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1. Full Text Left Ventricular Ejection Fraction Normalization in Cardiac Resynchronization Therapy and Risk of Ventricular Arrhythmias and Clinical Outcomes: Results From the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT–CRT) Trial
by Ruwald, Martin H and Solomon, Scott D and Foster, Elyse and Kutyifa, Valentina and Ruwald, Anne-Christine and Sherazi, Saadia and McNitt, Scott and Jons, Christian and Moss, Arthur J and Zareba, Wojciech
Circulation, ISSN 0009-7322, 12/2014, Volume 130, Issue 25, pp. 2278 - 2286
BACKGROUND—Appropriate guideline criteria for use of implantable cardioverter-defibrillators (ICDs) do not take into account potential recovery of left... 
arrhythmias, cardiac | ventricular dysfunction, left | cardiac resynchronization therapy | prognosis | defibrillators, implantable | MORTALITY | SURVIVAL | CHRONIC HEART-FAILURE | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOVERTER-DEFIBRILLATOR | GUIDELINES | FOLLOW-UP | EUROPEAN-SOCIETY | PREDICTORS | PERIPHERAL VASCULAR DISEASE | REVERSE | ASSOCIATION | Cardiac Resynchronization Therapy - methods | Prognosis | Follow-Up Studies | Humans | Middle Aged | Male | Ventricular Dysfunction, Left - mortality | Incidence | Heart Failure - therapy | Ventricular Dysfunction, Left - therapy | Recovery of Function - physiology | Female | Ventricular Function, Left - physiology | Cardiac Resynchronization Therapy - mortality | Heart Failure - mortality | Tachycardia, Ventricular - therapy | Defibrillators, Implantable - statistics & numerical data | Risk Factors | Ventricular Fibrillation - mortality | Kaplan-Meier Estimate | Proportional Hazards Models | Stroke Volume - physiology | Treatment Outcome | Tachycardia, Ventricular - mortality | Aged | Ventricular Fibrillation - therapy | Index Medicus | Abridged Index Medicus
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2. Full Text Normalization of NAD+ Redox Balance as a Therapy for Heart Failure
by Lee, Chi Fung and Chavez, Juan D and Garcia-Menendez, Lorena and Choi, Yongseon and Roe, Nathan D and Chiao, Ying Ann and Edgar, John S and Goo, Young Ah and Goodlett, David R and Bruce, James E and Tian, Rong
Circulation, ISSN 0009-7322, 09/2016, Volume 134, Issue 12, pp. 883 - 894
BACKGROUND:Impairments of mitochondrial function in the heart are linked intricately to the development of heart failure, but there is no therapy for... 
permeability transition pore | heart failure | cardiac metabolism | hypertrophy | mitochondria | TARGET | C-SUBUNIT | CARDIAC & CARDIOVASCULAR SYSTEMS | ACETYLATION | STATISTICAL-MODEL | MITOCHONDRIAL PERMEABILITY TRANSITION | ATP SYNTHASE | METABOLISM | FATTY-ACID OXIDATION | CARDIAC-HYPERTROPHY | PERIPHERAL VASCULAR DISEASE | PROTEINS | Heart Failure - therapy | Mitochondrial Membrane Transport Proteins - metabolism | Animals | Mitochondria, Heart - metabolism | Oxidation-Reduction | Calcium - metabolism | Humans | Biological Transport - physiology | Heart Failure - metabolism | Mice | NAD - metabolism | Heart failure | Care and treatment | Usage | Mitochondria | Heart enlargement | Development and progression | Research | Index Medicus | Abridged Index Medicus | apoptosis | metabolism
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3. Full Text Tumor Vessel Normalization by Chloroquine Independent of Autophagy
by Maes, Hannelore and Kuchnio, Anna and Peric, Aleksandar and Moens, Stijn and Nys, Kris and De Bock, Katrien and Quaegebeur, Annelies and Schoors, Sandra and Georgiadou, Maria and Wouters, Jasper and Vinckier, Stefan and Vankelecom, Hugo and Garmyn, Marjan and Vion, Anne-Clémence and Radtke, Freddy and Boulanger, Chantal and Gerhardt, Holger and Dejana, Elisabetta and Dewerchin, Mieke and Ghesquière, Bart and Annaert, Wim and Agostinis, Patrizia and Carmeliet, Peter
Cancer Cell, ISSN 1535-6108, 08/2014, Volume 26, Issue 2, pp. 190 - 206
Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy. We... 
REGRESSION | METASTASIS | INHIBITION | THERAPY | ANGIOGENESIS | ONCOLOGY | ENDOTHELIAL-CELLS | DISEASE | NOTCH | MICE | CANCER | CELL BIOLOGY | Skin Neoplasms - drug therapy | Microtubule-Associated Proteins - metabolism | Humans | Melanoma, Experimental - drug therapy | Endothelium, Vascular - drug effects | Autophagy | Chloroquine - pharmacology | Angiogenesis Inhibitors - therapeutic use | Neovascularization, Pathologic - prevention & control | Skin Neoplasms - blood supply | Endothelial Cells - physiology | Skin Neoplasms - pathology | Melanoma, Experimental - blood supply | Neoplasm Invasiveness | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Melanoma, Experimental - pathology | Chloroquine - therapeutic use | Receptor, Notch1 - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Autophagy-Related Protein 5 | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Endothelium, Vascular - pathology | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Camptothecin - pharmacology | Endothelial Cells - drug effects | Chemotherapy | Stem cells | Cancer | Tumors | Index Medicus
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4. Full Text Vascular normalization in Rgs5 -deficient tumours promotes immune destruction
by Hämmerling, Günter J and Marti, Hugo H and Arnold, Bernd and Hamzah, Juliana and Rabie, Tamer and Gröne, Hermann-Josef and Rigby, Paul and Kiessling, Fabian and Manzur, Mitali and Kaden, Sylvia and Ganss, Ruth and Jugold, Manfred
Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7193, pp. 410 - 414
The vasculature of solid tumours is morphologically aberrant and characterized by dilated and fragile vessels, intensive vessel sprouting and loss of... 
ANTIANGIOGENIC THERAPY | CELLS | RGS5 | HEPATOCELLULAR-CARCINOMA | PROTEIN | EDEMA | MULTIDISCIPLINARY SCIENCES | BLOOD-VESSELS | MODEL | TUMORIGENESIS | PERICYTES | RGS Proteins - genetics | Cell Hypoxia - physiology | Capillary Permeability | Pancreatic Neoplasms - metabolism | Pancreatic Neoplasms - blood supply | Male | Pancreatic Neoplasms - genetics | Oxygen - metabolism | Animals | Pancreatic Neoplasms - immunology | RGS Proteins - deficiency | RGS Proteins - metabolism | Female | Neovascularization, Pathologic - prevention & control | Mice | Physiological aspects | Management | Cardiovascular tumors | Immune system | Drugs | Immunization | Lymphocytes | Rodents | Hypoxia | Histology | Permeability | Cells | Tumors | Index Medicus
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5. Full Text Prevalence of C-reactive protein elevation and time course of normalization in acute pericarditis: Implications for the diagnosis, therapy, and prognosis of pericarditis
by Imazio, Massimo and Brucato, Antonio and Maestroni, Silvia and Cumetti, Davide and Dominelli, Antonio and Natale, Giuseppe and Trinchero, Rita
Circulation, ISSN 0009-7322, 03/2011, Volume 123, Issue 10, pp. 1092 - 1097
Background-The role of inflammatory markers is not well defined for either diagnosis or treatment of pericarditis. The aim of this study is to prospectively... 
diagnosis | C-reactive protein | pericarditis | prognosis | therapy | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | TRIAL | DISEASES | COLCHICINE | PERIPHERAL VASCULAR DISEASE | CORTICOSTEROIDS | HEMATOLOGY | RECURRENT PERICARDITIS | Acute Disease | Prognosis | Prospective Studies | Humans | Middle Aged | Pericarditis - drug therapy | Male | C-Reactive Protein - metabolism | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Aged | Chest Pain - diagnosis | C-Reactive Protein - analysis | Cohort Studies | Pericarditis - diagnosis | Measurement | Pericarditis | Care and treatment | Physiological aspects | Diagnosis | Research | Biological markers | Identification and classification | Index Medicus | Abridged Index Medicus
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6. Full Text Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
by Chauhan, Vikash P and Stylianopoulos, Triantafyllos and Martin, John D and PopoviÄ, Zoran and Chen, Ou and Kamoun, Walid S and Bawendi, Moungi G and Fukumura, Dai and Jain, Rakesh K
Nature Nanotechnology, ISSN 1748-3387, 2012, Volume 7, Issue 6, pp. 383 - 388
The blood vessels of cancerous tumours are leaky(1-3) and poorly organized(4-7). This can increase the interstitial fluid pressure inside tumours and reduce... 
VASCULAR NORMALIZATION | ANTIANGIOGENIC THERAPY | TRANSPORT | SOLID TUMORS | FLUID-FLOW | ANGIOGENESIS | MATERIALS SCIENCE, MULTIDISCIPLINARY | GROWTH | PENETRATION | NANOSCIENCE & NANOTECHNOLOGY | CANCER | GLIOBLASTOMA PATIENTS | Index Medicus
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7. Full Text Normalization of Blood Pressure and Renal Vascular Resistance in SHR With a Membrane-Permeable Superoxide Dismutase Mimetic: Role of Nitric Oxide
by Schnackenberg, Christine G and Welch, William J and Wilcox, Christopher S
Hypertension, ISSN 0194-911X, 07/1998, Volume 32, Issue 1, pp. 59 - 64
Superoxide radical (O2) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates endothelium-dependent... 
Antioxidants | Tempol | Superoxide dismutase | Blood pressure | Free radicals | Nitric oxide | blood pressure | TISSUE-INJURY | free radicals | nitric oxide | antioxidants | tempol | RELAXING FACTOR | DAMAGE | FREE-RADICALS | SPONTANEOUSLY HYPERTENSIVE RATS | INHIBITION | METABOLISM | ENDOTHELIUM | superoxide dismutase | PERIPHERAL VASCULAR DISEASE | BLOCKADE | Index Medicus
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8. Full Text Gastric Bypass Leads to Improvement of Diabetic Neuropathy Independent of Glucose Normalization—Results of a Prospective Cohort Study (DiaSurg 1 Study)
by Müller-Stich, Beat P and Fischer, Lars and Kenngott, Hannes G and Gondan, Matthias and Senft, Jonas and Clemens, Gabriella and Nickel, Felix and Fleming, Thomas and Nawroth, Peter P and Büchler, Markus W
Annals of Surgery, ISSN 0003-4932, 11/2013, Volume 258, Issue 5, pp. 760 - 766
OBJECTIVE:Surprisingly, 40% to 95% of patients with type 2 diabetes mellitus (T2DM) show early remission of hyperglycemia after obesity surgery. It is unknown... 
Diabetes-associated comorbidities | Laparoscopic gastric bypass | Obesity surgery | Metabolic surgery | Neuropathy | Diabetes mellitus | SURGERY | METABOLIC SYNDROME | POLYNEUROPATHY | obesity surgery | LAPAROSCOPIC TREATMENT | GLYCATION | diabetes mellitus | laparoscopic gastric bypass | LONG-TERM MORTALITY | MELLITUS | NEPHROPATHY | metabolic surgery | diabetes-associated comorbidities | LIFE-STYLE | CARDIOVASCULAR-DISEASE | neuropathy | BARIATRIC SURGERY | Body Mass Index | Severity of Illness Index | Prospective Studies | Humans | Middle Aged | Male | Treatment Outcome | Diabetic Neuropathies - surgery | Laparoscopy - methods | Pilot Projects | Female | Aged | Gastric Bypass - methods | Blood Glucose - metabolism | Diabetic Neuropathies - metabolism | Index Medicus | Abridged Index Medicus
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9. Full Text Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men
by Sharma, Rishi and Oni, Olurinde A and Gupta, Kamal and Chen, Guoqing and Sharma, Mukut and Dawn, Buddhadeb and Sharma, Ram and Parashara, Deepak and Savin, Virginia J and Ambrose, John A and Barua, Rajat S
European Heart Journal, ISSN 0195-668X, 2015, Volume 36, Issue 40, pp. 2706 - 2715
Aims There is a significant uncertainty regarding the effect of testosterone replacement therapy (TRT) on cardiovascular (CV) outcomes including myocardial... 
Myocardial infarction | Stroke | Testosterone replacement therapy | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | EVENTS | REPLACEMENT | ADULT MEN | THERAPY | PLACEBO-CONTROLLED TRIALS | ANDROGEN DEFICIENCY | OLDER MEN | CARDIOVASCULAR RISK | SERUM TESTOSTERONE | Drug Administration Routes | Myocardial Infarction - blood | United States - epidemiology | Myocardial Infarction - mortality | Stroke - prevention & control | Prospective Studies | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Hormone Replacement Therapy - mortality | Androgens - administration & dosage | Incidence | Stroke - blood | Testosterone - administration & dosage | Testosterone - deficiency | Aged | Myocardial Infarction - prevention & control | Retrospective Studies | Stroke - mortality | Testosterone - blood | Index Medicus
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10. Full Text Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
by Mazzone, Massimiliano and Dettori, Daniela and Leite de Oliveira, Rodrigo and Loges, Sonja and Schmidt, Thomas and Jonckx, Bart and Tian, Ya-Min and Lanahan, Anthony A and Pollard, Patrick and Ruiz de Almodovar, Carmen and De Smet, Frederik and Vinckier, Stefan and Aragonés, Julián and Debackere, Koen and Luttun, Aernout and Wyns, Sabine and Jordan, Benedicte and Pisacane, Alberto and Gallez, Bernard and Lampugnani, Maria Grazia and Dejana, Elisabetta and Simons, Michael and Ratcliffe, Peter and Maxwell, Patrick and Carmeliet, Peter
Cell, ISSN 0092-8674, 2009, Volume 136, Issue 5, pp. 839 - 851
A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen... 
CELLBIO | HUMDISEASE | CADHERIN | VASCULAR NORMALIZATION | CELLS | ACTIVATION | VESSELS | INDUCIBLE FACTOR-I | ANGIOGENESIS | VEGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPOXIA | CANCER | CELL BIOLOGY | Endothelial Cells - metabolism | Blood Vessels - metabolism | Neoplasms - blood supply | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Blood Vessels - cytology | Oxygen - metabolism | Hypoxia - metabolism | Blood Vessels - embryology | DNA-Binding Proteins - metabolism | Immediate-Early Proteins - metabolism | Neoplasm Metastasis | Animals | Immediate-Early Proteins - genetics | Endothelial Cells - cytology | Cell Shape | Glycolysis | Heterozygote | Mice | Neoplasms - pathology | Procollagen-Proline Dioxygenase | Proteins | Care and treatment | Antiship missile defenses | Oncology, Experimental | Oximetry | Research | Metastasis | Vascular endothelial growth factor | Cancer | Endothelium | Index Medicus
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11. Full Text Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: Insights from a mathematical model
by Jain, Rakesh K and Tong, Ricky T and Munn, Lance L
Cancer Research, ISSN 0008-5472, 03/2007, Volume 67, Issue 6, pp. 2729 - 2735
Preclinical and clinical evidence shows that antiangiogenic agents can decrease tumor vessel permeability and interstitial fluid pressure (IFP) in a process of... 
CANCER-CELLS | NODE METASTASIS | RECTAL-CANCER | TRANSPORT | SOLID TUMORS | ONCOLOGY | HYDRAULIC CONDUCTIVITY | IN-VIVO | FLUID PRESSURE | TUMOR VASCULATURE | ENDOTHELIAL GROWTH-FACTOR | Extracellular Fluid - physiology | Neoplasms - metabolism | Humans | Angiogenesis Inhibitors - pharmacology | Capillary Permeability - drug effects | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Neoplasms - blood supply | Lymphatic Metastasis | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Extracellular Fluid - drug effects | Neoplasms - drug therapy | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Animals | Models, Biological | Neovascularization, Pathologic - drug therapy | Vascular Endothelial Growth Factor C - metabolism | Edema - physiopathology | Neovascularization, Pathologic - metabolism | Edema - chemically induced | Neoplasms - pathology | Mathematical Computing | Index Medicus
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12. Full Text Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
by Winkler, Frank and Kozin, Sergey V and Tong, Ricky T and Chae, Sung-Suk and Booth, Michael F and Garkavtsev, Igor and Xu, Lei and Hicklin, Daniel J and Fukumura, Dai and di Tomaso, Emmanuelle and Munn, Lance L and Jain, Rakesh K
Cancer Cell, ISSN 1535-6108, 12/2004, Volume 6, Issue 6, pp. 553 - 563
The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that antiangiogenic therapy must be combined with cytotoxic therapy for the... 
Immunohistochemistry | Basement Membrane - drug effects | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Humans | Gamma Rays - therapeutic use | Antibodies, Monoclonal - therapeutic use | Male | Vascular Endothelial Growth Factor Receptor-2 - immunology | Pericytes - physiology | Blood Vessels - radiation effects | Pericytes - chemistry | Time Factors | Angiopoietin-1 - physiology | Neovascularization, Pathologic - radiotherapy | Fluorescein Angiography | Receptor, TIE-2 - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Brain Neoplasms - drug therapy | Basement Membrane - metabolism | Blotting, Western | Ephrin-B2 - genetics | Cell Movement - drug effects | Mice, Nude | Models, Biological | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Collagen Type IV - genetics | Mice | Glioma - drug therapy | Apoptosis - radiation effects | Pericytes - cytology | Basement Membrane - pathology | Glioma - radiotherapy | Brain Neoplasms - metabolism | Oxygen - metabolism | Glioma - metabolism | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Transfection | Antigens - analysis | Angiogenesis Inhibitors - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Brain Neoplasms - radiotherapy | Collagen Type IV - metabolism | Blood Vessels - chemistry | Dipeptides - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Proteoglycans - analysis | Up-Regulation - genetics | Receptor, TIE-2 - immunology | Collagen Type IV - analysis | Xenograft Model Antitumor Assays | Animals | Blood Vessels - drug effects | Matrix Metalloproteinase Inhibitors | Combined Modality Therapy - methods | Matrix Metalloproteinases - metabolism | Index Medicus
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