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vinblastine-type alkaloids (16) 16
derivatives (9) 9
index medicus (8) 8
vinblastine - analogs & derivatives (8) 8
chemistry, organic (7) 7
vinca alkaloids (7) 7
vincristine (7) 7
humans (6) 6
tubulin (6) 6
bisindole alkaloids (5) 5
vinblastine - chemistry (5) 5
analogs (4) 4
anhydrovinblastine (4) 4
antineoplastic agents, phytogenic - pharmacology (4) 4
biogenetic approach (4) 4
biological evaluation (4) 4
chemistry, medicinal (4) 4
indole alkaloids (4) 4
vinblastine - pharmacology (4) 4
vindoline (4) 4
vinorelbine (4) 4
-vinblastine (3) 3
alkaloids (3) 3
antineoplastic agents, phytogenic - chemical synthesis (3) 3
antitumor-activity (3) 3
biochemistry & molecular biology (3) 3
chemistry, multidisciplinary (3) 3
cytotoxicity (3) 3
natural-products (3) 3
stereoisomerism (3) 3
tubulin - metabolism (3) 3
vinca alkaloids - chemical synthesis (3) 3
vinca alkaloids - chemistry (3) 3
agents (2) 2
analysis (2) 2
animals (2) 2
antineoplastic agents, phytogenic - chemistry (2) 2
antitumor activity (2) 2
aspidosperma alkaloids (2) 2
binding sites (2) 2
cancer (2) 2
catharanthine (2) 2
catharanthus - chemistry (2) 2
chemistry, pharmaceutical - methods (2) 2
dimeric catharanthus alkaloids (2) 2
drug design (2) 2
drug screening assays, antitumor (2) 2
halogenation (2) 2
hela cells (2) 2
inhibitory concentration 50 (2) 2
microtubule dynamics (2) 2
microtubules - drug effects (2) 2
models, chemical (2) 2
molecular structure (2) 2
pharmacology & pharmacy (2) 2
stereochemistry (2) 2
stereocontrolled total-synthesis (2) 2
structure-activity relationship (2) 2
tabersonine (2) 2
taxol (2) 2
tubulin - chemistry (2) 2
vinblastine - chemical synthesis (2) 2
vinblastine - isolation & purification (2) 2
vinca alkaloids - pharmacology (2) 2
10 (1) 1
10 '-fluorovinblastine (1) 1
10 '-fluorovincristine (1) 1
10′-fluorovinblastine (1) 1
10′-fluorovincristine (1) 1
5 '-desmethylene-cyclopropano-vinblastine (1) 1
5'-nor (1) 1
a549 cell lines (1) 1
access (1) 1
acetic acid (1) 1
alkaloids - chemical synthesis (1) 1
allylic oxidation (1) 1
alpha-diketone monothioketal (1) 1
amide anhydrovinblastine analogs (1) 1
ammonium compounds (1) 1
ammonium paratungstate (1) 1
anti-tumor alkaloids (1) 1
anti-tumor compounds (1) 1
antineoplastic agents - chemical synthesis (1) 1
antineoplastic agents - pharmacology (1) 1
antineoplastic agents, phytogenic - isolation & purification (1) 1
antineoplastic agents, phytogenic - therapeutic use (1) 1
antitumor alkaloids (1) 1
article (1) 1
aspidosperma - chemistry (1) 1
asymmetric total-synthesis (1) 1
biological factors - chemistry (1) 1
biological factors - isolation & purification (1) 1
biological factors - therapeutic use (1) 1
biological products - isolation & purification (1) 1
biological products - pharmacology (1) 1
biological products - therapeutic use (1) 1
biological products - toxicity (1) 1
biomimetics - methods (1) 1
biosynthesis (1) 1
bis-indoles (1) 1
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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2011, Volume 2, Issue 12, pp. 948 - 952
Journal Article
Heterocycles, ISSN 0385-5414, 2015, Volume 90, Issue 1, pp. 316 - 326
Vinorelbine condensed with a cyclopropane ring in the position 14 and 15 of the vindoline monomer part was synthesized and was found to have excellent... 
CELL LUNG-CANCER | VINBLASTINE-TYPE ALKALOIDS | 5 '-Desmethylene-cyclopropano-vinblastine | FEASIBILITY | Different Tumor Cell Line | ANALOGS | Antitumor Activity | VINCRISTINE | CHEMISTRY, ORGANIC | N-1-Formyl-cyclopropano-vinorelbine | LINES
Journal Article
Science China Chemistry, ISSN 1674-7291, 7/2011, Volume 54, Issue 7, pp. 1039 - 1043
Novel C-17-chloro-substituted derivative of vinorelbine or vinflunine has been regio-selectively synthesized via the chlorination reaction in the presence of... 
Chemistry | regio-selectivity | substitution | Chemistry/Food Science, general | alkaloids | Lewis acids | halogenation | VINORELBINE | ANALOGS | VINDOLINE | CHEMISTRY, MULTIDISCIPLINARY | VINBLASTINE-TYPE ALKALOIDS | (+)-VINBLASTINE | CATHARANTHINE | BIOLOGICAL EVALUATION | ANHYDROVINBLASTINE | DERIVATIVES | ACCESS | Alkaloids
Journal Article
Journal Article
Synthesis, ISSN 0039-7881, 12/2014, Volume 46, Issue 23, pp. 3199 - 3206
Abstract A series of C-10-substituted tabersonine analogues have been synthesized via palladium-catalyzed cross-coupling reactions. To be specific, tabersonine... 
paper | Heck reaction | palladium catalysis | tabersonine | Sonogashira cross-coupling reaction | Suzuki-Miyaura cross-coupling reaction | VINDOLINE | NATURAL-PRODUCTS | DRUG DISCOVERY | CHEMISTRY, ORGANIC | RAPID ACCESS | VINBLASTINE-TYPE ALKALOIDS | BIOSYNTHESIS | INDOLE ALKALOIDS | SONOGASHIRA REACTIONS | DERIVATIVES | ASPIDOSPERMA ALKALOIDS
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 09/2000, Volume 60, Issue 18, pp. 5045 - 5051
Journal Article
Heterocycles, ISSN 0385-5414, 01/1999, Volume 50, Issue 1, pp. 169 - 194
Bisindole alkaloids of the vinblastine (VLB) type can be oxidized to give a Psi-aspidosperma-aspidosperma type skeleton via 3'-7'-transannular cyclization.... 
HIDDEN EXCHANGE PARTNER | CHEMISTRY, ORGANIC | BIS-INDOLES | INDOLE ALKALOIDS | NOE ANALYSIS | VINBLASTINE-TYPE
Journal Article
ACTUALITE CHIMIQUE, ISSN 0151-9093, 04/2003, Issue 4-5, pp. 89 - 92
Research on natural substances extracted from the Madagascar periwinkle (Catharanthus roseus) and the European yew tree (Taxus baccata) led to the discovery of... 
Taxus | vinorelbin | tubulin | VINCA-ROSEA | CHEMISTRY, MULTIDISCIPLINARY | VINBLASTINE-TYPE ALKALOIDS | ANTI-TUMOR ALKALOIDS | docetaxel | TAXOL | ANHYDROVINBLASTINE | 5'-NOR | DERIVATIVES | Catharanthus
Journal Article
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