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Journal of Vascular Surgery, ISSN 0741-5214, 2007, Volume 45, Issue 2, pp. 373 - 380
Background Varicose veins are a common disorder of extensive venous dilation and remodeling with an as-yet unclear mechanism. Studies have shown increased... 
Surgery | SURGERY | GENERAL-POPULATION | ABDOMINAL AORTIC-ANEURYSMS | ENDOTHELIAL-CELLS | NITRIC-OXIDE | SAPHENOUS-VEIN | MATRIX-METALLOPROTEINASE-9 | INSUFFICIENCY | PERIPHERAL VASCULAR DISEASE | ARTERIOLAR VASODILATION | VASCULAR SMOOTH-MUSCLE | EDINBURGH VEIN | Epoprostenol - metabolism | Muscle, Smooth, Vascular - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Potassium Channels - metabolism | Phenylephrine - pharmacology | Varicose Veins - metabolism | Potassium Chloride - pharmacology | Vasodilator Agents - metabolism | Potassium Channels, Calcium-Activated - metabolism | Dilatation, Pathologic | Matrix Metalloproteinase 2 - pharmacology | Potassium Channel Blockers - pharmacology | Muscle, Smooth, Vascular - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Matrix Metalloproteinase 2 - metabolism | Varicose Veins - physiopathology | Enzyme Inhibitors - pharmacology | Rats | Vena Cava, Inferior - metabolism | Varicose Veins - pathology | Potassium Channels - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Peptides - pharmacology | Animals | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits | Endothelium, Vascular - metabolism | Vasodilation - drug effects | Cromakalim - pharmacology | In Vitro Techniques | Nitric Oxide - metabolism
Journal Article
Laboratory Investigation, ISSN 0023-6837, 04/2016, Volume 96, Issue 4, pp. 399 - 408
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2012, Volume 55, Issue 5, pp. 1427 - 1439.e1
Background Venous hypoxia has been postulated to contribute to varicose vein (VV) formation. Direct measurements of vein wall oxygen tension have previously... 
Surgery | SURGERY | HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | HIF | DISEASE | INVOLVEMENT | PERIPHERAL VASCULAR DISEASE | MECHANISMS | FACTOR-I | VHL | HIF-1-ALPHA | EXPRESSION | CANCER-THERAPY | Up-Regulation | Dioxygenases - metabolism | Carbonic Anhydrases - genetics | Humans | Middle Aged | Glucose Transporter Type 1 - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Amino Acids, Dicarboxylic - pharmacology | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Case-Control Studies | Carbonic Anhydrases - metabolism | Procollagen-Proline Dioxygenase - metabolism | Cell Hypoxia | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Varicose Veins - metabolism | Aged, 80 and over | Antigens, Neoplasm - metabolism | Adult | Female | Membrane Proteins - metabolism | Real-Time Polymerase Chain Reaction | Organ Culture Techniques | Carbonic Anhydrase IX | Proto-Oncogene Proteins - metabolism | Antigens, Neoplasm - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Varicose Veins - genetics | Veins - drug effects | Dioxygenases - genetics | Glucose Transporter Type 1 - genetics | Procollagen-Proline Dioxygenase - genetics | Veins - metabolism | Aged | Genetic research | Enzymes | Universities and colleges | Genetic transcription | Genes | Varicose veins
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0158421
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e88021
Journal Article
European Journal of Clinical Investigation, ISSN 0014-2972, 09/2013, Volume 43, Issue 9, pp. 926 - 932
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2010, Volume 51, Issue 4, pp. 972 - 981
Background A greater incidence of varicose veins has been reported in premenopausal women than in men. We hypothesized that the sex differences in venous... 
Surgery | SURGERY | SAPHENOUS VEINS | RISK-FACTORS | CA2+ ENTRY MECHANISMS | ALPHA | PERIPHERAL VASCULAR DISEASE | GENDER-DIFFERENCES | HYPERTENSIVE-RATS | VASCULAR SMOOTH-MUSCLE | CORONARY-ARTERIES | 17-BETA-ESTRADIOL | BETA | Receptors, Angiotensin - metabolism | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Estrogens - pharmacology | Nitriles - pharmacology | Receptors, G-Protein-Coupled - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Estrogen Antagonists - pharmacology | Male | Dose-Response Relationship, Drug | Estrogen Receptor beta - metabolism | Phenylephrine - pharmacology | Varicose Veins - metabolism | Potassium Chloride - pharmacology | Estrogen Receptor alpha - metabolism | Female | Calcium Signaling | Estradiol - pharmacology | Phenols - pharmacology | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Adrenergic, alpha - metabolism | Vasoconstrictor Agents - pharmacology | Estradiol - metabolism | Angiotensin II - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Varicose Veins - physiopathology | Enzyme Inhibitors - pharmacology | Rats | Vena Cava, Inferior - metabolism | Rats, Sprague-Dawley | Vasoconstriction - drug effects | Vena Cava, Inferior - drug effects | Receptors, Estrogen - drug effects | Vena Cava, Inferior - physiopathology | Animals | Sex Factors | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | In Vitro Techniques | Phenols | Estrogen | endothelium | estrogen | nitric oxide | vein | vascular smooth muscle | sex hormones
Journal Article