders - congenital | Speech Disorders - enzymology | Methylation | Mental Retardation, X-Linked - metabolism | Antioxidants | Phosphates | Algorithms | Animal behavior | Physiological aspects | GABA | Glycine | Phosphotransferases | Medical research | Medicine, Experimental | Protein kinases | Life Sciences
Journal Article