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Journal of Inherited Metabolic Disease, ISSN 0141-8955, 2008, Volume 31, Issue 2, pp. 205 - 216
Journal Article
Journal Article
Journal Article
by Wang, W and Lin, R and Zhang, J and Mao, Y and Bu, X and Ji, Q and Zhai, X and Lin, Q and Yang, L and Zhang, K
Human & Experimental Toxicology, ISSN 0960-3271, 11/2012, Volume 31, Issue 11, pp. 1092 - 1101
Divalproex sodium is an antiepileptic drug. Hepatotoxicity is one of the most common side effects induced by divalproex sodium. Impaired fatty acid metabolism... 
PPARα | SREBP-1c | fatty acid metabolism | hepatotoxicity | Divalproex sodium | ALPHA TARGET GENES | PPAR-ALPHA | ELEMENT-BINDING PROTEIN-1C | PPAR alpha | PROLIFERATOR-ACTIVATED-RECEPTOR | LIVER | ANTIPSYCHOTIC-DRUGS | TOXICOLOGY | EXTENDED-RELEASE | EXPRESSION | CARNITINE PALMITOYLTRANSFERASE-I | ADIPOSE-TISSUE | L-Lactate Dehydrogenase - metabolism | Cell Survival - drug effects | Rats | Male | PPAR alpha - genetics | Hepatocytes - metabolism | RNA, Messenger - metabolism | Acetyltransferases - genetics | Rats, Sprague-Dawley | Stearoyl-CoA Desaturase - genetics | Anticonvulsants - toxicity | Valproic Acid - toxicity | Aspartate Aminotransferases - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Chemical and Drug Induced Liver Injury - metabolism | Alanine Transaminase - metabolism | Fatty Acid Synthases - genetics | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Side effects | Toxicity | Liver | Pharmacology | Metabolism | Gene expression | Fatty acids | Leakage | Transcription factors | Stearoyl-CoA desaturase | mRNA | Valproic acid | Fatty-acid synthase | L-Lactate dehydrogenase | sterol regulatory element-binding protein 1c | Acetyl-CoA carboxylase | Hepatocytes | Sodium | Aspartate transaminase | Alanine transaminase | Peroxisome proliferator-activated receptors
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 9, pp. 1027 - 1036
Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes... 
COLON-CANCER | PROGENITORS | INHIBITION | TCA CYCLE | GROWTH | VALPROIC ACID | DIFFERENTIATION | IDENTIFICATION | ADULT DROSOPHILA MIDGUT | CARRIER | CELL BIOLOGY | Intestines - drug effects | Mitochondrial Membrane Transport Proteins - antagonists & inhibitors | Receptors, G-Protein-Coupled - metabolism | Humans | Intestines - metabolism | Drosophila Proteins - metabolism | Stem Cells - metabolism | Mitochondrial Membrane Transport Proteins - genetics | Drosophila melanogaster - metabolism | Transfection | Anion Transport Proteins - antagonists & inhibitors | RNA Interference | Time Factors | Mitochondrial Proteins - metabolism | Acrylates - pharmacology | Pyruvic Acid - metabolism | Cell Differentiation | Mitochondrial Membrane Transport Proteins - metabolism | Signal Transduction | Tissue Culture Techniques | Lactic Acid - metabolism | Cells, Cultured | Drosophila melanogaster - cytology | Genotype | Mitochondria - metabolism | Mitochondria - drug effects | Anion Transport Proteins - metabolism | Mice, Knockout | Phenotype | Animals | Glycolysis | Stem Cells - drug effects | Cell Proliferation - drug effects | Receptors, G-Protein-Coupled - genetics | Drosophila Proteins - genetics | Anion Transport Proteins - genetics | Intestines - cytology | Cell proliferation | Drosophila | Pyruvic acid | Metabolism | Cytosol | Mitochondria | Clonal deletion | Organoids | Intestine | Stem cells | Deletion | Oxidation | Differentiation | Cancer
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 54, Issue 4, pp. 773 - 794
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | TRIGLYCERIDE TRANSFER PROTEIN | DNA-POLYMERASE-GAMMA | PREGNANE X-RECEPTOR | PROLIFERATOR-ACTIVATED RECEPTOR | HEPATIC CYTOCHROME-P450 2E1 | ELEMENT-BINDING PROTEINS | FATTY-ACID OXIDATION | CONSTITUTIVE ANDROSTANE RECEPTOR | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RELATED PARAMETERS | GASTROENTEROLOGY & HEPATOLOGY | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article