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Journal of Bone and Mineral Research, ISSN 0884-0431, 02/2012, Volume 27, Issue 2, pp. 474 - 485
Vascular calcification is closely related to cardiovascular morbidity and mortality. Accumulating data indicate that oxidative stress is associated with... 
ARTERIAL MEDIAL CALCIFICATION | OXIDATIVE STRESS | CHRONIC KIDNEY DISEASE | TEMPOL | ANTIOXIDANT | VITAMIN-D | BONE DISORDER | AORTIC-VALVE | ALL-CAUSE | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR MORTALITY | HEMODIALYSIS-PATIENTS | ANIMAL-MODELS | CARDIAC-VALVE CALCIFICATION | SMOOTH-MUSCLE-CELLS | STAGE RENAL-DISEASE | Tunica Media - pathology | Kidney - pathology | Tunica Media - drug effects | Myocytes, Smooth Muscle - pathology | NADPH Oxidases - metabolism | Male | Spin Labels | Aorta, Abdominal - drug effects | Hyperphosphatemia - pathology | Hyperphosphatemia - blood | Kidney - metabolism | Calcinosis - etiology | Uremia - pathology | Cyclic N-Oxides - pharmacology | Kidney Failure, Chronic - pathology | Cell Transdifferentiation - drug effects | Aorta, Abdominal - pathology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Biomarkers - metabolism | Hyperphosphatemia - complications | Kidney - drug effects | Osteoblasts - drug effects | Osteogenesis - drug effects | Rats | Arteries - drug effects | Antioxidants - pharmacology | Arteries - pathology | Calcinosis - blood | Uremia - complications | Aorta, Abdominal - enzymology | Rats, Sprague-Dawley | Osteoblasts - pathology | Phenotype | Animals | Kidney Failure, Chronic - blood | Uremia - blood | Kidney Failure, Chronic - complications | Calcinosis - prevention & control | Oxidative Stress - drug effects | Calcinosis - pathology | Osteoblasts - metabolism | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2012, Volume 32, Issue 11, pp. 2580 - 2588
OBJECTIVE—Vascular calcification significantly increases cardiovascular morbidity and mortality. We recently reported that the deficiency of cartilage... 
Smooth muscle cell | Calcification | Animal model of human disease remodeling | MicroRNA | Protease | animal model of human disease remodeling | CELLS | smooth muscle cell | PATHOBIOLOGY | MECHANISMS | OLIGOMERIC MATRIX PROTEIN | protease | PHOSPHATE | IN-VITRO | ROLES | ARTERIAL CALCIFICATION | ANEURYSM DEVELOPMENT | microRNA | PERIPHERAL VASCULAR DISEASE | calcification | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | Up-Regulation | Carotid Artery Diseases - chemically induced | Humans | MicroRNAs - metabolism | Matrilin Proteins | Nephrectomy | RNA Interference | Time Factors | Carotid Artery Diseases - pathology | Transcription, Genetic | 3' Untranslated Regions | Real-Time Polymerase Chain Reaction | Organ Culture Techniques | Disease Models, Animal | Uremia - enzymology | Myocytes, Smooth Muscle - enzymology | Down-Regulation | Computational Biology | Rats | Vascular Calcification - pathology | Rats, Sprague-Dawley | Kidney Failure, Chronic - genetics | ADAM Proteins - metabolism | Aortic Diseases - genetics | Carotid Artery Diseases - enzymology | Carotid Artery, Common - enzymology | Carotid Artery Diseases - genetics | Kidney Failure, Chronic - complications | ADAMTS7 Protein | Carotid Artery, Common - pathology | ADAM Proteins - genetics | Muscle, Smooth, Vascular - enzymology | Vascular Calcification - genetics | Glycoproteins - metabolism | Myocytes, Smooth Muscle - pathology | Aortic Diseases - chemically induced | Transfection | Uremia - pathology | Female | Vascular Calcification - enzymology | Aortic Diseases - enzymology | Aorta, Abdominal - pathology | Kidney Failure, Chronic - enzymology | Extracellular Matrix Proteins - metabolism | Aortic Diseases - pathology | Promoter Regions, Genetic | Calcium Chloride | Cartilage Oligomeric Matrix Protein | Cells, Cultured | Aorta, Abdominal - enzymology | Gene Expression Regulation, Enzymologic | Muscle, Smooth, Vascular - pathology | Animals | Vascular Calcification - chemically induced | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2010, Volume 30, Issue 9, pp. 1741 - 1750
OBJECTIVE—To investigate cell biological changes in calcified aortas of rats that experienced chronic renal failure. METHODS AND RESULTS—Vascular smooth muscle... 
molecular biology | vascular biology | chondrocytes | medial calcification | chronic renal failure | PHOSPHORUS | DEPENDENT PHOSPHATE COTRANSPORTER | ARTERY CALCIFICATION | BONE-FORMATION | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | MICE | GROWTH-FACTOR | DIFFERENTIATION | HEMATOLOGY | STAGE RENAL-DISEASE | Aortic Diseases - diagnostic imaging | Calcinosis - genetics | Immunohistochemistry | Biomarkers - urine | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | Myocytes, Smooth Muscle - pathology | Calcinosis - diagnostic imaging | Male | Uremia - diagnostic imaging | Cell Transdifferentiation - genetics | Uremia - metabolism | RNA, Messenger - metabolism | X-Ray Microtomography | Aortic Diseases - metabolism | Uremia - genetics | Calcium - blood | Muscle, Smooth, Vascular - diagnostic imaging | Calcinosis - etiology | Time Factors | Uremia - pathology | Kidney Failure, Chronic - pathology | Calcinosis - metabolism | Myocytes, Smooth Muscle - metabolism | Chondrocytes - metabolism | Aortic Diseases - pathology | Disease Models, Animal | Chondrocytes - pathology | Gene Expression Regulation | Adenine | Kidney Failure, Chronic - diagnostic imaging | Rats | Biomarkers - blood | Calcium - urine | Reverse Transcriptase Polymerase Chain Reaction | Kidney Failure, Chronic - metabolism | Kidney Failure, Chronic - genetics | Osteoblasts - pathology | Phosphorus, Dietary | Aortic Diseases - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Uremia - etiology | Calcinosis - pathology | Osteoblasts - metabolism | Aortic Diseases - etiology | Kidney Failure, Chronic - etiology | Index Medicus
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 2015, Volume 309, Issue 11, pp. F967 - F979
Vascular calcification (VC) is a critical complication in patients with chronic kidney disease (CKD). The effects of spironolactone (SPL), a mineralocorticoid... 
Hyperphosphatemia | Vascular calcification | Chronic kidney disease | Spironolactone | Mineralocorticoid receptor | chronic kidney disease | OXIDATIVE STRESS | PHYSIOLOGY | vascular calcification | HEART-FAILURE | CELL-PROLIFERATION | SERUM | mineralocorticoid receptor | spironolactone | PHOSPHATE | hyperphosphatemia | INFLAMMATION | REGULATED KINASE 1 | ALDOSTERONE BLOCKADE | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | CHRONIC-RENAL-FAILURE | Kidney - pathology | Apoptosis - drug effects | Humans | Uremia - physiopathology | Uremia - drug therapy | Male | Aorta, Abdominal - drug effects | Hyperphosphatemia - blood | Kidney - metabolism | Time Factors | Tunica Media - metabolism | Mineralocorticoid Receptor Antagonists - pharmacology | Aortic Diseases - prevention & control | Disease Models, Animal | Kidney - drug effects | Biomarkers - blood | Vascular Calcification - pathology | Rats, Sprague-Dawley | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Signal Transduction - drug effects | Hyperphosphatemia - drug therapy | Renal Insufficiency, Chronic - chemically induced | Tunica Media - pathology | Tunica Media - drug effects | Receptors, Mineralocorticoid - metabolism | Aortic Diseases - blood | Aortic Diseases - chemically induced | Renal Insufficiency, Chronic - drug therapy | Dose-Response Relationship, Drug | Receptors, Mineralocorticoid - drug effects | Uremia - chemically induced | Spironolactone - pharmacology | Uremia - pathology | Vascular Calcification - physiopathology | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Kidney - physiopathology | Aortic Diseases - pathology | Osteogenesis - drug effects | Vascular Calcification - blood | Adenine | Vascular Calcification - prevention & control | Renal Insufficiency, Chronic - pathology | Renal Insufficiency, Chronic - blood | Aortic Diseases - physiopathology | Animals | Uremia - blood | Vascular Calcification - chemically induced | Renin-Angiotensin System - drug effects | Antiandrogens | Calcification | Corticosteroids | Chronic kidney failure | Steroids | Cellular signal transduction | Observations | Health aspects | Signal transduction | Oxidative stress | Rodents | Blood pressure | Kidney diseases | Apoptosis | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 11/2003, Volume 64, Issue 5, pp. 1653 - 1661
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 12/2013, Volume 84, Issue 6, pp. 1145 - 1153
The role of hyperphosphatemia in the pathogenesis of secondary hyperparathyroidism, cardiovascular disease, and progression of renal failure is widely known.... 
mortality | phosphate | renal failure | FGF-23 | PTH | vascular calcification | MONCKEBERGS SCLEROSIS | MAINTENANCE HEMODIALYSIS-PATIENTS | CORONARY-ARTERY CALCIFICATION | DIALYSIS PATIENTS | GROWTH-FACTOR 23 | UROLOGY & NEPHROLOGY | LEFT-VENTRICULAR MASS | CHRONIC KIDNEY-DISEASE | REGULATING PROTEINS | STAGE RENAL-DISEASE | SEVELAMER HYDROCHLORIDE | Kidney - pathology | Calcium - metabolism | Phosphates - administration & dosage | Hyperphosphatemia - metabolism | Osteopontin - metabolism | Uremia - metabolism | Aorta - metabolism | Parathyroid Hormone - blood | Core Binding Factor Alpha 1 Subunit - metabolism | Uremia - therapy | Hyperphosphatemia - pathology | Vascular Calcification - metabolism | Kidney - metabolism | Time Factors | Uremia - pathology | Vascular Calcification - etiology | Myocardium - metabolism | Phosphates - blood | Female | Sevelamer | Hyperphosphatemia - therapy | Disease Models, Animal | Kidney - drug effects | Aorta - drug effects | Rats | Myocardium - pathology | Biomarkers - blood | Chelating Agents - pharmacology | Vascular Calcification - pathology | Rats, Sprague-Dawley | Aorta - pathology | Polyamines - pharmacology | Animals | Diet | Fibroblast Growth Factors - blood | Hyperphosphatemia - etiology | Fibrosis | Phosphates - deficiency | Uremia - etiology | Vascular Calcification - therapy | Index Medicus | Aorta
Journal Article