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Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e54001 - e54001
Background: Histone deacetylase (HDAC) inhibitors are promising anti-fibrosis drugs; however, nonselective inhibition of class I and class II HDACs does not... 
GROWTH-FACTOR-BETA | SOLID TUMORS | OBSTRUCTIVE NEPHROPATHY | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | INTERSTITIAL FIBROSIS | INJURY | ANGIOTENSIN-II | CHRONIC KIDNEY-DISEASE | FACTOR RECEPTOR | MOLECULAR-MECHANISMS | Kidney - pathology | Transforming Growth Factor beta1 - metabolism | Actins - metabolism | Smad3 Protein - metabolism | Ureteral Obstruction - metabolism | Leukocytes - immunology | Kidney - metabolism | Receptor, Epidermal Growth Factor - metabolism | Benzamides - therapeutic use | Benzamides - pharmacology | Phosphorylation - drug effects | Ureteral Obstruction - drug therapy | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - biosynthesis | Fibroblasts - metabolism | Pyridines - therapeutic use | Collagen Type I - metabolism | Kidney - drug effects | Histone Deacetylases - metabolism | Fibroblasts - pathology | Fibronectins - metabolism | Ureteral Obstruction - immunology | Gene Expression Regulation - drug effects | Acetylation - drug effects | Animals | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Ureteral Obstruction - pathology | Fibrosis | Histone Deacetylase Inhibitors - pharmacology | Leukocytes - drug effects | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Mice | Pyridines - pharmacology | Histones - metabolism | Fibronectins | Muscle proteins | Growth factors | Collagen | Analysis | Drugs | Histone deacetylase | Phosphorylation | Smad protein | Animal models | Collagen (type I) | Nephrology | Transcription | Syngeneic grafts | Transforming growth factor-b | Smooth muscle | Activation | Kinases | Fibronectin | Medical schools | Epidermal growth factor | Actin | Rodents | Cell cycle | Fibroblasts | Ureter | Inhibition | Kidneys | Transforming growth factor-b1 | Epidermal growth factor receptors | Pulmonary arteries | Fibrils | Muscles | Medicine | Signaling | Hospitals | Kidney diseases | Cancer | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 09/2018, Volume 315, Issue 3, pp. F445 - F453
It is well known that proteinuria following urinary tract obstruction is mainly of a tubular nature. However, it is unknown whether there are also changes in... 
Filtration barrier | Ureteral obstruction | Pore model | Glomerular | SIZE-SELECTIVITY | NEUTRAL FICOLL | PHYSIOLOGY | pore model | ureteral obstruction | filtration barrier | PERMEABILITY | RATS | ANGIOTENSIN-II | glomerular | T-TEST | IN-VIVO | NITRIC-OXIDE | UROLOGY & NEPHROLOGY | KIDNEY | Reactive Oxygen Species - metabolism | rho GTP-Binding Proteins - antagonists & inhibitors | Kidney Glomerulus - physiopathology | Male | Spin Labels | rho-Associated Kinases - antagonists & inhibitors | Heart Rate - drug effects | Glomerular Filtration Rate - drug effects | Time Factors | rho-Associated Kinases - metabolism | Cyclic N-Oxides - pharmacology | Arterial Pressure - drug effects | Nitric Oxide Synthase Type III - metabolism | Ureteral Obstruction - drug therapy | Aminoquinolines - pharmacology | Disease Models, Animal | Amides - pharmacology | Kidney Glomerulus - enzymology | NG-Nitroarginine Methyl Ester - pharmacology | Kidney Glomerulus - drug effects | Enzyme Inhibitors - pharmacology | Antioxidants - pharmacology | Pyrimidines - pharmacology | Rats, Sprague-Dawley | Ureteral Obstruction - physiopathology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Proteinuria - physiopathology | Proteinuria - enzymology | Animals | Proteinuria - drug therapy | rho GTP-Binding Proteins - metabolism | rac1 GTP-Binding Protein - antagonists & inhibitors | Pyridines - pharmacology | Oxidative Stress - drug effects | Ureteral Obstruction - enzymology | rac1 GTP-Binding Protein - metabolism | Complications and side effects | Medical research | Reactive oxygen species | Obstructions | Ureters | Physiological aspects | Medicine, Experimental | Permeability | Research | Kidney glomerulus | Risk factors | Proteinuria | Fluorescein isothiocyanate | Oxygen | Kidneys | Tempol | RhoA protein | Rac1 protein | Isothiocyanate | Urinary tract | Chromatography | Nitric-oxide synthase | Urinary tract diseases | NG-Nitroarginine methyl ester | Arginine | Rodents | Nitric oxide | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 06/2014, Volume 85, Issue 6, pp. 1318 - 1329
Hydrogen sulfide has recently been found decreased in chronic kidney disease. Here we determined the effect and underlying mechanisms of hydrogen sulfide on a... 
chronic inflammation | cell signaling | chronic renal disease | PATHWAYS | MECHANISMS | DAMAGE | EPITHELIAL-CELLS | INFLAMMATION | TUBULOINTERSTITIAL FIBROSIS | UROLOGY & NEPHROLOGY | GENERATION | CHRONIC KIDNEY-DISEASE | URETERAL OBSTRUCTION | ISCHEMIA/REPERFUSION | Hydrogen Sulfide - metabolism | Ureteral Obstruction - complications | Phosphorylation | Kidney - pathology | DNA Replication - drug effects | Actins - metabolism | Extracellular Matrix - metabolism | Cystathionine gamma-Lyase - metabolism | Male | Ureteral Obstruction - metabolism | Dose-Response Relationship, Drug | Kidney - metabolism | Nephritis, Interstitial - metabolism | Nephritis, Interstitial - pathology | Time Factors | Nephritis, Interstitial - prevention & control | Inflammation Mediators - metabolism | Sulfides - metabolism | Ureteral Obstruction - drug therapy | Cytoprotection | Disease Models, Animal | Kidney Diseases - metabolism | Sulfides - pharmacology | Cell Line | Hydrogen Sulfide - pharmacology | Kidney - drug effects | Cytokines - metabolism | Kidney Diseases - pathology | Kidney Diseases - prevention & control | Extracellular Matrix - drug effects | Cystathionine beta-Synthase - metabolism | Rats, Sprague-Dawley | Collagen - metabolism | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Ureteral Obstruction - pathology | Fibrosis | Macrophages - drug effects | Cell Proliferation - drug effects | Kidney Diseases - etiology | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | Basic Research
Journal Article
Life Sciences, ISSN 0024-3205, 01/2019, Volume 216, pp. 85 - 91
Journal Article
International Journal of Clinical Practice, ISSN 1368-5031, 09/2014, Volume 68, Issue 9, pp. 1174 - 1174
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0129283 - e0129283
Background Inflammation has a crucial role in renal interstitial fibrosis, which is the common pathway of chronic kidney diseases. Mefunidone (MFD) is a new... 
FIBROBLAST ACTIVATION | RENAL FIBROSIS | TISSUE GROWTH-FACTOR | KIDNEY FIBROSIS | PIRFENIDONE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | TUBULAR EPITHELIAL-CELLS | INTERSTITIAL FIBROSIS | GENE-EXPRESSION | DIABETIC-NEPHROPATHY | Kidney Diseases - physiopathology | Ureteral Obstruction - complications | Humans | Extracellular Matrix - metabolism | Male | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Kidney Function Tests | Phosphorylation - drug effects | Ureteral Obstruction - drug therapy | STAT3 Transcription Factor - metabolism | Transforming Growth Factor beta1 - pharmacology | Disease Models, Animal | Macrophages - pathology | Kidney Diseases - pathology | Extracellular Matrix - drug effects | Kidney Diseases - drug therapy | Piperazines - therapeutic use | Piperazines - pharmacology | Rats, Sprague-Dawley | Fibronectins - metabolism | Ureteral Obstruction - physiopathology | Collagen - metabolism | Animals | Fibrosis | Macrophages - drug effects | Cell Proliferation - drug effects | Mice, Inbred BALB C | Pyridones - therapeutic use | Kidney Diseases - etiology | Pyridones - pharmacology | Fibronectins | Obstructions | Chronic kidney failure | Ureters | Collagen | Muscle proteins | Collagen (type I) | Nephrology | Phosphorylation | Epithelial cells | Collagens | Smooth muscle | Lymphocytes T | Kinases | Macrophages | Fibronectin | Lipopolysaccharides | Signal transduction | Lymphocytes | Actin | Rodents | Fibroblasts | Extracellular matrix | Attenuation | Tumor necrosis factor-TNF | Inhibition | Growth factors | Drug dosages | Deposition | Pharmaceutical sciences | Solvents | Kidneys | Cytokines | Stat3 protein | Muscles | Extracellular signal-regulated kinase | Rats | Inflammation | CD3 antigen | Tumor necrosis factor-α | Gene expression | Hospitals | Kidney diseases | Laboratory animals | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 04/2017, Volume 91, Issue 4, pp. 830 - 841
Journal Article
Journal Article
Medicine, ISSN 0025-7974, 01/2015, Volume 94, Issue 4, pp. e419 - e419
The objective of this article is to investigate the clinical features of intestinal pseudo-obstruction (IPO) and/or ureterohydronephrosis in systemic lupus... 
CYSTITIS | MEDICINE, GENERAL & INTERNAL | BILIARY-TRACT DILATATION | MANIFESTATION | OF-THE-LITERATURE | Biliary Tract Diseases - complications | Hydronephrosis - complications | Blood Sedimentation | Recurrence | Ureteral Obstruction - complications | Glucocorticoids - administration & dosage | Lupus Erythematosus, Systemic - complications | Immunoglobulin G - blood | Fever - complications | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Lupus Erythematosus, Systemic - blood | Intestinal Pseudo-Obstruction - drug therapy | Case-Control Studies | Young Adult | Antibodies, Antinuclear - blood | Hydronephrosis - drug therapy | Lupus Erythematosus, Systemic - drug therapy | Adult | Female | Retrospective Studies | Ureteral Obstruction - drug therapy | Severity of Illness Index | Prednisone - administration & dosage | Hydronephrosis - blood | Intestinal Pseudo-Obstruction - complications | Glomerulonephritis - complications | Intestinal Pseudo-Obstruction - blood | Medication Adherence | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Dilatation, Pathologic - complications | Ureteral Obstruction - blood | Serositis - complications | Case studies | Intestines | Obstructions | Care and treatment | Systemic lupus erythematosus | Research | Diagnosis | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article