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Nature Cell Biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1202 - 1213
Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch... 
LYMPHATIC ENDOTHELIUM | KINASE-ACTIVITY | VASCULAR NETWORK FORMATION | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C | MOUSE EMBRYOS | EXTRACELLULAR-MATRIX | MONOCLONAL-ANTIBODY | TUMOR ANGIOGENESIS | FACTOR RECEPTOR-3 | CELL BIOLOGY | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Receptors, Notch - antagonists & inhibitors | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Vascular Endothelial Growth Factor D - genetics | Phosphatidylinositol 3-Kinase - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Transduction, Genetic | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Rhombencephalon - blood supply | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Forkhead Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Antibodies - pharmacology | Macrophages - metabolism | Vascular Endothelial Growth Factor D - metabolism | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Physiological aspects | Blood vessels | Cellular signal transduction | Growth factor receptors | Research | Vascular endothelial growth factor | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Journal Article
Angiogenesis, ISSN 0969-6970, 6/2012, Volume 15, Issue 2, pp. 171 - 185
Pharmacological inhibition of VEGF-A has proven to be effective in inhibiting angiogenesis and vascular leak associated with cancers and various eye diseases.... 
Biomedicine | Age-related macular degeneration | Cancer Research | Oncology | Affinity | Ophthalmology | VEGF receptor | Cardiology | Aflibercept | Placental growth factor | Biomedicine general | Cell Biology | EYE DISEASE | MACULAR DEGENERATION | PHASE-II | CHOROIDAL NEOVASCULARIZATION | FACTOR THERAPY | IN-VITRO | PROLIFERATIVE DIABETIC-RETINOPATHY | PATHOLOGICAL CONDITIONS | RETINAL DISEASES | PERIPHERAL VASCULAR DISEASE | INTRAVITREAL BEVACIZUMAB | Angiogenesis Inhibitors - immunology | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor B - antagonists & inhibitors | Recombinant Fusion Proteins - pharmacology | Endothelial Cells - metabolism | Humans | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor B - immunology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - immunology | Enzyme Activation - drug effects | Bevacizumab | Endothelial Cells - immunology | Vascular Endothelial Growth Factor B - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | HEK293 Cells | Ranibizumab | Vascular Endothelial Growth Factor Receptor-1 - immunology | Antibodies, Monoclonal, Humanized - immunology | Index Medicus | Original Paper
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 11, pp. 4274 - 4280
Glioblastoma (GBM) is the most malignant brain tumor and is highly resistant to intensive combination therapies and anti-VEGF therapies. To assess the... 
Angiogenesis | Myeloid cells | Cell lines | Blood vessels | Antibodies | Cultured cells | Mice | Endothelial cells | Tumors | Cancer | Hypoxia-inducible factor 1 | Mouse model | Glioma | GLIOMAS | VASCULOGENIC MIMICRY | mouse model | BEVACIZUMAB | angiogenesis | MULTIDISCIPLINARY SCIENCES | MOUSE | HYDROXYLATION | TUMORS | STEM-LIKE CELLS | THERAPY | hypoxia-inducible factor 1 | glioma | DIFFERENTIATION | HIF-ALPHA | Endothelial Cells - metabolism | Humans | Spheroids, Cellular - metabolism | Spheroids, Cellular - pathology | Vascular Endothelial Growth Factor A - metabolism | Cell Hypoxia | Xenograft Model Antitumor Assays | Cell Fusion | Receptor, Epidermal Growth Factor - metabolism | Animals | Receptors, Vascular Endothelial Growth Factor - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glioblastoma - pathology | Biomarkers, Tumor - metabolism | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Cell Transdifferentiation | Glioblastoma - metabolism | Neovascularization, Pathologic - metabolism | Tumor Cells, Cultured | Endothelial Cells - pathology | Disease Models, Animal | Transdifferentiation | Cancer cells | Diagnosis | Neovascularization | Research | Properties | Glioblastoma multiforme | Brain | Signal transduction | Transplants & implants | Rodents | Hypoxia | Vascular endothelial growth factor | Cancer therapies | Cells | Animal models | Tumor cells | Brain tumors | Glioblastoma | Cell fusion | Xenografts | Differentiation | glioblastoma cells | recombinase | Hippocampus | Oncogenes | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 6, pp. 2425 - 2430
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and... 
Proteins | Angiogenesis | Receptors | Vascular endothelial growth factors | Endothelial growth factors | Ligands | Dimers | Chimeras | Monomers | Crystal structure | Vascular endothelial growth factor receptor-2 | Lymphangiogenesis | Vascular endothelial growth factor C | ACTIVATION | COMPLEX | FACTOR-C | angiogenesis | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ORF-VIRUS | TYROSINE KINASES | vascular endothelial growth factor receptor-2 | VASCULAR-PERMEABILITY | FAMILY-MEMBER | lymphangiogenesis | KINASE DOMAIN RECEPTOR | vascular endothelial growth factor C | Humans | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Recombinant Fusion Proteins - metabolism | Spodoptera | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor Receptor-1 - genetics | Protein Structure, Tertiary | Cell Line | Cell Survival | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor Receptor-3 - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Hydrogen Bonding | Vascular Endothelial Growth Factor C - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Kinetics | Mutation | Vascular Endothelial Growth Factor Receptor-3 - genetics | Development and progression | Research | Growth factor receptors | Neovascularization | Properties | Vascular endothelial growth factor | Protein binding | Lymphangioma | Signal transduction | Immunoglobulins | Membranes | Biochemistry | Kinases | Binding sites | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7392, pp. 110 - 114
Developing tissues and growing tumours produce vascular endothelial growth factors (VEGFs), leading to the activation of the corresponding receptors in... 
TIP CELL-FORMATION | DLL4 | ACTIVATION | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | GROWTH | NETWORK FORMATION | KINASE INHIBITORS | TUMOR ANGIOGENESIS | EXPRESSION | Human Umbilical Vein Endothelial Cells | Neovascularization, Physiologic - drug effects | Up-Regulation | Vascular Endothelial Growth Factor Receptor-3 - biosynthesis | Receptors, Notch - metabolism | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Intracellular Signaling Peptides and Proteins - deficiency | Membrane Proteins - deficiency | Receptors, Notch - antagonists & inhibitors | HEK293 Cells | Female | Transcription, Genetic | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Endothelial Cells - metabolism | Membrane Proteins - genetics | Vascular Endothelial Growth Factor Receptor-2 - deficiency | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Neovascularization, Physiologic - physiology | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | Models, Biological | Mice | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Cellular control mechanisms | Physiological aspects | Growth factor receptors | Neovascularization | Research | Vascular endothelial growth factor | Endothelium | Angiogenesis | Ligands | Kinases | Rodents | Index Medicus
Journal Article
ACS Nano, ISSN 1936-0851, 04/2014, Volume 8, Issue 4, pp. 3202 - 3212
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2454 - 2468
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed.... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | NEURITE OUTGROWTH | NITRIC-OXIDE SYNTHASE | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | VASCULAR-PERMEABILITY | ENDOTHELIAL GROWTH-FACTOR | HUMAN GLIOBLASTOMA-MULTIFORME | Membrane Glycoproteins - metabolism | Humans | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Occludin | Brain - metabolism | Inflammation - metabolism | Nitric Oxide Synthase Type III - metabolism | Demyelinating Diseases | Multiple Sclerosis - metabolism | Interleukin-1beta - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Nuclear Proteins - metabolism | Permeability | Blood-Brain Barrier - metabolism | Membrane Glycoproteins - genetics | Membrane Proteins | Nerve Tissue Proteins - metabolism | Blood-Brain Barrier - pathology | Lymphocytes - pathology | Animals | Brain - pathology | Multiple Sclerosis - pathology | Mice | Primary Cell Culture | Vascular Endothelial Growth Factor A - physiology | Astrocytes - metabolism | Physiological aspects | Central nervous system diseases | Research | Blood-brain barrier | Vascular endothelial growth factor | Index Medicus | Abridged Index Medicus
Journal Article
European Urology, ISSN 0302-2838, 11/2018, Volume 74, Issue 5, pp. 611 - 620
Journal Article