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Science Signaling, ISSN 1945-0877, 05/2012, Volume 5, Issue 225, pp. ra38 - ra38
Interferon-beta (IFN-beta) is widely used to treat multiple sclerosis (MS), and its efficacy was demonstrated in the setting of experimental autoimmune... 
RESPONSES | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | MECHANISM | CASPASE-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CENTRAL-NERVOUS-SYSTEM | EXPRESSION | NALP3 INFLAMMASOME | CELL BIOLOGY | Recombinant Proteins - therapeutic use | Proto-Oncogene Proteins c-vav - antagonists & inhibitors | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Encephalomyelitis, Autoimmune, Experimental - immunology | Suppressor of Cytokine Signaling 1 Protein | Male | Receptor, Interferon alpha-beta - physiology | Interleukin-1beta - genetics | Neuropeptides - physiology | Proto-Oncogene Proteins c-vav - physiology | Cytoskeletal Proteins - deficiency | Interferon-beta - therapeutic use | rac GTP-Binding Proteins - antagonists & inhibitors | Interleukin-1beta - biosynthesis | Caspase 1 - physiology | rac GTP-Binding Proteins - physiology | Disease Models, Animal | Carrier Proteins - physiology | Macrophages - physiology | Encephalomyelitis, Autoimmune, Experimental - physiopathology | Receptor, Interferon alpha-beta - deficiency | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Mice, Transgenic | Mice, Knockout | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Inflammasomes - physiology | Animals | Apoptosis Regulatory Proteins | Interferon beta-1b | CD4-Positive T-Lymphocytes - transplantation | CARD Signaling Adaptor Proteins | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - physiology | Mice | Enzyme Activation | rac1 GTP-Binding Protein | Neuropeptides - antagonists & inhibitors
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e53964
The receptor tyrosine kinase MERTK plays an essential role in the phagocytic uptake of shed photoreceptor membranes by the retinal pigment epithelium (RPE). A... 
C-MER | MULTIDISCIPLINARY SCIENCES | APOPTOTIC CELLS | ROD-CONE DYSTROPHY | ALPHA-V-BETA-5 INTEGRIN | FOCAL ADHESION KINASE | NF-KAPPA-B | MEDIATED PHAGOCYTOSIS | RETINITIS-PIGMENTOSA | RECEPTOR TYROSINE KINASE | OUTER SEGMENTS | Retinal Pigment Epithelium - metabolism | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Proto-Oncogene Proteins c-vav - genetics | Rod Cell Outer Segment - metabolism | Humans | Phagocytosis - genetics | Recombinant Fusion Proteins - metabolism | Phosphotyrosine - metabolism | GRB2 Adaptor Protein - genetics | c-Mer Tyrosine Kinase | HEK293 Cells | src-Family Kinases - metabolism | Eye Proteins - genetics | Class Ia Phosphatidylinositol 3-Kinase - genetics | Binding Sites | Proto-Oncogene Proteins - metabolism | Choroid - metabolism | Signal Transduction | Gene Expression Regulation | Rats | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | src Homology Domains | Animals | Eye Proteins - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Escherichia coli - genetics | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | GRB2 Adaptor Protein - metabolism | src-Family Kinases - genetics | Proto-Oncogene Proteins c-vav - metabolism | Physiological aspects | Photoreceptors | Retina | Genetic aspects | Research | Epithelium | Membranes | Phosphorylation | Phosphotyrosine | Phagosomes | Homology | Activation | Kinases | Retinal pigment epithelium | Recruitment | Proteins | Phagocytes | Signal transduction | E coli | Rodents | Protein-tyrosine kinase receptors | Fusion protein | Protein-tyrosine kinase | Recombinant | Tyrosine | siRNA | Src protein | Chromatography | Grb2 protein | Studies | Signaling | Cytoskeleton | Transduction | Mutation | Intracellular | Adapter proteins | Phagocytosis
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2005, Volume 175, Issue 4, pp. 2449 - 2458
Activation of T cells via the stimulation of the TCR plays a central role in the adaptive immunological response. Although much is known about TCR-stimulated... 
PHOSPHOLIPASE C-GAMMA-1 | SLP-76 DOMAINS | ACTIVATION | TYROSINE RESIDUES | NEGATIVE REGULATION | T-CELL-RECEPTOR | FAMILY KINASES | IMMUNOLOGY | ANTIGEN RECEPTOR | ADAPTER PROTEIN | LAT | Phosphoproteins - immunology | Antibody Specificity | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Proto-Oncogene Proteins c-vav - genetics | ZAP-70 Protein-Tyrosine Kinase - deficiency | Antibodies - metabolism | Humans | Phosphoproteins - metabolism | Protein-Tyrosine Kinases - pharmacology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | T-Lymphocytes - metabolism | Membrane Proteins - physiology | Adaptor Proteins, Signal Transducing - immunology | ZAP-70 Protein-Tyrosine Kinase - metabolism | Membrane Proteins - metabolism | Phosphoproteins - physiology | Protein-Tyrosine Kinases - biosynthesis | Phospholipase C gamma - metabolism | Jurkat Cells | Membrane Proteins - genetics | RNA, Small Interfering - pharmacology | Proto-Oncogene Proteins c-vav - deficiency | Membrane Proteins - immunology | Signal Transduction - genetics | Phosphoproteins - genetics | Receptors, Antigen, T-Cell - physiology | Proto-Oncogene Proteins c-cbl - physiology | Adaptor Proteins, Signal Transducing - physiology | Phospholipase C gamma - immunology | Tyrosine - metabolism | Phosphoproteins - deficiency | Adaptor Proteins, Signal Transducing - genetics | ZAP-70 Protein-Tyrosine Kinase - immunology | Kinetics | Adaptor Proteins, Signal Transducing - metabolism | Phospholipase C gamma - physiology | Proto-Oncogene Proteins c-cbl - immunology
Journal Article
Cell, ISSN 0092-8674, 2005, Volume 121, Issue 3, pp. 425 - 436
Journal Article
Journal Article
EXPERIMENTAL CELL RESEARCH, ISSN 0014-4827, 07/2007, Volume 313, Issue 11, pp. 2504 - 2520
Pyostaglandin E-2 (PGE(2)) and prostacyclin are lipid mediators produced by cyclooxygenase and implicated in the regulation of vascular function, wound repair,... 
cytoskeleton | PROTEIN-KINASE | permeability | small GTPases | PKA | EXCHANGE FACTOR TIAM1 | lung endothelium | GEFs | SPHINGOSINE 1-PHOSPHATE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | CYCLIC-AMP | PROSTANOID RECEPTORS | CELL JUNCTIONS | ONCOLOGY | IN-VIVO | RHO GTPASES | CYTOSKELETAL REARRANGEMENT | Proto-Oncogene Proteins c-vav - antagonists & inhibitors | Proto-Oncogene Proteins c-vav - genetics | Humans | rac GTP-Binding Proteins - metabolism | Male | Lung - cytology | Respiratory Distress Syndrome, Adult - metabolism | Adherens Junctions - metabolism | rac GTP-Binding Proteins - antagonists & inhibitors | Blood-Air Barrier - drug effects | Cyclic AMP-Dependent Protein Kinases - genetics | Guanine Nucleotide Exchange Factors - metabolism | rac GTP-Binding Proteins - genetics | Epoprostenol - pharmacology | Lung - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | Cyclic AMP-Dependent Protein Kinases - metabolism | Dinoprostone - pharmacology | Guanine Nucleotide Exchange Factors - genetics | Cytoskeleton - pathology | Respiratory Distress Syndrome, Adult - prevention & control | Endothelial Cells - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Blood-Air Barrier - cytology | Permeability | Adherens Junctions - pathology | Epoprostenol - analogs & derivatives | Animals | Blood-Air Barrier - metabolism | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Lung - drug effects | Adherens Junctions - drug effects | rac1 GTP-Binding Protein - antagonists & inhibitors | Cytoskeleton - metabolism | Mice | Cytoskeleton - drug effects | Proto-Oncogene Proteins c-vav - metabolism | rac1 GTP-Binding Protein - metabolism | Endothelial Cells - drug effects | rac1 GTP-Binding Protein - genetics
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2008, Volume 380, Issue 5, pp. 828 - 843
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 05/2005, Volume 16, Issue 5, pp. 2207 - 2217
Neurite outgrowth is an important process in the formation of neuronal networks. Rac1 and Cdc42, members of the Rho-family GTPases, positively regulate neurite... 
SYSTEM | RHO-FAMILY GTPASES | SPATIOTEMPORAL REGULATION | RAC | NUCLEOTIDE EXCHANGE FACTOR | RECEPTOR | GUANOSINE TRIPHOSPHATASES | DISTINCT ROLES | 3-KINASE ACTIVATION | MAMMALIAN-CELLS | CELL BIOLOGY | Oncogene Proteins - genetics | Phosphatidylinositol Phosphates - metabolism | Proto-Oncogene Proteins c-vav - antagonists & inhibitors | Proto-Oncogene Proteins c-vav - genetics | cdc42 GTP-Binding Protein - metabolism | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | PC12 Cells | Cell Cycle Proteins - antagonists & inhibitors | Neurons - ultrastructure | RNA Interference | Feedback | Neurites - ultrastructure | Base Sequence | Cell Cycle Proteins - genetics | Fluorescence Resonance Energy Transfer | Cell Membrane - metabolism | Neurons - metabolism | Neurons - drug effects | Cell Membrane - drug effects | Neurites - drug effects | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Biological Transport, Active - drug effects | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | SOS1 Protein - metabolism | Nerve Growth Factor - pharmacology | Rats | Proto-Oncogene Proteins - genetics | Neurites - metabolism | Son of Sevenless Proteins - metabolism | Oncogene Proteins - antagonists & inhibitors | Animals | Proto-Oncogene Proteins c-vav - metabolism | rac1 GTP-Binding Protein - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 7, p. e11465
Background: Thymocyte expressed molecule involved in selection 1 (Themis1, SwissProt accession number Q8BGW0) is the recently characterised founder member of a... 
TUMOR-NECROSIS-FACTOR | BRUTONS TYROSINE KINASE | RICH ELEMENT | ACTIVATED PROTEIN-KINASE | POSITIVE SELECTION | MULTIDISCIPLINARY SCIENCES | MESSENGER-RNA STABILITY | MEMBRANE-PROTEINS | TNF-ALPHA PRODUCTION | NF-KAPPA-B | CANCER CELL-LINES | Immunoprecipitation | Proto-Oncogene Proteins c-vav - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Tandem Mass Spectrometry | RNA Interference | GRB2 Adaptor Protein - genetics | Toll-Like Receptors - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Cell Line | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Signal Transduction - genetics | Toll-Like Receptor 4 - metabolism | Tumor Necrosis Factor-alpha | Proteins - genetics | Animals | Proteins - metabolism | Signal Transduction - drug effects | Toll-Like Receptors - genetics | Lipopolysaccharides - pharmacology | Protein Binding | Mice | GRB2 Adaptor Protein - metabolism | Proto-Oncogene Proteins c-vav - metabolism | Tyrosine | B cells | Cytokines | RNA | Macrophages | Phosphotransferases | Osteoprogenitor cells | Biotechnology | Phosphorylation | Proline | Infections | Activation | Kinases | Guanine | Lipopolysaccharides | Interleukin 6 | Proteins | Signal transduction | Cell growth | Toll-like receptors | Bone marrow | Tumor necrosis factor-TNF | Guanine nucleotide exchange factor | Growth factors | Immune system | Pathogens | NF-κB protein | Immunoglobulins | Rheumatology | Extracellular signal-regulated kinase | JNK protein | Inflammation | Gene expression | Ribonucleic acid--RNA | TLR3 protein | Grb2 protein | Signaling | Protein arrays | Overexpression | Mutagenesis | Lymphocytes B | Interferon regulatory factor 3 | Tumor necrosis factor | Plasmids | TLR2 protein | Interferon | Cyclooxygenase-2 | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20735
Virus proteins alter protein pathways of the host toward the synthesis of viral particles by breaking and making edges via binding to host proteins. In this... 
MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | DYNAMICS | LINEAR MOTIFS | INTERACTION SITES | SH3 DOMAINS | INFECTION | DISCOVERY | EPITOPES | STRATEGIES | INSIGHTS | Humans | Molecular Sequence Data | Neoplasm Proteins - metabolism | nef Gene Products, Human Immunodeficiency Virus - chemistry | HLA-A Antigens - metabolism | Mitogen-Activated Protein Kinase 1 - chemistry | Proto-Oncogene Proteins c-hck - chemistry | Receptors for Activated C Kinase | nef Gene Products, Human Immunodeficiency Virus - metabolism | Receptors, Cell Surface - chemistry | Proto-Oncogene Proteins c-fyn - chemistry | Amino Acid Sequence | Computational Biology - methods | GTP-Binding Proteins - chemistry | Proto-Oncogene Proteins c-vav - chemistry | Proto-Oncogene Proteins c-hck - metabolism | Receptors, Cell Surface - metabolism | Neoplasm Proteins - chemistry | Amino Acid Motifs | Proto-Oncogene Proteins c-fyn - metabolism | CD4 Antigens - chemistry | Protein Binding | HLA-A Antigens - chemistry | Proto-Oncogene Proteins c-vav - metabolism | CD4 Antigens - metabolism | GTP-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Case studies | Killer cells | Histocompatibility antigens | Algorithms | Viral proteins | HLA histocompatibility antigens | Amino acids | HIV (Viruses) | T cells | Antigenic determinants | Protein binding | Data collections | Computational neuroscience | C protein | Toxicity | CD8 antigen | Crosstalk | Cytotoxicity | Viruses | Kinases | Drug resistance | Proteins | T-cell receptor | Hepatitis | Pathways | Human immunodeficiency virus--HIV | Natural killer cells | Fyn protein | Hot spots | Epitopes | Crowding | CD4 antigen | Studies | Signaling | Nef protein | Lck protein | Computer applications | Predictions | Histocompatibility antigen HLA | Hepatitis C virus | Hepatitis C | Binding sites | HIV | Human immunodeficiency virus
Journal Article
Immunity, ISSN 1074-7613, 2000, Volume 13, Issue 4, pp. 463 - 473
Stimulation of T cells via the antigen and costimulatory receptors leads to the organization of a supramolecular activation cluster called the immune synapse.... 
SIGNAL-TRANSDUCTION | ACTIVATION | PROTEIN | CYTOSKELETAL REORGANIZATION | C-CBL | COSTIMULATION | VAV | DEFICIENT MICE | IMMUNOLOGY | REQUIREMENT | LYMPHOCYTES | T-Lymphocytes - enzymology | Humans | cdc42 GTP-Binding Protein - metabolism | Transcriptional Activation - immunology | Genetic Complementation Test | Wiskott-Aldrich Syndrome - genetics | Autoimmune Diseases - genetics | Membrane Microdomains - immunology | Lymphocyte Activation - genetics | T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-cbl | Calcium Signaling - immunology | Receptors, Antigen, T-Cell - metabolism | Proto-Oncogene Proteins - deficiency | Down-Regulation - genetics | Receptors, Antigen, T-Cell - physiology | Mice, Knockout | Nuclear Proteins | Ubiquitin-Protein Ligases | Adaptor Proteins, Signal Transducing | Tyrosine - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Wiskott-Aldrich Syndrome Protein | T-Lymphocytes - immunology | Mice | Calcium Signaling - genetics | Enzyme Activation - genetics | Interleukin-2 - biosynthesis | Cell Cycle Proteins | Phosphorylation | Membrane Microdomains - metabolism | Enzyme Activation - immunology | DNA-Binding Proteins - metabolism | Receptor Aggregation - genetics | Proto-Oncogene Proteins c-vav | Phosphoproteins - physiology | Receptor Aggregation - immunology | Carrier Proteins - physiology | T-Lymphocytes, Cytotoxic - immunology | Cytotoxicity, Immunologic - genetics | Proteins - physiology | Wiskott-Aldrich Syndrome - immunology | Proto-Oncogene Proteins - genetics | Lymphoproliferative Disorders - genetics | NFATC Transcription Factors | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Down-Regulation - immunology | Phosphoproteins - deficiency | Proto-Oncogene Proteins - physiology | Membrane Microdomains - genetics
Journal Article
Cell Death and Disease, ISSN 2041-4889, 04/2016, Volume 7, Issue 4, pp. e2181 - e2181
Journal Article