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Journal of Biological Chemistry, ISSN 0021-9258, 09/2006, Volume 281, Issue 36, pp. 26159 - 26169
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 688 - 703
Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription.... 
DVC1 | progeria | protease | formaldehyde | Spartan | Wss1 | Ruijs-Aalfs syndrome | SPRTN | topoisomerase | DNA-protein crosslinks | DNA repair | hepatocellular carcinoma | GENOMIC INSTABILITY | CELLS | DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPARTAN/C1ORF124 | DVC1 C1ORF124 | FANCONI-ANEMIA | HELICASE | NUCLEOTIDE EXCISION-REPAIR | CELL BIOLOGY | Schizosaccharomyces pombe Proteins - chemistry | Fibroblasts - enzymology | Formaldehyde - chemistry | Caenorhabditis elegans Proteins - chemistry | Humans | Caenorhabditis elegans Proteins - metabolism | Substrate Specificity | Crystallography, X-Ray | DNA-Binding Proteins - metabolism | Schizosaccharomyces - genetics | Cisplatin - chemistry | Ultraviolet Rays | Schizosaccharomyces pombe Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Amino Acid Sequence | Cell Line | Xeroderma Pigmentosum Group A Protein - metabolism | Cross-Linking Reagents - chemistry | Schizosaccharomyces pombe Proteins - genetics | Protein Structure, Secondary | Caenorhabditis elegans - genetics | Xeroderma Pigmentosum Group A Protein - genetics | Models, Molecular | DNA - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Caenorhabditis elegans - radiation effects | Xeroderma Pigmentosum Group A Protein - chemistry | DNA - genetics | Sequence Homology, Amino Acid | DNA - chemistry | Sequence Alignment | Animals | Caenorhabditis elegans - drug effects | Fibroblasts - radiation effects | DNA Repair | Fibroblasts - drug effects | Protein Binding | Schizosaccharomyces - enzymology | Fibroblasts - cytology | Mice | HeLa Cells | Kinetics | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Ubiquitin | Chromatin | Proteases | DNA | Genetic research | Genetic transcription | Molecular biology | Formaldehyde | BASIC BIOLOGICAL SCIENCES | protease Ruijs-Aalfs syndrome
Journal Article
Circulation Research, ISSN 0009-7330, 03/2017, Volume 120, Issue 11, pp. 1776 - 1788
RATIONALE:20-Hydroxyeicosatetraenoic acid (20-HETE), one of the principle cytochrome P450 (CYP) eicosanoids, is a potent vasoactive lipid whose vascular... 
cytochrome P-450 enzyme system | cardiovascular diseases | receptor, epidermal growth factor | vascular remodeling | hypertension | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | ARACHIDONIC-ACID | ANGIOTENSIN-CONVERTING ENZYME | BLOOD-PRESSURE | SALT-SENSITIVE RATS | CHANNEL | URINARY 20-HYDROXYEICOSATETRAENOIC ACID | PERIPHERAL VASCULAR DISEASE | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | C-SRC | Receptors, G-Protein-Coupled - metabolism | Humans | Cells, Cultured | Hydroxyeicosatetraenoic Acids - toxicity | Rats | Endothelium, Vascular - drug effects | Male | Mice, Transgenic | Endothelium, Vascular - physiology | Hypertension - metabolism | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Signal Transduction - drug effects | Hydroxyeicosatetraenoic Acids - pharmacology | Hypertension - chemically induced | Signal Transduction - physiology | Vascular Remodeling - physiology | Mice | Vascular Remodeling - drug effects | Protein Binding - physiology | Myocardial infarction | Phosphorylation | Protein kinase C | G protein-coupled receptors | Eicosanoids | Smooth muscle | Antagonists | Inositol phosphate | Kinases | Proteins | Epidermal growth factor | Vascular diseases | Peptidyl-dipeptidase A | Vasoactive agents | Blood pressure | Growth factors | Hypertension | Cerebral infarction | Enzymes | Cytochrome P450 | Vasoconstriction | Src protein | Muscle contraction | Endothelial cells | Angiotensin | Cardiovascular diseases | Binding sites | Cell migration | 20-HETE | Vascular Remodeling | ACE | Signal Transduction | Vascular Biology | GPR75 | cytochrome P450 | Remodeling | EGFR | eicosanoids | Cell Signaling | GIT1
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2017, Volume 292, Issue 38, pp. 15952 - 15963
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 01/2012, Volume 167, Issue 1, pp. 137 - 148
Summary The ready access to commercially available multiplex assays and the importance of inflammation in disease pathogenesis has resulted in an abundance of... 
hepatitis C virus | chemokines/monokines | bladder cancer | BCG | Hepatitis C virus | Bladder cancer | Chemokines/monokines | BACILLUS-CALMETTE-GUERIN | DIPEPTIDYL-PEPTIDASE-IV | LIGANDS CXCL9 | MURINE CEREBRAL MALARIA | IFN-GAMMA | CHEMOKINE RECEPTOR CXCR3 | HEPATITIS-C-VIRUS | monokines | IMMUNOLOGY | chemokines | INTERFERON-INDUCIBLE PROTEIN-10 | LEVELS CORRELATE | ADAPTIVE IMMUNE-RESPONSES | Enzyme-Linked Immunosorbent Assay - methods | Dipeptidyl Peptidase 4 - metabolism | Carcinoma, Transitional Cell - urine | Humans | Middle Aged | Culture Media, Conditioned - chemistry | Recombinant Fusion Proteins - analysis | Male | Neoplasm Proteins - urine | Chemokine CXCL10 - analysis | Peptide Fragments - immunology | Chemokine CXCL10 - immunology | Aged, 80 and over | Adult | Female | Antibodies, Monoclonal - immunology | Protein Structure, Tertiary | Urinary Bladder Neoplasms - urine | Body Fluids - chemistry | Protein Isoforms - analysis | Inflammation | Hepatitis C, Chronic - blood | Peptide Fragments - analysis | Immunoenzyme Techniques - methods | Biomarkers | Aged | Protein Processing, Post-Translational | Protein Isoforms - immunology | Universities and colleges | Dendritic cells | Hepatitis C | Atopic dermatitis | Hepatitis | Pathogenesis | Discrimination | Urine | CD26 antigen | biomarkers | Abundance | Inflammatory diseases | Asthma | Tuberculosis | CXCL10 protein | Post-translation | Immunoassays | Injuries | Cancer | Kidney transplantation | Recombinant Fusion Proteins/analysis | Chemokine CXCL10/analysis | Hepatitis C, Chronic/blood | Culture Media, Conditioned/chemistry | Carcinoma, Transitional Cell/urine | Life Sciences | Chemokine CXCL10/immunology | Antibodies, Monoclonal/immunology | Immunology | Neoplasm Proteins/urine | Protein Isoforms/immunology | Urinary Bladder Neoplasms/urine | Body Fluids/chemistry | Peptide Fragments/immunology | Protein Isoforms/analysis | Enzyme-Linked Immunosorbent Assay/methods | Dipeptidyl Peptidase 4/metabolism | Immunoenzyme Techniques/methods | Peptide Fragments/analysis | Translational Studies
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2006, Volume 12, Issue 7, pp. 2109 - 2116
Purpose: Aberrant promoter hypermethylation of Wnt-antagonist genes contributes to the pathogenesis of several cancers. We hypothesized that combined... 
secreted frizzled-related protein-1, 2, 4 and 5 | Wnt inhibitory factor-1 | Dickkopf family proteins-3 | bladder cancer | methylation | INACTIVATION | HUMAN PROSTATE-CANCER | PROMOTER HYPERMETHYLATION | SFRP GENES | METHYLATION | INHIBITORY FACTOR-I | ONCOLOGY | SIGNALING PATHWAY | COLORECTAL-CANCER | TUMOR-SUPPRESSOR GENES | URINE | Intercellular Signaling Peptides and Proteins - analysis | Multivariate Analysis | Carrier Proteins - urine | Urinary Bladder Neoplasms - diagnosis | Carcinoma, Transitional Cell - urine | Humans | Proto-Oncogene Proteins - urine | Membrane Proteins - urine | Repressor Proteins - analysis | Membrane Proteins - analysis | DNA Methylation | Urinary Bladder Neoplasms - genetics | Biomarkers, Tumor - urine | Proto-Oncogene Proteins - analysis | Sensitivity and Specificity | Eye Proteins - genetics | Carrier Proteins - analysis | Carcinoma, Transitional Cell - genetics | Repressor Proteins - urine | Urinary Bladder Neoplasms - urine | Biomarkers, Tumor - analysis | Membrane Proteins - genetics | Carcinoma, Transitional Cell - diagnosis | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Intercellular Signaling Peptides and Proteins - urine | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Eye Proteins - analysis | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Biomarkers, Tumor - genetics | Eye Proteins - urine | Urinary Bladder - physiology
Journal Article
Journal Article
Blood, ISSN 0006-4971, 07/2004, Volume 104, Issue 1, pp. 256 - 262
Two upstream regions of the human urokinase (uPA) gene regulate its transcription: the minimal promoter (MP) and the enhancer element. The activity of the... 
UROKINASE EXPRESSION | AP-1 SITES | PLASMINOGEN-ACTIVATOR | SIGNALING PATHWAY | ENHANCER | INDUCTION | C-JUN | HEMATOLOGY | BINDING | PROTEIN-KINASES | ENDOTHELIAL GROWTH-FACTOR | Phosphorylation | Cricetulus | Nitriles - pharmacology | Humans | Transcriptional Activation - drug effects | Sp1 Transcription Factor - metabolism | Promoter Regions, Genetic - genetics | MAP Kinase Signaling System | Dose-Response Relationship, Drug | RNA, Messenger - biosynthesis | Mitogen-Activated Protein Kinase 1 - genetics | JNK Mitogen-Activated Protein Kinases | Fibroblasts - metabolism | Recombinant Proteins - metabolism | Butadienes - pharmacology | Cricetinae | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Genes, Reporter - genetics | Recombinant Proteins - genetics | Urokinase-Type Plasminogen Activator - genetics | Animals | Mitogen-Activated Protein Kinase 1 - pharmacology | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - pharmacology | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Urokinase-Type Plasminogen Activator - biosynthesis | Fibroblasts - cytology | HeLa Cells | Enzyme Activation - genetics | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Enzyme Inhibitors | Recombinant Proteins | Urinary Plasminogen Activator | Life Sciences | Fibroblasts | Nitriles | Sp1 Transcription Factor | Genes, Reporter | Mitogen-Activated Protein Kinases | Promoter Regions (Genetics) | Trans-Activation (Genetics) | Biochemistry, Molecular Biology | Butadienes | Enzyme Activation | Mitogen-Activated Protein Kinase 1 | Molecular biology | RNA, Messenger | Hela Cells | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63425
Although the effects of sanguinarine, a benzophenanthridine alkaloid, on the inhibition of some kinds of cancer cell growth have been established, the... 
CARCINOMA-CELLS | ACTIVATION | DEPOLARIZATION | MITOCHONDRIAL PATHWAY | MULTIDISCIPLINARY SCIENCES | ROS | PTEN | EGR-1 TRANSCRIPTION | DEATH | KAPPA-B | EXPRESSION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Cell Survival - genetics | Apoptosis - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | BH3 Interacting Domain Death Agonist Protein - genetics | Caspases - metabolism | Isoquinolines - pharmacology | Urinary Bladder Neoplasms - genetics | Early Growth Response Protein 1 - genetics | Antineoplastic Agents - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Urinary Bladder Neoplasms - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Cell Survival - drug effects | Caspases - genetics | bcl-2-Associated X Protein - metabolism | Up-Regulation - genetics | Urinary Bladder Neoplasms - drug therapy | Down-Regulation - drug effects | Benzophenanthridines - pharmacology | X-Linked Inhibitor of Apoptosis Protein - genetics | Up-Regulation - drug effects | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Early Growth Response Protein 1 - metabolism | Proteins | Prevention | Cysteine | Care and treatment | Growth | Genes | Cancer cells | Free radicals (Chemistry) | Bladder cancer | Apoptosis | Cancer | Oxidative stress | Reactive oxygen species | Deregulation | Transcription factors | Bax protein | Bladder | Acetylcysteine | XIAP protein | Activation | Biochemistry | Kinases | Cancer therapies | Anticancer properties | Mitochondria | Cell growth | Urinary bladder | Physiology | Interception | Inhibition | Pretreatment | Free radicals | EGR-1 protein | c-Jun protein | siRNA | Tumor cell lines | Metabolism | Gene expression | Sanguinarine | Ribonucleic acid--RNA | Medicine | Studies | Tumors | RNA | Ribonucleic acid
Journal Article