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Atherosclerosis, ISSN 0021-9150, 2015, Volume 242, Issue 1, pp. 251 - 260
Abstract Background Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. We previously proposed that valvular... 
Cardiovascular | Calcification | Endothelial-to-mesenchymal transformation | Calcific aortic valve disease | Valvular interstitial cells | Valvular endothelial cells | PROGENITOR CELLS | CARDIAC-VALVE | MITRAL REGURGITATION | HEART | GROWTH-FACTOR-BETA | WORKING GROUP | IN-VITRO | ADAPTATION | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | AORTIC-VALVE DISEASE | Calcinosis - genetics | Aortic Valve Stenosis - genetics | Apolipoproteins E - deficiency | Coculture Techniques | Humans | Aortic Valve - drug effects | Male | RNA, Messenger - metabolism | Culture Media - metabolism | Aortic Valve - pathology | Cell Differentiation - genetics | Time Factors | Epithelial-Mesenchymal Transition | Calcinosis - metabolism | Osteogenesis - genetics | Transforming Growth Factor beta1 - pharmacology | Disease Models, Animal | Biomarkers - metabolism | Endothelial Cells - metabolism | Osteogenesis - drug effects | Cells, Cultured | Gene Expression Regulation | Aortic Valve - metabolism | Mice, Knockout | Animals | Aortic Valve Stenosis - pathology | Cell Differentiation - drug effects | Apolipoproteins E - genetics | Cell Communication - drug effects | Aortic Valve Stenosis - metabolism | Sheep | Calcinosis - pathology | Endothelial Cells - pathology | Cell Movement | Endothelial Cells - drug effects | Stem cells | Endothelium
Journal Article
Journal Article
Journal Article
Journal Article
Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN 0962-8436, 08/2007, Volume 362, Issue 1484, pp. 1437 - 1443
Journal Article
Journal of Biomechanics, ISSN 0021-9290, 2011, Volume 45, Issue 5, pp. 882 - 887
Journal Article
11/2012
The cellular mechanical environment, including the elasticity of the extracellular matrix, profoundly affects cellular mechanical and biological responses.... 
Atomic force microscopy | 0541 | cell mechanics | heart valve | nuclear mechanics | 0548
Dissertation
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 511, Issue 4, pp. 826 - 832
OIP5-AS1, a highly abundant imprinted long non-coding RNA (lncRNA), has been implicated in calcific aortic valve disease (CAVD). However, the function and... 
Valve interstitial cells | miR-137 | OIP5-AS1 | Long non-coding RNA | Osteoblast differentiation | H19 | METASTASIS | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | PROLIFERATION | SPONGES
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2019, Volume 509, Issue 2, pp. 455 - 461
Calcific aortic valve disease (CAVD) is the most common valvular disease worldwide. The osteoblastic transdifferentiation of aortic valve interstitial cells... 
Aortic valve interstitial cells | Meis2 | Osteoblastic transdifferentiation | Calcific aortic valve disease | Notch1 | TRANSFORMATION | CLEFT-PALATE | ACTIVATION | ZEBRAFISH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | CARDIAC DEVELOPMENT | HOX | BIOPHYSICS | DISEASE | REGULATORS | LINEAGE
Journal Article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 03/2011, Volume 31, Issue 3, pp. 590 - 597
Objective-In calcific aortic valve disease, myofibroblasts and activation of the transforming growth factor-beta 1 (TGF-beta 1) and Wnt/beta-catenin pathways... 
beta-catenin | SMOOTH MUSCLE ACTIN | SIGNALING PATHWAYS | TGF-BETA | myofibroblast | NUCLEAR TRANSLOCATION | transforming growth factor-beta | WNT PATHWAYS | heart valves | MESENCHYMAL PROGENITOR CELLS | EARLY LESION | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | Wnt | IDIOPATHIC PULMONARY-FIBROSIS | HEMATOLOGY | extracellular matrix mechanics | CARDIAC VALVES
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, p. e0208774
The development of a substance or inhibitor-based treatment strategy for the prevention of aortic valve stenosis is a challenge and a main focus of medical... 
HEART | ACTIVATION |