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1. Full Text VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
by Tammela, Tuomas and Zarkada, Georgia and Nurmi, Harri and Jakobsson, Lars and Heinolainen, Krista and Tvorogov, Denis and Zheng, Wei and Franco, Claudio A and Murtomäki, Aino and Aranda, Evelyn and Miura, Naoyuki and Ylä-Herttuala, Seppo and Fruttiger, Marcus and Mäkinen, Taija and Eichmann, Anne and Pollard, Jeffrey W and Gerhardt, Holger and Alitalo, Kari
Nature cell biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1202 - 1213
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Receptors, Notch - antagonists & inhibitors | Transfection | RNA Interference | Time Factors | Forkhead Transcription Factors - metabolism | Vascular Endothelial Growth Factor D - genetics | Phosphatidylinositol 3-Kinase - metabolism | Vascular Endothelial Growth Factor Receptor-3 - deficiency | Transduction, Genetic | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Rhombencephalon - blood supply | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Forkhead Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Mice, Knockout | Antibodies - pharmacology | Macrophages - metabolism | Vascular Endothelial Growth Factor D - metabolism | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Vascular Endothelial Growth Factor C - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Vascular Endothelial Growth Factor B - genetics | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial Cells - drug effects | Physiological aspects | Blood vessels | Cellular signal transduction | Growth factor receptors | Research | Vascular endothelial growth factor | Index Medicus | Medicin och hälsovetenskap
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2. Full Text Impaired Angiogenesis After Hindlimb Ischemia in Type 2 Diabetes Mellitus: Differential Regulation of Vascular Endothelial Growth Factor Receptor 1 and Soluble Vascular Endothelial Growth Factor Receptor 1
by Hazarika, Surovi and Dokun, Ayotunde O and Li, Yongjun and Popel, Aleksander S and Kontos, Christopher D and Annex, Brian H
Circulation research, ISSN 0009-7330, 10/2007, Volume 101, Issue 9, pp. 948 - 956
Vascular disease | Growth factors | Nitric oxide | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Diabetes. Impaired glucose tolerance | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Vertebrates: cardiovascular system | Endocrine pancreas. Apud cells (diseases) | Male | Vascular Endothelial Growth Factor A - metabolism | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Neovascularization, Pathologic - etiology | Diabetic Angiopathies - physiopathology | Ischemia - complications | Gene Expression - physiology | Up-Regulation - physiology | Diabetic Angiopathies - complications | Neovascularization, Pathologic - physiopathology | Diabetes Mellitus, Type 2 - complications | Disease Models, Animal | Vascular Endothelial Growth Factor Receptor-1 - genetics | Diabetic Angiopathies - metabolism | Mice, Inbred C57BL | Solubility | Ischemia - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Ischemia - physiopathology | Animals | Diabetes Mellitus, Type 2 - physiopathology | Hindlimb - blood supply | Signal Transduction - physiology | Mice | Neovascularization, Pathologic - metabolism | Nitric Oxide - metabolism | Regional Blood Flow - physiology | Index Medicus
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3. Full Text Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): A dual receptor antagonism
by Goyal, Atul and Pal, Nutan and Concannon, Matthew and Paul, Matthew and Doran, Mike and Poluzzi, Chiara and Sekiguchi, Kiyotoshi and Whitelock, John M and Neill, Thomas and Iozzo, Renato V
The Journal of biological chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 29, pp. 25947 - 25962
Transcription, Genetic - drug effects | Vascular Endothelial Growth Factor A - biosynthesis | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Humans | Angiostatic Proteins - pharmacology | Peptide Fragments - pharmacology | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Vascular Endothelial Growth Factor A - pharmacology | Heparan Sulfate Proteoglycans - chemistry | Protein Structure, Tertiary | Cell Line | Peptide Fragments - metabolism | Endothelial Cells - metabolism | Angiostatic Proteins - chemistry | Rats | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Down-Regulation - drug effects | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Protein Transport | Peptide Fragments - chemistry | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Heparan Sulfate Proteoglycans - metabolism | Integrin alpha2beta1 - antagonists & inhibitors | Protein Binding | Integrin alpha2beta1 - metabolism | Angiostatic Proteins - metabolism | Endothelial Cells - drug effects | Heparan Sulfate Proteoglycans - pharmacology | Index Medicus | Proteoglycan Structure | VEGFR2 | Basement Membrane | Perlecan | Heparan Sulfate | Glycobiology and Extracellular Matrices | Cell Surface Receptor | α2β1 Integrin | Protein-Protein Interactions | Endorepellin | Heparan Sulfate Proteoglycan
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4. Full Text Vascular endothelial‐cadherin stimulates syndecan‐1‐coupled insulin‐like growth factor‐1 receptor and cross‐talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis
by Rapraeger, Alan C and Ell, Brian J and Roy, Madhuchhanda and Li, Xuehui and Morrison, Orrianne R and Thomas, Grant M and Beauvais, DeannaLee M
The FEBS journal, ISSN 1742-464X, 05/2013, Volume 280, Issue 10, pp. 2194 - 2206
scratch wound | aortic ring | blocking antibodies | synstatin | Human Umbilical Vein Endothelial Cells | Neovascularization, Physiologic - drug effects | Phosphorylation | Antibodies - metabolism | Cadherins - metabolism | Humans | Aorta - metabolism | Ternary Complex Factors - metabolism | Integrin alphaVbeta3 - metabolism | Antigens, CD - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Receptor Cross-Talk | Syndecan-1 - metabolism | Endothelial Cells - metabolism | Aorta - drug effects | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Cell Adhesion | Peptides - pharmacology | Protein Interaction Mapping | Collagen - metabolism | Animals | Receptors, Somatomedin - metabolism | Protein Binding | Cadherins - antagonists & inhibitors | Mice | Receptors, Somatomedin - antagonists & inhibitors | Cell Movement | Endothelial Cells - drug effects | Index Medicus
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5. Full Text Simultaneous blockade of programmed death 1 and vascular endothelial growth factor receptor 2 (VEGFR2) induces synergistic anti‐tumour effect in vivo
by Yasuda, S and Sho, M and Yamato, I and Yoshiji, H and Wakatsuki, K and Nishiwada, S and Yagita, H and Nakajima, Y
Clinical and experimental immunology, ISSN 0009-9104, 06/2013, Volume 172, Issue 3, pp. 500 - 506
VEGFR2 | anti‐angiogenesis | PD‐1 | immune checkpoint | anti‐tumour immunity | Anti-tumour immunity | Immune checkpoint | Anti-angiogenesis | PD-1 | Life Sciences & Biomedicine | Immunology | Science & Technology | Colonic Neoplasms - therapy | Colonic Neoplasms - blood supply | Adenocarcinoma - immunology | Humans | Neoplasms, Experimental - therapy | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - immunology | Adenocarcinoma - blood supply | Drug Synergism | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Angiogenesis Inhibitors - administration & dosage | Animals | Adenocarcinoma - therapy | Antibodies, Monoclonal - administration & dosage | Colonic Neoplasms - immunology | Neoplasms, Experimental - immunology | Cell Line, Tumor | Female | Neovascularization, Pathologic - prevention & control | Mice | Mice, Inbred BALB C | Programmed Cell Death 1 Receptor - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Neoplasms, Experimental - blood supply | Monoclonal antibodies | Neovascularization | Endothelial growth factors | Tumors | Medical research | Vascular endothelial growth factor | Index Medicus | anti-tumour immunity | Original | anti-angiogenesis
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6. Full Text Vascular endothelial growth factor receptor 2 as a marker for malignant vascular tumors and mesothelioma: An immunohistochemical study of 262 vascular endothelial and 1640 nonvascular tumors
by Miettinen, Markku and Rikala, Maarit-Sarlomo and Rys, Janusz and Lasota, Jerzy and Wang, Zeng-Feng
The American journal of surgical pathology, ISSN 0147-5185, 04/2012, Volume 36, Issue 4, pp. 629 - 639
VEGFR2 | Kaposi sarcoma | endothelial cell | angiosarcoma | fetal tis-sue | malignant meso-thelioma | adult tissue | mesothelial cell | Pathology | Life Sciences & Biomedicine | Surgery | Science & Technology | Immunohistochemistry | Neoplasms - metabolism | Vascular Neoplasms - surgery | Mesothelioma - pathology | Neoplasms - surgery | Tissue Array Analysis | Humans | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Male | Gestational Age | Embryo, Mammalian - metabolism | Mesothelioma - metabolism | Mesothelioma - surgery | Endothelium, Vascular - metabolism | Biomarkers, Tumor - metabolism | Vascular Neoplasms - pathology | Endothelium, Vascular - pathology | Female | Vascular Neoplasms - metabolism | Neoplasms - pathology | Endothelium, Vascular - embryology | Index Medicus | malignant mesothelioma | fetal tissue
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7. Full Text Endorepellin laminin‐like globular 1/2 domains bind Ig3–5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro‐angiogenic signaling by VEGFA in endothelial cells
by Willis, Chris D and Poluzzi, Chiara and Mongiat, Maurizio and Iozzo, Renato V
The FEBS journal, ISSN 1742-464X, 05/2013, Volume 280, Issue 10, pp. 2271 - 2284
VEGF receptor 2 | perlecan | endorepellin | angiogenesis | VEGFA | Phosphorylation | Allosteric Regulation | Humans | Transcriptional Activation | Actins - metabolism | Peptide Fragments - pharmacology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Transfection | HEK293 Cells | Binding Sites | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Actin Cytoskeleton | Promoter Regions, Genetic | Peptide Fragments - metabolism | Signal Transduction | Endothelial Cells - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Recombinant Proteins - genetics | Collagen - metabolism | Tyrosine - metabolism | Angiogenesis Inhibitors - metabolism | Heparan Sulfate Proteoglycans - metabolism | Protein Binding | Integrin alpha2beta1 - metabolism | Neovascularization, Physiologic | Cell Movement | Heparan Sulfate Proteoglycans - pharmacology | Proteins | Laminin | Vascular endothelial growth factor | Integrins | Signal transduction | Angiogenesis | Cellular biology | Binding sites | Index Medicus
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8. Full Text Prognostic value of vascular endothelial growth factor (VEGF), VEGF receptor 2, platelet-derived growth factor-β (PDGF-β), and PDGF-β receptor expression in papillary renal cell carcinoma
by Kim, Myong and Sohn, Mooyoung and Shim, Myungsun and Choi, Seung-Kwon and Park, Myungchan and Kim, Eunna and Go, Heounjeong and Park, Yangsoon and Cho, Yong Mee and Ro, Jae Y and Jeong, In Gab and Song, Cheryn and Hong, Jun Hyuk and Kim, Choung-Soo and Ahn, Hanjong
Human pathology, ISSN 0046-8177, 2016, Volume 61, pp. 78 - 89
Pathology | Treatment response | Prognosis | Platelet-derived growth factor | Papillary renal cell carcinoma | Vascular endothelial growth factor | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Multivariate Analysis | Proto-Oncogene Proteins c-sis - analysis | Carcinoma, Renal Cell - chemistry | Humans | Middle Aged | Male | Kidney Neoplasms - chemistry | Molecular Targeted Therapy | Nephrectomy | Time Factors | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Retrospective Studies | Chemotherapy, Adjuvant | Kidney Neoplasms - therapy | Receptor, Platelet-Derived Growth Factor beta - analysis | Vascular Endothelial Growth Factor Receptor-2 - analysis | Biomarkers, Tumor - analysis | Carcinoma, Renal Cell - pathology | Kaplan-Meier Estimate | Proportional Hazards Models | Logistic Models | Treatment Outcome | Vascular Endothelial Growth Factor A - analysis | Chi-Square Distribution | Kidney Neoplasms - mortality | Carcinoma, Renal Cell - mortality | Disease-Free Survival | Biopsy | Carcinoma, Renal Cell - therapy | Kidney Neoplasms - pathology | Aged | Index Medicus
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