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ACS Chemical Neuroscience, ISSN 1948-7193, 05/2017, Volume 8, Issue 5, pp. 1004 - 1010
The development of probe molecules that can be used to investigate G protein-coupled receptor (GPCR) pharmacology, trafficking, and relationship with other... 
WAY163909 derivatives | Serotonin | 5-HT | receptor agonist | CUE REACTIVITY | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | COCAINE | CHO-CELLS | IMPULSIVITY | NEUROSCIENCES | INVERSE AGONISTS | IN-VIVO | WAY-163909 | SELECTIVE AGONIST | HOMODIMERS | 5-HT2C receptor agonist
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2224 - 2228
This letter describes progress towards an M-4 PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant... 
Aldehyde oxidase (AO) | CHEMISTRY, MEDICINAL | SERIES | PRECLINICAL CANDIDATE | CHEMISTRY, ORGANIC | RECEPTOR | CHALLENGES | Muscarinic acetylcholine receptor | Structure-activity relationship (SAR) | VIVO TOOL COMPOUND | M-4 | Positive allosteric modulator (PAM) | POSITIVE ALLOSTERIC MODULATORS | OPTIMIZATION | POTENTIATORS
Journal Article
TRENDS IN PHARMACOLOGICAL SCIENCES, ISSN 0165-6147, 12/2019, Volume 40, Issue 12, pp. 1006 - 1020
Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex behaviors such as cognition, movement, and reward, making them ideally... 
VIVO TOOL COMPOUND | RAT | M-4 RECEPTOR | DOPAMINE | POSITIVE ALLOSTERIC MODULATORS | CNS | PHARMACOLOGY & PHARMACY | XANOMELINE | PAM | AGONIST | Nervous system diseases | Care and treatment | Neurosciences | Enzyme inhibitors | Schizophrenia | Development and progression | Substance abuse | Drug discovery | Alzheimer's disease
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2017, Volume 8, Issue 1, pp. 73 - 77
The area of multitarget compounds, joining two pharmacophores within one molecule, is a vivid field of research in medicinal chemistry. Not only pharmacophoric... 
Hydrazone linker | NK1 antagonists | Bifunctional ligands | Opioid agonists | BIPHALIN | DESIGN | CHEMISTRY, MEDICINAL | NEUROKININ-1 RECEPTOR | DELTA-OPIOID RECEPTOR | PEPTIDE | NEUROPATHIC PAIN | opioid agonists | IN-VIVO | BIOLOGICAL EVALUATION | NKI antagonists | hydrazone linker | 1 RECEPTOR ANTAGONIST | AGONIST
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Journal Article
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