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1. Full Text Insulin resistance in chronic kidney disease: New lessons from experimental models
by Koppe, Laetitia and Pelletier, Caroline C and Alix, Pascaline M and Kalbacher, Emilie and Fouque, Denis and Soulage, Christophe O and Guebre-Egziabher, Fitsum
Nephrology Dialysis Transplantation, ISSN 0931-0509, 2014, Volume 29, Issue 9, pp. 1666 - 1674
Insulin resistance (IR) is a common feature of chronic kidney disease (CKD), but the underlying mechanisms still remain unclear. A growing body of evidence... 
Insulin resistance | Chronic kidney disease | Inflammation | Uraemic toxins | Lipotoxicity | chronic kidney disease | METABOLIC SYNDROME | UREMIC HUMAN-SERUM | MUSCLE | NECROSIS-FACTOR-ALPHA | TIGHT JUNCTION | TRANSPLANTATION | RECEPTOR KINASE | uraemic toxins | inflammation | CHRONIC RENAL-FAILURE | lipotoxicity | HEMODIALYSIS-PATIENTS | UROLOGY & NEPHROLOGY | insulin resistance | ADIPOSE-TISSUE | GLUCOSE-PRODUCTION | Humans | Uremia - physiopathology | Homeostasis | Adipose Tissue, White - physiopathology | Obesity - physiopathology | Liver - physiopathology | Renal Insufficiency, Chronic - physiopathology | Animals | Intestines - microbiology | Insulin Resistance - physiology | Muscle, Skeletal - physiopathology | Models, Animal | Signal Transduction - physiology | Energy Metabolism - physiology | Inflammation - physiopathology | Index Medicus | Life Sciences
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2. Full Text Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity
by Lilitkarntakul, Pajaree and Dhaun, Neeraj and Melville, Vanessa and Blackwell, Scott and Talwar, Dinesh K and Liebman, Barbara and Asai, Takae and Pollock, Jennifer and Goddard, Jane and Webb, David J
Atherosclerosis, ISSN 0021-9150, 2011, Volume 216, Issue 1, pp. 217 - 225
Abstract Introduction Patients with chronic kidney disease (CKD) have increased risk of cardiovascular disease to which co-morbidity and associated... 
Cardiovascular | Oxidative stress | Asymmetric dimethylarginine | Chronic kidney disease | Inflammation | Endothelin | Nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | AORTIC STIFFNESS | FAILURE | HYPERTENSIVE PATIENTS | DIMETHYLARGININE ADMA LEVELS | RISK-FACTOR | DEPENDENT VASODILATATION | CARDIOVASCULAR-DISEASE | HEMODIALYSIS-PATIENTS | PERIPHERAL VASCULAR DISEASE | STAGE RENAL-DISEASE | Blood Pressure | Kidney Diseases - physiopathology | Prospective Studies | Compliance | Pulsatile Flow | Humans | Middle Aged | Uremia - physiopathology | Male | Scotland - epidemiology | Arginine - analogs & derivatives | Case-Control Studies | Vasodilation | Kidney Diseases - epidemiology | Peripheral Arterial Disease - blood | Adult | Brachial Artery - physiopathology | Female | Kidney Diseases - blood | Uremia - epidemiology | C-Reactive Protein - analysis | Kidney - physiopathology | Glomerular Filtration Rate | Cross-Sectional Studies | Risk Assessment | Comorbidity | Femoral Artery - physiopathology | Risk Factors | Endothelium, Vascular - physiopathology | Linear Models | Biomarkers - blood | Disease Progression | Endothelin-1 - blood | Peripheral Arterial Disease - physiopathology | Analysis of Variance | Carotid Arteries - physiopathology | Peripheral Arterial Disease - epidemiology | Arginine - blood | Isoprostanes - blood | Chronic Disease | Care and treatment | Chronic kidney failure | Atherosclerosis | Blood pressure | Risk factors | Endothelium | Index Medicus
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3. Full Text Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study
by Niewczas, Monika A and Sirich, Tammy L and Mathew, Anna V and Skupien, Jan and Mohney, Robert P and Warram, James H and Smiles, Adam and Huang, Xiaoping and Walker, Walker and Byun, Jaeman and Karoly, Edward D and Kensicki, Elizabeth M and Berry, Gerard T and Bonventre, Joseph V and Pennathur, Subramaniam and Meyer, Timothy W and Krolewski, Andrzej S
Kidney International, ISSN 0085-2538, 05/2014, Volume 85, Issue 5, pp. 1214 - 1224
Here we studied plasma metabolomic profiles as determinants of progression to end-stage renal disease (ESRD) in patients with type 2 diabetes (T2D). This... 
uremic toxins | end-stage renal disease | diabetic nephropathy | metabolomic study | End-stage renal disease | Metabolomic study | Diabetic nephropathy | Uremic toxins | KIDNEY-DISEASE | MYOINOSITOL OXYGENASE | AMINO-ACID | METABONOMICS | PSEUDOURIDINE | TOXINS | UROLOGY & NEPHROLOGY | PROTEIN C-MANNOSYLATION | MOLECULAR-CLONING | SERUM | MASS-SPECTROMETRY | Glycated Hemoglobin A - analysis | Uremia - diagnosis | Diabetic Nephropathies - etiology | Humans | Middle Aged | Uremia - physiopathology | Male | Diabetic Nephropathies - blood | Diabetic Nephropathies - diagnosis | Case-Control Studies | Diabetic Nephropathies - physiopathology | Time Factors | Mass Spectrometry | Female | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology | Boston | Kidney Failure, Chronic - physiopathology | Glomerular Filtration Rate | Kidney Failure, Chronic - diagnosis | Biomarkers - blood | Metabolomics - methods | Disease Progression | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Kidney Failure, Chronic - blood | Uremia - blood | Amino Acids, Essential - blood | Aged | Uremia - etiology | Kidney Failure, Chronic - etiology | Index Medicus
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4. Full Text Simultaneous liver, pancreas-duodenum and kidney transplantation in a patient with hepatitis B cirrhosis, uremia and insulin dependent diabetes mellitus
by Jiang Li Qing-Jun Guo Jin-Zhen Cai Cheng Pan Zhong-Yang Shen Wen-Tao Jiang
世界胃肠病学杂志：英文版, ISSN 1007-9327, 2017, Volume 23, Issue 45, pp. 8104 - 8108
Simultaneous liver,pancreas-duodenum,and kidney transplantation has been rarely reported in the literature. Here we present a new and more efficient en bloc... 
Cirrhosis | En bloc | Liver-pancreas | Transplantation | Chronic renal failure | Insulin dependent diabetes mellitus | WOLCOTT-RALLISON SYNDROME | DISEASE | NONALCOHOLIC STEATOHEPATITIS | RECIPIENTS | GASTROENTEROLOGY & HEPATOLOGY | PRIMARY SCLEROSING CHOLANGITIS | Diabetes Mellitus, Type 1 - surgery | Humans | Uremia - physiopathology | Hepatitis B - virology | Uremia - surgery | Male | End Stage Liver Disease - blood | Hepatitis B - blood | Kidney Transplantation - methods | Hepatitis B - physiopathology | End Stage Liver Disease - surgery | Liver Transplantation - methods | Renal Insufficiency - physiopathology | Duodenum - transplantation | Adult | Renal Insufficiency - blood | Renal Insufficiency - surgery | Diabetes Mellitus, Type 1 - physiopathology | Liver Cirrhosis - blood | End Stage Liver Disease - physiopathology | Ileum | Hepatitis B - surgery | Liver Cirrhosis - virology | Pancreas Transplantation - methods | Uremia - blood | Diabetes Mellitus, Type 1 - blood | Liver Cirrhosis - surgery | Liver Cirrhosis - physiopathology | End Stage Liver Disease - virology | Transplantation, Heterotopic - methods | Index Medicus | Case Report
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5. Full Text Artery calcification in uremic rats is increased by a low protein diet and prevented by treatment with ibandronate
by Price, P.A and Roublick, A.M and Williamson, M.K
Kidney International, ISSN 0085-2538, 11/2006, Volume 70, Issue 9, pp. 1577 - 1583
The present experiments investigate medial artery calcification in adult rats made uremic by feeding a synthetic diet containing 0.75% adenine for 4 weeks.... 
low protein diet | chronic kidney disease | bone Gla protein (osteocalcin) | medial artery calcification | ibandronate | Chronic kidney disease | Bone Gla protein (osteocalcin) | Ibandronate | Low protein diet | Medial artery calcification | FETUIN-MINERAL COMPLEX | VITAMIN-D | INHIBIT BONE-RESORPTION | MATRIX GLA PROTEIN | VASCULAR CALCIFICATION | SERUM | WARFARIN | ELASTIC LAMELLAE | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | STAGE RENAL-DISEASE | Vascular Diseases - prevention & control | Kidney - blood supply | Renal Artery - pathology | Bone Density - physiology | Vascular Diseases - etiology | Uremia - physiopathology | Male | alpha-Fetoproteins - analysis | Bone and Bones - drug effects | Osteocalcin - blood | Calcinosis - etiology | Uremia - pathology | Diet, Protein-Restricted - adverse effects | Dietary Proteins - pharmacology | Diphosphonates - therapeutic use | Calcium-Binding Proteins - blood | Kidney - physiopathology | Bone Resorption - physiopathology | Bone Resorption - drug therapy | Bone Density Conservation Agents - therapeutic use | Rats | Extracellular Matrix Proteins - blood | Vascular Diseases - physiopathology | Rats, Sprague-Dawley | Bone Density - drug effects | Bone and Bones - physiopathology | Animals | Uremia - blood | Calcinosis - prevention & control | Renal Artery - drug effects | Calcinosis - physiopathology | Index Medicus
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6. Full Text Role of Nrf2 Dysfunction in Uremia-Associated Intestinal Inflammation and Epithelial Barrier Disruption
by Lau, Wei Ling and Liu, Shu-Man and Pahlevan, Sogol and Yuan, Jun and Khazaeli, Mahyar and Ni, Zhenmin and Chan, Jefferson Y and Vaziri, Nosratola D
Digestive Diseases and Sciences, ISSN 0163-2116, 5/2015, Volume 60, Issue 5, pp. 1215 - 1222
Gut inflammation is prevalent in chronic kidney disease (CKD) and likely contributes to systemic inflammation via disruption of the epithelial tight junction... 
Biochemistry, general | Medicine & Public Health | Nrf2 | Hepatology | Gastroenterology | Oncology | Colon inflammation | Chronic kidney disease | Transplant Surgery | Epithelial tight junction | OXIDATIVE STRESS | ENDOTOXEMIA | MICROBIOTA | TIGHT JUNCTION | SYSTEMIC INFLAMMATION | GUT BACTERIAL TRANSLOCATION | TRANSCRIPTION FACTOR NRF2 | HEMODIALYSIS-PATIENTS | CARDIOVASCULAR-DISEASE | CHRONIC KIDNEY-DISEASE | GASTROENTEROLOGY & HEPATOLOGY | Intestinal Mucosa - metabolism | Intestinal Mucosa - physiopathology | Oxidative Stress | Oleanolic Acid - analogs & derivatives | Uremia - physiopathology | Colon - drug effects | Oleanolic Acid - pharmacology | Colitis - pathology | Male | NF-E2-Related Factor 2 - agonists | Uremia - metabolism | Renal Insufficiency, Chronic - complications | Case-Control Studies | Intestinal Mucosa - drug effects | Renal Insufficiency, Chronic - metabolism | Nephrectomy | Inflammation Mediators - metabolism | Colon - physiopathology | Colitis - drug therapy | Tight Junction Proteins - metabolism | Disease Models, Animal | Biomarkers - metabolism | Tight Junctions - metabolism | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Rats, Sprague-Dawley | Renal Insufficiency, Chronic - physiopathology | Colon - metabolism | Colitis - etiology | Animals | Colitis - physiopathology | NF-E2-Related Factor 2 - metabolism | Colitis - metabolism | Uremia - etiology | Intestinal Mucosa - pathology | Proteins | Yuan (China) | Inflammation | Colitis | Chronic kidney failure | Analysis | Index Medicus | Abridged Index Medicus
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7. Full Text Elevated Circulating Levels and Tissue Expression of Pentraxin 3 in Uremia: A Reflection of Endothelial Dysfunction
by Witasp, Anna and Rydén, Mikael and Carrero, Juan Jesús and Qureshi, Abdul Rashid and Nordfors, Louise and Näslund, Erik and Hammarqvist, Folke and Arefin, Samsul and Kublickiene, Karolina and Stenvinkel, Peter
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e63493 - e63493
Elevated systemic pentraxin 3 (PTX3) levels appear to be a powerful marker of inflammatory status and a superior outcome predictor in patients with chronic... 
C-REACTIVE PROTEIN | HUMAN ADIPOSE-TISSUE | INFLAMMATORY MARKER | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | ACUTE MYOCARDIAL-INFARCTION | RECOGNITION RECEPTOR PTX3 | CARDIOVASCULAR-DISEASE | HEMODIALYSIS-PATIENTS | CHRONIC KIDNEY-DISEASE | STAGE RENAL-DISEASE | Prognosis | Humans | Middle Aged | Uremia - physiopathology | Male | Uremia - metabolism | Renal Insufficiency, Chronic - complications | RNA, Messenger - metabolism | Arginine - analogs & derivatives | Case-Control Studies | Renal Insufficiency, Chronic - metabolism | Cardiovascular Diseases - complications | Kidney - metabolism | C-Reactive Protein - metabolism | Adult | Female | Kidney - physiopathology | Biomarkers - metabolism | Cardiovascular Diseases - physiopathology | Gene Expression | Vascular Resistance | Cardiovascular Diseases - metabolism | RNA, Messenger - genetics | C-Reactive Protein - genetics | Renal Insufficiency, Chronic - physiopathology | Endothelium - physiopathology | Serum Amyloid P-Component - genetics | Subcutaneous Fat, Abdominal - pathology | Endothelium - metabolism | Aged | Serum Amyloid P-Component - metabolism | Uremia - etiology | Subcutaneous Fat, Abdominal - metabolism | Arginine - metabolism | Adipose tissues | Immunohistochemistry | Medical research | Chronic kidney failure | RNA | Nitric oxide | Medicine, Experimental | Endothelium | Heart attacks | Adipose tissue | Science | Cardiovascular disease | Adipocytes | Males | Arteries | Prostaglandin endoperoxide synthase | Proteins | Surgery | Atherosclerosis | Tumor necrosis factor-TNF | Divisions | Age | Pentraxins | Obesity | Complications | Mortality | Gynecology | Inflammation | Gene expression | Disease control | Patients | Obstetrics | Nitric-oxide synthase | Endothelial cells | Medicine | Preeclampsia | Insulin resistance | Diabetes | Kidney diseases | Immunoreactivity | Cardiovascular diseases | Uremia | Kidney transplantation | Index Medicus
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8. Full Text Is the kidney just a modified blood vessel? Unravelling the direction of causality between cardiovascular and renal disease
by Tomlinson, Laurie A and Holt, Stephen G
Atherosclerosis, ISSN 0021-9150, 2011, Volume 216, Issue 2, pp. 275 - 276
Cardiovascular | Cardiovascular disease | Vascular stiffness | Renal failure | MODERATE | EVENTS | ARTERIAL STIFFNESS | INFLAMMATION | RISK | PERIPHERAL VASCULAR DISEASE | PREVALENCE | ASYMMETRIC DIMETHYLARGININE ADMA | CKD | Blood Pressure | Kidney Diseases - physiopathology | Peripheral Arterial Disease - physiopathology | Carotid Arteries - physiopathology | Femoral Artery - physiopathology | Humans | Uremia - physiopathology | Endothelium, Vascular - physiopathology | Brachial Artery - physiopathology | Female | Male | Vasodilation | Index Medicus
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9. Full Text Electrocardiographic abnormalities and uremic cardiomyopathy
by Stewart, Graham A and Gansevoort, R.O.N. T and Mark, Patrick B and Rooney, Esther and Mcdonagh, Theresa A and Dargie, Henry J and Stuart, R and Rodger, C and Jardine, Alan G
Kidney International, ISSN 0085-2538, 01/2005, Volume 67, Issue 1, pp. 217 - 226
Electrocardiographic abnormalities and uremic cardiomyopathy. Progressive renal disease is associated with an increased risk of cardiovascular death,... 
dialysis | QT interval | left ventricular hypertrophy | chronic renal failure | arrhythmia | transplantation | hypertension | Hypertension | Chronic renal failure | Arrhythmia | Left ventricular hypertrophy | Dialysis | Transplantation | YOUNG-ADULTS | POLYCYSTIC KIDNEY-DISEASE | CARDIAC-ARRHYTHMIAS | LEFT-VENTRICULAR HYPERTROPHY | BLOOD-PRESSURE | HEART-DISEASE | HEMODIALYSIS-PATIENTS | UROLOGY & NEPHROLOGY | QT DISPERSION | CHRONIC-RENAL-FAILURE | CARDIOVASCULAR RISK-FACTORS | Humans | Middle Aged | Uremia - physiopathology | Male | Death, Sudden, Cardiac - etiology | Cardiomyopathies - etiology | Arrhythmias, Cardiac - physiopathology | Uremia - therapy | Long QT Syndrome - physiopathology | Cardiomyopathies - physiopathology | Cardiomyopathies - diagnosis | Electrocardiography | Adult | Female | Echocardiography | Cross-Sectional Studies | Long QT Syndrome - etiology | Hypertrophy, Left Ventricular - etiology | Risk Factors | Arrhythmias, Cardiac - etiology | Kidney Transplantation | Uremia - complications | Aged | Hypertrophy, Left Ventricular - physiopathology | Renal Dialysis | Index Medicus
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10. Full Text Uremia modulates the phenotype of aortic smooth muscle cells
by Madsen, Marie and Aarup, Annemarie and Albinsson, Sebastian and Hartvigsen, Karsten and Sørensen, Charlotte M and Turczynska, Karolina and Nielsen, Lars B and Pedersen, Tanja Xenia and Molekylär kärlfysiologi and Lund University and Molecular Vascular Physiology and Vascular Physiology and Kärlfysiologi and Lunds universitet
Atherosclerosis, ISSN 0021-9150, 2016, Volume 257, pp. 64 - 70
Abstract Background and aims Chronic kidney disease leads to uremia and markedly accelerates atherosclerosis. Phenotypic modulation of smooth muscle cells... 
Cardiovascular | Uremia | Smooth muscle cells | Phenotypic modulation | MYOCARDIN | ATHEROGENESIS | CARDIAC & CARDIOVASCULAR SYSTEMS | ATHEROSCLEROSIS | RATS | HYPERPLASIA | PERIPHERAL VASCULAR DISEASE | CHRONIC KIDNEY-DISEASE | E-DEFICIENT MICE | EXPRESSION | CARDIOVASCULAR RISK | CHRONIC-RENAL-FAILURE | Apolipoproteins E - deficiency | Muscle, Smooth, Vascular - metabolism | Atherosclerosis - genetics | Aortic Diseases - blood | Myocytes, Smooth Muscle - pathology | MicroRNAs - metabolism | RNA, Messenger - metabolism | Muscle, Smooth, Vascular - physiopathology | Inflammation - blood | Atherosclerosis - etiology | Myocytes, Smooth Muscle - metabolism | Aorta, Thoracic - pathology | Disease Models, Animal | Genetic Predisposition to Disease | Atherosclerosis - physiopathology | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Vasoconstriction | Aorta, Thoracic - metabolism | Uremia - complications | Aorta, Thoracic - physiopathology | Inflammation - etiology | Disease Progression | Mice, Knockout | Atherosclerosis - blood | Aortic Diseases - genetics | Aortic Diseases - physiopathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Uremia - blood | Apolipoproteins E - genetics | Inflammation - genetics | MicroRNAs - genetics | Aortic Diseases - etiology | Inflammation - physiopathology | Smooth muscle | Genetic aspects | Chronic kidney failure | Atherosclerosis | Kidney diseases | Gene expression | Analysis | Index Medicus | Kardiologi | Urologi och njurmedicin | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Urology and Nephrology
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11. Full Text Mechanisms of aortic and cardiac dysfunction in uremic mice with aortic calcification
by Maizel, Julien and Six, Isabelle and Slama, Michel and Tribouilloy, Christophe and Sevestre, Henry and Poirot, Sabrina and Giummelly, Philippe and Atkinson, Jeffrey and Choukroun, Gabriel and Andrejak, Michel and Kamel, Said and Mazière, Jean Claude and Massy, Ziad A
Circulation, ISSN 0009-7322, 01/2009, Volume 119, Issue 2, pp. 306 - 313
Background-Chronic renal failure (CRF) is associated with cardiac dysfunction and increased aortic stiffness. The mechanisms involved are not clearly... 
Chronic | Echocardiography | Kidney failure | Uremia | kidney failure, chronic | uremia | CARDIAC & CARDIOVASCULAR SYSTEMS | PULSE-WAVE VELOCITY | echocardiography | ATHEROSCLEROSIS | E-KNOCKOUT MICE | ARTERIAL STIFFNESS | PERIPHERAL VASCULAR DISEASE | GROWTH-FACTOR | CHRONIC KIDNEY-DISEASE | HYPERTENSION | HEMATOLOGY | E-DEFICIENT MICE | STAGE RENAL-DISEASE | Kidney Failure, Chronic - physiopathology | Cardiomyopathies - blood | Kidney Failure, Chronic - diagnosis | Hypertrophy, Left Ventricular - blood | Cholesterol - blood | Mice, Inbred C57BL | Uremia - physiopathology | Aortic Diseases - blood | Calcinosis - blood | Random Allocation | Mice, Knockout | Aortic Diseases - physiopathology | Cardiomyopathies - physiopathology | Animals | Kidney Failure, Chronic - blood | Uremia - blood | Aorta | Female | Mice | Hypertrophy, Left Ventricular - physiopathology | In Vitro Techniques | Calcinosis - physiopathology | Disease Models, Animal | Heart | Usage | Animal models in research | Abnormalities | Physiological aspects | Research | Aortic valve | Index Medicus | Abridged Index Medicus
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12. Full Text Reversible cytotoxic brain edema and facial weakness in uremic encephalopathy
by Prüss, Harald and Siebert, Eberhard and Masuhr, Florian
Journal of Neurology, ISSN 0340-5354, 08/2009, Volume 256, Issue 8, pp. 1372 - 1373
DIFFUSION-WEIGHTED MRI | HEMODIALYSIS | UTILITY | POSTERIOR LEUKOENCEPHALOPATHY SYNDROME | CLINICAL NEUROLOGY | Humans | Middle Aged | Uremia - physiopathology | Brain - metabolism | Consciousness Disorders - etiology | Facial Nerve Diseases - etiology | Aphasia, Broca - etiology | Recovery of Function - physiology | Female | Glomerulonephritis - physiopathology | Muscle Weakness - etiology | Brain Edema - etiology | Brain - physiopathology | Treatment Outcome | Facial Nerve Diseases - physiopathology | Glomerulonephritis - complications | Uremia - complications | Facial Muscles - physiopathology | Brain Edema - physiopathology | Brain Diseases, Metabolic - physiopathology | Diffusion Magnetic Resonance Imaging | Brain - pathology | Facial Muscles - innervation | Muscle Weakness - physiopathology | Brain Diseases, Metabolic - complications | Renal Dialysis
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