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[ sdv.can ] life sciences [q-bio]/cancer (1) 1
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1. Full Text VEGF Secretion by Neuroendocrine Tumor Cells Is Inhibited by Octreotide and by Inhibitors of the PI3K/AKT/mTOR Pathway
by Villaume, Karine and Blanc, Martine and Gouysse, Géraldine and Walter, Thomas and Couderc, Christophe and Nejjari, Mimoun and Vercherat, Cécile and Cordier-Bussat, Martine and Roche, Colette and Scoazec, Jean-Yves
Neuroendocrinology, ISSN 0028-3835, 06/2010, Volume 91, Issue 3, pp. 268 - 278
Gastroenteropancreatic (GEP) endocrine tumors are hypervascular tumors able to synthesize and secrete high amounts of VEGF. We aimed to study the regulation of... 
Neuroendocrine Tumors | Angiogenesis | Neuroendocrine cell lines | Octreotide | VEGF-mTOR inhibitors | HYPOXIA-INDUCIBLE FACTOR | SOMATOSTATIN ANALOGS | PHOSPHATIDYLINOSITOL 3-KINASE | MICROVESSEL DENSITY | NEUROSCIENCES | RAD001 EVEROLIMUS | EPIDERMAL CL41 CELLS | IN-VITRO | SIGNALING PATHWAY | ENDOCRINOLOGY & METABOLISM | UP-REGULATION | ENDOTHELIAL GROWTH-FACTOR | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Neuroendocrine Tumors - enzymology | Somatostatin - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Flavonoids - pharmacology | Phosphorylation - drug effects | Chromones - pharmacology | Insulin Secretion | Somatostatin - metabolism | Cell Survival - drug effects | MAP Kinase Kinase 1 - antagonists & inhibitors | Neuroendocrine Tumors - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Morpholines - pharmacology | Rats | Imidazoles - pharmacology | Octreotide - pharmacology | Sirolimus - pharmacology | Drug Synergism | Insulin - metabolism | Animals | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Mice | Pyridines - pharmacology | TOR Serine-Threonine Kinases | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Life Sciences | Cancer
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