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A genotyping study of human immunodeficiency virus type-1 drug resistance in a small Brazilian municipality, 12/2005
In Brazil, surveillance studies on antiretroviral drug resistance among drug-naïve and treatment-experienced patients have focused primarily on patients living... 
antiretroviral resistance - genotyping - human immunodeficiency virus type-1 - small municipalities - subtypes - Brazil
Journal
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 6, p. e11052
Background: HIV-1 Protease Inhibitors, namely PIs, originally designed to inhibit HIV-1 aspartic protease, can modulate the immune response by mechanisms... 
NK CELLS | MACROPHAGES | BIOLOGY | ATHEROSCLEROTIC LESION FORMATION | HIV-1 PROTEASE | ANTIRETROVIRAL THERAPY | INFECTION | DIFFERENTIATION | DYSLIPIDEMIA | ANTIFUNGAL | T-CELLS | HIV Protease Inhibitors - pharmacology | Cell Proliferation | Flow Cytometry | HIV Protease - drug effects | Enzyme-Linked Immunosorbent Assay | Dendritic Cells - immunology | Humans | Killer Cells, Natural - immunology | Dendritic Cells - drug effects | Immunophenotyping | Killer Cells, Natural - drug effects | Autoimmunity | Killer cells | Protease inhibitors | Dendritic cells | Proteases | Analysis | Inflammation | Ritonavir | Cytotoxicity | Saquinavir | Acquired immune deficiency syndrome--AIDS | Protease | Human immunodeficiency virus--HIV | Nelfinavir | Natural killer cells | Immunomodulators | Antigens | Lymphatic system | Cytokines | Immunomodulation | Interleukin 12 | T cell receptors | Proteinase inhibitors | Interleukin 15 | Pathology | Hypoxia | Rehabilitation | Aberration | Drugs | CD86 antigen | Laboratories | Toxicity | Inflammatory response | Viruses | Infections | Metabolic syndrome | Immunosuppressive agents | Immunology | Lymphocytes | Aspartic endopeptidase | Atherosclerosis | Bacteria | Tumor necrosis factor-TNF | Drug therapy | Indinavir | Immune system | Killing | Immune response | CD36 antigen | Monocytes | Molecular biology | Amprenavir | Cancer | Acquired immune deficiency syndrome | AIDS | Human immunodeficiency virus | HIV
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 03/2019, Volume 85, Issue 3, pp. 508 - 515
Journal Article
Nature, ISSN 0028-0836, 01/1995, Volume 373, Issue 6510, pp. 117 - 122
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/1994, Volume 91, Issue 9, pp. 4096 - 4100
To date, numerous inhibitors of the human immunodeficiency virus type 1 protease have been reported, but few have been studied extensively in humans, primarily... 
Enzymes | Cell culture techniques | Protease inhibitors | Virions | Antivirals | Viruses | Infections | Bioavailability | HIV 1 | Blood plasma | TARGET | DESIGN | MULTIDISCIPLINARY SCIENCES | REVERSE-TRANSCRIPTASE | SEQUENCE | AIDS | HIV-1 PROTEASE | PROTEINASE | Research | HIV (Viruses) | Analysis
Journal Article
Journal of Clinical Virology, ISSN 1386-6532, 2009, Volume 47, Issue 1, pp. 8 - 12
Abstract Human Immunodeficiency Virus Type-1 (HIV-1) drug-resistance testing is challenging for viral loads below 1,000 copies/mL, but, according to HIV-1... 
Infectious Disease | Allergy and Immunology | HIV-1 | Genotypic test | protease inhibitor | Direct full-population sequencing | reverse transcriptase | nucleoside reverse transcriptase inhibitor | NNRTI | Drug resistance | NucliSENS easyMAG | protease | Nucleic acid extraction | Human Immunodeficiency Virus Type-1 | NeM | NRTI | PCR | polymerase chain reaction | non-nucleoside reverse transcriptase inhibitor | NNRTI, non-nucleoside reverse transcriptase inhibitor | ASSAY | PERFORMANCE | HIV-1, Human Immunodeficiency Virus | SENSITIVITY | POPULATIONS | Type-1 | NeM, NucliSENS easyMAG | PI, protease inhibitor | P, protease | VIROLOGY | HIV-1 GENOTYPING SYSTEM | PCR, polymerase chain reaction | RT, reverse transcriptase | HCV | NRTI, nucleoside reverse transcriptase inhibitor | TAQMAN HIV-1 | MUTATIONS | Anti-HIV Agents - pharmacology | HIV Infections - blood | HIV-1 - drug effects | HIV Infections - virology | Humans | Drug Resistance, Viral | Genotype | Chi-Square Distribution | HIV-1 - genetics | Magnetics | Viral Load | Sequence Analysis, RNA - methods | HIV-1 - chemistry | Silicon Dioxide | Polymerase Chain Reaction | HIV Infections - drug therapy | Retrospective Studies | RNA, Viral - isolation & purification | Viremia - blood | Polymerase chain reaction | Reverse transcriptase | Protease inhibitors | RNA | Proteases | HIV (Viruses)
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2019, Volume 62, Issue 17, pp. 8062 - 8079
A structure-guided design strategy was used to improve the resistance profile of HIV-1 protease inhibitors by optimizing hydrogen bonding and van der Waals... 
DESIGN | POTENT | CHEMISTRY, MEDICINAL | MECHANISM | RESPONSE CURVE SLOPE | IMMUNODEFICIENCY-VIRUS TYPE-1 | BIOLOGICAL EVALUATION | X-RAY | DRUG-RESISTANCE | DISCOVERY
Journal Article