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Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 298 - 305
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e27970
Background: Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and... 
STEROIDOGENESIS | THERAPY | TESTOSTERONE | EPIDERMAL-GROWTH-FACTOR | BIOLOGY | GENE-EXPRESSION | FACTOR-I | BONE | CELL-LINES | SPLICE VARIANTS | PROGRESSION | Neoplasms, Hormone-Dependent - metabolism | Prostatic Neoplasms - metabolism | Prostatic Hyperplasia - pathology | Prognosis | Alternative Splicing | Humans | Middle Aged | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Bone Neoplasms - secondary | Male | Immunoenzyme Techniques | Prostate - metabolism | Bone Neoplasms - metabolism | Neoplasms, Hormone-Dependent - genetics | Prostate - pathology | Prostatic Neoplasms - genetics | Castration | Aged, 80 and over | Adult | Bone Neoplasms - genetics | Real-Time Polymerase Chain Reaction | Soft Tissue Neoplasms - genetics | Prostatic Neoplasms - pathology | Soft Tissue Neoplasms - secondary | RNA, Messenger - genetics | Soft Tissue Neoplasms - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Prostatic Hyperplasia - genetics | Blotting, Western | Prostatic Hyperplasia - metabolism | Receptors, Androgen - genetics | Neoplasms, Hormone-Dependent - pathology | Cell Line, Tumor | Aged | Proteins | Viral antibodies | Antibodies | Androgens | Metastasis | Prostate cancer | Alternative splicing | Phosphorylation | Staining | Kinases | Tissues | Urology | Metastases | Angiogenesis | Xenografts | Localization | Medical research | Lymphatic system | Immunoglobulins | Review boards | C-Terminus | Gene expression | Polymerase chain reaction | Chemotherapy | Ligands | Immunoreactivity | Prostate | Cancer
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 02/2013, Volume 105, Issue 4, pp. 274 - 279
Journal Article
Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 23, pp. 6142 - 6152
Androgen receptor (AR) signaling persists in castration-resistant prostate carcinomas (CRPC), because of several mechanisms that include increased AR... 
STEROIDOGENESIS | SELECTIVE INHIBITOR | DIHYDROTESTOSTERONE LEVELS | ONCOLOGY | ABIRATERONE ACETATE | RECEPTOR | INCREASED SURVIVAL | CYP17 INHIBITOR | CASTRATION | I CLINICAL-TRIAL | HORMONAL-THERAPY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Immunohistochemistry | Neoplasms, Hormone-Dependent - metabolism | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Androgens - biosynthesis | Data Mining | Male | Hydroxyprostaglandin Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - genetics | RNA, Messenger - biosynthesis | Neoplasm Metastasis | Prostatic Neoplasms - genetics | Cytochrome P-450 CYP3A - genetics | Receptors, Androgen - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - enzymology | Cytochrome P-450 CYP3A - biosynthesis | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Receptors, Androgen - genetics | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Neoplasms, Hormone-Dependent - pathology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Cell Line, Tumor | Prostatic Neoplasms - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | abiraterone | androgen synthesis | testosterone | dihydrotestosterone | AKR1C3 | CYP17 | MDV3100 (enzalutamide) | Prostate cancer
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7693, pp. 544 - 548
Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients... 
METASTATIC MELANOMA | CTLA-4 BLOCKADE | BLADDER-CANCER | THERAPY | LANDSCAPE | SUBTYPES | UROTHELIAL CARCINOMA | MULTIDISCIPLINARY SCIENCES | GENES | ADAPTIVE IMMUNE RESISTANCE | MPDL3280A | CD8-Positive T-Lymphocytes - cytology | Humans | Antibodies, Monoclonal - therapeutic use | Urothelium - pathology | Urologic Neoplasms - pathology | Neoplasm Metastasis | Urologic Neoplasms - drug therapy | Urologic Neoplasms - genetics | Immunotherapy | Antibodies - immunology | Antigens, Neoplasm - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Antigens, Neoplasm - analysis | Disease Models, Animal | Fibroblasts - metabolism | Antibodies - therapeutic use | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - pharmacology | Treatment Outcome | B7-H1 Antigen - immunology | Urologic Neoplasms - immunology | Antibodies - pharmacology | Tumor Microenvironment - immunology | Collagen - metabolism | Phenotype | Animals | B7-H1 Antigen - antagonists & inhibitors | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | CD8-Positive T-Lymphocytes - drug effects | Urothelium - immunology | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Urothelium - drug effects | Transforming Growth Factor beta - metabolism | Cohort Studies | Drug Resistance, Neoplasm - drug effects | PD-1 protein | CD8 antigen | Transforming growth factor-a | Antibodies | Parenchyma | Lymphocytes T | Metastasis | Immunity | Metastases | Genotype & phenotype | Signal transduction | Lymphocytes | Cell cycle | Fibroblasts | Growth factors | Urothelial cancer | Phenotypes | Cytokines | Melanoma | Blocking | Gene expression | Patients | Generalized linear models | Signaling | Stromal cells | Medical prognosis | Collagen | PD-L1 protein | Ligands | Determinants | Infiltration | Cancer | Tumors | Apoptosis | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2016, Volume 29, Issue 6, pp. 846 - 858
Journal Article
Cancer Research, ISSN 0008-5472, 12/2013, Volume 73, Issue 24, pp. 7162 - 7167
Activating mutations occur in the promoter of the telomerase reverse transcriptase (TERT) gene in 66% of muscle-invasive urothe