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Neuropsychopharmacology, ISSN 0893-133X, 01/2012, Volume 37, Issue 2, pp. 478 - 486
The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating anxiety-and panic-related responses. Given the cellular and behavioral... 
vanilloid | anxiety | anandamide | cannabinoid | periaqueductal gray | panic | PSYCHIATRY | ENDOCANNABINOID SYSTEM | GREY-MATTER | NEUROSCIENCES | PREFRONTAL CORTEX | DORSOLATERAL PERIAQUEDUCTAL GRAY | ACID AMIDE HYDROLASE | LONG-TERM DEPRESSION | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | BRAIN | Rats, Wistar | Capsaicin - pharmacology | Cinnamates - administration & dosage | Microinjections - methods | Periaqueductal Gray - drug effects | Male | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - physiology | Capsaicin - administration & dosage | TRPV Cation Channels - metabolism | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Arachidonic Acids - administration & dosage | TRPV Cation Channels - antagonists & inhibitors | Electric Stimulation - methods | Pyrazoles - pharmacology | Panic - drug effects | Piperidines - administration & dosage | TRPV Cation Channels - physiology | Rats | Capsaicin - analogs & derivatives | Cinnamates - pharmacology | Arachidonic Acids - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Panic - physiology | Pyrazoles - administration & dosage | Animals | Anilides - administration & dosage | Anilides - pharmacology | Periaqueductal Gray - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Pyrazoles - antagonists & inhibitors | Index Medicus | animal models | psychopharmacology | mood | stress disorders | cannabinoids | Original
Journal Article
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 10/2018, Volume 470, Issue 10, pp. 1521 - 1542
The ventral medial prefrontal cortex (vMPFC) facilitates the cardiac baroreflex response through N-methyl-d-aspartate (NMDA) receptor activation and nitric... 
Medial prefrontal cortex | Neurosciences | Receptors | Biomedicine | Human Physiology | Baroreflex | Nitric oxide | CB 1 receptors | TRPV 1 receptors | Molecular Medicine | NMDA receptors | Cell Biology | TRPV | receptors | POSTTRAUMATIC-STRESS-DISORDER | CARDIOVASCULAR-RESPONSES | PHYSIOLOGY | AUTONOMIC DYSFUNCTION | ENDOCANNABINOID SYSTEM | CANNABINOID RECEPTOR | TRPV1 receptors | MULTIPLE-SCLEROSIS | HEART-RATE-VARIABILITY | CB1 receptors | VANILLOID RECEPTORS | NITRIC-OXIDE | MAJOR DEPRESSIVE DISORDER | Heart Rate | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Rats, Wistar | Heart - physiology | TRPV Cation Channels - agonists | Enzyme Inhibitors - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Rats | Male | Excitatory Amino Acid Antagonists - pharmacology | Guanylate Cyclase - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - metabolism | TRPV Cation Channels - metabolism | Animals | Prefrontal Cortex - drug effects | Nitric Oxide Synthase Type I - antagonists & inhibitors | Prefrontal Cortex - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Nitric Oxide - metabolism | Prefrontal Cortex - physiology | Methyl aspartate | Medical colleges | Glutamate | Neurons | Heart | Baroreceptors | Cortex (prefrontal) | Femoral artery | Femur | Glutamic acid receptors (ionotropic) | N-Methyl-D-aspartic acid receptors | Capsaicin receptors | Glutamic acid receptors | Cannabinoid CB1 receptors | Guanylate cyclase | Nitric-oxide synthase | Transient receptor potential proteins | Microinjection | Stainless steel | Rodents | Glutamatergic transmission | Receptor mechanisms | Heart diseases | Reflexes | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2013, Volume 71, Issue 100, pp. 255 - 263
The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI) tract remains unknown. Here we studied... 
Cannabidiol | Gastrointestinal motility | Colon | Cannabinoid | GPR55 | ENDOCANNABINOID SYSTEM | MOUSE COLON | FUNCTIONAL GASTROINTESTINAL DISORDERS | NEUROSCIENCES | PATHOPHYSIOLOGY | IN-VITRO | CANNABINOID RECEPTOR | CB1 | LIGANDS | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | IRRITABLE-BOWEL-SYNDROME | Colon - cytology | Tissue Banks | Receptor, Cannabinoid, CB2 - agonists | Humans | Colon - drug effects | Gastrointestinal Motility - drug effects | Cannabidiol - analogs & derivatives | Colon - innervation | Colonic Diseases, Functional - drug therapy | Male | Neurons - cytology | Myenteric Plexus - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Molecular Targeted Therapy | Receptor, Cannabinoid, CB2 - genetics | Receptors, Cannabinoid - metabolism | Muscle, Smooth - drug effects | Receptor, Cannabinoid, CB1 - agonists | Cannabinoid Receptor Antagonists - pharmacology | Cannabidiol - therapeutic use | Neurons - metabolism | Neurons - drug effects | Receptors, Cannabinoid - chemistry | Receptors, Cannabinoid - genetics | Nerve Tissue Proteins - antagonists & inhibitors | Muscle, Smooth - innervation | Nerve Tissue Proteins - agonists | Gene Expression Regulation | Myenteric Plexus - drug effects | Cannabidiol - pharmacology | Myenteric Plexus - cytology | Muscle, Smooth - metabolism | Mice, Inbred Strains | Nerve Tissue Proteins - genetics | Colon - metabolism | Cannabinoids - pharmacology | Mice, Knockout | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Animals | Receptor, Cannabinoid, CB1 - genetics | Mice | Colonic Diseases, Functional - metabolism | Muscle, Smooth - cytology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Chronic diseases | Physiological aspects | Medical colleges | G proteins | Membrane proteins | Index Medicus | G protein-coupled receptors | COX-2, cyclooxygenase-2 | CB2, cannabinoid-2 | GI, gastrointestinal | ECS, endocannabinoid system | cDNA, complementary DNA | MAGL, monoacylglycerol lipase | CBD, cannabidiol | CB1, cannabinoid-1 | GE, gastric emptying | LMMP, longitudinal muscle-myenteric plexus layer | GPR55, G protein-coupled receptor 55 | i.c.v., intracerebroventricular administration | i.p., intraperitoneal | FAAH, fatty acid amide hydrolase | EFS, electrical field stimulation | KRS, Krebs–Ringer solution | RT-PCR, reverse transcription polymerase chain reaction | PPARα, peroxisome proliferator-activated receptor-alpha | TRPV1, transient receptor potential vanilloid 1
Journal Article
Journal Article
Neuroscience, ISSN 0306-4522, 2016, Volume 324, pp. 151 - 162
Highlights • SZV-1287 is a new 3-(4,5-diphenyl-l,3-oxazol-2-yl)propanal oxime SSAO inhibitor. • Structure of oxime derivatives described as TRPA1 antagonists... 
Neurology | sensory neuron | SZV-1287 | Transient Receptor Potential Ankyrin 1 and Vanilloid 1 receptors | allyl-isothiocyanate | semicarbazide-sensitive amine-oxidase | capsaicin | Sensory neuron | Semicarbazide-sensitive amine-oxidase | Transient receptor potential ankyrin 1 and vanilloid 1 receptors | Allyl-isothiocyanate | Capsaicin | ACTIVATION | ION-CHANNEL TRPA1 | NEUROGENIC INFLAMMATION | TRPV1 RECEPTOR | NEUROSCIENCES | TRIGEMINAL SENSORY NEURONS | SSAO INHIBITORS | NERVE-TERMINALS | PAIN | CELL-LINE | SENSITIVE AMINE OXIDASES | Transient Receptor Potential Channels - antagonists & inhibitors | Cricetulus | Rats, Wistar | Calcium - metabolism | Capsaicin - pharmacology | Trigeminal Ganglion - drug effects | Oxazoles - chemistry | Sensory System Agents - pharmacology | Dose-Response Relationship, Drug | Cations, Divalent - metabolism | Enzyme Inhibitors - chemistry | Neurotransmitter Agents - pharmacology | Neurons - physiology | Molecular Structure | Transient Receptor Potential Channels - metabolism | Calcitonin Gene-Related Peptide - metabolism | Drug Evaluation, Preclinical | Neurons - drug effects | Isothiocyanates - pharmacology | CHO Cells | Trigeminal Ganglion - physiology | Cell Line | Enzyme Inhibitors - pharmacology | Sensory System Agents - chemistry | Oximes - chemical synthesis | Trachea - innervation | Transient Receptor Potential Channels - agonists | Oximes - chemistry | Oxazoles - chemical synthesis | Animals | Oximes - pharmacology | Oxazoles - pharmacology | Sensory System Agents - chemical synthesis | Index Medicus
Journal Article
Experimental Eye Research, ISSN 0014-4835, 2010, Volume 91, Issue 3, pp. 462 - 471
Corneal epithelial injury induces release of endogenous metabolites that are cannabinoid receptor 1 (CB1) and transient receptor potential vanilloid 1 (TRPV1)... 
proinflammatory cytokine | cell proliferation | epidermal growth factor receptor (EGFR) | cell migration | transient receptor potential vanilloid 1 (TRPV1) | protein phosphorylation | cannabinoid receptor 1 (CB1) | transactivation | Cell proliferation | Transient receptor potential vanilloid 1 (TRPV1) | Epidermal growth factor receptor (EGFR) | Proinflammatory cytokine | Protein phosphorylation | Transactivation | Cannabinoid receptor 1 (CB1) | Cell migration | STIMULATION | EGFR ACTIVATION | MAP KINASE | WOUNDING SHEETS | ANANDAMIDE | PROLIFERATION | MECHANISMS | INFLAMMATION | NEURONS | OPHTHALMOLOGY | MOTILITY | Phosphorylation | Cell Proliferation | Capsaicin - pharmacology | Humans | Quinazolines | TRPV Cation Channels - metabolism | Receptor, Epidermal Growth Factor - metabolism | Piperidines - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Epithelium, Corneal - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Fluorescent Antibody Technique, Indirect | Pyrazoles - pharmacology | Enzyme-Linked Immunosorbent Assay | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Cells, Cultured | Morpholines - pharmacology | Tyrphostins - pharmacology | Blotting, Western | Naphthalenes - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Benzoxazines - pharmacology | Epithelium, Corneal - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Transcriptional Activation - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Cell Movement | Mitogen-Activated Protein Kinase 1 - metabolism | Tyrosine | Anticoagulants (Medicine) | Glycosaminoglycans | Epidermal growth factor | Metabolites | Index Medicus
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2012, Volume 27, Issue 10, pp. 2097 - 2107
Transient receptor potential cation channel, subfamily V, member 6 (TRPV6) is an apical membrane calcium (Ca) channel in the small intestine proposed to be... 
INTESTINE | ABSORPTION | TRPV6 | CALBINDIN D | VITAMIN D | CALBINDIN-D-9K | RAT INTESTINE | CALBINDIN D9K | BINDING PROTEIN | VANILLOID TYPE-6 | TRANSPORT | MESSENGER-RNA | IN-VIVO | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | 1,25-DIHYDROXYVITAMIN D-3 | KIDNEY | Calcium Channels - metabolism | Calcium - metabolism | Humans | Intestines - metabolism | Promoter Regions, Genetic - genetics | X-Ray Microtomography | Intestinal Absorption | Bone and Bones - anatomy & histology | Calbindins | Calcium - blood | TRPV Cation Channels - metabolism | Kidney - metabolism | Transfection | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Calcium Channels - genetics | Microfilament Proteins - genetics | Caco-2 Cells | Receptors, Calcitriol - deficiency | Transgenes - genetics | Gene Expression Regulation | Receptors, Calcitriol - metabolism | Organ Specificity | TRPV Cation Channels - genetics | Mice, Knockout | S100 Calcium Binding Protein G - metabolism | Phenotype | Animals | Mice | Messenger RNA | Vitamin D | Oncology, Experimental | Cytochrome P-450 | Physiological aspects | Calcifediol | Bones | Genetic engineering | Alfacalcidol | Research | Density | Cancer | Index Medicus | Calcification (ectopic) | Femur | Hydroxylase | Transgenic mice | mRNA | Bone turnover | Gene expression | transient receptor potential proteins | Small intestine | Kidney | Calcium absorption | Soft tissues | Diets | Hypercalcemia | cation channels | Bone mineral density | Vitamin D receptors | Calbindin-D9K
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, pp. e115731 - e115731
Normal and painful stimuli are detected by specialized subgroups of peripheral sensory neurons. The understanding of the functional differences of each... 
CAPSAICIN RECEPTOR | PERIPHERAL SENSORY NEURONS | GENE-RELATED PEPTIDE | PRIMARY AFFERENT NEURONS | MULTIDISCIPLINARY SCIENCES | INFLAMMATORY PAIN | PROSTATIC ACID-PHOSPHATASE | VANILLOID RECEPTOR-1 | DORSAL-ROOT GANGLION | KINASE-II | MOLECULAR-MECHANISMS | Receptors, G-Protein-Coupled - metabolism | Capsaicin - pharmacology | TRPV Cation Channels - agonists | Cells, Cultured | Paracrine Communication - genetics | Rats | Male | Gene Expression Profiling | Rats, Sprague-Dawley | Sequence Analysis, DNA | TRPV Cation Channels - genetics | Potassium Channels - metabolism | TRPV Cation Channels - metabolism | Animals | Pain - genetics | Prostaglandin D2 - metabolism | Base Sequence | Phosphatidylinositols - metabolism | Nociceptors - metabolism | Prostaglandin D2 - biosynthesis | Ganglia, Spinal - metabolism | Proteins | Somatotropin | RNA | Neurons | Analysis | Enrichment | Intensive care | Calcium | Genomics | Centrifugation | Genes | Paracrine signalling | Capsaicin receptors | Genomes | Arthritis | Kinases | Subgroups | Gene sequencing | Calcium signalling | Phosphatidylinositol | Receptors | Pain | Prostaglandin D2 synthase | Sensory neurons | Genetics | Ion channels | Bioinformatics | Sensitizing | Adenosine | Pain perception | Gene expression | Ribonucleic acid--RNA | Ganglia | Medicine | Studies | DNA microarrays | Microscopy | Anesthesiology | Binding sites | Index Medicus | Ribonucleic acid
Journal Article