Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 8, pp. 782 - 789
Summary Background MEK is a member of the MAPK signalling cascade that is commonly activated in melanoma. Direct inhibition of MEK blocks cell proliferation...
Hematology, Oncology and Palliative Medicine | SURVIVAL | BRAF | ONCOLOGY | RAF | SOMATIC MUTATIONS | PROGRESSION | Skin Neoplasms - drug therapy | United States | Humans | Middle Aged | Melanoma - enzymology | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Uveal Neoplasms - enzymology | Young Adult | Pyridones - administration & dosage | Skin Neoplasms - enzymology | Time Factors | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Melanoma - genetics | Skin Neoplasms - mortality | Adult | Female | Skin Neoplasms - pathology | MAP Kinase Kinase 1 - antagonists & inhibitors | Uveal Neoplasms - genetics | Uveal Neoplasms - pathology | Drug Administration Schedule | Administration, Oral | Pyrimidinones - adverse effects | Kaplan-Meier Estimate | MAP Kinase Kinase 1 - metabolism | Treatment Outcome | MAP Kinase Kinase 2 - metabolism | Melanoma - pathology | Uveal Neoplasms - drug therapy | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | MAP Kinase Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Uveal Neoplasms - mortality | Aged | Pyrimidinones - administration & dosage | Mutation | Pyridones - adverse effects | Melanoma - mortality | Prevention | Care and treatment | Melanoma | Cancer | Index Medicus
Hematology, Oncology and Palliative Medicine | SURVIVAL | BRAF | ONCOLOGY | RAF | SOMATIC MUTATIONS | PROGRESSION | Skin Neoplasms - drug therapy | United States | Humans | Middle Aged | Melanoma - enzymology | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Uveal Neoplasms - enzymology | Young Adult | Pyridones - administration & dosage | Skin Neoplasms - enzymology | Time Factors | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Melanoma - genetics | Skin Neoplasms - mortality | Adult | Female | Skin Neoplasms - pathology | MAP Kinase Kinase 1 - antagonists & inhibitors | Uveal Neoplasms - genetics | Uveal Neoplasms - pathology | Drug Administration Schedule | Administration, Oral | Pyrimidinones - adverse effects | Kaplan-Meier Estimate | MAP Kinase Kinase 1 - metabolism | Treatment Outcome | MAP Kinase Kinase 2 - metabolism | Melanoma - pathology | Uveal Neoplasms - drug therapy | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | MAP Kinase Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Uveal Neoplasms - mortality | Aged | Pyrimidinones - administration & dosage | Mutation | Pyridones - adverse effects | Melanoma - mortality | Prevention | Care and treatment | Melanoma | Cancer | Index Medicus
Journal Article
Cancer, ISSN 0008-543X, 11/2016, Volume 122, Issue 21, pp. 3354 - 3362
BACKGROUND Therapeutic antibodies against programmed cell death receptor 1 (PD‐1) are considered front‐line therapy in metastatic melanoma. The efficacy of...
pembrolizumab | mucosal melanoma | anti‐programmed cell death receptor 1 (anti‐PD‐1) | acral melanoma | nivolumab | immunotherapy | anti-programmed cell death receptor 1 (anti-PD-1) | CTLA-4 BLOCKADE | SAFETY | PD-1 BLOCKADE | BIOCHEMOTHERAPY | CANCER | UNTREATED MELANOMA | UVEAL MELANOMA | ONCOLOGY | IPILIMUMAB | Prognosis | Skin Neoplasms - drug therapy | Follow-Up Studies | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Brain Neoplasms - secondary | Antibodies, Monoclonal, Humanized - administration & dosage | Brain Neoplasms - immunology | Aged, 80 and over | Adult | Female | Retrospective Studies | Mucous Membrane - drug effects | Liver Neoplasms - secondary | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Liver Neoplasms - drug therapy | Liver Neoplasms - immunology | Survival Rate | Melanoma - pathology | Brain Neoplasms - drug therapy | Mucous Membrane - pathology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Melanoma - immunology | Melanoma - drug therapy | Aged | Programmed Cell Death 1 Receptor - immunology | Neoplasm Staging | Care and treatment | Research | Diagnosis | Melanoma | Apoptosis | Index Medicus | Abridged Index Medicus | anti-PD-1
pembrolizumab | mucosal melanoma | anti‐programmed cell death receptor 1 (anti‐PD‐1) | acral melanoma | nivolumab | immunotherapy | anti-programmed cell death receptor 1 (anti-PD-1) | CTLA-4 BLOCKADE | SAFETY | PD-1 BLOCKADE | BIOCHEMOTHERAPY | CANCER | UNTREATED MELANOMA | UVEAL MELANOMA | ONCOLOGY | IPILIMUMAB | Prognosis | Skin Neoplasms - drug therapy | Follow-Up Studies | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Brain Neoplasms - secondary | Antibodies, Monoclonal, Humanized - administration & dosage | Brain Neoplasms - immunology | Aged, 80 and over | Adult | Female | Retrospective Studies | Mucous Membrane - drug effects | Liver Neoplasms - secondary | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Liver Neoplasms - drug therapy | Liver Neoplasms - immunology | Survival Rate | Melanoma - pathology | Brain Neoplasms - drug therapy | Mucous Membrane - pathology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Melanoma - immunology | Melanoma - drug therapy | Aged | Programmed Cell Death 1 Receptor - immunology | Neoplasm Staging | Care and treatment | Research | Diagnosis | Melanoma | Apoptosis | Index Medicus | Abridged Index Medicus | anti-PD-1
Journal Article
Cancer, ISSN 0008-543X, 10/2013, Volume 119, Issue 20, pp. 3687 - 3695
Uveal melanoma exhibits a high incidence of metastases; and, to date, there is no systemic therapy that clearly improves outcomes. The anticytotoxic...
absolute lymphocyte count | cytotoxic T-lymphocyte - associated protein 4 | uveal melanoma | immunotherapy | ipilimumab | Prognosis | Skin Neoplasms - drug therapy | Follow-Up Studies | Humans | Ipilimumab | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Universities | Neoplasm Metastasis | Skin Neoplasms - mortality | Aged, 80 and over | Adult | Female | Retrospective Studies | Uveal Neoplasms - pathology | Survival Rate | Melanoma - pathology | CTLA-4 Antigen - immunology | Uveal Neoplasms - drug therapy | Melanoma - drug therapy | Skin Neoplasms - secondary | Uveal Neoplasms - mortality | Aged | CTLA-4 Antigen - antagonists & inhibitors | Neoplasm Staging | Melanoma - mortality | Eye cancer | Patient outcomes | Melanoma | Dosage and administration | Research | Drug therapy | Index Medicus | Abridged Index Medicus | CTLA-4
absolute lymphocyte count | cytotoxic T-lymphocyte - associated protein 4 | uveal melanoma | immunotherapy | ipilimumab | Prognosis | Skin Neoplasms - drug therapy | Follow-Up Studies | Humans | Ipilimumab | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Universities | Neoplasm Metastasis | Skin Neoplasms - mortality | Aged, 80 and over | Adult | Female | Retrospective Studies | Uveal Neoplasms - pathology | Survival Rate | Melanoma - pathology | CTLA-4 Antigen - immunology | Uveal Neoplasms - drug therapy | Melanoma - drug therapy | Skin Neoplasms - secondary | Uveal Neoplasms - mortality | Aged | CTLA-4 Antigen - antagonists & inhibitors | Neoplasm Staging | Melanoma - mortality | Eye cancer | Patient outcomes | Melanoma | Dosage and administration | Research | Drug therapy | Index Medicus | Abridged Index Medicus | CTLA-4
Journal Article
Annals of Oncology, ISSN 0923-7534, 11/2013, Volume 24, Issue 11, pp. 2911 - 2915
Patients with advanced uveal melanoma have a poor prognosis and limited treatment options. Ipilimumab is approved for pre-treated adult patients with advanced...
Expanded access programme | Uveal melanoma | Efficacy | Metastatic melanoma | Safety | Ipilimumab | MANAGEMENT | ONCOLOGY | metastatic melanoma | uveal melanoma | safety | ipilimumab | BRAF | ABSENCE | MUTATIONS | efficacy | expanded access programme | PROGRESSION | Skin Neoplasms - pathology | Skin Neoplasms - drug therapy | Uveal Neoplasms - pathology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Treatment Outcome | Melanoma - pathology | Uveal Neoplasms - drug therapy | Disease-Free Survival | Neoplasm Metastasis | Antibodies, Monoclonal - administration & dosage | Skin Neoplasms - mortality | Melanoma - drug therapy | Uveal Neoplasms - mortality | Aged, 80 and over | Adult | Female | Aged | Neoplasm Staging | Melanoma - mortality
Expanded access programme | Uveal melanoma | Efficacy | Metastatic melanoma | Safety | Ipilimumab | MANAGEMENT | ONCOLOGY | metastatic melanoma | uveal melanoma | safety | ipilimumab | BRAF | ABSENCE | MUTATIONS | efficacy | expanded access programme | PROGRESSION | Skin Neoplasms - pathology | Skin Neoplasms - drug therapy | Uveal Neoplasms - pathology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Treatment Outcome | Melanoma - pathology | Uveal Neoplasms - drug therapy | Disease-Free Survival | Neoplasm Metastasis | Antibodies, Monoclonal - administration & dosage | Skin Neoplasms - mortality | Melanoma - drug therapy | Uveal Neoplasms - mortality | Aged, 80 and over | Adult | Female | Aged | Neoplasm Staging | Melanoma - mortality
Journal Article
Cancer, ISSN 0008-543X, 11/2016, Volume 122, Issue 21, pp. 3344 - 3353
BACKGROUND Antibodies inhibiting the programmed death receptor 1 (PD‐1) have demonstrated significant activity in the treatment of advanced cutaneous melanoma....
pembrolizumab | atezolizumab | nivolumab | uveal melanoma | immunotherapy | SURVIVAL | CTLA-4 BLOCKADE | SAFETY | CHEMOTHERAPY | RESPONSES | ONCOLOGY | MUTATIONS | ANTI-PD-1 | IPILIMUMAB | Prognosis | Follow-Up Studies | Humans | Middle Aged | Male | Antibodies, Monoclonal, Humanized - administration & dosage | Aged, 80 and over | Adult | Female | Retrospective Studies | Mucous Membrane - drug effects | Uveal Neoplasms - pathology | Survival Rate | Melanoma - pathology | B7-H1 Antigen - immunology | Uveal Neoplasms - drug therapy | Mucous Membrane - pathology | Uveal Neoplasms - immunology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Melanoma - immunology | Melanoma - drug therapy | Skin Neoplasms | Aged | Programmed Cell Death 1 Receptor - immunology | Neoplasm Staging | Viral antibodies | Care and treatment | Usage | Melanoma | Antibodies | Research | Patients | Health aspects | Apoptosis | Index Medicus | Abridged Index Medicus
pembrolizumab | atezolizumab | nivolumab | uveal melanoma | immunotherapy | SURVIVAL | CTLA-4 BLOCKADE | SAFETY | CHEMOTHERAPY | RESPONSES | ONCOLOGY | MUTATIONS | ANTI-PD-1 | IPILIMUMAB | Prognosis | Follow-Up Studies | Humans | Middle Aged | Male | Antibodies, Monoclonal, Humanized - administration & dosage | Aged, 80 and over | Adult | Female | Retrospective Studies | Mucous Membrane - drug effects | Uveal Neoplasms - pathology | Survival Rate | Melanoma - pathology | B7-H1 Antigen - immunology | Uveal Neoplasms - drug therapy | Mucous Membrane - pathology | Uveal Neoplasms - immunology | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Melanoma - immunology | Melanoma - drug therapy | Skin Neoplasms | Aged | Programmed Cell Death 1 Receptor - immunology | Neoplasm Staging | Viral antibodies | Care and treatment | Usage | Melanoma | Antibodies | Research | Patients | Health aspects | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2016, Volume 96, Issue 4, pp. 808 - 819
Abstract Purpose /Objective(s): To report clinical outcomes of head and neck reirradiation with proton therapy. Methods and Materials Between 2004–2014, 61...
Radiology | Hematology, Oncology and Palliative Medicine | SALVAGE REIRRADIATION | CETUXIMAB | MANAGEMENT | PROGNOSTIC-FACTORS | UVEAL MELANOMA | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | PERINEURAL SPREAD | RADIOTHERAPY | RADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CHEMOTHERAPY | Neoplasm Recurrence, Local - radiotherapy | Follow-Up Studies | Skin Neoplasms - radiotherapy | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Salvage Therapy | Male | Neoplasms, Second Primary - mortality | Carcinoma, Squamous Cell - radiotherapy | Neoplasm Recurrence, Local - mortality | Neoplasms, Second Primary - radiotherapy | Neoplasm, Residual | Carcinoma, Squamous Cell - mortality | Karnofsky Performance Status | Time Factors | Aged, 80 and over | Adult | Female | Radiotherapy Dosage | Carcinoma, Adenoid Cystic - pathology | Re-Irradiation - adverse effects | Head and Neck Neoplasms - drug therapy | Kaplan-Meier Estimate | Treatment Outcome | Head and Neck Neoplasms - pathology | Head and Neck Neoplasms - radiotherapy | Carcinoma, Adenoid Cystic - mortality | Carcinoma, Squamous Cell - drug therapy | Proton Therapy | Aged | Carcinoma, Adenoid Cystic - radiotherapy | Head and Neck Neoplasms - mortality | Relative Biological Effectiveness | Yuan (China) | Medical colleges | Care and treatment | Health aspects | Radiation | Cancer | Index Medicus | HEAD | PATIENTS | NEOPLASMS | RADIOLOGY AND NUCLEAR MEDICINE | PROTON BEAMS | DEATH | RADIATION DOSES | NECK | GY RANGE 10-100
Radiology | Hematology, Oncology and Palliative Medicine | SALVAGE REIRRADIATION | CETUXIMAB | MANAGEMENT | PROGNOSTIC-FACTORS | UVEAL MELANOMA | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | PERINEURAL SPREAD | RADIOTHERAPY | RADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CHEMOTHERAPY | Neoplasm Recurrence, Local - radiotherapy | Follow-Up Studies | Skin Neoplasms - radiotherapy | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Salvage Therapy | Male | Neoplasms, Second Primary - mortality | Carcinoma, Squamous Cell - radiotherapy | Neoplasm Recurrence, Local - mortality | Neoplasms, Second Primary - radiotherapy | Neoplasm, Residual | Carcinoma, Squamous Cell - mortality | Karnofsky Performance Status | Time Factors | Aged, 80 and over | Adult | Female | Radiotherapy Dosage | Carcinoma, Adenoid Cystic - pathology | Re-Irradiation - adverse effects | Head and Neck Neoplasms - drug therapy | Kaplan-Meier Estimate | Treatment Outcome | Head and Neck Neoplasms - pathology | Head and Neck Neoplasms - radiotherapy | Carcinoma, Adenoid Cystic - mortality | Carcinoma, Squamous Cell - drug therapy | Proton Therapy | Aged | Carcinoma, Adenoid Cystic - radiotherapy | Head and Neck Neoplasms - mortality | Relative Biological Effectiveness | Yuan (China) | Medical colleges | Care and treatment | Health aspects | Radiation | Cancer | Index Medicus | HEAD | PATIENTS | NEOPLASMS | RADIOLOGY AND NUCLEAR MEDICINE | PROTON BEAMS | DEATH | RADIATION DOSES | NECK | GY RANGE 10-100
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 4/2016, Volume 23, Issue 4, pp. 1309 - 1319
There is no consensus for the treatment of melanoma metastatic to the liver. Percutaneous hepatic perfusion with melphalan (PHP-Mel) is a method of delivering...
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | OCULAR MELANOMA | SURGERY | ISOLATED LIMB INFUSION | UVEAL MELANOMA | SURVIVAL BENEFIT | ONCOLOGY | SAFETY | SINGLE-INSTITUTION EXPERIENCE | REGIONAL THERAPY | IMMUNOEMBOLIZATION | MELPHALAN | ADVANCED EXTREMITY MELANOMA | Prognosis | Skin Neoplasms - drug therapy | Follow-Up Studies | Humans | Middle Aged | Hepatic Artery | Liver Neoplasms - drug therapy | Eye Neoplasms - secondary | Male | Survival Rate | Embolization, Therapeutic | Melanoma - pathology | Eye Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Perfusion | Melanoma - drug therapy | Skin Neoplasms - secondary | Adult | Female | Aged | Liver Neoplasms - secondary | Neoplasm Staging | Chemotherapy, Cancer, Regional Perfusion | Infusions, Intra-Arterial | Clinical trials | Liver cancer | Care and treatment | Metastasis | Comparative analysis | Patients
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | OCULAR MELANOMA | SURGERY | ISOLATED LIMB INFUSION | UVEAL MELANOMA | SURVIVAL BENEFIT | ONCOLOGY | SAFETY | SINGLE-INSTITUTION EXPERIENCE | REGIONAL THERAPY | IMMUNOEMBOLIZATION | MELPHALAN | ADVANCED EXTREMITY MELANOMA | Prognosis | Skin Neoplasms - drug therapy | Follow-Up Studies | Humans | Middle Aged | Hepatic Artery | Liver Neoplasms - drug therapy | Eye Neoplasms - secondary | Male | Survival Rate | Embolization, Therapeutic | Melanoma - pathology | Eye Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Perfusion | Melanoma - drug therapy | Skin Neoplasms - secondary | Adult | Female | Aged | Liver Neoplasms - secondary | Neoplasm Staging | Chemotherapy, Cancer, Regional Perfusion | Infusions, Intra-Arterial | Clinical trials | Liver cancer | Care and treatment | Metastasis | Comparative analysis | Patients
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2016, Volume 34, Issue 29, pp. 3562 - 3569
PurposeInterleukin-10 (IL-10) stimulates the expansion and cytotoxicity of tumor-infiltrating CD8+ T cells and inhibits inflammatory CD4+ T cells. Pegylation...
MELANOMA | THERAPY | ONCOLOGY | INFLAMMATION | RECEPTOR | NIVOLUMAB | CANCER | CD8(+) T-CELLS | IL-10 | IPILIMUMAB | Recombinant Proteins - therapeutic use | Humans | Middle Aged | Polyethylene Glycols - adverse effects | Male | Recombinant Proteins - pharmacokinetics | Fatigue - chemically induced | Injections, Subcutaneous - adverse effects | Recombinant Proteins - adverse effects | Fever - chemically induced | Polyethylene Glycols - therapeutic use | Young Adult | Exanthema - chemically induced | Aged, 80 and over | Adult | Female | Carcinoma, Renal Cell - drug therapy | Interleukin-8 - blood | Cytokines - blood | Drug Eruptions - etiology | Interleukin-10 - pharmacokinetics | Anemia - chemically induced | Polyethylene Glycols - pharmacokinetics | Thrombocytopenia - chemically induced | Transforming Growth Factor beta - blood | Uveal Neoplasms - drug therapy | Neoplasms - drug therapy | Interleukin-4 - blood | Interleukin-10 - adverse effects | Recombinant Proteins - immunology | Melanoma - drug therapy | Aged | Interleukin-10 - therapeutic use | Kidney Neoplasms - drug therapy | Neoplasms - pathology | Interleukin-10 - immunology | Interferon-gamma - blood | Original Reports
MELANOMA | THERAPY | ONCOLOGY | INFLAMMATION | RECEPTOR | NIVOLUMAB | CANCER | CD8(+) T-CELLS | IL-10 | IPILIMUMAB | Recombinant Proteins - therapeutic use | Humans | Middle Aged | Polyethylene Glycols - adverse effects | Male | Recombinant Proteins - pharmacokinetics | Fatigue - chemically induced | Injections, Subcutaneous - adverse effects | Recombinant Proteins - adverse effects | Fever - chemically induced | Polyethylene Glycols - therapeutic use | Young Adult | Exanthema - chemically induced | Aged, 80 and over | Adult | Female | Carcinoma, Renal Cell - drug therapy | Interleukin-8 - blood | Cytokines - blood | Drug Eruptions - etiology | Interleukin-10 - pharmacokinetics | Anemia - chemically induced | Polyethylene Glycols - pharmacokinetics | Thrombocytopenia - chemically induced | Transforming Growth Factor beta - blood | Uveal Neoplasms - drug therapy | Neoplasms - drug therapy | Interleukin-4 - blood | Interleukin-10 - adverse effects | Recombinant Proteins - immunology | Melanoma - drug therapy | Aged | Interleukin-10 - therapeutic use | Kidney Neoplasms - drug therapy | Neoplasms - pathology | Interleukin-10 - immunology | Interferon-gamma - blood | Original Reports
Journal Article
Medical Journal of Australia, ISSN 0025-729X, 07/2014, Volume 201, Issue 1, pp. 49 - 53
Objectives: To evaluate the efficacy and tolerability of ipilimumab in an Australian clinical setting, and to assess the association of response with melanoma...
Skin and connective tissue diseases | SURVIVAL | MEDICINE, GENERAL & INTERNAL | Skin Neoplasms - drug therapy | Humans | Ipilimumab | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Mucous Membrane | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Melanoma - genetics | Skin Neoplasms - mortality | Retrospective Studies | Skin Neoplasms - pathology | Uveal Neoplasms - genetics | Uveal Neoplasms - pathology | Drug Administration Schedule | Melanoma - pathology | Disease Progression | Uveal Neoplasms - drug therapy | Disease-Free Survival | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Uveal Neoplasms - mortality | Lymphocyte Count | Neoplasm Staging | Melanoma - mortality | Care and treatment | Dosage and administration | Analysis | Risk factors | Melanoma
Skin and connective tissue diseases | SURVIVAL | MEDICINE, GENERAL & INTERNAL | Skin Neoplasms - drug therapy | Humans | Ipilimumab | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Mucous Membrane | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Melanoma - genetics | Skin Neoplasms - mortality | Retrospective Studies | Skin Neoplasms - pathology | Uveal Neoplasms - genetics | Uveal Neoplasms - pathology | Drug Administration Schedule | Melanoma - pathology | Disease Progression | Uveal Neoplasms - drug therapy | Disease-Free Survival | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Uveal Neoplasms - mortality | Lymphocyte Count | Neoplasm Staging | Melanoma - mortality | Care and treatment | Dosage and administration | Analysis | Risk factors | Melanoma
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2018, Volume 36, Issue 12, pp. 1232 - 1239
PurposeUveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option in the metastatic setting....
ONCOLOGY | GNAQ | GROWTH | MUTATIONS | AZD6244 ARRY-142886 | INHIBITOR | CANCER | Dacarbazine - administration & dosage | Dacarbazine - adverse effects | Uveal Neoplasms - pathology | Double-Blind Method | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Melanoma - pathology | Uveal Neoplasms - drug therapy | Neoplasm Metastasis | Benzimidazoles - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Melanoma - drug therapy | Progression-Free Survival | Placebos | Adult | Female | Aged | Benzimidazoles - adverse effects
ONCOLOGY | GNAQ | GROWTH | MUTATIONS | AZD6244 ARRY-142886 | INHIBITOR | CANCER | Dacarbazine - administration & dosage | Dacarbazine - adverse effects | Uveal Neoplasms - pathology | Double-Blind Method | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Melanoma - pathology | Uveal Neoplasms - drug therapy | Neoplasm Metastasis | Benzimidazoles - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Melanoma - drug therapy | Progression-Free Survival | Placebos | Adult | Female | Aged | Benzimidazoles - adverse effects
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 03/2015, Volume 28, Issue 2, pp. 135 - 147
Summary Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to...
MEK | Ocular | metastasis | GNAQ | GNA11 | Melanoma | cancer | Uveal | Metastasis | Cancer | Melanoma - etiology | Uveal Neoplasms - pathology | Signal Transduction | Humans | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Melanoma - pathology | Uveal Neoplasms - etiology | Uveal Neoplasms - drug therapy | Uveal Neoplasms - immunology | Melanoma - immunology | Melanoma - drug therapy | Biomedical Research | Neoplasm Staging | Therapeutics | Homeopathy | Materia medica and therapeutics | Medical research | Drug therapy | Gene expression
MEK | Ocular | metastasis | GNAQ | GNA11 | Melanoma | cancer | Uveal | Metastasis | Cancer | Melanoma - etiology | Uveal Neoplasms - pathology | Signal Transduction | Humans | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Melanoma - pathology | Uveal Neoplasms - etiology | Uveal Neoplasms - drug therapy | Uveal Neoplasms - immunology | Melanoma - immunology | Melanoma - drug therapy | Biomedical Research | Neoplasm Staging | Therapeutics | Homeopathy | Materia medica and therapeutics | Medical research | Drug therapy | Gene expression
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0118564 - e0118564
Purpose Up to 50% of patients with uveal melanoma (UM) develop metastatic disease with limited treatment options. The immunomodulating agent ipilimumab has...
SURVIVAL | TRIAL | CONJUNCTIVAL | DOSE-ESCALATION | SAFETY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | INTRAVENOUS FOTEMUSTINE | MUTATIONS | CANCER | TUMORS | History, Ancient | Uveal Neoplasms - pathology | Humans | Ipilimumab | Middle Aged | Antibodies, Monoclonal - adverse effects | Kaplan-Meier Estimate | Proportional Hazards Models | Antibodies, Monoclonal - therapeutic use | Treatment Outcome | Antineoplastic Agents - therapeutic use | Melanoma - secondary | Uveal Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Melanoma - drug therapy | Uveal Neoplasms - mortality | Aged, 80 and over | Adult | Female | Aged | Melanoma - mortality | Life expectancy | Dermatology | Toxicity | Medical treatment | Melanoma | Medical services | Clinical trials | Metastasis | Criteria | Dosage | Kinases | Disease control | Patients | Survival | Two phase | Metastases | Skin cancer | Lymphocytes | Medical prognosis | Pancytopenia | Mutation | Tumors | Index Medicus
SURVIVAL | TRIAL | CONJUNCTIVAL | DOSE-ESCALATION | SAFETY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | INTRAVENOUS FOTEMUSTINE | MUTATIONS | CANCER | TUMORS | History, Ancient | Uveal Neoplasms - pathology | Humans | Ipilimumab | Middle Aged | Antibodies, Monoclonal - adverse effects | Kaplan-Meier Estimate | Proportional Hazards Models | Antibodies, Monoclonal - therapeutic use | Treatment Outcome | Antineoplastic Agents - therapeutic use | Melanoma - secondary | Uveal Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Melanoma - drug therapy | Uveal Neoplasms - mortality | Aged, 80 and over | Adult | Female | Aged | Melanoma - mortality | Life expectancy | Dermatology | Toxicity | Medical treatment | Melanoma | Medical services | Clinical trials | Metastasis | Criteria | Dosage | Kinases | Disease control | Patients | Survival | Two phase | Metastases | Skin cancer | Lymphocytes | Medical prognosis | Pancytopenia | Mutation | Tumors | Index Medicus
Journal Article