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06/2012
Vacuolar-type ATPases (V-ATPases) are ubiquitous membrane-bound protein complexes present in the endo-membrane system of all eukaryotic cells. In eukaryotic... 
V-ATPase | cryo-EM
Dissertation
06/2012
Osteopetrosis is characterized by increased bone density and fragility. The R444L missense mutation in the human V-ATPase a3 subunit causes this disease.... 
0567 | osteopetrosis | 0487 | v-atpase
Dissertation
11/2011
The Vo sector of the vacuolar H+-ATPase is a multi-subunit complex that forms a proteolipid pore. The largest subunit in this complex is the a subunit which... 
transmitter uptake | V-ATPase | Voa | 0719 | acidification
Dissertation
03/2013
Single particle electron cryomicroscopy (cryo-EM) is a rapidly developing structural biology technique for the study of macromolecular protein complexes.... 
V-ATPase | 0786 | Structural Biology | Cryo-EM | Protein Purification | 0307
Dissertation
06/2012
Adenosine triphosphate (ATP) is the molecular currency of intracellular energy transfer in living organisms. The enzyme ATP synthase is primarily responsible... 
ATP synthase | electron cryomicroscopy | V-ATPase | membrane protein
Dissertation
03/2012
For bone resorption, vacuolar-type H+-ATPases (V-ATPases) on the plasma membranes of osteoclasts acidifies the extracellular millieu adjacent to the bone... 
0567 | V-ATPase | 0487 | drug development | Bone | Luteolin | osteoclast
Dissertation
Oncology Reports, ISSN 1021-335X, 03/2018, Volume 39, Issue 3, pp. 921 - 928
Journal Article
Nature cell biology, ISSN 1465-7392, 12/2018, Volume 20, Issue 12, pp. 1421 - 1433
Vesicular acidification and trafficking are associated with various cellular processes. However, their pathologic relevance to cancer remains elusive. We... 
β-catenin | colorectal cancer | TMEM9 | Wnt | v-ATPase | ATP6AP2
Journal Article
Nature, ISSN 0028-0836, 01/2013, Volume 493, Issue 7434, pp. 703 - 707
In various cellular membrane systems, vacuolar ATPases (V-ATPases) function as proton pumps, which are involved in many processes such as bone resorption and... 
V-ATPASE | NA+-ATPASE | F1-ATPASE | COMPLEX | MULTIDISCIPLINARY SCIENCES | F-1-ATPASE | RESOLUTION | VALIDATION | F-1 | ROTOR RING | BINDING
Journal Article
FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 04/2019, Volume 10
Journal Article
Oncotarget, ISSN 1949-2553, 08/2018, Volume 9, Issue 61, pp. 31793 - 31794
Journal Article
Autophagy, ISSN 1554-8627, 08/2019, Volume 15, Issue 8, pp. 1467 - 1469
Abnormal accumulation of proteins is a hallmark of a variety of neurological diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia... 
ALS | ER stress | lysosomal acidification | Drosophila | MTOR | v-ATPase | CELL BIOLOGY
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7380, pp. 214 - 219
Ion-translocating rotary ATPases serve either as ATP synthases, using energy from a transmembrane ion motive force to create the cell's supply of ATP, or as... 
V-ATPASE | NA+-ATPASE | ELECTRON CRYOMICROSCOPY | SUBUNIT-C | SINGLE-PARTICLE STRUCTURES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PROTON TRANSLOCATION | ROTOR RING | MEMBRANE TOPOLOGY | CENTRAL STALK
Journal Article
The European journal of neuroscience, ISSN 0953-816X, 6/2013, Volume 37, Issue 12, pp. 1949 - 1961
Autophagy is a lysosomal degradative process to recycle cellular waste and eliminate potentially toxic damaged organelles and protein aggregates. The important... 
neurodegeneration | Autophagy | lysosome | presenilin | v-ATPase
Journal Article
Natural Product Reports, ISSN 0265-0568, 2/2017, Volume 34, Issue 2, pp. 135 - 16
Covering: 2011-July 2016 Myxobacteria are a rich source for structurally diverse secondary metabolites with intriguing biological activities. Here we report on... 
STREPTOCOCCUS-MUTANS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ACETYL-COA CARBOXYLASE | GLIDING BACTERIA | STRUCTURE ELUCIDATION | MYXOCOCCUS-XANTHUS | V-ATPASE INHIBITION | SORANGIUM-CELLULOSUM MYXOBACTERIA | BIOLOGICAL EVALUATION | SECONDARY METABOLITE | BACTERIAL RNA-SYNTHESIS
Journal Article
Fungal Biology, ISSN 1878-6146, 10/2019, Volume 123, Issue 10, pp. 709 - 722
Hyphal morphogenesis of is important for its pathogenesis. Here, we showed that the filamentous growth of requires vacuolar H -ATPase function. Results showed... 
Morphogenesis | V-ATPase | C. albicans | Candida drug | Pathogenesis | Antiparasitic agents | Fluconazole | Amphotericin B | Analysis | Adenosine triphosphatase
Journal Article
International Journal of Oral & Maxillofacial Surgery, ISSN 0901-5027, 11/2019, Volume 48, Issue 11, pp. 1494 - 1503
Cleft palate is a common malformation of craniofacial development, and postnatal deficiencies in palate formation may occur. The aim of this study was to... 
development | V-ATPase | collagens | TGF-β1 | alendronate | bone | BMP-2
Journal Article
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