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Nature Cell Biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1202 - 1213
Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch... 
LYMPHATIC ENDOTHELIUM | KINASE-ACTIVITY | VASCULAR NETWORK FORMATION | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C | MOUSE EMBRYOS | EXTRACELLULAR-MATRIX | MONOCLONAL-ANTIBODY | TUMOR ANGIOGENESIS | FACTOR RECEPTOR-3 | CELL BIOLOGY | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Receptors, Notch - antagonists & inhibitors | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Vascular Endothelial Growth Factor D - genetics | Phosphatidylinositol 3-Kinase - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Transduction, Genetic | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Rhombencephalon - blood supply | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Forkhead Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Antibodies - pharmacology | Macrophages - metabolism | Vascular Endothelial Growth Factor D - metabolism | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Physiological aspects | Blood vessels | Cellular signal transduction | Growth factor receptors | Research | Vascular endothelial growth factor | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 6, pp. 2425 - 2430
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and... 
Proteins | Angiogenesis | Receptors | Vascular endothelial growth factors | Endothelial growth factors | Ligands | Dimers | Chimeras | Monomers | Crystal structure | Vascular endothelial growth factor receptor-2 | Lymphangiogenesis | Vascular endothelial growth factor C | ACTIVATION | COMPLEX | FACTOR-C | angiogenesis | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ORF-VIRUS | TYROSINE KINASES | vascular endothelial growth factor receptor-2 | VASCULAR-PERMEABILITY | FAMILY-MEMBER | lymphangiogenesis | KINASE DOMAIN RECEPTOR | vascular endothelial growth factor C | Humans | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Recombinant Fusion Proteins - metabolism | Spodoptera | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor Receptor-1 - genetics | Protein Structure, Tertiary | Cell Line | Cell Survival | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor Receptor-3 - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Hydrogen Bonding | Vascular Endothelial Growth Factor C - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Kinetics | Mutation | Vascular Endothelial Growth Factor Receptor-3 - genetics | Development and progression | Research | Growth factor receptors | Neovascularization | Properties | Vascular endothelial growth factor | Protein binding | Lymphangioma | Signal transduction | Immunoglobulins | Membranes | Biochemistry | Kinases | Binding sites | Index Medicus | Biological Sciences
Journal Article
Circulation, ISSN 0009-7322, 05/2014, Volume 129, Issue 19, pp. 1962 - 1971
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7297, pp. 483 - 486
In development, tissue regeneration or certain diseases, angiogenic growth leads to the expansion of blood vessels and the lymphatic vasculature. This involves... 
CARDIOVASCULAR DEVELOPMENT | ARTERIAL | SMOOTH-MUSCLE | TRANSGENIC MOUSE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | AXON GUIDANCE | MOLECULAR REGULATION | RECEPTORS | EXPRESSION | ADULT | Humans | rac GTP-Binding Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Embryo, Mammalian - metabolism | Receptor, EphB4 - genetics | Endocytosis | Lymphatic Vessels | Female | Proto-Oncogene Proteins c-akt - metabolism | Ephrin-B2 - deficiency | Receptor, EphB4 - deficiency | Signal Transduction | Endothelial Cells - metabolism | Neovascularization, Physiologic - genetics | Embryo, Mammalian - blood supply | Cells, Cultured | Mice, Transgenic | Neuropeptides - metabolism | Zebrafish | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Ephrin-B2 - metabolism | Receptor, EphB4 - metabolism | Ephrin-B2 - genetics | Pregnancy | Embryo Loss | Animals | Endothelial Cells - cytology | Vascular Endothelial Growth Factor C - metabolism | Mice | rac1 GTP-Binding Protein | Lymphangiogenesis - genetics | Ephrins | Control | Physiological aspects | Genetic aspects | Research | Neovascularization | Vascular endothelial growth factor | Angiogenesis | Kinases | Rodents | Cell adhesion & migration | Index Medicus | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2016, Volume 126, Issue 6, pp. 2167 - 2180
Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and... 
VASCULAR DEVELOPMENT | MEDICINE, RESEARCH & EXPERIMENTAL | EMBRYONIC LYMPHANGIOGENESIS | SKELETAL-MUSCLE | CCBE1 | LYMPHATIC VESSELS | FACTOR-C | TYROSINE KINASES | LIGAND | LYMPHEDEMA | ENDOTHELIAL GROWTH-FACTOR | Cell Proliferation | Humans | Vascular Endothelial Growth Factor D - deficiency | Vascular Endothelial Growth Factor C - deficiency | ADAMTS Proteins - deficiency | Lymphatic Vessels - metabolism | Procollagen N-Endopeptidase - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | HEK293 Cells | Vascular Endothelial Growth Factor D - genetics | Peptide Hydrolases - metabolism | Calcium-Binding Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | ADAMTS Proteins - metabolism | Endothelial Cells - metabolism | Procollagen N-Endopeptidase - genetics | Lymphangiogenesis - physiology | Calcium-Binding Proteins - deficiency | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Vascular Endothelial Growth Factor D - metabolism | Animals | Endothelial Cells - cytology | Models, Biological | Vascular Endothelial Growth Factor C - metabolism | Ligands | Mice | Lymphangiogenesis - genetics | ADAMTS Proteins - genetics | Calcium-Binding Proteins - genetics | Genetic aspects | Neovascularization | Proteolysis | Vascular endothelial growth factor | Health aspects | Studies | Lymphatic system | Lymphedema | Rodents | Cloning | Zebrafish | Skin | Experiments | Defects | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2010, Volume 188, Issue 1, pp. 115 - 130
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 39, pp. 15894 - 15899
Interplay between various lymphangiogenic factors in promoting lymphangiogenesis and lymphatic metastasis remains poorly understood. Here we show that FGF-2... 
Angiogenesis | Cornea | Quantification | Blood vessels | Metastasis | Lymphatic vessels | Endothelial cells | Lymph nodes | Tumors | Cancer | Cancer spread | Neovascularization | Antiangiogenic therapy | Growth factors | Signaling interplay | antiangiogenic therapy | cancer spread | growth factors | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | neovascularization | FIBROBLAST-GROWTH-FACTOR | MECHANISMS | signaling interplay | INHIBITION | EXPRESSION | PDGF-BB | RECEPTOR-3 | Neoplasm Transplantation | Humans | Tumor Microenvironment | Transplantation, Heterologous | Neoplasm Proteins - metabolism | Neovascularization, Pathologic - pathology | Lymphoma - metabolism | Neoplasm Metastasis | Lymphoma - therapy | Fibroblast Growth Factor 2 - metabolism | Lymphoma - pathology | Neoplasm Proteins - genetics | Neovascularization, Pathologic - therapy | Endothelial Cells - metabolism | Lymphoma - genetics | Signal Transduction - genetics | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Mice, SCID | Vascular Endothelial Growth Factor C - genetics | Animals | Fibroblast Growth Factor 2 - genetics | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Endothelial Cells - pathology | Cell Line, Transformed | Vascular Endothelial Growth Factor Receptor-3 - genetics | Fibroblast growth factors | Research | Properties | Vascular endothelial growth factor | Signal transduction | Lymphatic system | Gene expression | Cells | Index Medicus | Biological Sciences | Samhällsvetenskap | Social Sciences
Journal Article
Immunity, ISSN 1074-7613, 04/2014, Volume 40, Issue 4, pp. 501 - 514
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 7, pp. 1438 - 1451.e8
Background & Aims Colorectal cancer (CRC) is highly metastatic. Metastases spread directly into local tissue or invade distant organs via blood and lymphatic... 
Gastroenterology and Hepatology | VEGFC | Tumor Progression | Colon Cancer | Mouse Model | ANGIOGENESIS | LEUKOCYTE EXTRAVASATION | VEGF-C | FACTOR RECEPTOR | CADHERIN | INFLAMMATORY-BOWEL-DISEASE | VESSELS | TUMOR-METASTASIS | IN-VIVO | LYMPHANGIOGENESIS | GASTROENTEROLOGY & HEPATOLOGY | Cell Proliferation | Cadherins - metabolism | Colorectal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Case-Control Studies | Antigens, CD - metabolism | Transfection | Lung Neoplasms - secondary | Time Factors | Transendothelial and Transepithelial Migration | Endothelium, Lymphatic - metabolism | Liver Neoplasms - secondary | Lymphangiogenesis | Colorectal Neoplasms - metabolism | Endothelium, Lymphatic - pathology | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Signal Transduction | Endothelial Cells - metabolism | Neoplasm Invasiveness | Lymphatic Metastasis | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor C - genetics | Animals | Endothelium, Vascular - metabolism | Mice, Nude | Vascular Endothelial Growth Factor C - metabolism | Liver Neoplasms - metabolism | Cell Line, Tumor | Endothelium, Vascular - pathology | Mice, Inbred BALB C | Colorectal Neoplasms - pathology | Endothelial Cells - pathology | Endothelial growth factors | Gastrointestinal diseases | Colorectal cancer | Index Medicus | Abridged Index Medicus
Journal Article