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Journal of Clinical Investigation, ISSN 0021-9738, 04/2016, Volume 126, Issue 4, pp. 1323 - 1336
Vascular calcification is a common feature of major cardiovascular diseases. Extracellular vesicles participate in the formation of microcalcifications that... 
MEDICINE, RESEARCH & EXPERIMENTAL | MYOCARDIAL-INFARCTION | NONSPECIFIC ALKALINE-PHOSPHATASE | MINERALIZATION | TRANS-GOLGI NETWORK | CARDIOVASCULAR-DISEASE | ATHEROSCLEROSIS | MATRIX VESICLES | PROTEINS | MASS-SPECTROMETRY | GENOME-WIDE ASSOCIATION | Phosphorylation | Muscle, Smooth, Vascular - metabolism | Casein Kinase I - genetics | Humans | Vascular Calcification - genetics | Adaptor Proteins, Vesicular Transport - genetics | Myocytes, Smooth Muscle - pathology | rab GTP-Binding Proteins - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Vascular Calcification - metabolism | Cell-Derived Microparticles - metabolism | Plaque, Atherosclerotic - pathology | Myocytes, Smooth Muscle - metabolism | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | rab GTP-Binding Proteins - metabolism | Alkaline Phosphatase - genetics | Plaque, Atherosclerotic - metabolism | Cell-Derived Microparticles - genetics | Carrier Proteins - biosynthesis | Extracellular Matrix Proteins - genetics | Cells, Cultured | Vascular Calcification - pathology | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | Muscle, Smooth, Vascular - pathology | Animals | Alkaline Phosphatase - biosynthesis | Casein Kinase I - metabolism | Mice | Casein Kinase II - metabolism | Calcium-Binding Proteins - genetics | Calcification | Phosphatases | Cellular proteins | Molecular targeted therapy | Innovations | Development and progression | Genetic aspects | Properties | Coronary heart disease | Proteins | Statistical analysis | Rodents | Acute coronary syndromes | Metabolism | Experiments | Manuscripts | Carotid arteries | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 01/2012, Volume 90, Issue 1, pp. 25 - 39
Journal Article
Circulation Research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1312 - 1323
Rationale: Matrix vesicles (MVs), secreted by vascular smooth muscle cells (VSMCs), form the first nidus for mineralization and fetuin-A, a potent circulating... 
exosomes | extracellular matrix | vascular calcification | CALCIPROTEIN PARTICLES | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | RETICULOCYTE MATURATION | EXTRACELLULAR CALCIUM | MATRIX VESICLES | HUMAN ATHEROSCLEROTIC PLAQUES | MULTIVESICULAR ENDOSOMES | ARTERIAL CALCIFICATION | PERIPHERAL VASCULAR DISEASE | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | FETUIN-A | Exosomes - metabolism | Sphingomyelin Phosphodiesterase - genetics | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Humans | Middle Aged | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Secretory Vesicles - metabolism | Exosomes - pathology | Male | Exocytosis | Case-Control Studies | Young Adult | Intercellular Signaling Peptides and Proteins - metabolism | Vascular Calcification - metabolism | Transfection | RNA Interference | Time Factors | Sphingomyelin Phosphodiesterase - metabolism | Vascular Calcification - physiopathology | Adult | Female | Proteomics - methods | Tetraspanins - metabolism | Myocytes, Smooth Muscle - metabolism | Exosomes - secretion | Cytokines - metabolism | Cells, Cultured | Vascular Calcification - pathology | Myocytes, Smooth Muscle - secretion | Protein Transport | Secretory Vesicles - secretion | Muscle, Smooth, Vascular - pathology | Adolescent | alpha-2-HS-Glycoprotein - metabolism | Secretory Vesicles - pathology | Muscle, Smooth, Vascular - secretion | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2013, Volume 33, Issue 11, pp. 2625 - 2632
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 175 - 183
OBJECTIVE—Vascular calcification is a characteristic feature of atherosclerosis, diabetes mellitus, and end-stage renal disease. We have demonstrated that... 
PTEN | AKT | FOXO1/3 | ubiquitination | vascular calcification | Runx2 | TRANSCRIPTION FACTORS | OSTEOBLAST DIFFERENTIATION | TUMOR-SUPPRESSOR GENE | NEOINTIMA FORMATION | INACTIVATION | PROSTATE-CANCER | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Phosphorylation | Apolipoproteins E - deficiency | Muscle, Smooth, Vascular - metabolism | Atherosclerosis - genetics | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Aorta - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Aortic Diseases - metabolism | Vascular Calcification - metabolism | Ubiquitination | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Microfilament Proteins - genetics | Myocytes, Smooth Muscle - metabolism | Aortic Diseases - pathology | Disease Models, Animal | PTEN Phosphohydrolase - genetics | Atherosclerosis - pathology | PTEN Phosphohydrolase - deficiency | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Genotype | Forkhead Transcription Factors - genetics | Vascular Calcification - pathology | Atherosclerosis - metabolism | Mice, Knockout | Protein Transport | Aorta - pathology | Muscle Proteins - genetics | Aortic Diseases - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Apolipoproteins E - genetics | Forkhead Box Protein O1 | Enzyme Activation | Forkhead Box Protein O3 | Integrases - genetics | Index Medicus | Vascular calcification | FOXO1
Journal Article
Journal Article
Arteriosclerosis Thrombosis and Vascular Biology, ISSN 1079-5642, 02/2015, Volume 35, Issue 2, pp. 399 - 408
OBJECTIVE—Vascular and valvular calcifications are pathological processes regulated by resident cells, and depending on a complex interplay between... 
aortic valve | multivesicular bodies | calcification of | gene expression | vascular calcification | AORTIC-STENOSIS | MATRIX VESICLES | VALVE | aortic valve, calcification of | CARTILAGE | DISEASE | VITAMIN-K | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | FETUIN-A | INSIGHTS | Calcinosis - genetics | Aortic Valve Stenosis - genetics | Calcium - metabolism | Humans | Middle Aged | Vascular Calcification - genetics | Actins - metabolism | Osteocalcin - genetics | Male | Aorta - metabolism | Case-Control Studies | Aortic Valve - pathology | Coronary Vessels - metabolism | Aortic Valve Stenosis - prevention & control | Vascular Calcification - metabolism | Coronary Artery Disease - pathology | Aged, 80 and over | Adult | Female | Calcinosis - metabolism | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | Coronary Vessels - pathology | Osteocalcin - metabolism | Tissue Culture Techniques | Coronary Artery Disease - metabolism | Extracellular Matrix Proteins - genetics | Coronary Artery Disease - prevention & control | Gene Expression Regulation | Vascular Calcification - prevention & control | Vascular Calcification - pathology | Aortic Valve - metabolism | Aorta - pathology | Proteins - genetics | Aortic Valve Stenosis - pathology | Proteins - metabolism | Coronary Artery Disease - genetics | alpha-2-HS-Glycoprotein - metabolism | Aortic Valve Stenosis - metabolism | Aged | Calcinosis - prevention & control | Calcinosis - pathology | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 02/2015, Volume 96, Issue 2, pp. 266 - 274
Singleton-Merten syndrome (SMS) is an autosomal-dominant multi-system disorder characterized by dental dysplasia, aortic calcification, skeletal abnormalities,... 
OPEN-ANGLE GLAUCOMA | ACTIVATION | RNA | GENE | GENETICS & HEREDITY | CALCIFICATION | SENSOR | SPECTRUM | IDENTIFICATION | GAIN | MDA5 | Odontodysplasia - pathology | Humans | Vascular Calcification - genetics | Child, Preschool | Molecular Sequence Data | Male | Metacarpus - abnormalities | Mutation, Missense - genetics | Base Sequence | Adult | Female | Osteoporosis - genetics | Odontodysplasia - diagnostic imaging | DEAD-box RNA Helicases - chemistry | Aortic Diseases - pathology | DEAD Box Protein 58 | Musculoskeletal Abnormalities - diagnostic imaging | Cells, Cultured | Models, Molecular | Muscular Diseases - pathology | Vascular Calcification - pathology | Sequence Analysis, DNA | Radiography | DEAD-box RNA Helicases - genetics | Aortic Diseases - genetics | Exome - genetics | Osteoporosis - pathology | Pedigree | Musculoskeletal Abnormalities - genetics | Metacarpus - pathology | Polymorphism, Single Nucleotide - genetics | Odontodysplasia - genetics | Muscular Diseases - genetics | Dental Enamel Hypoplasia - pathology | Glaucoma - genetics | Dental Enamel Hypoplasia - genetics | Genes, Dominant - genetics | Physiological aspects | Genetic research | Genetic disorders | Research | Gene mutations | Glaucoma | Psoriasis | RNA-protein interactions | ABC transporters | Mutation | Gene expression | Index Medicus | Report
Journal Article
Nature Communications, ISSN 2041-1723, 12/2015, Volume 6, Issue 1, pp. 10006 - 10006
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 44, pp. 17008 - 17020
Vascular calcification (or mineralization) is a common complication of chronic kidney disease (CKD) and is closely associated with increased mortality and... 
vascular calcification | fatty acid | cyclin-dependent kinase (CDK) | kidney disease | vascular biology | ENDOPLASMIC-RETICULUM STRESS | SMOOTH-MUSCLE | IN-VITRO | GENE-EXPRESSION | CHOP | saturated fatty acids | vascular smooth muscle cells | atherosclerosis | RNA-POLYMERASE-II | MAMMALIAN TARGET | cardiovascular disease | BIOCHEMISTRY & MOLECULAR BIOLOGY | ER stress | endoplasmic reticulum stress (ER stress) | renal dysfunction | P-TEFB | CDK9 | ARTERIAL CALCIFICATION | CHRONIC KIDNEY-DISEASE | CELL-DIFFERENTIATION | Transcription Factor CHOP - genetics | Phosphorylation | Cyclin T - metabolism | Humans | Vascular Calcification - genetics | Male | Renal Insufficiency, Chronic - complications | Renal Insufficiency, Chronic - metabolism | Vascular Calcification - metabolism | Vascular Calcification - etiology | Renal Insufficiency, Chronic - genetics | Vascular Calcification - physiopathology | Mice, Inbred DBA | Fatty Acids - metabolism | Myocytes, Smooth Muscle - metabolism | Cyclin-Dependent Kinase 9 - genetics | Cyclin T - genetics | Activating Transcription Factor 4 - genetics | Mice, Transgenic | Renal Insufficiency, Chronic - physiopathology | Animals | Activating Transcription Factor 4 - metabolism | Endoplasmic Reticulum Stress | Protein Binding | Cyclin-Dependent Kinase 9 - metabolism | Mice | Transcription Factor CHOP - metabolism | Index Medicus | Lipids
Journal Article
Atherosclerosis, ISSN 0021-9150, 2012, Volume 221, Issue 2, pp. 387 - 396
Highlights ► STZ–CML–HFD for 4 months could induce atherosclerotic calcification of diabetes. ► We constructed a new calcification model in a high-lipid,... 
Cardiovascular | Advanced glycation end-products | Phenotype transformation | OSTEOGENIC DIFFERENTIATION | RECEPTOR | MECHANISMS | RAGE | CORONARY-ARTERY CALCIFICATION | Atherosclerosis | DISEASE | Vascular calcification | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | INTRAVASCULAR ULTRASOUND | APOPTOTIC BODIES | Diabetes | Vascular smooth muscle cells | Apoptosis | Immunohistochemistry | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Alkaline Phosphatase - metabolism | Diabetic Angiopathies - etiology | Male | Vascular Calcification - metabolism | Time Factors | Vascular Calcification - etiology | Diet, High-Fat | Cell Differentiation | Diabetes Mellitus, Experimental - complications | Lipoproteins, LDL - metabolism | Lysine - metabolism | Receptor for Advanced Glycation End Products | Lysine - analogs & derivatives | Atherosclerosis - pathology | Core Binding Factor Alpha 2 Subunit - metabolism | Macrophages - pathology | Lysine - administration & dosage | Rats | Vascular Calcification - pathology | Atherosclerosis - metabolism | Blotting, Western | Disease Progression | Mice, Knockout | Macrophages - metabolism | Staining and Labeling | Glucose - metabolism | Mice | Injections, Intravenous | Muscle, Smooth, Vascular - metabolism | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Atherosclerosis - etiology | Diabetic Angiopathies - pathology | Bone Morphogenetic Protein 2 - metabolism | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Myocytes, Smooth Muscle - metabolism | Cell Line | Diabetic Angiopathies - metabolism | Mice, Inbred C57BL | Muscle, Smooth, Vascular - pathology | Animals | Apolipoproteins E - genetics | Osteogenesis | Receptors, Immunologic - metabolism | Index Medicus
Journal Article