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Infection and Immunity, ISSN 0019-9567, 12/2015, Volume 83, Issue 12, pp. 4740 - 4749
Interferon (IFN)-inducible guanylate binding proteins (GBPs) mediate cell-autonomous host resistance to bacterial pathogens and promote inflammasome... 
IFN | AIM2 INFLAMMASOME | IMMUNITY | INFECTIOUS DISEASES | CASPASE-1 | SUSCEPTIBILITY | TRACHOMATIS | INNATE | PYROPTOSIS | IMMUNOLOGY | HOST-RESISTANCE | PROTECTS | Interleukin-18 - immunology | Caspases - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Chlamydia trachomatis - immunology | Interleukin-1beta - genetics | GTP-Binding Proteins - genetics | Chlamydia muridarum - immunology | Chlamydia Infections - immunology | Chlamydia Infections - pathology | Vacuoles - immunology | Chlamydia Infections - genetics | Inclusion Bodies - microbiology | Fibroblasts - microbiology | Interferon-gamma - genetics | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Chlamydia trachomatis - genetics | Inclusion Bodies - immunology | Vacuoles - microbiology | DNA-Binding Proteins - immunology | GTP-Binding Proteins - immunology | Signal Transduction | Caspases - genetics | Mice, Inbred C57BL | Chlamydia muridarum - genetics | Gene Expression Regulation | Interleukin-1beta - immunology | DNA-Binding Proteins - genetics | Inflammasomes - genetics | Mice, Knockout | Host-Pathogen Interactions | Carrier Proteins - genetics | Animals | Chlamydia Infections - microbiology | Chlamydia muridarum - pathogenicity | Inflammasomes - immunology | Interferon-gamma - immunology | Chlamydia trachomatis - pathogenicity | Fibroblasts - immunology | Mice | Primary Cell Culture | Interleukin-18 - genetics | Cellular Microbiology | Pathogen-Host Cell Molecular Interactions | Spotlight
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6532 - 6542
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e97515
Mycobacterium tuberculosis (Mtb) is transmitted via inhalation of aerosolized particles. While alveolar macrophages are thought to play a central role in the... 
PHAGOSOME MATURATION | ARREST | ACTIVATION | FUSION | INTERFERON-GAMMA | PATHWAY | MULTIDISCIPLINARY SCIENCES | INFECTION | IRON | ANTIGEN | LYMPHOCYTES | Endosomes - immunology | Endosomes - microbiology | CD8-Positive T-Lymphocytes - pathology | Coculture Techniques | Humans | Mycobacterium tuberculosis - immunology | rab GTP-Binding Proteins - genetics | Vacuoles - pathology | Lysosome-Associated Membrane Glycoproteins - immunology | Respiratory Mucosa - pathology | Respiratory Mucosa - microbiology | Vacuoles - immunology | Respiratory Mucosa - immunology | Interferon-gamma - genetics | HLA-B Antigens - genetics | Cell Line | Gene Expression | Vacuoles - microbiology | CD8-Positive T-Lymphocytes - microbiology | HLA-B Antigens - immunology | Histocompatibility Antigens Class I - immunology | Epithelial Cells - pathology | Histocompatibility Antigens Class I - genetics | Endosomes - pathology | rab GTP-Binding Proteins - immunology | Epithelial Cells - immunology | Epithelial Cells - microbiology | Interferon-gamma - immunology | Lysosome-Associated Membrane Glycoproteins - genetics | Primary Cell Culture | CD8-Positive T-Lymphocytes - immunology | Pediatrics | Epithelial cells | CD8 antigen | Critical care | Acidification | Infections | Lymphocytes T | Macrophages | Clinical outcomes | Respiratory tract | Immunology | Lymphocytes | Bacteria | Localization | Alveoli | Antigens | Cytokines | Markers | Epithelium | Inhalation | Medicine | Studies | Tuberculosis | Lungs | γ-Interferon | Histocompatibility antigen HLA | Respiration | Endosomes
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 07/2016, Volume 12, Issue 7, p. e1006189
Nonreplicating type I uracil auxotrophic mutants of Toxoplasma gondii possess a potent ability to activate therapeutic immunity to established solid tumors by... 
INTESTINAL INFLAMMATION | PROTECTIVE IMMUNITY | IFN-GAMMA PRODUCTION | PARASITOPHOROUS VACUOLE | GENETICS & HEREDITY | STABLE TRANSFORMATION | PERITONEAL-MACROPHAGES | VIRULENCE FACTOR ROP18 | NANOTUBULAR NETWORK | PSEUDOKINASE ROP5 | CD8-ALPHA(+) DENDRITIC CELLS | Toxoplasma - immunology | Antigens, Protozoan - immunology | Virulence Factors - genetics | Dendritic Cells - immunology | Humans | Immunity, Innate - genetics | Virulence Factors - immunology | Protozoan Proteins - genetics | Host-Pathogen Interactions - immunology | Cancer Vaccines - genetics | Female | Antigens, Protozoan - genetics | Interferon-gamma - genetics | Ovarian Neoplasms - prevention & control | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Toxoplasma - pathogenicity | Tumor Microenvironment - immunology | Cancer Vaccines - immunology | Animals | Host-Pathogen Interactions - genetics | Interferon-gamma - immunology | Ovarian Neoplasms - therapy | Parasitic Diseases - immunology | Protein-Serine-Threonine Kinases - immunology | T-Lymphocytes - immunology | Uracil - metabolism | Mice | Protozoan Proteins - immunology | Ovarian Neoplasms - immunology | Toxoplasma | Care and treatment | Genetic aspects | Binding proteins | Gene expression | Health aspects | Methods | Cancer | Pathogens | Funding | Genes | Infections | Vaccines | Parasites | Kinases | Mammals | Experiments | Ovarian cancer | Proteins | Cysts | Plasmids | Genetic engineering | Localization | Tumors
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2010, Volume 6, Issue 8, pp. 83 - 84
UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence... 
INTRACELLULAR FATE | DENDRITIC CELLS | IFN-GAMMA | TRYPANOSOMA-CRUZI | MICROBIOLOGY | PARASITOPHOROUS VACUOLE MEMBRANE | NALP3 INFLAMMASOME | TOLL-LIKE RECEPTOR-3 | CAENORHABDITIS-ELEGANS | VIROLOGY | INTERFERON-GAMMA | MUSCLE-CONTRACTION | PARASITOLOGY | Toxoplasma - immunology | Macrophage Activation - genetics | Toxoplasmosis, Animal - genetics | Immunoblotting | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Flow Cytometry | Membrane Transport Proteins - genetics | Mice, Mutant Strains | Macrophages - immunology | Macrophages - microbiology | Interleukin-12 - biosynthesis | Cell Separation | Macrophage Activation - immunology | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Reverse Transcriptase Polymerase Chain Reaction | Antigen-Presenting Cells - immunology | Microscopy, Confocal | Animals | Toxoplasma - genetics | Interferon-gamma - immunology | Toll-Like Receptors - genetics | Fluorescent Antibody Technique | Interleukin-12 - immunology | Toxoplasmosis, Animal - immunology | T-Lymphocytes - immunology | Mice | Membrane Transport Proteins - immunology | Interferon-gamma - biosynthesis | Toxoplasma | Drug resistance in microorganisms | Toll-like receptors | Physiological aspects | Genetic aspects | Research | Endoplasmic reticulum | Proteins | Infections | Immunology | Parasites | Immune system
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 10/2014, Volume 55, pp. 196 - 208
Establishment of infection by an intracellular pathogen depends on successful internalization with a concomitant neutralization of host defense machinery. , an... 
SREBP2 | Mitochondria | HMGCR | Visceral leishmaniasis | Cholesterol | PHAGOCYTOSIS | ENTRY | MECHANISM |