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The Journal of Nutritional Biochemistry, ISSN 0955-2863, 09/2019, p. 108230
Journal Article
Yaoxue Xuebao, ISSN 0513-4870, 04/2017, Volume 52, Issue 4, pp. 531 - 540
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2013, Volume 23, Issue 10, pp. 2962 - 2967
We report a novel VEGFR-2 inhibitor, developed by the back-to-front approach. Docking experiments indicated that the 3-chloromethylphenylurea motif of the lead... 
CuAAC reaction | VEGFR-2 | Molecular modeling | Antiangiogenesis | KDR | VEGFR-2 inhibitor | 1,4-Disubstituted 1,2,3-triazoles | VEGFR-2 KDR VEGFR-2 inhibitor Molecular modeling Antiangiogenesis 1,4-Disubstituted 1,2,3-triazoles CuAAC reaction | DESIGN | CHEMISTRY, MEDICINAL | ANGIOGENESIS | STRATEGY | CHEMISTRY, ORGANIC | CONFORMATION | DISCOVERY | POTENT | RECEPTOR TYROSINE KINASES | PATHWAY | ANTIANGIOGENIC AGENTS | ENDOTHELIAL GROWTH-FACTOR | Indazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Dose-Response Relationship, Drug | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | MCF-7 Cells | Phenylurea Compounds - chemistry | Human Umbilical Vein Endothelial Cells - cytology | Antineoplastic Agents - pharmacology | Molecular Structure | Protein Kinase Inhibitors - chemical synthesis | Human Umbilical Vein Endothelial Cells - drug effects | Indazoles - chemistry | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Antineoplastic Agents - chemistry | Hep G2 Cells | Indazoles - pharmacology | Phenylurea Compounds - chemical synthesis | Cell Line, Tumor | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Drug Screening Assays, Antitumor | Endothelial growth factors
Journal Article
BMB reports, ISSN 1976-6696, 08/2019, Volume 52, Issue 9, pp. 560 - 565
Benign prostatic hyperplasia (BPH), a common disease in elderly males, is accompanied by non-malignant growth of prostate tissues, subsequently causing hypoxia... 
Benign prostatic hyperplasia | Dihydrotestosterone | 6-Siallylactose | VEGF | VEGFR-2
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 04/2019, Volume 20, Issue 4, pp. 497 - 504
Objective: Angiogenesis is one of the key processes in the development of malignant tumors. The vascular endothelial growth factor (VEGF) and VEGF receptor-2... 
VEGFR-2 genetic polymorphism | gastric cancer | VEGF/VEGFR-2 | prognosis | ANGIOGENESIS | ONCOLOGY | FACTOR RECEPTOR 2 | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | SINGLE NUCLEOTIDE POLYMORPHISMS
Journal Article
Gene, ISSN 0378-1119, 10/2019, Volume 717, p. 144047
Vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) signaling pathways play important roles in the formation of the blood vascular... 
Decapitation | FGF-1 | Head regeneration | Hydra | FGFR-1 | VEGFR-2
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 11/2019, Volume 92, p. 103251
Worldwide, Hepatocellular Carcinoma (HCC) endures to be a prominent cause of cancer death. Treatment of HCC follows multiple therapies which are not entirely... 
Pyridazinoquinazoline | Caspase | HCC | Docking | VEGFR-2 inhibitors | Radiation
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111609
A series of new pyrazolo-benzothiazole hybrids ( ) were synthesised and screened for their cytotoxic activity towards several cancer cell lines [colon (HT-29),... 
Angiogenesis | Benzothiazole | VEGFR-2 | Zebrafish | Anticancer | Pyrazole | Apoptosis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 181, p. 111552
Tyrosine kinase inhibitors (TKIs) have achieved substantial clinical effects for cancer treatment while causing a number of adverse effects. Since hypoxia is... 
Hypoxia | Vandetanib | 3-Nitro-1,2,4-triazole | Tyrosine kinase inhibitor | VEGFR-2 | EGFR
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 9, pp. 2381 - 2391
Thioether and nicotinamide-containing sorafenib analogues with better anti-proliferative and anti-angiogenic activities than sorafenib were well designed and... 
Nicotinamide | B-Raf | Kinase inhibitor | VEGFR-2 | Antitumor
Journal Article
Experimental Biology and Medicine, ISSN 1535-3702, 8/2014, Volume 239, Issue 8, pp. 948 - 953
Previous studies revealed that copper (Cu)-induced regression of cardiomyocyte hypertrophy is associated with enhanced activity in the vascular endothelial... 
Copper | hypertrophy | VEGF | VEGFR-2 | cardiomyocyte | VEGFR-1
Journal Article
Diabetes Research and Clinical Practice, ISSN 0168-8227, 05/2017, Volume 127, pp. 147 - 155
Aims This study investigated the effect of low-intensity cathodal direct current (CDC) of electrical stimulation (ES) on the release of hypoxic inducible... 
VEGF | VEGFR-2 | Electrical stimulation | HIF-1α | Diabetic foot ulcers
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 11/2019, Volume 92, p. 103189
Angiogenesis is a hallmark in cancer. Most antiangiogenic agents block the action of vascular endothelial growth factor (VEGF). In clinic, patients develop... 
Thienopyridine | Pyridine | PIM-1 Kinase | Anticancer | VEGFR-2 | Apoptosis
Journal Article
Future medicinal chemistry, 09/2019
Gefitinib and sorafenib have been proved effective for the treatment of cancers in clinical practice for years. We intended to integrate the structural... 
Journal Article
International Journal of Hematology, ISSN 0925-5710, 1/2015, Volume 101, Issue 1, pp. 23 - 31
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2018, Volume 158, pp. 814 - 831
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 5/2013, Volume 23, Issue 10, pp. 2962 - 2967
Novel lead was developed as VEGFR-2 inhibitor by the back-to-front approach. Docking experiment guided that the 3-chloromethylphenylurea motif occupied the... 
1,4-disubstituted 1 | CuAAC reaction | molecular modeling | VEGFR-2 | VEGFR-2 inhibitor | 2,3-triazoles | antiangiogenesis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2018, Volume 155, pp. 210 - 228
Aiming to explore novel BRAF and VEGFR-2 dual inhibitors, a series of 1 -pyrazolo[3,4-d]pyrimidine derivatives were designed, synthesized and biologically... 
Tyrosine kinase | 1H-pyrazolo[3,4-d]pyrimidine | BRAFV600E | Dual inhibitor | VEGFR-2 | BRAF
Journal Article
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