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Nature Reviews Drug Discovery, ISSN 1474-1776, 10/2017, Volume 16, Issue 11, pp. 787 - 810
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0182110
The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition... 
ACTIVATION | GRK2 | INHIBITION | MYOCYTES | MEMBRANE | MULTIDISCIPLINARY SCIENCES | ABLATION | PREVENTS | PHOSPHOINOSITIDE 3-KINASE | FAILURE | EXPRESSION | Lymphocyte Activation | Mice, Inbred C57BL | Cells, Cultured | Rats | Male | Phosphatidylinositol 3-Kinases - metabolism | G-Protein-Coupled Receptor Kinase 2 - genetics | G-Protein-Coupled Receptor Kinase 2 - metabolism | Glycogen Synthase Kinase 3 beta - metabolism | Animals | Myocytes, Cardiac - metabolism | T-Lymphocytes - immunology | Heart Ventricles - metabolism | Mice | Cardiomegaly - genetics | Proto-Oncogene Proteins c-akt - metabolism | Heart Ventricles - pathology | Cardiomegaly - metabolism | Research | G proteins | Protein kinases | Hypertrophy | Heart | Neonates | Animal models | Phosphorylation | G protein-coupled receptors | b-Adrenergic-receptor kinase | AKT protein | Stimulation | mRNA | Activation | Myocytes | NF-AT protein | Kinases | Remodeling | Inactivation | G protein-coupled receptor kinase 2 | Eutrophication | Proteins | Signal transduction | Rodents | Phenylephrine | Constrictions | Aorta | Physiology | Inhibition | Angiotensin II | Cardiology | Heart diseases | Heart failure | Deactivation | Internal medicine | Glycogen | Glycogen synthase kinase 3 | Cardiomyocytes | Pharmacology | 1-Phosphatidylinositol 3-kinase | Medicine | G protein-coupled receptor kinase | Hospitals | Molecular modelling | Protein kinase | Angiotensin | Ventricle | Laboratory animals | In vitro methods and tests
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