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Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2007, Volume 27, Issue 12, pp. 2589 - 2596
OBJECTIVE—Aortic calcification is prevalent in type II diabetes (T2DM), enhancing morbidity and tracking metabolic syndrome parameters... 
Aortic calcification | Diabetes | TNF-α | Metabolic syndrome | Wnt | TNF-alpha | BONE MORPHOGENETIC PROTEIN-2 | MATRIX GLA PROTEIN | VASCULAR CALCIFICATION | aortic calcification | DEFICIENT MICE | metabolic syndrome | INFLAMMATION | IN-VIVO | ARTERIAL CALCIFICATION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | HEMATOLOGY | diabetes | EXPRESSION | Inflammation - pathology | Fibroblasts - enzymology | Homeodomain Proteins - metabolism | Tumor Necrosis Factor-alpha - blood | Tumor Necrosis Factor-alpha - genetics | Antibodies, Monoclonal - therapeutic use | Male | Aorta - metabolism | Haptoglobins - metabolism | RNA, Messenger - metabolism | Wnt Proteins - metabolism | Aortic Diseases - metabolism | Bone Morphogenetic Proteins - metabolism | Inflammation - metabolism | Calcinosis - etiology | Dietary Fats - administration & dosage | Anti-Inflammatory Agents - therapeutic use | Aortic Diseases - prevention & control | Disease Models, Animal | Fibroblasts - metabolism | Anti-Inflammatory Agents - pharmacology | Antibodies, Monoclonal - pharmacology | Receptors, LDL - metabolism | Mice, Transgenic | Mice, Knockout | Aorta - pathology | Muscle Proteins - genetics | Signal Transduction - drug effects | Wnt3 Protein | Calcinosis - prevention & control | Inflammation - prevention & control | Mice | Diabetes Mellitus, Type 2 - pathology | Calcinosis - pathology | Wnt3A Protein | Tumor Necrosis Factor-alpha - metabolism | Alkaline Phosphatase | Diabetes Mellitus, Type 2 - metabolism | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - genetics | Infliximab | Receptors, LDL - deficiency | Calcinosis - metabolism | Microfilament Proteins - genetics | Aorta - enzymology | Diabetes Mellitus, Type 2 - complications | Aortic Diseases - pathology | Promoter Regions, Genetic | Receptors, LDL - genetics | Bone Morphogenetic Protein 2 | Mice, Inbred C57BL | Cells, Cultured | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | Diabetes Mellitus, Type 2 - chemically induced | Transforming Growth Factor beta - metabolism | Aortic Diseases - etiology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2017, Volume 69, Issue 24, pp. 2949 - 2951
...Calcification of vascular structures is poorly understood, but genetic studies are offering important clues as to mechanisms. Calcification of the aortic valve... 
Cardiovascular | Internal Medicine | mitral valve | lipids | Mendelian randomization | triglycerides | single nucleotide polymorphism | prevention | CARDIAC & CARDIOVASCULAR SYSTEMS | VARIANTS | RISK | LP(A) LIPOPROTEIN | HEART-DISEASE | DENSITY-LIPOPROTEIN | ACCUMULATION | Calcification (ectopic) | Calcification | Cardiovascular disease | Genetics | Mutation | Health risk assessment | Low density lipoprotein
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2016, Volume 126, Issue 4, pp. 1323 - 1336
Vascular calcification is a common feature of major cardiovascular diseases. Extracellular vesicles participate in the formation of microcalcifications that are implicated in atherosclerotic plaque rupture... 
MEDICINE, RESEARCH & EXPERIMENTAL | MYOCARDIAL-INFARCTION | NONSPECIFIC ALKALINE-PHOSPHATASE | MINERALIZATION | TRANS-GOLGI NETWORK | CARDIOVASCULAR-DISEASE | ATHEROSCLEROSIS | MATRIX VESICLES | PROTEINS | MASS-SPECTROMETRY | GENOME-WIDE ASSOCIATION | Phosphorylation | Muscle, Smooth, Vascular - metabolism | Casein Kinase I - genetics | Humans | Vascular Calcification - genetics | Adaptor Proteins, Vesicular Transport - genetics | Myocytes, Smooth Muscle - pathology | rab GTP-Binding Proteins - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Vascular Calcification - metabolism | Cell-Derived Microparticles - metabolism | Plaque, Atherosclerotic - pathology | Myocytes, Smooth Muscle - metabolism | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | rab GTP-Binding Proteins - metabolism | Alkaline Phosphatase - genetics | Plaque, Atherosclerotic - metabolism | Cell-Derived Microparticles - genetics | Carrier Proteins - biosynthesis | Extracellular Matrix Proteins - genetics | Cells, Cultured | Vascular Calcification - pathology | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | Muscle, Smooth, Vascular - pathology | Animals | Alkaline Phosphatase - biosynthesis | Casein Kinase I - metabolism | Mice | Casein Kinase II - metabolism | Calcium-Binding Proteins - genetics | Calcification | Phosphatases | Cellular proteins | Molecular targeted therapy | Innovations | Development and progression | Genetic aspects | Properties | Coronary heart disease | Proteins | Statistical analysis | Rodents | Acute coronary syndromes | Metabolism | Experiments | Manuscripts | Carotid arteries | Veins & arteries
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2013, Volume 368, Issue 6, pp. 503 - 512
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2015, Volume 35, Issue 1, pp. 175 - 183
OBJECTIVE—Vascular calcification is a characteristic feature of atherosclerosis, diabetes mellitus, and end-stage renal disease... 
PTEN | AKT | FOXO1/3 | ubiquitination | vascular calcification | Runx2 | TRANSCRIPTION FACTORS | OSTEOBLAST DIFFERENTIATION | TUMOR-SUPPRESSOR GENE | NEOINTIMA FORMATION | INACTIVATION | PROSTATE-CANCER | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Phosphorylation | Apolipoproteins E - deficiency | Muscle, Smooth, Vascular - metabolism | Atherosclerosis - genetics | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Aorta - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Aortic Diseases - metabolism | Vascular Calcification - metabolism | Ubiquitination | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Microfilament Proteins - genetics | Myocytes, Smooth Muscle - metabolism | Aortic Diseases - pathology | Disease Models, Animal | PTEN Phosphohydrolase - genetics | Atherosclerosis - pathology | PTEN Phosphohydrolase - deficiency | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Genotype | Forkhead Transcription Factors - genetics | Vascular Calcification - pathology | Atherosclerosis - metabolism | Mice, Knockout | Protein Transport | Aorta - pathology | Muscle Proteins - genetics | Aortic Diseases - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Apolipoproteins E - genetics | Forkhead Box Protein O1 | Enzyme Activation | Forkhead Box Protein O3 | Integrases - genetics | Vascular calcification | FOXO1
Journal Article
Chinese medical journal, ISSN 0366-6999, 2017, Volume 130, Issue 9, pp. 1113 - 1121
Objective: Vascular calcification is the consequence of the complex interaction between genetic, environmental, and vascular factors, which ultimately lead to the deposition of calcium in the tunica intima... 
血管 | 病理生理学 | 环境因素 | 动脉粥样硬化 | 复杂现象 | PubMed | 遗传学基础 | 钙化 | OSTEOBLAST DIFFERENTIATION | Cardiovascular Risk | PSEUDOXANTHOMA ELASTICUM | BONE MORPHOGENETIC PROTEINS | CALCIUM SCORE | Polymorphisms | MEDICINE, GENERAL & INTERNAL | IN-VITRO | CORONARY-ARTERY CALCIFICATION | Atherosclerosis | Genetics | SMOOTH-MUSCLE-CELLS | ATHEROSCLEROTIC PLAQUE | MATRIX-GLA-PROTEIN | CHRONIC KIDNEY-DISEASE | Vascular Calcification | Kidney Failure, Chronic - physiopathology | Humans | Tunica Intima - physiopathology | Diabetes Mellitus - metabolism | Renal Insufficiency, Chronic - physiopathology | Kidney Failure, Chronic - metabolism | Renal Insufficiency, Chronic - metabolism | Tunica Intima - metabolism | Vascular Calcification - metabolism | Diabetes Mellitus - physiopathology | Tunica Media - metabolism | Dyslipidemias - metabolism | Vascular Calcification - physiopathology | Tunica Media - physiopathology | Dyslipidemias - physiopathology | Calcification | Genetic aspects | Research | Chronic kidney failure | Hypertension | Medical imaging | Cardiovascular disease | Smooth muscle | Hydroxyapatite | Kinases | Calcium phosphates | Studies | Pathology | Coronary vessels | Tomography | Molecular biology | Cardiology | Veins & arteries | Review | Atherosclerosis; Cardiovascular Risk; Genetics; Polymorphisms; Vascular Calcification
Journal Article