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Nature Medicine, ISSN 1078-8956, 09/2009, Volume 15, Issue 9, pp. 1023 - 1030
Journal Article
Experimental cell research, ISSN 0014-4827, 2014, Volume 322, Issue 1, pp. 89 - 98
Vascular endothelial growth factor (VEGF) triggers crucial signaling processes that regulate tumor angiogenesis and, therefore, represents an attractive target for the development of novel anticancer therapeutics... 
Angiogenesis | Endothelial cell | Olive oil | Signaling pathway | VEGF/VEGFR-2 | KINASE-ACTIVITY | MEDITERRANEAN DIET | PHENOLIC-COMPOUNDS | HUMANS | TUMOR ANGIOGENESIS | CELL MIGRATION | VEGF-A | CELL BIOLOGY | SIGNAL-TRANSDUCTION | ONCOLOGY | TYROSINE RESIDUES | CANCER-RISK | Neovascularization, Physiologic - drug effects | Quercetin - analogs & derivatives | Plant Oils - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Phenylethyl Alcohol - analogs & derivatives | Plant Extracts - pharmacology | Humans | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Olive Oil | Down-Regulation - drug effects | Cell Movement - drug effects | Phenylethyl Alcohol - pharmacology | Human Umbilical Vein Endothelial Cells - physiology | Oleic Acid - pharmacology | Protein Processing, Post-Translational - drug effects | Quercetin - pharmacology | Cell Proliferation - drug effects | Phosphorylation - drug effects | Plant Oils - chemistry | Antioxidants | Monounsaturated fatty acids | Angiogenesis inhibitors | Vascular endothelial growth factor | Phosphorylation | Cellular biology | Cell adhesion & migration | HUMAN POPULATIONS | VEINS | ANGIOGENESIS | ANTIOXIDANTS | NEOPLASMS | PHOSPHORYLATION | CATTLE | SIGNALS | COMPARATIVE EVALUATIONS | 60 APPLIED LIFE SCIENCES | GROWTH FACTORS | CAPILLARIES | OLEIC ACID | INHIBITION | DIET | PHENOLS | IN VITRO | OLIVE OIL | PLANTS | NUTRITION | RECEPTORS | FOOD
Journal Article
Molecular Imaging and Biology, ISSN 1536-1632, 2/2018, Volume 20, Issue 1, pp. 85 - 93
Plaque vulnerability is associated with inflammation and angiogenesis, processes that rely on vascular endothelial growth factor (VEGF... 
Molecular imaging | Vascular endothelial growth factor receptor (VEGFR) | Diabetes | Medicine & Public Health | Imaging / Radiology | Atherosclerosis | CELLS | IDENTIFY | INSTABILITY | VEGF RECEPTORS | PLAQUE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Atherosclerosis - pathology | Diabetes Mellitus, Experimental - diagnosis | Apolipoproteins E - deficiency | Tomography, Emission-Computed, Single-Photon | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Atherosclerosis - complications | Male | Molecular Imaging - methods | Polyethylene Glycols - chemistry | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Apolipoproteins E - metabolism | Atherosclerosis - metabolism | Diabetes Mellitus, Experimental - blood | Tissue Distribution | Animals | Atherosclerosis - diagnosis | Diabetes Mellitus, Experimental - complications | Mice | Single-Chain Antibodies | Blood Glucose - metabolism | Diabetes Mellitus, Experimental - metabolism | Selectivity | Biology | Proteins | Angiogenesis | Receptors | Computed tomography | Apolipoprotein E | Polyethylene glycol | Imaging | Tomography | Aorta | Lesions | Vascular endothelial growth factor | Plaques | Photon emission | Medical imaging | Diabetes mellitus | Blood vessels | Software reliability | Single photon emission computed tomography | Mutants | Vascular endothelial growth factor receptors | Signaling | Computation | Arteriosclerosis | Coronary vessels | Tracers
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2016, Volume 55, Issue 43, pp. 13524 - 13528
.... Moreover, compared with known anti‐cancer ruthenium complexes, Ru‐1 is distinct in that it suppressed the expression of vascular endothelial growth factor receptor‐2 (VEGFR2... 
ruthenium | VEGFRs | anti-cancer | angiogenesis | VITRO | SIGNALING PATHWAYS | METASTASIS | ORGANOMETALLIC COMPLEXES | CANCER | CHEMISTRY, MULTIDISCIPLINARY | NAMI-A | ARENE COMPLEXES | ANTICANCER DRUGS | CELL | BINDING | Macrocyclic Compounds - chemistry | Humans | Structure-Activity Relationship | Ruthenium - chemistry | Macrocyclic Compounds - pharmacology | Neovascularization, Pathologic - pathology | Dose-Response Relationship, Drug | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Mammary Neoplasms, Experimental - pathology | Coordination Complexes - pharmacology | Female | Antineoplastic Agents - pharmacology | Mammary Neoplasms, Experimental - drug therapy | Human Umbilical Vein Endothelial Cells - drug effects | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Zebrafish | Antineoplastic Agents - chemistry | Down-Regulation - drug effects | Coordination Complexes - chemistry | Ruthenium - pharmacology | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Ruthenium | Endothelial growth factors | Analysis | Cancer | Angiogenesis | Vascular endothelial growth factor | Rodents | Biotechnology | Cytotoxicity | Tumor cell lines | Vascular endothelial growth factor receptors | Down-regulation | Xenografts | Inhibition
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 6, pp. 2425 - 2430
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and -3... 
Proteins | Angiogenesis | Receptors | Vascular endothelial growth factors | Endothelial growth factors | Ligands | Dimers | Chimeras | Monomers | Crystal structure | Vascular endothelial growth factor receptor-2 | Lymphangiogenesis | Vascular endothelial growth factor C | ACTIVATION | COMPLEX | FACTOR-C | angiogenesis | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ORF-VIRUS | TYROSINE KINASES | vascular endothelial growth factor receptor-2 | VASCULAR-PERMEABILITY | FAMILY-MEMBER | lymphangiogenesis | KINASE DOMAIN RECEPTOR | vascular endothelial growth factor C | Humans | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Recombinant Fusion Proteins - metabolism | Spodoptera | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor Receptor-1 - genetics | Protein Structure, Tertiary | Cell Line | Cell Survival | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor Receptor-3 - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Hydrogen Bonding | Vascular Endothelial Growth Factor C - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Kinetics | Mutation | Vascular Endothelial Growth Factor Receptor-3 - genetics | Development and progression | Research | Growth factor receptors | Neovascularization | Properties | Vascular endothelial growth factor | Protein binding | Lymphangioma | Biological Sciences
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 03/2015, Volume 113, Issue 2, pp. 329 - 337
Journal Article
Nature medicine, ISSN 1546-170X, 2003, Volume 9, Issue 4, pp. 407 - 415
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 01/2017, Volume 22, Issue 1, pp. 126 - 126
Anti-angiogenesis targeting vascular endothelial growth factor receptor-2 (VEGFR-2) has been considered as an important strategy for cancer therapy... 
Penduliflaworosin | VEGF receptor-2 | Anti-angiogenesis | CLERODANE DITERPENOIDS | MECHANISM | ENDOTHELIAL-GROWTH-FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | anti-angiogenesis | penduliflaworosin | CANCER | CHEMISTRY, MULTIDISCIPLINARY | Human Umbilical Vein Endothelial Cells | Neovascularization, Physiologic - drug effects | Plant Extracts - chemistry | TOR Serine-Threonine Kinases - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Aorta - metabolism | Vascular Endothelial Growth Factor A - genetics | Proto-Oncogene Proteins c-akt - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Protein Domains | Proto-Oncogene Proteins c-akt - metabolism | Diterpenes - chemistry | Diterpenes - pharmacology | Protein Structure, Secondary | Signal Transduction | Tissue Culture Techniques | Aorta - drug effects | Diterpenes - isolation & purification | Mice, Inbred C57BL | Gene Expression Regulation | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Antineoplastic Agents, Phytogenic - chemistry | Cell Movement - drug effects | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Croton - chemistry | Hydrogen Bonding | Cell Line, Tumor | Protein Binding | Angiogenesis Inhibitors - isolation & purification | Mice | Aorta - cytology | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Angiogenesis Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - isolation & purification | Cell proliferation | Phosphorylation | Toxicity | Cytotoxicity | Zebrafish | Kinases | Hydrogen bonding | Endothelial cells | Western blotting | Molecular docking | Vascular endothelial growth factor receptors | Angiogenesis | Signal transduction | Signaling | Hydrogen bonds | Antiangiogenics | Aorta | Inhibition | Vascular endothelial growth factor | Umbilical vein | Growth factors | Cell migration | Cancer
Journal Article
Journal Article