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European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2019, Volume 171, pp. 310 - 331
Microtubules are a protein which is made of α- and β-heterodimer. It is one of the main components of the cell which play a vital role in cell division... 
Depolymerization | Vinca | Taxol | Microtubules | Polymerization | Colchicine | Cancer | DESIGN | CHEMISTRY, MEDICINAL | ANTICANCER AGENTS | TUBULIN POLYMERIZATION | PHASE-II | IN-VITRO | GENE-CLUSTER | BIOLOGICAL EVALUATION | INHIBITORS | ENANTIOSELECTIVE TOTAL-SYNTHESIS | Antimitotic agents | Antineoplastic agents | Tubulins
Journal Article
Combinatorial Chemistry and High Throughput Screening, ISSN 1386-2073, 09/2017, Volume 20, Issue 8, pp. 682 - 695
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13817 - 13821
The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubuledestabilizing agents. Here, we... 
Microtubules | Drug interactions | Antineoplastics | Ligands | Dimers | Breast cancer | Molecular mechanisms of action | Crystallography | Binding sites | Crystal structure | X-ray crystallography | Microtubule-targeting agents | Drug mechanism | microtubule-targeting agents | BETA-TUBULIN | VINCA-DOMAIN | MAYTANSINE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ANTIMITOTIC AGENTS | MACROCYCLIC LACTONE ANTIBIOTICS | POTENT ANTITUMOR-ACTIVITY | BREAST-CANCER | STRUCTURAL BASIS | RHIZOXIN | drug mechanism | Tubulin Modulators - chemistry | Humans | Polyketides - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Maytansine - therapeutic use | Breast Neoplasms - drug therapy | Tubulin Modulators - therapeutic use | Pyrones - chemistry | Animals | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - therapeutic use | Macrolides - chemistry | Cattle | Maytansine - chemistry | Pyrones - therapeutic use | Female | Microtubules - chemistry | Tubulin - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Macrolides - therapeutic use | Polyketides - therapeutic use | Binding Sites | Clinical Trials, Phase I as Topic | Antimitotic agents | Pharmaceutical research | Physiological aspects | Dosage and administration | Research | Tubulins | Antineoplastic agents | Binding sites (Biochemistry) | Mutagenesis | Medical treatment | Cancer | Biological Sciences
Journal Article