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1. Full Text Immunogenicity, reactogenicity and safety of an inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine: A phase III, randomized trial in adults aged ≥18 years
by Kieninger, Dorothee and Sheldon, Eric and Lin, Wen-Yuan and Yu, Chong-Jen and Bayas, Jose M and Gabor, Julian J and Esen, Meral and Fernandez Roure, Jose Luis and Narejos Perez, Silvia and Alvarez Sanchez, Carmen and Feng, Yang and Claeys, Carine and Peeters, Mathieu and Innis, Bruce L and Jain, Varsha
BMC Infectious Diseases, ISSN 1471-2334, 07/2013, Volume 13, Issue 1, pp. 343 - 343
Background: Two antigenically distinct influenza B lineages have co-circulated since the 1980s, yet inactivated trivalent influenza vaccines (TIVs) include... 
Seasonal influenza | Quadrivalent | Trivalent | Non-inferiority | Superiority | INFECTIOUS DISEASES | VIRUS | EFFICACY | ILLNESS | LINEAGES | CHILDREN | IMPACT | DISEASE BURDEN | Influenza A Virus, H1N1 Subtype - immunology | Influenza Vaccines - administration & dosage | Humans | Middle Aged | Influenza Vaccines - adverse effects | Male | Influenza A Virus, H3N2 Subtype - immunology | Antibodies, Viral - blood | Hemagglutination Inhibition Tests | Young Adult | Vaccines, Inactivated - adverse effects | Vaccines, Inactivated - immunology | Influenza Vaccines - immunology | Vaccines, Inactivated - administration & dosage | Adolescent | Aged, 80 and over | Adult | Female | Influenza A virus - immunology | Aged | Influenza B virus - immunology | Influenza, Human - prevention & control | Influenza vaccines | Antigens | Medical research | Immune response | Vaccination | Medicine, Experimental | Biological products industry | Product development | Immunization | Hospitalization | Vaccines | Seasons | Preventive medicine | Influenza
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2. Full Text Immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged ≥18 years: A phase III, randomized trial
by Tinoco, Juan Carlos and Pavia-Ruz, Noris and Cruz-Valdez, Aurelio and Aranza Doniz, Carlos and Chandrasekaran, Vijayalakshmi and Dewé, Walthère and Liu, Aixue and Innis, Bruce L and Jain, Varsha K
Vaccine, ISSN 0264-410X, 2014, Volume 32, Issue 13, pp. 1480 - 1487
Highlights • Immunogenicity of QIV was non-inferior versus TIV for shared strains in adults. • Immunogenicity of QIV was superior to TIV for the... 
Allergy and Immunology | Inactivated quadrivalent influenza vaccine | Seasonal influenza | Yamagata lineage | Victoria lineage | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNOLOGY | CHILDREN | Influenza A Virus, H3N2 Subtype | Double-Blind Method | Influenza Vaccines - classification | Humans | Middle Aged | Male | Influenza B virus | Antibodies, Viral - blood | Hemagglutination Inhibition Tests | Young Adult | Adolescent | Aged, 80 and over | Antibody Formation | Influenza A Virus, H1N1 Subtype | Influenza Vaccines - therapeutic use | Adult | Female | Aged | Vaccines, Inactivated - therapeutic use | Influenza, Human - prevention & control | Influenza vaccines | Product development | Adults | Influenza | Public health | Confidence intervals | Immunization | Vaccines | Seasons
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3. Full Text Safety and immunogenicity of a freeze-dried, Vero cell culture-derived, inactivated Japanese encephalitis vaccine (KD-287, ENCEVAC ® ) versus a mouse brain-derived inactivated Japanese encephalitis vaccine in children: A phase III, multicenter, double-blinded, randomized trial
by Yun, Ki Wook and Lee, Hoan Jong and Kang, Jin Han and Eun, Byung Wook and Kim, Yae-Jean and Kim, Kyung-Hyo and Kim, Nam Hee and Hong, Young Jin and Kim, Dong Ho and Kim, Hwang Min and Cha, Sung-Ho
BMC Infectious Diseases, ISSN 1471-2334, 01/2015, Volume 15, Issue 1, pp. 7 - 7
Background: Although mouse brain-derived, inactivated Japanese encephalitis vaccines (JE-MBs) have been successfully used for a long time, potential rare... 
Clinical trial | Vaccine | Vero cells | Japanese encephalitis | IMMUNITY | INFECTIOUS DISEASES | EFFICACY | TAIWAN | JE VACCINE | IC51 | CLINICAL-TRIALS | COMPLICATIONS | STRAIN | IXIARO(R) | Japanese Encephalitis Vaccines - administration & dosage | Vero Cells - virology | Double-Blind Method | Encephalitis, Japanese - virology | Humans | Japanese Encephalitis Vaccines - immunology | Vaccination | Brain - virology | Cercopithecus aethiops | Infant | Male | Neutralization Tests | Japanese Encephalitis Vaccines - adverse effects | Vaccines, Inactivated - adverse effects | Antibodies, Neutralizing - immunology | Vaccines, Inactivated - immunology | Animals | Immunization, Secondary | Vaccines, Inactivated - administration & dosage | Encephalitis, Japanese - immunology | Antibodies, Viral - immunology | Female | Mice | Korea | Clinical trials | Usage | Venture capital
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4. Full Text Randomized Trials Comparing Inactivated Vaccine After Medium- or High-titer Measles Vaccine With Standard Titer Measles Vaccine After Inactivated Vaccine: A Meta-analysis
by Aaby, Peter and Ravn, Henrik and Benn, Christine S and Rodrigues, Amabelia and Samb, Badara and Ibrahim, Salah A and Libman, Michael D and Whittle, Hilton C
The Pediatric Infectious Disease Journal, ISSN 0891-3668, 11/2016, Volume 35, Issue 11, pp. 1232 - 1241
BACKGROUND:Observational studies have suggested that girls have higher mortality if their most recent immunization is an inactivated vaccine rather than a live... 
diphtheria-tetanus-pertussis vaccine | high-titer measles vaccine | inactivated vaccines | measles vaccine | sex-differential effects | nonspecific effects of vaccines | CHILDHOOD SURVIVAL | INFECTIOUS DISEASES | LONG-TERM SURVIVAL | NO EVIDENCE | IMMUNOLOGY | BIRTH-WEIGHT CHILDREN | DIPHTHERIA-TETANUS-PERTUSSIS | IMMUNIZATIONS | GUINEA-BISSAU | ROUTINE VACCINATIONS | EDMONSTON-ZAGREB | FEMALE-MALE MORTALITY | PEDIATRICS
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5. Full Text Surveillance of adverse events after the first trivalent inactivated influenza vaccine produced in mammalian cell culture (Flucelvax® ) reported to the Vaccine Adverse Event Reporting System (VAERS), United States, 2013–2015
by Moro, Pedro L and Winiecki, Scott and Lewis, Paige and Shimabukuro, Tom T and Cano, Maria
Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue 48, pp. 6684 - 6688
Abstract Background In November 2012, the first cell cultured influenza vaccine, a trivalent subunit inactivated influenza vaccine (Flucelvax® , ccIIV3), was... 
Allergy and Immunology | Adverse event | Cell culture | Vaccine safety | Surveillance | Trivalent inactivated influenza vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNIZATION | COLLECTION | GUILLAIN-BARRE-SYNDROME | SEASONAL INFLUENZA | GUIDELINES | IMMUNOLOGY | United States - epidemiology | Influenza Vaccines - administration & dosage | Humans | Middle Aged | Influenza Vaccines - adverse effects | Child, Preschool | Infant | Male | Technology, Pharmaceutical - methods | Cell Culture Techniques - methods | Drug-Related Side Effects and Adverse Reactions - epidemiology | Drug-Related Side Effects and Adverse Reactions - pathology | Young Adult | Vaccines, Inactivated - adverse effects | Vaccines, Inactivated - administration & dosage | Adolescent | Aged, 80 and over | Product Surveillance, Postmarketing | Adult | Female | Aged | Child | Prevention | Influenza vaccines | Influenza | Cells | Studies | Medical records | Vaccines | Disease control | vaccine safety | adverse event | surveillance | trivalent inactivated influenza vaccine | cell culture
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6. Full Text Heterologous HA DNA vaccine prime—inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses
by Wang, Shixia and Parker, Chris and Taaffe, Jessica and Solórzano, Alicia and García-Sastre, Adolfo and Lu, Shan
Vaccine, ISSN 0264-410X, 2008, Volume 26, Issue 29, pp. 3626 - 3633
Abstract The trivalent inactivated vaccine (TIV) is used to prevent seasonal influenza virus infection in humans, however, the immunogenicity of this vaccine... 
Allergy and Immunology | DNA vaccine | Prime-boost | Influenza virus | HA protein | Inactivated flu vaccine | A VIRUS | SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | inactivated flu vaccine | RESCUE | influenza virus | prime-boost | VETERINARY SCIENCES | GENERATION | IMMUNOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Rabbits | Enzyme-Linked Immunosorbent Assay | Immunoglobulin G - blood | Hemagglutinins, Viral - genetics | Humans | Vaccines, DNA - immunology | Neutralization Tests | Orthomyxoviridae | Influenza A Virus, H3N2 Subtype - immunology | Antibodies, Viral - blood | Hemagglutinins, Viral - immunology | Hemagglutination Inhibition Tests | Vaccines, Inactivated - immunology | Animals | Immunization, Secondary | Influenza Vaccines - immunology | Iridovirus | Pandemics | Vaccines | Avian flu | Genes
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7. Full Text Comparison of the immunogenicity and safety of a split-virion, inactivated, trivalent influenza vaccine (Fluzone® ) administered by intradermal and intramuscular route in healthy adults
by Frenck, Robert W and Belshe, Robert and Brady, Rebecca C and Winokur, Patricia L and Campbell, James D and Treanor, John and Hay, Christine M and Dekker, Cornelia L and Walter, Emmanuel B and Cate, Thomas R and Edwards, Kathryn M and Hill, Heather and Wolff, Mark and LeDuc, Tom and Tornieporth, Nadia
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 34, pp. 5666 - 5674
Abstract The aim of the study was to determine whether reduced doses of trivalent inactivated influenza vaccine (TIV) administered by the intradermal (ID)... 
Allergy and Immunology | Influenza | Intradermal | Vaccine | SYSTEM | TRIAL | MEDICINE, RESEARCH & EXPERIMENTAL | HALF | SHORTAGE | SCALE | IMMUNOLOGY | ANTIBODY-RESPONSES | DELIVERY | Influenza A Virus, H1N1 Subtype - immunology | Influenza Vaccines - administration & dosage | Humans | Middle Aged | Vaccination | Influenza Vaccines - adverse effects | Male | Injections, Intramuscular | Influenza A Virus, H3N2 Subtype - immunology | Antibodies, Viral - blood | Hemagglutination Inhibition Tests | Influenza Vaccines - immunology | Antibody Formation | Adult | Antibodies, Viral - immunology | Female | Pain Measurement | Influenza, Human - prevention & control | Influenza, Human - immunology | Injections, Intradermal | Influenza vaccines | Medical colleges | Antigens | Safety and security measures | Trademarks | Adults | Comparative analysis | Immunization | Hospitals | Pain | Biomedical research | Licenses | Vaccines | Drug dosages | Age
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8. Full Text Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children A Cluster Randomized Blinded Trial
by Loeb, M and Russell, ML and Manning, V and Fonseca, K and Earn, DJD and Horsman, G and Chokani, K and Vooght, M and Babiuk, L and Schwartz, L and Neupane, B and Singh, P and Walter, SD and Pullenayegum, E
ANNALS OF INTERNAL MEDICINE, ISSN 0003-4819, 11/2016, Volume 165, Issue 9, pp. 617 - 617
Background: Whether vaccinating children with intranasal live attenuated influenza vaccine (LAIV) is more effective than inactivated influenza vaccine (IIV) in... 
UNITED-STATES | TRIVALENT | MEDICINE, GENERAL & INTERNAL | INFECTIONS | VIRUS | METAANALYSIS | SCHOOLCHILDREN | EFFICACY | FAMILIES | SEASONAL INFLUENZA | YOUNG-CHILDREN | Influenza Vaccines - administration & dosage | Humans | Vaccination | Influenza Vaccines - adverse effects | Child, Preschool | Immunity, Herd | Influenza, Human - epidemiology | Vaccines, Inactivated - adverse effects | Canada - epidemiology | Vaccines, Inactivated - administration & dosage | Rural Population | Vaccines, Attenuated - administration & dosage | Adolescent | Vaccines, Attenuated - adverse effects | Child | Influenza, Human - prevention & control | Influenza vaccines | Prevention | Children | Comparative analysis | Hutterian Brethren | Health aspects | Diseases
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9. Full Text Long-term antibody persistence after vaccination with a 2-dose Havrix ™ (inactivated hepatitis A vaccine): 20 years of observed data, and long-term model-based predictions
by Theeten, Heidi and Van Herck, Koen and Van Der Meeren, Olivier and Crasta, Priya and Van Damme, Pierre and Hens, Niel
Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue 42, pp. 5723 - 5727
Highlights • More than 97% subjects remained seropositive 20 years after HAV vaccination. • Mathematical modelling predicts ≥95% subjects will remain... 
Allergy and Immunology | Long-term follow-up | Mathematical modelling | Immunogenicity | Inactivated hepatitis A vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | ADULTS | FOLLOW-UP | IMMUNOLOGY | Double-Blind Method | Follow-Up Studies | Humans | Middle Aged | Linear Models | Male | Hepatitis A Vaccines - administration & dosage | Immunization, Secondary | Vaccination - methods | Vaccines, Inactivated - administration & dosage | Hepatitis A Antibodies - blood | Adult | Female | Hepatitis A - prevention & control | Models | Rites, ceremonies and celebrations | Analysis | Vaccination | Hepatitis A | Hepatitis A vaccine | Studies | Confidence intervals | Enzymes | Immunoglobulins | Funding | Clinical trials | Vaccines
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10. Full Text CD4⁺ T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine
by Jennifer L. Nayak and Theresa F. Fitzgerald and Katherine A. Richards and Hongmei Yang and John J. Treanor and Andrea J. Sant
The Journal of Infectious Diseases, ISSN 0022-1899, 1/2013, Volume 207, Issue 2, pp. 297 - 305
Background. The ability of influenza vaccines to elicit CD4⁺ T cells and the relationship between induction of CD4⁺ T cells and vaccine-induced neutralizing... 
T lymphocytes | Influenza vaccines | Pandemics | Neutralizing antibodies | Vaccination | Influenza | Antibodies | Orthomyxoviridae | Viruses | Epitopes | cellular immune response | epitopes | CD4 | influenza vaccines | pandemic H1N1 influenza | influenza virus | immunodominance | T cells | INFECTIOUS DISEASES | SWINE | HUMANS | MICROBIOLOGY | IMMUNOLOGY | EMERGENCE | CHILDREN | HEALTHY-ADULTS | IN-VITRO | A H5N1 VACCINE | IMMUNE-RESPONSES | SEASONAL INFLUENZA | CD4(+) T cells | Immunodominant Epitopes - immunology | Influenza A Virus, H1N1 Subtype - immunology | Predictive Value of Tests | Lymphocyte Activation | Humans | Middle Aged | Male | Antibodies, Viral - blood | CD4-Positive T-Lymphocytes - immunology | Young Adult | Vaccines, Inactivated - immunology | Influenza Vaccines - immunology | Adolescent | Adult | Female | Influenza, Human - virology | Aged | Influenza, Human - prevention & control | Antibodies, Neutralizing - blood | Viral antibodies | Immune response | CD4 lymphocytes | Physiological aspects | Dosage and administration | Cellular immunity | Research | Major and Brief Reports | CD4+ T cells
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11. Full Text Comparison of Side Effects of the 2015-2016 High-Dose, Inactivated, Trivalent Influenza Vaccine and Standard Dose, Inactivated, Trivalent Influenza Vaccine in Adults >= 65 Years
by Kaka, AS and Filice, GA and Myllenbeck, S and Nichol, KL
OPEN FORUM INFECTIOUS DISEASES, ISSN 2328-8957, 01/2017, Volume 4, Issue 1, p. ofx001
Background. High-dose, inactivated, trivalent influenza vaccine (HD) is associated with higher rates of side effects than standard dose (SD) vaccine, which may... 
influenza | UNITED-STATES | influenza vaccine | side effect | INFECTIOUS DISEASES | EFFICACY | SAFETY | OLDER-ADULTS | ELDERLY PERSONS | IMMUNOGENICITY | NURSING-HOME RESIDENTS | ADVERSE REACTIONS | high-dose influenza vaccine | PLACEBO-CONTROLLED TRIAL | EPIDEMIC
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12. Full Text Clinical Efficacy of Cell Culture—Derived and Egg-Derived Inactivated Subunit Influenza Vaccines in Healthy Adults
by Sharon Frey and Timo Vesikari and Agnieszka Szymczakiewicz-Multanowska and Maria Lattanzi and Allen Izu and Nicola Groth and Sandra Holmes
Clinical Infectious Diseases, ISSN 1058-4838, 11/2010, Volume 51, Issue 9, pp. 997 - 1004
Background. More efficient methods are needed to manufacture influenza vaccines. This trial compared the efficacy of cell culture—derived influenza vaccine... 
Influenza vaccines | Cell culture techniques | Immune response | Vaccination | Cell lines | Placebos | Viruses | Cultured cells | Orthomyxoviridae | ARTICLES AND COMMENTARIES | Diseases | TRIVALENT | INFECTIOUS DISEASES | IMMUNOGENICITY | SAFETY | PANDEMIC INFLUENZA | MICROBIOLOGY | IMMUNOLOGY | Influenza Vaccines - administration & dosage | United States | Humans | Middle Aged | Male | Orthomyxoviridae - immunology | Young Adult | Technology, Pharmaceutical | Poland | Adult | Female | Vaccines, Subunit - adverse effects | Cell Culture Techniques | Placebos - administration & dosage | Nasal Mucosa - virology | Influenza Vaccines - adverse effects | Pharynx - virology | Vaccines, Subunit - immunology | Vaccines, Inactivated - adverse effects | Vaccines, Inactivated - immunology | Influenza Vaccines - immunology | Vaccines, Inactivated - administration & dosage | Vaccines, Subunit - administration & dosage | Adolescent | Finland | Orthomyxoviridae - genetics | Influenza, Human - prevention & control | Orthomyxoviridae - isolation & purification | Prevention | Cell culture | Usage | Influenza | Physiological aspects | Research | Health aspects
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13. Full Text Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010–11 and 2011–12
by Donahue, James G and Kieke, Burney A and King, Jennifer P and DeStefano, Frank and Mascola, Maria A and Irving, Stephanie A and Cheetham, T. Craig and Glanz, Jason M and Jackson, Lisa A and Klein, Nicola P and Naleway, Allison L and Weintraub, Eric and Belongia, Edward A
Vaccine, ISSN 0264-410X, 09/2017, Volume 35, Issue 40, pp. 5314 - 5322
Inactivated influenza vaccine is recommended in any stage of pregnancy, but evidence of safety in early pregnancy is limited, including for vaccines containing... 
Pregnancy | Spontaneous abortion | Influenza vaccine | Influenza | PRETERM DELIVERY | MEDICINE, RESEARCH & EXPERIMENTAL | VIRUS | IMMUNIZATION PRACTICES ACIP | SAFETY | IMMUNOLOGY | FETAL-DEATH | WOMEN | ADVISORY-COMMITTEE | PREGNANCY BIRTH-DEFECTS | SEASONAL INFLUENZA | CELL | Influenza A Virus, H1N1 Subtype - immunology | Humans | Influenza Vaccines - adverse effects | Influenza A Virus, H1N1 Subtype - pathogenicity | Case-Control Studies | Young Adult | Vaccines, Inactivated - adverse effects | Vaccines, Inactivated - immunology | Abortion, Spontaneous - etiology | Influenza Vaccines - therapeutic use | Adult | Female | Vaccines, Inactivated - therapeutic use | Odds Ratio | Influenza, Human - prevention & control | Influenza, Human - immunology | Influenza vaccines | Miscarriage | Abortion | Influenza viruses | Prevention | Antigens | Analysis | Vaccination | Medical records | Menstruation | Womens health | Exposure | Vaccines | Safety | Health risk assessment
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