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Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 5, pp. 2535 - 2546
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 08/2014, Volume 10, Issue 10, pp. 810 - 812
Approximately 25% of cytoplasmic tRNAs in eukaryotic organisms have the wobble uridine (U34) modified at C5 through a process that, according to genetic... 
DOMAIN | PROTEIN | POLYMERASE-II HOLOENZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | HISTONE ACETYLTRANSFERASE | SACCHAROMYCES-CEREVISIAE | ELONGATOR COMPLEX | EXPRESSION | SAM | Histone Acetyltransferases - chemistry | Archaeal Proteins - chemistry | Histone Acetyltransferases - genetics | Molecular Sequence Data | S-Adenosylmethionine - chemistry | Protein Subunits - metabolism | Nerve Tissue Proteins - chemistry | Histone Acetyltransferases - metabolism | Escherichia coli - metabolism | Conserved Sequence | Free Radicals - metabolism | Archaeal Proteins - genetics | RNA, Transfer - chemistry | Methanocaldococcus - chemistry | Uridine - chemistry | Protein Subunits - genetics | Archaeal Proteins - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Gene Expression | Biocatalysis | Free Radicals - chemistry | RNA, Transfer - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Escherichia coli - genetics | Methanocaldococcus - enzymology | Saccharomyces cerevisiae Proteins - metabolism | Uridine - metabolism | Protein Subunits - chemistry | Structural Homology, Protein | S-Adenosylmethionine - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Eukaryotes | Biocatalysts | Cytoplasm | Transfer RNA
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 2014, Volume 58, Issue 7, pp. 928 - 936
Background. Several combinations of 2 or 3 direct-acting antivirals (DAAs) can cure hepatitis C virus (HCV) in the majority of treatment-naive patients. DAAs... 
sofosbuvir | faldaprevir | ribavirin | simeprevir | daclatasvir | INFECTIOUS DISEASES | MICROBIOLOGY | IMMUNOLOGY | POTENT | BI 201335 | HIV | INHIBITOR | ANTIRETROVIRAL TREATMENT | Heterocyclic Compounds, 3-Ring - economics | Simeprevir | Oligopeptides - economics | Hepatitis C - drug therapy | Ribavirin - economics | Humans | Imidazoles - chemistry | Uridine Monophosphate - chemistry | Uridine Monophosphate - economics | Thiazoles - therapeutic use | Health Services Accessibility - economics | Oligopeptides - therapeutic use | Antiviral Agents - chemistry | Drug Industry - economics | Imidazoles - therapeutic use | Drug Therapy, Combination | Oligopeptides - chemistry | Thiazoles - economics | Uridine Monophosphate - therapeutic use | Sulfonamides - chemistry | Antiviral Agents - therapeutic use | Ribavirin - therapeutic use | Ribavirin - chemistry | Anti-HIV Agents - chemistry | Sulfonamides - therapeutic use | Imidazoles - economics | Heterocyclic Compounds, 3-Ring - chemistry | Heterocyclic Compounds, 3-Ring - therapeutic use | Sulfonamides - economics | Uridine Monophosphate - analogs & derivatives | Thiazoles - chemistry | Developing Countries | Antiviral Agents - economics | Hepacivirus | Sofosbuvir | Economic aspects | Antiviral agents | Production management | Care and treatment | Hepatitis C | and Commentaries
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, pp. e0198476 - e0198476
Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development... 
POTENTIAL-DRUG TARGET | INTESTINAL-ABSORPTION | ENERGY | EPIISOPILOTURINE | PERMEABILITY | MULTIDISCIPLINARY SCIENCES | ELECTRONEGATIVITY | AUTOMATED DOCKING | DENSITY-FUNCTIONAL THEORY | CARBON NANOTUBES | DISCOVERY | Schistosoma mansoni - drug effects | Alkaloids - pharmacology | Plant Extracts - pharmacology | 4-Butyrolactone - pharmacology | Imidazoles - chemistry | Models, Molecular | Imidazoles - pharmacology | Anthelmintics - chemistry | Thermodynamics | Quantum Theory | Animals | Anthelmintics - pharmacology | 4-Butyrolactone - chemistry | Molecular Docking Simulation | 4-Butyrolactone - analogs & derivatives | Pilocarpus - chemistry | Alkaloids - chemistry | Pharmacology, Experimental | Pharmacognosy | Imidazole | Anthelmintics | Chemical properties | Research | Plant metabolites | Pharmaceutical chemistry | Histone deacetylase | Biotechnology | Quantum chemistry | Disease | Toxicity | Praziquantel | Arginase | Thioredoxin | Isomers | Optimization | Molecular docking | Alkaloids | Computational chemistry | Schistosomiasis | Carcinogens | Metabolites | Glutathione reductase | Mathematical models | Libraries | Pharmaceutical sciences | Glutathione | Enzymes | Excretion | Adenosine | Research & development--R&D | Pharmacology | Permeability | Phosphorylase | Molecular chains | Organic chemistry | Chemistry | Properties (attributes) | 5'-Methylthioadenosine phosphorylase | Uridine phosphorylase | Computer applications | Uridine | Software | Reductase | Index Medicus | Research & development | R&D
Journal Article
Science, ISSN 0036-8075, 2013, Volume 342, Issue 6163, pp. 1235 - 1239
Journal Article
Carbohydrate Research, ISSN 0008-6215, 07/2012, Volume 356, pp. 44 - 61
There is no doubt now that the synthesis of compounds of varying complexity such as saccharides and derivatives thereof continuously grows with enzymatic... 
Hexofuranosyl-containing conjugates | Enzymes | Furanosides | GLYCOSIDE HYDROLASE FAMILY | LIPOPOLYSACCHARIDE O ANTIGEN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | MYCOBACTERIUM-TUBERCULOSIS ARABINOGALACTAN | WALL ARABINAN BIOSYNTHESIS | PENICILLIUM-CHRYSOGENUM EXO-1,5-ALPHA-L-ARABINANASE | UDP-GALACTOPYRANOSE MUTASE | ALPHA-L-ARABINOFURANOSIDASE | LIPASE-CATALYZED SYNTHESIS | BETA-D-GALACTOFURANOSIDASE | ESCHERICHIA-COLI K-12 | CHEMISTRY, APPLIED | Fungal Proteins - chemistry | Monosaccharides - chemical synthesis | Galactose - metabolism | Polysaccharides - chemical synthesis | Uridine Diphosphate - analogs & derivatives | Bacterial Proteins - chemistry | Molecular Sequence Data | Polysaccharides - biosynthesis | Galactose - analogs & derivatives | Glycoside Hydrolases - chemistry | Intramolecular Transferases - chemistry | Carbohydrate Sequence | Biocatalysis | Monosaccharides - biosynthesis | Glycosyltransferases - chemistry | Glycoconjugates - biosynthesis | Uridine Diphosphate - chemistry | Lipase - metabolism | Lipase - chemistry | Uridine Diphosphate - metabolism | Glycoconjugates - chemical synthesis | Intramolecular Transferases - metabolism | Galactose - chemistry | Glycosyltransferases - metabolism | Bacterial Proteins - metabolism | Glycoside Hydrolases - metabolism | Fungal Proteins - metabolism | Physiological aspects | Organic chemistry | Chemical Sciences
Journal Article
FEMS Microbiology Reviews, ISSN 0168-6445, 03/2008, Volume 32, Issue 2, pp. 208 - 233
The biosynthesis of bacterial cell wall peptidoglycan is a complex process involving many different steps taking place in the cytoplasm (synthesis of the... 
peptidoglycan | UppP phosphatases | undecaprenyl phosphate | UppS synthase | MraY translocase | MurG transferase | Peptidoglycan | Undecaprenyl phosphate | ACETYLMURAMYL-PENTAPEPTIDE-TRANSLOCASE | BACTERIAL CELL-WALLS | ENTEROBACTERIAL COMMON ANTIGEN | ESCHERICHIA-COLI MURG | MICROBIOLOGY | SITE-DIRECTED MUTAGENESIS | N-ACETYLGLUCOSAMINE TRANSFERASE | UNDECAPRENYL-PYROPHOSPHATE SYNTHASE | BACITRACIN ABC TRANSPORTER | POSITIONAL ISOTOPE EXCHANGE | UDP-MURNAC-PENTAPEPTIDE | Monosaccharides - chemical synthesis | Polyisoprenyl Phosphates - chemistry | Bacteria - chemistry | N-Acetylglucosaminyltransferases - isolation & purification | Uridine Diphosphate N-Acetylmuramic Acid - chemistry | Bacterial Proteins - chemistry | Substrate Specificity | Lipids - biosynthesis | N-Acetylglucosaminyltransferases - chemistry | Uridine Diphosphate N-Acetylmuramic Acid - metabolism | Lipids - chemistry | Terpenes - metabolism | Transferases - metabolism | Transferases - antagonists & inhibitors | Oligopeptides - chemistry | Bacterial Outer Membrane Proteins - antagonists & inhibitors | Bacterial Proteins - antagonists & inhibitors | Oligopeptides - chemical synthesis | Uridine Diphosphate N-Acetylmuramic Acid - analogs & derivatives | Bacteria - metabolism | Bacterial Outer Membrane Proteins - chemistry | Transferases - isolation & purification | Oligopeptides - metabolism | Bacterial Outer Membrane Proteins - isolation & purification | Polyisoprenyl Phosphates - metabolism | N-Acetylglucosaminyltransferases - metabolism | Peptidoglycan - biosynthesis | Bacterial Outer Membrane Proteins - metabolism | Uridine Diphosphate N-Acetylmuramic Acid - chemical synthesis | N-Acetylglucosaminyltransferases - antagonists & inhibitors | Bacterial Proteins - metabolism | Kinetics | Monosaccharides - metabolism | Bacterial Proteins - isolation & purification | Monosaccharides - chemistry | Physiological aspects | Peptidoglycans | Chemical properties
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 10/2011, Volume 76, Issue 20, pp. 8311 - 8319
Journal Article