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1. Full Text Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold
by Wang, De-pu and Liu, Kai-li and Li, Xin-yang and Lu, Guo-qing and Xue, Wen-han and Qian, Xin-hua and Mohamed O, Kamara and Meng, Fan-hao
European journal of medicinal chemistry, ISSN 0223-5234, 02/2021, Volume 211, pp. 113083 - 113083
Zebrafish | 1,2,3-Triazole | Anti-angiogenesis | VEGFR-2 | Drugstores | Molecular dynamics | Triazoles | Vascular endothelial growth factor | Pharmacy | Analysis | Index Medicus
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2. Full Text AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
by Wedge, Stephen R and Kendrew, Jane and Hennequin, Laurent F and Valentine, Paula J and Barry, Simon T and Brave, Sandra R and Smith, Neil R and James, Neil H and Dukes, Michael and Curwen, Jon O and Chester, Rosemary and Jackson, Janet A and Boffey, Sarah J and Kilburn, Lyndsey L and Barnett, Sharon and Richmond, Graham H.P and Wadsworth, Peter F and Walker, Mike and Bigley, Alison L and Taylor, Sian T and Cooper, Lee and Beck, Sarah and Jürgensmeier, Juliane M and Ogilvie, Donald J
Cancer research (Chicago, Ill.), ISSN 0008-5472, 05/2005, Volume 65, Issue 10, pp. 4389 - 4400
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | Corpus Luteum - drug effects | Corpus Luteum - growth & development | Humans | Quinazolines - pharmacokinetics | Biological Availability | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Extracellular Matrix Proteins | Female | Phosphorylation - drug effects | Protein Kinase Inhibitors - pharmacokinetics | Bone Development - drug effects | Administration, Oral | Endothelial Cells - metabolism | Neoplasms - enzymology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Neoplasms - blood supply | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Myosin Heavy Chains | Nonmuscle Myosin Type IIB | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Quinazolines - pharmacology | Endothelial Cells - enzymology | Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors | Endothelial Cells - drug effects | Index Medicus
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3. Full Text Bone Morphogenetic Protein Receptor-2 Signaling Promotes Pulmonary Arterial Endothelial Cell Survival: Implications for Loss-of-Function Mutations in the Pathogenesis of Pulmonary Hypertension
by Teichert-Kuliszewska, Krystyna and Kutryk, Michael J.B and Kuliszewski, Michael A and Karoubi, Golnaz and Courtman, David W and Zucco, Liana and Granton, John and Stewart, Duncan J
Circulation research, ISSN 0009-7330, 02/2006, Volume 98, Issue 2, pp. 209 - 217
Bone morphogenetic proteins | Bone morphogenetic receptor-2 | Pulmonary arterial hypertension | Endothelial cells | Endothelial progenitor cells | Apoptosis | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases | Medical sciences | Vertebrates: cardiovascular system | Pneumology | Bone Morphogenetic Protein Receptors, Type II - genetics | Bone Morphogenetic Protein 2 | Cell Survival | Humans | Middle Aged | Cells, Cultured | Male | Transforming Growth Factor beta - pharmacology | Stem Cells - drug effects | Adult | Female | Signal Transduction - physiology | Aged | Bone Morphogenetic Protein Receptors, Type II - analysis | Bone Morphogenetic Protein Receptors, Type II - physiology | Mutation | Endothelial Cells - pathology | Bone Morphogenetic Proteins - pharmacology | Hypertension, Pulmonary - etiology | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Endothelial Cells - drug effects | Index Medicus
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4. Full Text Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor‐2 inhibitor
by Xie, Chengying and Wan, Xiaozhe and Quan, Haitian and Zheng, Mingyue and Fu, Li and Li, Yun and Lou, Liguang
Cancer science, ISSN 1347-9032, 04/2018, Volume 109, Issue 4, pp. 1207 - 1219
VEGFR2 | tyrosine kinase inhibitor | anlotinib | angiogenesis | VEGF | Life Sciences & Biomedicine | Oncology | Science & Technology | Human Umbilical Vein Endothelial Cells | Humans | Male | Vascular Endothelial Growth Factor A - metabolism | Quinolines - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Sunitinib | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Line | Angiogenesis Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Mice, Nude | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Vascular endothelial growth factor | Analysis | Cell proliferation | Lung cancer | Metastasis | Kinases | Drug resistance | Cancer therapies | Cell adhesion & migration | Angiogenesis | Hydrogen bonds | Aorta | Drug dosages | Protein-tyrosine kinase | Explants | Immunoglobulins | Regression analysis | Studies | Chemotherapy | Antitumor activity | Hypoxia | Mutation | Angiogenesis inhibitors | Cell migration | Pharmaceuticals | Tumors | Index Medicus | Original
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5. Full Text Selective Imaging of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Atherosclerotic Lesions in Diabetic and Non-diabetic ApoE−/− Mice
by Tekabe, Yared and Tekabe, Yared and Johnson, Lynne L and Johnson, Lynne L and Rodriquez, Krissy and Rodriquez, Krissy and Li, Qing and Li, Qing and Backer, Marina and Backer, Marina and Backer, Joseph M and Backer, Joseph M
Molecular imaging and biology, ISSN 1536-1632, 2/2018, Volume 20, Issue 1, pp. 85 - 93
Molecular imaging | Vascular endothelial growth factor receptor (VEGFR) | Diabetes | Medicine & Public Health | Imaging / Radiology | Atherosclerosis | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Atherosclerosis - pathology | Diabetes Mellitus, Experimental - diagnosis | Apolipoproteins E - deficiency | Tomography, Emission-Computed, Single-Photon | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Atherosclerosis - complications | Male | Molecular Imaging - methods | Polyethylene Glycols - chemistry | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Apolipoproteins E - metabolism | Atherosclerosis - metabolism | Diabetes Mellitus, Experimental - blood | Tissue Distribution | Animals | Atherosclerosis - diagnosis | Diabetes Mellitus, Experimental - complications | Mice | Single-Chain Antibodies | Blood Glucose - metabolism | Diabetes Mellitus, Experimental - metabolism | Selectivity | Biology | Proteins | Angiogenesis | Receptors | Computed tomography | Apolipoprotein E | Polyethylene glycol | Imaging | Tomography | Aorta | Lesions | Vascular endothelial growth factor | Plaques | Photon emission | Medical imaging | Diabetes mellitus | Blood vessels | Single photon emission computed tomography | Mutants | Vascular endothelial growth factor receptors | Signaling | Computation | Arteriosclerosis | Coronary vessels | Tracers | Index Medicus
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6. Full Text Phase I study of every 2- or 3-week dosing of ramucirumab, a human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2 in patients with advanced solid tumors
by Chiorean, E.G and Hurwitz, H.I and Cohen, R.B and Schwartz, J.D and Dalal, R.P and Fox, F.E and Gao, L and Sweeney, C.J
Annals of oncology, ISSN 0923-7534, 06/2015, Volume 26, Issue 6, pp. 1230 - 1237
phase I study | ramucirumab | VEGFR-2 | vascular endothelial growth factor | solid tumors | Phase I study | Ramucirumab | Solid tumors | Vascular endothelial growth factor | Life Sciences & Biomedicine | Oncology | Science & Technology | United States | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Vascular Endothelial Growth Factor Receptor-2 - immunology | Angiogenesis Inhibitors - blood | Antibodies, Monoclonal - blood | Antibodies, Monoclonal, Humanized | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Angiogenesis Inhibitors - administration & dosage | Neoplasms - blood | Adult | Female | Angiogenesis Inhibitors - adverse effects | Drug Administration Schedule | Vascular Endothelial Growth Factor A - blood | Antibodies, Monoclonal - pharmacokinetics | Neoplasms - enzymology | Vascular Endothelial Growth Factor Receptor-2 - blood | Treatment Outcome | Angiogenesis Inhibitors - pharmacokinetics | Disease Progression | Neoplasms - drug therapy | Biomarkers, Tumor - blood | Maximum Tolerated Dose | Antibodies, Monoclonal - administration & dosage | Neoplasms - immunology | Aged | Neoplasms - pathology | Vascular Endothelial Growth Factor Receptor-1 - blood | Index Medicus
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7. Full Text A Macrocyclic Ruthenium(III) Complex Inhibits Angiogenesis with Down‐Regulation of Vascular Endothelial Growth Factor Receptor‐2 and Suppresses Tumor Growth In Vivo
by Kwong, Wai‐Lun and Lam, Kar‐Yee and Lok, Chun‐Nam and Lai, Yau‐Tsz and Lee, Pui‐Yan and Che, Chi‐Ming
Angewandte Chemie (International ed.), ISSN 1433-7851, 10/2016, Volume 55, Issue 43, pp. 13524 - 13528
ruthenium | VEGFRs | anti-cancer | angiogenesis | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Ruthenium | Endothelial growth factors | Analysis | Cancer | Angiogenesis | Vascular endothelial growth factor | Rodents | Biotechnology | Cytotoxicity | Zebrafish | Tumor cell lines | Vascular endothelial growth factor receptors | Down-regulation | Xenografts | Inhibition | Index Medicus
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8. Full Text VEGF receptor‐2/neuropilin 1 trans‐complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival
by Morin, Eric and Sjöberg, Elin and Tjomsland, Vegard and Testini, Chiara and Lindskog, Cecilia and Franklin, Oskar and Sund, Malin and Öhlund, Daniel and Kiflemariam, Sara and Sjöblom, Tobias and Claesson‐Welsh, Lena
The Journal of pathology, ISSN 0022-3417, 11/2018, Volume 246, Issue 3, pp. 311 - 322
neuropilin 1 | pancreatic adenocarcinoma | trans‐complex | branching | VEGF | trans-complex | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | Antigen-antibody reactions | Endothelial growth factors | Sarcoma | RNA | Biological control | Antibodies | Development and progression | Pests | Endothelium | Viral antibodies | Pancreatic cancer | Analysis | Cellular signal transduction | Cell proliferation | Adenocarcinoma | Complex formation | Cell survival | Tumor cells | Neuropilin | Fibrosarcoma | Survival | Endothelial cells | Signal transduction | Angiogenesis | Cell growth | Vascular endothelial growth factor | Growth factors | Cancer | Tumors | Index Medicus | Original Papers | Original Paper
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9. Full Text Upregulated autocrine vascular endothelial growth factor (VEGF)/VEGF receptor‐2 loop prevents apoptosis in haemangioma‐derived endothelial cells
by Ji, Y and Chen, S and Li, K and Xiao, X and Xu, T and Zheng, S
British journal of dermatology (1951), ISSN 0007-0963, 01/2014, Volume 170, Issue 1, pp. 78 - 86
Life Sciences & Biomedicine | Dermatology | Science & Technology | Public health. Hygiene-occupational medicine | Public health. Hygiene | Biological and medical sciences | Medical sciences | Prevention and actions | Human Umbilical Vein Endothelial Cells | Humans | Angiogenesis Inhibitors - pharmacology | Hemangioma - physiopathology | Adrenergic beta-Antagonists - pharmacology | Phthalazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Propranolol - pharmacology | Up-Regulation - physiology | Pyridines - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - physiology | Apoptosis - physiology | Culture Media, Serum-Free - pharmacology | Propanolamines - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Vascular Endothelial Growth Factor A - physiology | Cell Survival - physiology | Endothelial Cells - physiology | Propranolol hydrochloride | Hemangioma | Starvation | Vascular endothelial growth factor | Analysis | Apoptosis | Index Medicus
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