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Journal of Molecular Biology, ISSN 0022-2836, 2002, Volume 316, Issue 3, pp. 769 - 787
Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific mediator of angiogenesis and vasculogenesis. VEGF is involved pathologically in... 
protein structure | NMR | angiogenesis | vascular endothelial growth factor | peptide antagonist | Angiogenesis | Peptide antagonist | Protein structure | Vascular endothelial growth factor | MOLECULAR-DYNAMICS | TRIPLE-RESONANCE EXPERIMENTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-STRUCTURE DETERMINATION | RECEPTOR-BINDING DOMAIN | BIOACTIVE CONFORMATION | ANGSTROM RESOLUTION | DE-NOVO DESIGN | IMPROVED SENSITIVITY | INTERPROTON DISTANCE RESTRAINTS | Disulfides - metabolism | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Vascular Endothelial Growth Factors | Humans | Molecular Sequence Data | Receptors, Growth Factor - antagonists & inhibitors | Crystallography, X-Ray | Endothelial Growth Factors - chemistry | Proto-Oncogene Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-1 | Lymphokines - genetics | Peptides - chemical synthesis | Peptides - metabolism | Alanine - genetics | Solutions | Lymphokines - antagonists & inhibitors | Protein Structure, Quaternary | Lymphokines - metabolism | Nuclear Magnetic Resonance, Biomolecular | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Binding Sites | Dimerization | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Bacteriophages - chemistry | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Alanine - metabolism | Mutation - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Receptors, Growth Factor - chemistry | Peptides - pharmacology | Endothelial Growth Factors - antagonists & inhibitors | Lymphokines - chemistry | Endothelial Growth Factors - genetics | Hydrophobic and Hydrophilic Interactions | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Growth Factor - metabolism | Index Medicus
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1202 - 1213
Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch... 
LYMPHATIC ENDOTHELIUM | KINASE-ACTIVITY | VASCULAR NETWORK FORMATION | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C | MOUSE EMBRYOS | EXTRACELLULAR-MATRIX | MONOCLONAL-ANTIBODY | TUMOR ANGIOGENESIS | FACTOR RECEPTOR-3 | CELL BIOLOGY | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Receptors, Notch - antagonists & inhibitors | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Vascular Endothelial Growth Factor D - genetics | Phosphatidylinositol 3-Kinase - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Transduction, Genetic | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Rhombencephalon - blood supply | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Forkhead Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Antibodies - pharmacology | Macrophages - metabolism | Vascular Endothelial Growth Factor D - metabolism | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Physiological aspects | Blood vessels | Cellular signal transduction | Growth factor receptors | Research | Vascular endothelial growth factor | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2003, Volume 108, Issue 16, pp. 1933 - 1938
Background -"Therapeutic angiogenesis" seeks to improve perfusion by the growth of new blood vessels. The Regional Angiogenesis with Vascular Endothelial... 
Peripheral vascular disease | Angiogenesis | Claudication | Viruses | Gene therapy | viruses | CILOSTAZOL | MULTICENTER | CARDIAC & CARDIOVASCULAR SYSTEMS | WALKING DISTANCES | VEGF121 CDNA | angiogenesis | gene therapy | ISCHEMIA | MEDIATED GENE-TRANSFER | peripheral vascular disease | VECTOR | TRIAL | THERAPY | NEOVASCULARIZATION | HEMATOLOGY | claudication | Neovascularization, Physiologic - drug effects | Vascular Endothelial Growth Factor A | Genetic Vectors - administration & dosage | Peripheral Vascular Diseases - therapy | Vascular Endothelial Growth Factors | Humans | Middle Aged | Male | Dose-Response Relationship, Drug | Endothelial Growth Factors - adverse effects | Lymphokines - adverse effects | Lymphokines - genetics | Adenoviridae - genetics | Female | Intermittent Claudication - therapy | Walking - statistics & numerical data | Intercellular Signaling Peptides and Proteins - administration & dosage | Double-Blind Method | Peripheral Vascular Diseases - complications | Intercellular Signaling Peptides and Proteins - genetics | Intermittent Claudication - etiology | Treatment Outcome | Lymphokines - administration & dosage | Endothelial Growth Factors - administration & dosage | Endothelial Growth Factors - genetics | Quality of Life | Aged | Edema - chemically induced | Intercellular Signaling Peptides and Proteins - adverse effects | Genetic Therapy - adverse effects | Genetic Therapy - methods | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/1998, Volume 273, Issue 46, pp. 30336 - 30343
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 6, pp. 2425 - 2430
Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel formation through activation of three receptor tyrosine kinases, VEGFR-1, -2, and... 
Proteins | Angiogenesis | Receptors | Vascular endothelial growth factors | Endothelial growth factors | Ligands | Dimers | Chimeras | Monomers | Crystal structure | Vascular endothelial growth factor receptor-2 | Lymphangiogenesis | Vascular endothelial growth factor C | ACTIVATION | COMPLEX | FACTOR-C | angiogenesis | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ORF-VIRUS | TYROSINE KINASES | vascular endothelial growth factor receptor-2 | VASCULAR-PERMEABILITY | FAMILY-MEMBER | lymphangiogenesis | KINASE DOMAIN RECEPTOR | vascular endothelial growth factor C | Humans | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Recombinant Fusion Proteins - metabolism | Spodoptera | Vascular Endothelial Growth Factor Receptor-2 - genetics | Vascular Endothelial Growth Factor A - chemistry | Vascular Endothelial Growth Factor C - chemistry | Vascular Endothelial Growth Factor Receptor-1 - genetics | Protein Structure, Tertiary | Cell Line | Cell Survival | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Binding Sites - genetics | Recombinant Fusion Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor Receptor-3 - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Hydrogen Bonding | Vascular Endothelial Growth Factor C - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Kinetics | Mutation | Vascular Endothelial Growth Factor Receptor-3 - genetics | Development and progression | Research | Growth factor receptors | Neovascularization | Properties | Vascular endothelial growth factor | Protein binding | Lymphangioma | Signal transduction | Immunoglobulins | Membranes | Biochemistry | Kinases | Binding sites | Index Medicus | Biological Sciences
Journal Article
Nature Genetics, ISSN 1061-4036, 01/2003, Volume 34, Issue 4, pp. 383 - 394
Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons. We recently reported that reduced expression of Vegfa causes ALS-like... 
TRANSFORMATION | PATHOGENESIS | GENETIC ASSOCIATION | MESSENGER-RNA | HEAVY NEUROFILAMENT SUBUNIT | DISEASE | GENETICS & HEREDITY | POLYMORPHISM | HIPPOCAMPAL-NEURONS | SPORADIC ALS | ENDOTHELIAL GROWTH-FACTOR | Haplotypes | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factors | Humans | Middle Aged | Spinal Cord Ischemia - drug therapy | Child, Preschool | Nerve Degeneration - genetics | Male | Amyotrophic Lateral Sclerosis - drug therapy | Motor Neurons - pathology | Intercellular Signaling Peptides and Proteins - physiology | Genetic Variation | Sweden | Lymphokines - genetics | Spinal Cord Ischemia - pathology | Female | Amyotrophic Lateral Sclerosis - etiology | Cell Death - drug effects | Endothelial Growth Factors - therapeutic use | Child | Ischemia - pathology | Lymphokines - therapeutic use | Motor Neurons - drug effects | Paralysis - etiology | Endothelial Growth Factors - physiology | Amyotrophic Lateral Sclerosis - genetics | Lymphokines - physiology | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Mice, Knockout | Amyotrophic Lateral Sclerosis - pathology | Animals | Endothelial Growth Factors - genetics | Alleles | Aged | Intercellular Signaling Peptides and Proteins - therapeutic use | Mice | Motor neurons | Physiological aspects | Amyotrophic lateral sclerosis | Genetic aspects | Diagnosis | Research | Vascular endothelial growth factor | Risk factors | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2003, Volume 299, Issue 5608, pp. 890 - 893
The vascular endothelium was once thought to function primarily in nutrient and oxygen delivery, but recent evidence suggests that it may play a broader role... 
Cell growth | Hepatocytes | Liver | Medical treatment | Stem cells | Agonists | Reports | CHO cells | Endothelial cells | Endothelium | Necrosis | MIGRATION | CELLS | GROWTH-FACTOR VEGF | TYROSINE KINASE | REGENERATION | MULTIDISCIPLINARY SCIENCES | KDR | FLT-1 VEGFR-1 | RECEPTOR | BINDING | MITOGEN | Endothelium, Vascular - cytology | Up-Regulation | Endothelial Growth Factors - metabolism | Liver - pathology | Vascular Endothelial Growth Factors | Coculture Techniques | Humans | Liver Diseases - pathology | Endothelial Growth Factors - pharmacology | Hepatocyte Growth Factor - pharmacology | RNA, Messenger - metabolism | Growth Substances - genetics | Hepatocyte Growth Factor - genetics | Lymphokines - metabolism | Signal Transduction | Liver Diseases - prevention & control | Hepatocyte Growth Factor - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Mice, Nude | Liver - physiology | Liver - cytology | Mice | Mutation | Vascular Endothelial Growth Factor A | Mitosis | Hepatocytes - pathology | Endothelium, Vascular - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Hepatocytes - cytology | Lymphokines - genetics | Cell Division | Lymphokines - pharmacology | Hepatocytes - physiology | CHO Cells | Cricetinae | Liver Regeneration | Paracrine Communication | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | DNA Replication | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Carbon Tetrachloride - toxicity | Liver - blood supply | Animals | Endothelial Growth Factors - genetics | Chemical and Drug Induced Liver Injury | Liver Diseases - metabolism | Neovascularization, Physiologic | Growth Substances - metabolism | Observations | Vascular endothelial growth factor | Medical disorders | Cells | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 01/2001, Volume 28, Issue 2, pp. 131 - 138