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1. Full Text RNA Interference-directed Knockdown of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Inhibits Prostate Cancer Cell Invasion, Survival, and Tumorigenicity in Vivo
by Sai MuraliKrishna Pulukuri and Christopher S. Gondi and Sajani S. Lakka and Aman Jutla and Norman Estes and Meena Gujrati and Jasti S. Rao
The Journal of biological chemistry, ISSN 0021-9258, 10/2005, Volume 280, Issue 43, pp. 36529 - 36540
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Laminin - pharmacology | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Cell Proliferation | Humans | Extracellular Matrix - metabolism | Collagen - chemistry | Immunoblotting | Male | Proteoglycans - chemistry | Neoplasm Metastasis | Transfection | RNA Interference | Time Factors | Collagen - pharmacology | Prostatic Neoplasms - pathology | Signal Transduction | Cell Survival | Neoplasm Invasiveness | Electrophoresis, Polyacrylamide Gel | Gene Silencing | Tetrazolium Salts - pharmacology | Urokinase-Type Plasminogen Activator - genetics | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Proteoglycans - pharmacology | Urokinase-Type Plasminogen Activator - metabolism | Mice, Nude | Cell Line, Tumor | Laminin - chemistry | Mice | Thiazoles - pharmacology | Neoplasms - pathology | Drug Combinations | Microscopy, Fluorescence | Apoptosis | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Index Medicus | RNAi | uPAR (uPA receptor) | shRNA (small hairpin RNA) | uPA (urokinaseplasminogen activator) | survival | siRNA (small interfering RNA) | prostate cancer | invasion | uPA and uPAR | ANOVA (analysis of variance) | RNAi (RNA interference) | RT (reverse transcription) | TPBS (tween-20 (0.1%) phospate buffered saline) | BSA (bovine serum albumin)
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2. Full Text Impacts of aging and amyloid-β deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimers disease
by Bi Oh, Shin and Suh, Nayoung and Kim, Inki and Lee, Joo-Yong
Brain research, ISSN 0006-8993, 02/2015, Volume 1597, pp. 159 - 167
Amyloid degrading enzymes | Amyloid pathogenesis | Amyloid plaques | Plasmin | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurons - pathology | Tissue Plasminogen Activator - metabolism | Neuroglia - pathology | Humans | Cerebral Cortex - pathology | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Fibrinolysin - metabolism | Disease Models, Animal | Plaque, Amyloid - pathology | Mice, Inbred C57BL | Mice, Transgenic | Hippocampus - pathology | Hippocampus - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Urokinase-Type Plasminogen Activator - metabolism | Alzheimer Disease - metabolism | Neuroglia - metabolism | Plaque, Amyloid - metabolism | Serpin E2 - metabolism | Aging - metabolism | Index Medicus
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3. Full Text Urokinase‐type plasminogen activator modulates mammalian circadian clock phase regulation in tissue‐type plasminogen activator knockout mice
by Cooper, Joanna M and Rastogi, Ashutosh and Krizo, Jessica A and Mintz, Eric M and Prosser, Rebecca A and Silver, Rae
The European journal of neuroscience, ISSN 0953-816X, 03/2017, Volume 45, Issue 6, pp. 805 - 815
urokinase‐type plasminogen activator | circadian rhythms | suprachiasmatic nucleus | tissue‐type plasminogen activator | urokinase-type plasminogen activator | tissue-type plasminogen activator | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain-Derived Neurotrophic Factor - genetics | Suprachiasmatic Nucleus - drug effects | Tissue Plasminogen Activator - metabolism | Mice, Inbred C57BL | Plasminogen Inactivators - pharmacology | Male | Tissue Plasminogen Activator - genetics | Suprachiasmatic Nucleus - physiology | Animals | Urokinase-Type Plasminogen Activator - metabolism | Proteolysis | Circadian Clocks | Female | Suprachiasmatic Nucleus - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Mice | Urokinase | Glutamate | Tissue plasminogen activator | Laws, regulations and rules | Suprachiasmatic nucleus | Glutamic acid | Brain | Night | Glutamic acid receptors (ionotropic) | Brain slice preparation | Nuclei | Phase transitions | Plasmin | t-Plasminogen activator | Receptors | Casein | Rodents | Entrainment | Inhibition | Biological clocks | Circadian rhythms | Phase shift | Polyamide-imides | N-Methyl-D-aspartic acid receptors | Circadian rhythm | Mammals | U-Plasminogen activator | Brain-derived neurotrophic factor | Inhibitors | Plasminogen activator inhibitors | TrkB receptors | Glutamatergic transmission | Gates | Index Medicus
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4. Full Text Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies
by Iyer, A.M and Zurolo, E and Boer, K and Baayen, J.C and Giangaspero, F and Arcella, A and Di Gennaro, G.C and Esposito, V and Spliet, W.G.M and van Rijen, P.C and Troost, D and Gorter, J.A and Aronica, E
Neuroscience, ISSN 0306-4522, 2010, Volume 167, Issue 3, pp. 929 - 945
Neurology | Hippocampal sclerosis | Tuberous sclerosis | Ganglioglioma | Focal cortical dysplasia | Epilepsy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy | Biological and medical sciences | Medical sciences | Nervous system (semeiology, syndromes) | Immunohistochemistry | Microglia - metabolism | Tissue Plasminogen Activator - metabolism | Tuberous Sclerosis - complications | Humans | Middle Aged | Brain Neoplasms - physiopathology | Epilepsy - metabolism | Male | Brain - abnormalities | Epilepsy - physiopathology | Brain Neoplasms - complications | RNA, Messenger - metabolism | Tissue Plasminogen Activator - genetics | Epilepsy - etiology | Brain Neoplasms - metabolism | Brain - metabolism | Ganglioglioma - complications | Young Adult | Urokinase-Type Plasminogen Activator - analysis | Nervous System Malformations - metabolism | Malformations of Cortical Development - physiopathology | Nervous System Malformations - physiopathology | Adult | Female | Child | Biomarkers - metabolism | Malformations of Cortical Development - metabolism | Hippocampus - pathology | Urokinase-Type Plasminogen Activator - genetics | Reverse Transcriptase Polymerase Chain Reaction | Malformations of Cortical Development - complications | Blotting, Western | Receptors, Urokinase Plasminogen Activator - metabolism | Hippocampus - metabolism | Tuberous Sclerosis - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Tuberous Sclerosis - physiopathology | Adolescent | Nervous System Malformations - complications | Brain - pathology | Tissue Plasminogen Activator - analysis | Ganglioglioma - metabolism | Hippocampus - physiopathology | Ganglioglioma - physiopathology | Astrocytes - metabolism | Index Medicus
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5. Full Text Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: Cutting edge and cleavage sites
by Ji, Hong-Long and Zhao, Runzhen and Komissarov, Andrey A and Chang, Yongchang and Liu, Yongfeng and Matthay, Michael A
The Journal of biological chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 9, pp. 5241 - 5255
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Up-Regulation | Humans | Epithelial Sodium Channels - metabolism | Sodium - metabolism | Ion Channel Gating - physiology | Epithelial Sodium Channels - genetics | Plasminogen Activator Inhibitor 1 - metabolism | Proteolysis | Female | Urokinase-Type Plasminogen Activator - chemistry | Plasminogen Activator Inhibitor 1 - genetics | Protein Structure, Tertiary | Catalytic Domain | Oocytes - metabolism | Xenopus laevis | Models, Molecular | Binding Sites - genetics | Urokinase-Type Plasminogen Activator - genetics | Epithelial Sodium Channels - chemistry | Blotting, Western | Patch-Clamp Techniques | Animals | Ion Channel Gating - genetics | Oocytes - physiology | Plasminogen Activator Inhibitor 1 - chemistry | Urokinase-Type Plasminogen Activator - metabolism | Protein Binding | Kinetics | Mutation | Index Medicus | Plasma Membrane | Epithelial Sodium Channel (ENaC) | Membrane Biology | Enzyme Catalysis | Gel Electrophoresis | Electrophysiology
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6. Full Text Urokinase-type plasminogen activator
by Crippa, Massimo P
The international journal of biochemistry & cell biology, ISSN 1357-2725, 2007, Volume 39, Issue 4, pp. 690 - 694
cell migration | Urokinase-type plasminogen activator receptor | Urokinase-type plasminogen activator | Extracellular matrix | Tissue remodeling | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Receptors, Urokinase Plasminogen Activator | Animals | Urokinase-Type Plasminogen Activator - metabolism | Models, Biological | Humans | Regulatory Sequences, Nucleic Acid | Protein Binding | Receptors, Cell Surface - metabolism | Plasminogen - metabolism | Protein Conformation | Urokinase-Type Plasminogen Activator - chemistry | Urokinase-Type Plasminogen Activator - genetics | Index Medicus
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7. Full Text CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer
by Xie, C and Jiang, X.H and Zhang, J.T and Sun, T.T and Dong, J.D and Sanders, A.J and Diao, R.Y and Wang, Y and Fok, K.L and Tsang, L.L and Yu, M.K and Zhang, X.H and Chung, Y.W and Ye, L and Zhao, M.Y and Guo, J.H and Xiao, Z.J and Lan, H.Y and Ng, C.F and Lau, K.M and Cai, Z.M and Jiang, W.G and Chan, H.C
Oncogene, ISSN 0950-9232, 05/2013, Volume 32, Issue 18, pp. 2282 - 2291
CFTR | miR-193b | uPA | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Prostatic Neoplasms - metabolism | Receptors, Urokinase Plasminogen Activator - immunology | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Male | Cell Movement - genetics | Gene Knockdown Techniques | Prostatic Neoplasms - genetics | Base Sequence | Female | Urokinase-Type Plasminogen Activator - immunology | Prostatic Neoplasms - pathology | Down-Regulation | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Urokinase-Type Plasminogen Activator - genetics | Receptors, Urokinase Plasminogen Activator - metabolism | Xenograft Model Antitumor Assays | Animals | Urokinase-Type Plasminogen Activator - metabolism | Mice, Nude | Cell Line, Tumor | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | MicroRNAs - genetics | Receptors, Urokinase Plasminogen Activator - genetics | Urokinase | Tissue plasminogen activator | Physiological aspects | Development and progression | Tumor suppressor genes | Genetic aspects | Research | Prostate cancer | Cystic fibrosis | Membranes | Tumors | Index Medicus
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8. Full Text Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells
by Jo, Minji and Eastman, Boryana M and Webb, Drue L and Stoletov, Konstantin and Klemke, Richard and Gonias, Steven L
Cancer research (Chicago, Ill.), ISSN 0008-5472, 11/2010, Volume 70, Issue 21, pp. 8948 - 8958
Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Epithelial Cells - metabolism | Humans | Mesoderm - cytology | Breast Neoplasms - metabolism | Flow Cytometry | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Female | Cell Membrane - metabolism | Membrane Proteins - metabolism | Tumor Cells, Cultured | Biotinylation | Signal Transduction | RNA, Messenger - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Integrin beta1 - metabolism | Receptors, Urokinase Plasminogen Activator - metabolism | Animals | Breast Neoplasms - pathology | Fluorescent Antibody Technique | Mesoderm - metabolism | Mice | Receptors, Urokinase Plasminogen Activator - genetics | Cell Movement | Index Medicus | urokinase-type plasminogen activator | cell-signaling | uPAR | epithelial-mesenchymal transition | cancer stem cell | integrin
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9. Full Text Mechanisms of Urokinase Plasminogen Activator (uPA)-mediated atherosclerosis: Role of the uPA receptor and S100A8/A9 proteins
by Farris, Stephen D and Hu, Jie Hong and Krishnan, Ranjini and Emery, Isaac and Chu, Talyn and Du, Liang and Kremen, Michal and Dichek, Helén L and Gold, Elizabeth and Ramsey, Stephen A and Dichek, David A
The Journal of biological chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 25, pp. 22665 - 22677
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Up-Regulation | Calgranulin B - metabolism | Calgranulin A - metabolism | Atherosclerosis - genetics | Humans | Aorta - metabolism | Calgranulin A - genetics | RNA, Messenger - metabolism | Vasodilation | Coronary Artery Disease - physiopathology | Time Factors | Coronary Artery Disease - pathology | Female | Lipid Metabolism - genetics | Transcription, Genetic | Calgranulin B - genetics | Aorta - physiopathology | Transgenes | Aorta - enzymology | Atherosclerosis - pathology | Atherosclerosis - physiopathology | Coronary Artery Disease - metabolism | RNA, Messenger - genetics | Apolipoprotein A-I - metabolism | Urokinase-Type Plasminogen Activator - genetics | Atherosclerosis - metabolism | Protein Interaction Mapping | Aorta - pathology | Receptors, Urokinase Plasminogen Activator - metabolism | Macrophages - metabolism | Animals | Receptors, Scavenger - genetics | Urokinase-Type Plasminogen Activator - metabolism | Coronary Artery Disease - genetics | Mice | Receptors, Urokinase Plasminogen Activator - genetics | Index Medicus | Molecular Bases of Disease | Urokinase | Atherosclerosis | Lipoprotein | Plasminogen | Microarray | Plasminogen Activation | Macrophage
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