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1. Full Text Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
by Grashoff, Carsten and Hoffman, Brenton D and Brenner, Michael D and Zhou, Ruobo and Parsons, Maddy and Yang, Michael T and McLean, Mark A and Sligar, Stephen G and Chen, Christopher S and Ha, Taekjip and Schwartz, Martin A
Nature, ISSN 0028-0836, 07/2010, Volume 466, Issue 7303, pp. 263 - 266
Mechanical forces are central to developmental, physiological and pathological processes(1). However, limited understanding of force transmission within... 
COMPLEX | FORCE | ACTIN | MULTIDISCIPLINARY SCIENCES | CELL-MATRIX ADHESIONS | TALIN | SWITCH | MECHANOSENSORS | Cell Line | Movement | Humans | Vinculin - metabolism | Spectrometry, Fluorescence | Stress, Mechanical | Calibration | Cell Movement - physiology | Vinculin - chemistry | Microscopy, Confocal | Vinculin - deficiency | Animals | Vinculin - genetics | Cattle | Focal Adhesions - metabolism | Biosensing Techniques | Mice | Optical Tweezers | Fluorescent Dyes | Cytoskeletal proteins | Biophysics | Research | Properties | Membrane proteins | Amino acids | Peptides | Bacterial proteins | Efficiency | Spectrum analysis | Methods | Proteins | Obstacles | Molecular structure | Filaments | Vinculin | Biosensors | Adhesion | Recruitment
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2. Full Text Force-dependent conformational switch of α -catenin controls vinculin binding
by Yao, Mingxi and Qiu, Wu and Liu, Ruchuan and Efremov, Artem K and Cong, Peiwen and Seddiki, Rima and Payre, Manon and Lim, Chwee Teck and Ladoux, Benoit and Mège, René-Marc and Yan, Jie
Nature Communications, ISSN 2041-1723, 07/2014, Volume 5, Issue 1, p. 4525
Force sensing at cadherin-mediated adhesions is critical for their proper function. alpha-Catenin, which links cadherins to actomyosin, has a crucial role in... 
F-ACTIN | MULTIDISCIPLINARY SCIENCES | MECHANICAL FORCE | SITES | ACTIN DYNAMICS | TALIN | E-CADHERIN | ADHERENS JUNCTIONS | BETA-CATENIN | CELL-CELL ADHESION | ACTIVATE VINCULIN | Protein Structure, Tertiary | Actin Cytoskeleton - metabolism | Protein Structure, Secondary | alpha Catenin - metabolism | alpha Catenin - chemistry | Gene Expression Regulation | Vinculin - metabolism | Actin Cytoskeleton - chemistry | Stress, Mechanical | Recombinant Fusion Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Vinculin - chemistry | Mechanotransduction, Cellular | Animals | Vinculin - genetics | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | Optical Tweezers | alpha Catenin - genetics | Magnetic Fields | Binding Sites
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3. Full Text Recruitment of the Arp2/3 Complex to Vinculin: Coupling Membrane Protrusion to Matrix Adhesion
by Kris A. DeMali and Christy A. Barlow and Keith Burridge
The Journal of Cell Biology, ISSN 0021-9525, 12/2002, Volume 159, Issue 5, pp. 881 - 891
Cell migration involves many steps, including membrane protrusion and the development of new adhesions. Here we have investigated whether there is a link... 
Lymphocytes | Cell adhesion | Actins | Polymerization | Pseudopodia | Focal adhesions | Physiological regulation | Cells | Binding sites | Integrins | Arp2/3 complex | Adhesion | Migration | Vinculin | ACTIN-FILAMENTS | adhesion | BINDING PROTEIN | CELL BIOLOGY | integrins | vinculin | RHO ACTIVITY | RAC | INTRAMOLECULAR ASSOCIATION | migration | ACIDIC PHOSPHOLIPIDS | WISKOTT-ALDRICH SYNDROME | CELL LOCOMOTION | FILAMENT NETWORK FORMATION | N-WASP | Green Fluorescent Proteins | Embryo, Mammalian | Humans | Actins - metabolism | Vinculin - metabolism | Extracellular Matrix - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Integrins - metabolism | Recombinant Fusion Proteins - metabolism | Phosphatidylinositol 3-Kinases - pharmacology | Cytoskeletal Proteins - metabolism | Cell Line | Cells, Cultured | Binding Sites - genetics | Cell Adhesion | Vinculin - chemistry | Point Mutation | Animals | Vinculin - genetics | Androstadienes - pharmacology | Pseudopodia - metabolism | Actin-Related Protein 2 | Fibronectins - physiology | Protein Binding | Actin-Related Protein 3 | Vinculin - antagonists & inhibitors | Mice | Epidermal Growth Factor - pharmacology | HeLa Cells | 3T3 Cells | rac1 GTP-Binding Protein - metabolism | Cell Movement | Luminescent Proteins - metabolism | Proteins | Physiological aspects | Actin | Cell migration | Cellular biology | Membranes | vinculin; Arp2 | 3 complex; integrins; adhesion; migration
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4. Full Text Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization
by Krishna Chinthalapudi and Erumbi S. Rangarajan and David T. Brown and Tina Izard and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 34, pp. 9539 - 9544
The main cause of death globally remains debilitating heart conditions, such as dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), which are... 
Cytoskeleton | Cardiomyopathy | Vinculin | Cell adhesion | Metavinculin | FOCAL-ADHESION | metavinculin | cytoskeleton | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | F-ACTIN-BINDING | CELL-ADHESION | DILATED CARDIOMYOPATHY | META-VINCULIN | ALPHA-ACTININ | PROTEIN VINCULIN | vinculin | cell adhesion | INTRAMOLECULAR ASSOCIATION | TALIN | cardiomyopathy | Humans | Protein Multimerization | Vinculin - metabolism | Crystallography, X-Ray | Phosphatidylinositol 4,5-Diphosphate - metabolism | Thermodynamics | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Phosphatidylinositol 4,5-Diphosphate - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Vinculin - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Vinculin - genetics | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Mutation | Protein Isoforms - genetics | Physiological aspects | Lipid metabolism | Observations | Heart diseases | Binding sites (Biochemistry) | Proteins | Heart failure | Lipids | Binding sites | Cell adhesion & migration | Biological Sciences
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5. Full Text α-Catenin as a tension transducer that induces adherens junction development
by Shibata, Mai and Yonemura, Shigenobu and Watanabe, Toshiyuki and Wada, Yuko and Nagafuchi, Akira
Nature Cell Biology, ISSN 1465-7392, 06/2010, Volume 12, Issue 6, pp. 533 - 542
Adherens junctions (AJs), which are organized by adhesion proteins and the underlying actin cytoskeleton, probably sense pulling forces from adjacent cells and... 
F-ACTIN | ADHESION | MORPHOGENESIS | CELL-CELL CONTACTS | COMPLEX | EPITHELIAL-CELLS | DYNAMICS | VINCULIN | E-CADHERIN | DOMAINS | CELL BIOLOGY | Microfilament Proteins - chemistry | Animals | alpha Catenin - metabolism | Adherens Junctions - physiology | Vinculin - metabolism | Cytoskeleton - metabolism | Cytoskeleton - physiology | Microfilament Proteins - metabolism | Vinculin - physiology | Adherens Junctions - metabolism
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6. Full Text α-Catenin Is a Molecular Switch that Binds E-Cadherin-β-Catenin and Regulates Actin-Filament Assembly
by Drees, Frauke and Pokutta, Sabine and Yamada, Soichiro and Nelson, W. James and Weis, William I
Cell, ISSN 0092-8674, 12/2005, Volume 123, Issue 5, pp. 903 - 915
Epithelial cell-cell junctions, organized by adhesion proteins and the underlying actin cytoskeleton, are considered to be stable structures maintaining the... 
CYTOPLASMIC DOMAIN | F-ACTIN | PROTEIN | EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYNAMICS | VINCULIN | ARP2/3 COMPLEX | JUNCTIONAL COMPLEX | CELL-CELL ADHESION | INTERCELLULAR-ADHESION | CELL BIOLOGY | Cadherins - metabolism | alpha Catenin - metabolism | Multiprotein Complexes | Actins - metabolism | Vinculin - metabolism | Protein Subunits - metabolism | Actins - genetics | Actin-Related Protein 2-3 Complex - metabolism | Actins - chemistry | Cell Membrane - metabolism | Cadherins - genetics | Dimerization | Protein Subunits - genetics | Recombinant Proteins - metabolism | alpha Catenin - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | beta Catenin - metabolism | beta Catenin - genetics | Vinculin - chemistry | Animals | Vinculin - genetics | Cell Adhesion - physiology | Cytoskeleton - metabolism | Protein Binding | Protein Conformation | Mice | Protein Subunits - chemistry | alpha Catenin - genetics | Protein research | Research | Actin | Cell adhesion
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7. Full Text Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties
by Thompson, Peter M and Tolbert, Caitlin E and Shen, Kai and Kota, Pradeep and Palmer, Sean M and Plevock, Karen M and Orlova, Albina and Galkin, Vitold E and Burridge, Keith and Egelman, Edward H and Dokholyan, Nikolay V and Superfine, Richard and Campbell, Sharon L
Structure, ISSN 0969-2126, 05/2014, Volume 22, Issue 5, pp. 697 - 706
Summary Vinculin, a cytoskeletal scaffold protein essential for embryogenesis and cardiovascular function, localizes to focal adhesions and adherens junctions,... 
F-ACTIN | ACTIVATION | PROTON-EXCHANGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISCRETE MOLECULAR-DYNAMICS | ELECTRON-MICROSCOPY | TAIL DOMAINS | CELL BIOLOGY | PROTEIN VINCULIN | CLEANEX-PM | BIOPHYSICS | FORCE | INTRAMOLECULAR ASSOCIATION | Rabbits | Avian Proteins - metabolism | Actins - metabolism | Cells, Cultured | Vinculin - metabolism | Focal Adhesions | Models, Molecular | Avian Proteins - chemistry | Vinculin - chemistry | Point Mutation | Animals | Vinculin - genetics | Microscopy, Electron - methods | Hydrophobic and Hydrophilic Interactions | Fibroblasts - cytology | Mice | Binding Sites | Avian Proteins - genetics | Molecular genetics | Actin | Analysis | Physiological aspects | Chemical properties | Muscle proteins | Electron microscopy | Cells | Proteins | Bundling | Binding | Cellular | Vinculin | Molecular dynamics | Mathematical models | Adhesion
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8. Full Text An autoinhibited structure of α-catenin and its implications for vinculin recruitment to adherens junctions
by Ishiyama, Noboru and Tanaka, Nobutoshi and Abe, Kentaro and Yang, Yoo Jeong and Abbas, Yazan M and Umitsu, Masataka and Nagar, Bhushan and Bueler, Stephanie A and Rubinstein, John L and Takeichi, Masatoshi and Ikura, Mitsuhiko
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 22, pp. 15913 - 15925
a-Catenin is an actin- and vinculin-binding protein that regulates cell-cell adhesion by interacting with cadherin adhesion receptors through beta-catenin, but... 
IN-VITRO | BIOLOGICAL MACROMOLECULES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SOLUTION SCATTERING | ACTIN-BINDING | CELL-ADHESION | E-CADHERIN | FLUORESCENT PROTEIN | BETA-CATENIN | N-CATENIN | Adherens Junctions - genetics | Protein Structure, Tertiary | Cell Line | Actin Cytoskeleton - metabolism | alpha Catenin - metabolism | alpha Catenin - chemistry | Vinculin - metabolism | Actin Cytoskeleton - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Nerve Tissue Proteins - genetics | Adherens Junctions - metabolism | Vinculin - chemistry | Nerve Tissue Proteins - metabolism | Nerve Tissue Proteins - chemistry | Animals | Vinculin - genetics | Models, Biological | Mice | alpha Catenin - genetics | Adherens Junctions - chemistry | Actin Cytoskeleton - genetics | Adherens Junction | α-Catenin | Vinculin | Cadherins | Cytoskeleton | Catenin | Cell Adhesion | Cell Biology
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9. Full Text Extracellular rigidity sensing by talin isoform-specific mechanical linkages
by Austen, Katharina and Ringer, Pia and Mehlich, Alexander and Chrostek-Grashoff, Anna and Kluger, Carleen and Klingner, Christoph and Sabass, Benedikt and Zent, Roy and Rief, Matthias and Grashoff, Carsten
Nature Cell Biology, ISSN 1465-7392, 11/2015, Volume 17, Issue 12, pp. 1597 - 1606
The ability of cells to adhere and sense differences in tissue stiffness is crucial for organ development and function. The central mechanisms by which... 
VINCULIN BINDING | ACTIVATION | INTEGRIN | NANOSCALE ARCHITECTURE | TENSION | FORCES | E-CADHERIN | PROTEINS | REVEALS | CELL BIOLOGY | Actins - metabolism | Peptides - genetics | Vinculin - metabolism | Extracellular Matrix - metabolism | Peptides - metabolism | Talin - genetics | Fluorescence Resonance Energy Transfer | Microfilament Proteins - metabolism | Optical Tweezers | Microfilament Proteins - genetics | Fibroblasts - metabolism | Actin Cytoskeleton - metabolism | Cells, Cultured | Mice, Transgenic | Talin - metabolism | Cell Adhesion | Blotting, Western | Mice, Knockout | Microscopy, Confocal | Animals | Vinculin - genetics | Focal Adhesions - metabolism | Protein Binding | Biosensing Techniques - methods | Luminescent Proteins - genetics | Fibroblasts - cytology | Mechanical Phenomena | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Extracellular matrix | Cytoskeletal proteins | Genetic aspects | Observations | Properties | Cell adhesion
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10. Full Text Mechanosensitive systems at the cadherin-F-actin interface
by Huveneers, S and de Rooij, J
Journal of Cell Science, ISSN 0021-9533, 2013, Volume 126, Issue Pt 2, pp. 403 - 413
Cells integrate biochemical and mechanical information to function within multicellular tissue. Within developing and remodeling tissues, mechanical forces... 
Focal adherens junction | Actin | Vinculin | Myosin | Mechanotransduction | Cadherin | Catenin | CYTOPLASMIC DOMAIN | LEUKOCYTE EXTRAVASATION | EPITHELIAL ZONULA ADHERENS | SPATIAL-ORGANIZATION | JUNCTIONAL COMPLEX | TISSUE MORPHOGENESIS | CELL BIOLOGY | ALPHA-CATENIN | MEDIATED ADHESIONS | VINCULIN-BINDING PROTEIN | CELL-CELL ADHESION | Animals | Cadherins - metabolism | Signal Transduction | alpha Catenin - metabolism | Humans | Actins - metabolism | Vinculin - metabolism | Adherens Junctions - metabolism
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11. Full Text Vinculin and metavinculin: Oligomerization and interactions with F-actin
by Thompson, Peter M and Tolbert, Caitlin E and Campbell, Sharon L
FEBS Letters, ISSN 0014-5793, 04/2013, Volume 587, Issue 8, pp. 1220 - 1229
Vinculin, and its splice variant metavinculin, are scaffolding proteins that localize to cellular adhesions. Vinculin is a key player in mediating cell... 
Oligomerization | Actin | Vinculin | PIP2 | Metavinculin | PIP | FOCAL-ADHESION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN-TISSUES | META-VINCULIN | BINDING PROTEIN | ALPHA-ACTININ | CELL BIOLOGY | SELF-ASSOCIATION | CELL-CELL | BIOPHYSICS | INTRAMOLECULAR ASSOCIATION | CHICKEN GIZZARD | Protein Structure, Tertiary | Actin Cytoskeleton - metabolism | Vinculin - genetics | Humans | Protein Multimerization | Actins - metabolism | Vinculin - metabolism | Actin Cytoskeleton - chemistry | Actins - chemistry | Models, Molecular | Protein Binding | Vinculin - chemistry | Oligomers | Physiological aspects | Muscle proteins | Cells
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