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Journal of the American College of Cardiology, ISSN 0735-1097, 11/2016, Volume 68, Issue 19, pp. 2123 - 2125
Journal Article
Kidney International, ISSN 0085-2538, 05/2014, Volume 85, Issue 5, pp. 1103 - 1111
Fibroblast growth factor 23 (FGF23) is a phosphate-regulating hormone that acts primarily on the kidney and parathyroid. With declining kidney function there... 
phosphate | chronic kidney disease | Klotho | fibroblast growth factor 23 | vascular calcification | Vascular calcification | Chronic kidney disease | Fibroblast growth factor 23 | Phosphate | VITAMIN-D | AORTIC CALCIFICATION | OSTEOBLAST DIFFERENTIATION | CARDIOVASCULAR EVENTS | FGF RECEPTOR 1 | ENDOTHELIAL-CELLS | ARTERIAL CALCIFICATION | HEMODIALYSIS-PATIENTS | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | CHRONIC KIDNEY-DISEASE | Phosphorylation | Muscle, Smooth, Vascular - metabolism | Glucuronidase - metabolism | Myocytes, Smooth Muscle - pathology | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Aorta - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Renal Insufficiency, Chronic - complications | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Aortic Diseases - chemically induced | Aortic Diseases - metabolism | Glucuronidase - deficiency | Dose-Response Relationship, Drug | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Vascular Calcification - metabolism | Transfection | Phosphates - toxicity | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Aortic Diseases - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Aorta - drug effects | Osteoblasts - drug effects | Cells, Cultured | Vascular Calcification - pathology | Rats, Sprague-Dawley | Aorta - pathology | Osteoblasts - pathology | Muscle, Smooth, Vascular - pathology | Animals | Glucuronidase - genetics | Signal Transduction - drug effects | Cell Differentiation - drug effects | Vascular Calcification - chemically induced | Recombinant Proteins - toxicity | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Osteoblasts - metabolism | Fibroblast Growth Factors - toxicity
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 06/2014, Volume 306, Issue 12, pp. F1418 - F1428
Hyperphosphatemia contributes to increased cardiovascular mortality through vascular calcification (VC) in patients with chronic kidney disease (CKD).... 
Vascular calcification | Chronic kidney disease | Inflammation | Malnutrition-inflammation-atherosclerosis syndrome | Malnutrition | Phosphate | MINERAL COMPLEX | chronic kidney disease | OXIDATIVE STRESS | PHYSIOLOGY | vascular calcification | phosphate | ATHEROSCLEROSIS | malnutrition | ALL-CAUSE | inflammation | ARTERIAL CALCIFICATION | DISEASE | ANIMAL-MODELS | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | FETUIN-A | malnutrition-inflammation-atherosclerosis syndrome | CHRONIC-RENAL-FAILURE | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Oxidative Stress - physiology | Uremia - physiopathology | Malnutrition - metabolism | Male | Uremia - metabolism | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Renal Insufficiency, Chronic - metabolism | Vascular Calcification - metabolism | Hepatocytes - cytology | Inflammation - metabolism | Adenine - adverse effects | Malnutrition - chemically induced | Blood Pressure - drug effects | Blood Pressure - physiology | Phosphates - pharmacology | Hepatocytes - drug effects | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Acute-Phase Proteins - metabolism | Cells, Cultured | Rats | Muscle, Smooth, Vascular - cytology | Renal Insufficiency, Chronic - physiopathology | Animals | Phosphates - adverse effects | Vascular Calcification - chemically induced | Oxidative Stress - drug effects | Renal Insufficiency, Chronic - chemically induced | Phosphates | Medical research | Physiological aspects | Calcification | Medicine, Experimental | Research | Uremia | Health aspects
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 05/2013, Volume 83, Issue 5, pp. 835 - 844
Journal Article
Cardiovascular Research, ISSN 0008-6363, 06/2016, Volume 110, Issue 3, pp. 408 - 418
Reduced homoarginine plasma levels are associated with unfavourable cardiovascular outcome in chronic kidney disease (CKD). Cardiovascular events in CKD are... 
Vascular calcification | Osteo-/chondrogenic signalling | Homoarginine | Nitric oxide | Vascular smooth muscle cells | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | NITRIC-OXIDE SYNTHASE | ALKALINE-PHOSPHATASE | BLOOD-PRESSURE | chondrogenic signalling | IN-VITRO | Osteo | L-ARGININE | DEFICIENT | CALCIFICATION | MICE | CARDIOVASCULAR RISK | Chondrogenesis - drug effects | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Humans | Vascular Calcification - genetics | Glucuronidase - metabolism | Myocytes, Smooth Muscle - pathology | Homoarginine - toxicity | Hyperphosphatemia - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Hyperphosphatemia - pathology | Dose-Response Relationship, Drug | Nephrectomy | Time Factors | Cell Transdifferentiation - drug effects | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Renal Insufficiency - genetics | Genetic Predisposition to Disease | Cholecalciferol | Osteogenesis - drug effects | Vascular Calcification - blood | Cells, Cultured | Homoarginine - blood | Renal Insufficiency - metabolism | Biomarkers - blood | Vascular Calcification - pathology | Mice, Knockout | Gene Expression Regulation - drug effects | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Glucuronidase - genetics | Renal Insufficiency - pathology | Vascular Calcification - chemically induced | Hyperphosphatemia - genetics | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism | Index Medicus
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 05/2013, Volume 28, Issue 5, pp. 1080 - 1084
In chronic kidney disease (CKD), increased plasma phosphate concentrations cause vascular calcification which substantially contribute to cardiovascular events... 
osteoinductive signalling | klotho | chronic kidney disease | mineralocorticoid receptor | spironolactone | Hyperphosphatemia - complications | Vascular Calcification - metabolism | Animals | Humans | Vascular Calcification - chemically induced | Aldosterone - adverse effects | Mice | Renal Insufficiency, Chronic - complications
Journal Article
International Journal of Cardiology, ISSN 0167-5273, 2015, Volume 184, Issue 1, pp. 581 - 586
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2012, Volume 32, Issue 11, pp. 2580 - 2588
OBJECTIVE—Vascular calcification significantly increases cardiovascular morbidity and mortality. We recently reported that the deficiency of cartilage... 
Smooth muscle cell | Calcification | Animal model of human disease remodeling | MicroRNA | Protease | animal model of human disease remodeling | CELLS | smooth muscle cell | PATHOBIOLOGY | MECHANISMS | OLIGOMERIC MATRIX PROTEIN | protease | PHOSPHATE | IN-VITRO | ROLES | ARTERIAL CALCIFICATION | ANEURYSM DEVELOPMENT | microRNA | PERIPHERAL VASCULAR DISEASE | calcification | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | Up-Regulation | Carotid Artery Diseases - chemically induced | Humans | MicroRNAs - metabolism | Matrilin Proteins | Nephrectomy | RNA Interference | Time Factors | Carotid Artery Diseases - pathology | Transcription, Genetic | 3' Untranslated Regions | Real-Time Polymerase Chain Reaction | Organ Culture Techniques | Disease Models, Animal | Uremia - enzymology | Myocytes, Smooth Muscle - enzymology | Down-Regulation | Computational Biology | Rats | Vascular Calcification - pathology | Rats, Sprague-Dawley | Kidney Failure, Chronic - genetics | ADAM Proteins - metabolism | Aortic Diseases - genetics | Carotid Artery Diseases - enzymology | Carotid Artery, Common - enzymology | Carotid Artery Diseases - genetics | Kidney Failure, Chronic - complications | ADAMTS7 Protein | Carotid Artery, Common - pathology | ADAM Proteins - genetics | Muscle, Smooth, Vascular - enzymology | Vascular Calcification - genetics | Glycoproteins - metabolism | Myocytes, Smooth Muscle - pathology | Aortic Diseases - chemically induced | Transfection | Uremia - pathology | Female | Vascular Calcification - enzymology | Aortic Diseases - enzymology | Aorta, Abdominal - pathology | Kidney Failure, Chronic - enzymology | Extracellular Matrix Proteins - metabolism | Aortic Diseases - pathology | Promoter Regions, Genetic | Calcium Chloride | Cartilage Oligomeric Matrix Protein | Cells, Cultured | Aorta, Abdominal - enzymology | Gene Expression Regulation, Enzymologic | Muscle, Smooth, Vascular - pathology | Animals | Vascular Calcification - chemically induced
Journal Article