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Journal Article
Journal Article
Steroids, ISSN 0039-128X, 05/2015, Volume 97, pp. 2 - 7
•We review isolation and structural elucidation of thapsigargin.•We review medicinal chemistry of thapsigargin.•We review the effect of thapsigargin on the... 
Thapsigargin | Prodrug | Sarco/endoplasmic reticulum (SERCA) | Targeting drugs | Prostate specific antigen (PSA) | Prostate specific membrane antigen (PSMA) | ANALOGS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SARCOPLASMIC-RETICULUM | TRILOBOLIDE | CA2+-ATPASE | PROSTATE-CANCER CELLS | CALCIUM | ENDOCRINOLOGY & METABOLISM | BINDING-SITE | LIBERATING SESQUITERPENE LACTONES | THAPSIA-GARGANICA L | Apoptosis - drug effects | Humans | Soft Tissue Neoplasms - drug therapy | Male | Prodrugs - isolation & purification | Prodrugs - chemistry | Neovascularization, Pathologic - pathology | Enzyme Inhibitors - chemistry | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Apiaceae - chemistry | Molecular Structure | Prostatic Neoplasms - drug therapy | Thapsigargin - chemistry | Prostatic Neoplasms - pathology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Enzyme Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Enzyme Inhibitors - isolation & purification | Thapsigargin - isolation & purification | Animals | Neovascularization, Pathologic - drug therapy | Soft Tissue Neoplasms - pathology | Thapsigargin - pharmacology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Prodrugs - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Tumors | endoplasmic reticulum (SERCA) | Sarco
Journal Article