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Immunity, ISSN 1074-7613, 04/2014, Volume 40, Issue 4, pp. 501 - 514
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1202 - 1213
Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch... 
LYMPHATIC ENDOTHELIUM | KINASE-ACTIVITY | VASCULAR NETWORK FORMATION | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C | MOUSE EMBRYOS | EXTRACELLULAR-MATRIX | MONOCLONAL-ANTIBODY | TUMOR ANGIOGENESIS | FACTOR RECEPTOR-3 | CELL BIOLOGY | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Receptors, Notch - antagonists & inhibitors | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Vascular Endothelial Growth Factor D - genetics | Phosphatidylinositol 3-Kinase - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Transduction, Genetic | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Rhombencephalon - blood supply | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Forkhead Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Antibodies - pharmacology | Macrophages - metabolism | Vascular Endothelial Growth Factor D - metabolism | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Physiological aspects | Blood vessels | Cellular signal transduction | Growth factor receptors | Research | Vascular endothelial growth factor | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7392, pp. 110 - 114
Developing tissues and growing tumours produce vascular endothelial growth factors (VEGFs), leading to the activation of the corresponding receptors in... 
TIP CELL-FORMATION | DLL4 | PATHWAYS | ACTIVATION | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | GROWTH | MOUSE | LIGAND | INHIBIT | D114 | Human Umbilical Vein Endothelial Cells | Neovascularization, Physiologic - drug effects | Up-Regulation | Vascular Endothelial Growth Factor Receptor-3 - biosynthesis | Receptors, Notch - metabolism | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | Intracellular Signaling Peptides and Proteins - deficiency | Membrane Proteins - deficiency | Receptors, Notch - antagonists & inhibitors | HEK293 Cells | Female | Transcription, Genetic | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Endothelial Cells - metabolism | Membrane Proteins - genetics | Vascular Endothelial Growth Factor Receptor-2 - deficiency | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Neovascularization, Physiologic - physiology | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | Models, Biological | Mice | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Cellular control mechanisms | Physiological aspects | Growth factor receptors | Neovascularization | Research | Vascular endothelial growth factor | Endothelium | Angiogenesis | Ligands | Kinases | Rodents
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2015, Volume 208, Issue 7, pp. 975 - 986
Journal Article
Cancer Research, ISSN 0008-5472, 06/2008, Volume 68, Issue 12, pp. 4754 - 4762
Solid tumors express a range of factors required to sustain their growth and promote their dissemination. Among these are vascular endothelial growth factor-A... 
BREAST-CANCER | ACTIVATION | LYMPH-NODE METASTASIS | ANGIOGENESIS | ONCOLOGY | CANCER METASTASIS | TUMOR LYMPHANGIOGENESIS | VEGF-C | AZD2171 | GENE-TRANSFER | FACTOR SIGNALING INHIBITOR | Endothelium, Vascular - cytology | Skin - cytology | Immunoprecipitation | Skin - metabolism | Humans | Endothelium, Vascular - drug effects | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Adenoviridae - genetics | Neovascularization, Pathologic - prevention & control | Phosphorylation - drug effects | Vascular Endothelial Growth Factor D - genetics | Cell Survival - drug effects | Signal Transduction | Lymphangiogenesis - physiology | Angiogenesis Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Blotting, Western | Vascular Endothelial Growth Factor C - genetics | Lymphangiogenesis - drug effects | Cell Movement - drug effects | Vascular Endothelial Growth Factor D - metabolism | Animals | Endothelium, Vascular - metabolism | Mice, Nude | Vascular Endothelial Growth Factor C - metabolism | Cell Membrane Permeability - drug effects | Cell Proliferation - drug effects | Mice | Quinazolines - pharmacology | Skin - drug effects | Vascular Endothelial Growth Factor Receptor-3 - genetics
Journal Article
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 3/2013, Volume 91, Issue 3, pp. 395 - 405
Endothelin receptor B (ETBR) is a G-protein-coupled receptor overexpressed in melanoma, blood, and lymphatic endothelial cells. Given that aberrant signal... 
Human Genetics | Vascular endothelial growth factor receptor-3 | Biomedicine | Endothelin B receptor | Melanoma cells | Endothelin-1 | Internal Medicine | Molecular Medicine | Hypoxia-inducible factor-α | MEDICINE, RESEARCH & EXPERIMENTAL | METASTASIS | ANGIOGENESIS | FACTOR-C | Hypoxia-inducible factor-alpha | VEGF | MALIGNANT-MELANOMA | CANCER | AUTOCRINE | GENETICS & HEREDITY | LYMPHANGIOGENESIS | EXPRESSION | PROGRESSION | Phosphorylation | Humans | Gene Expression Regulation, Neoplastic | Transplantation, Heterologous | Proto-Oncogene Proteins c-akt - genetics | Neoplasm Metastasis | Melanoma - genetics | Vascular Endothelial Growth Factor D - genetics | Melanoma - metabolism | Signal Transduction | Endothelin-1 - genetics | Endothelin-1 - metabolism | Melanoma - pathology | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor C - genetics | Receptor, Endothelin B - genetics | Vascular Endothelial Growth Factor D - metabolism | Animals | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Mice | Receptor, Endothelin B - metabolism | Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-3 - genetics | Cell Movement | Endothelin | Melanoma | Physiological aspects | Development and progression | Genetic aspects | Research | Growth factor receptors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 6, pp. 2425 - 2430
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and... 
Proteins | Angiogenesis | Receptors | Vascular endothelial growth factors | Endothelial growth factors | Ligands | Dimers | Chimeras | Monomers | Crystal structure | Vascular endothelial growth factor receptor-2 | Lymphangiogenesis | Vascular endothelial growth factor C | ACTIVATION | COMPLEX | FACTOR-C | angiogenesis | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ORF-VIRUS | TYROSINE KINASES | vascular endothelial growth factor receptor-2 | VASCULAR-PERMEABILITY | FAMILY-MEMBER | lymphangiogenesis | KINASE DOMAIN RECEPTOR | vascular endothelial growth factor C | Humans | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Recombinant Fusion Proteins - metabolism | Spodoptera | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor Receptor-1 - genetics | Protein Structure, Tertiary | Cell Line | Cell Survival | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor Receptor-3 - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Hydrogen Bonding | Vascular Endothelial Growth Factor C - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Kinetics | Mutation | Vascular Endothelial Growth Factor Receptor-3 - genetics | Development and progression | Research | Growth factor receptors | Neovascularization | Properties | Vascular endothelial growth factor | Protein binding | Lymphangioma | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 39, pp. 15894 - 15899
Interplay between various lymphangiogenic factors in promoting lymphangiogenesis and lymphatic metastasis remains poorly understood. Here we show that FGF-2... 
Angiogenesis | Cornea | Quantification | Blood vessels | Metastasis | Lymphatic vessels | Endothelial cells | Lymph nodes | Tumors | Cancer | Cancer spread | Neovascularization | Antiangiogenic therapy | Growth factors | Signaling interplay | antiangiogenic therapy | cancer spread | growth factors | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | neovascularization | FIBROBLAST-GROWTH-FACTOR | MECHANISMS | signaling interplay | INHIBITION | EXPRESSION | PDGF-BB | RECEPTOR-3 | Neoplasm Transplantation | Humans | Tumor Microenvironment | Transplantation, Heterologous | Neoplasm Proteins - metabolism | Neovascularization, Pathologic - pathology | Lymphoma - metabolism | Neoplasm Metastasis | Lymphoma - therapy | Fibroblast Growth Factor 2 - metabolism | Lymphoma - pathology | Neoplasm Proteins - genetics | Neovascularization, Pathologic - therapy | Endothelial Cells - metabolism | Lymphoma - genetics | Signal Transduction - genetics | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Mice, SCID | Vascular Endothelial Growth Factor C - genetics | Animals | Fibroblast Growth Factor 2 - genetics | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Endothelial Cells - pathology | Cell Line, Transformed | Vascular Endothelial Growth Factor Receptor-3 - genetics | Fibroblast growth factors | Research | Properties | Vascular endothelial growth factor | Biological Sciences | Samhällsvetenskap | Social Sciences
Journal Article
Development, ISSN 0950-1991, 03/2014, Volume 141, Issue 6, pp. 1239 - 49
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2004, Volume 5, Issue 1, pp. 74 - 80
Journal Article