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Clinical & Experimental Immunology, ISSN 0009-9104, 09/2015, Volume 181, Issue 3, pp. 518 - 527
The interaction between neutrophils and activation of alternative complement pathway plays a pivotal role in the pathogenesis of anti‐neutrophil cytoplasmic... 
neutrophil extracellular traps | complement | ANCA | vasculitis | alternative complement pathway | Complement | Vasculitis | Alternative complement pathway | Neutrophil extracellular traps | GLOMERULONEPHRITIS | ANTIBODY-ASSOCIATED VASCULITIS | PROTEIN C3 | DENDRITIC CELLS | DEPOSITION | IMMUNOLOGY | INHIBITION | DISEASE | ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES | GENERATION | Neutrophils - cytology | Complement Membrane Attack Complex - metabolism | Extracellular Traps - metabolism | Humans | Serum - drug effects | Complement C5a - metabolism | Immunoblotting | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood | Complement Membrane Attack Complex - immunology | Complement Activation - immunology | Antibodies, Antineutrophil Cytoplasmic - immunology | Serum - immunology | Antibodies, Antineutrophil Cytoplasmic - metabolism | Complement C3b - metabolism | Extracellular Traps - immunology | Complement Factor B - metabolism | Properdin - immunology | Extracellular Traps - drug effects | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - metabolism | Complement C3a - metabolism | Neutrophils - metabolism | Complement Activation - drug effects | Cells, Cultured | Neutrophils - immunology | Hot Temperature | Egtazic Acid - immunology | Microscopy, Confocal | Egtazic Acid - pharmacology | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology | Complement Pathway, Alternative - drug effects | Complement Pathway, Alternative - immunology | Complement Factor B - immunology | Complement C3a - immunology | Complement C5a - immunology | Complement C3b - immunology | Properdin - metabolism | Index Medicus | Translational
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7562, pp. 612 - 616
The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular... 
RESPONSES | INTERFERON | PREDICTS PROGNOSIS | ACUTE HEPATITIS-C | MULTIDISCIPLINARY SCIENCES | DISEASE | BIOLOGY | GENE-EXPRESSION | ACTIVITY INDEX | SIGNATURE | Inflammation - pathology | CD8-Positive T-Lymphocytes - pathology | Humans | Inflammatory Bowel Diseases - immunology | Transcriptome | Autoimmunity - genetics | Infection - virology | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - pathology | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Autoimmunity - immunology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Lupus Erythematosus, Systemic - immunology | CD8-Positive T-Lymphocytes - metabolism | Receptors, Antigen, T-Cell - immunology | Autoimmune Diseases - pathology | Receptors, Interleukin-7 - immunology | Receptors, Interleukin-7 - metabolism | Infection - immunology | Autoimmune Diseases - immunology | CD4-Positive T-Lymphocytes - metabolism | Inflammation - virology | Programmed Cell Death 1 Receptor - metabolism | Inflammation - immunology | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics | Infection - genetics | Phenotype | Animals | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology | Infection - pathology | Lupus Erythematosus, Systemic - genetics | Mice | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Lupus Erythematosus, Systemic - pathology | CD2 Antigens - immunology | Viral antibodies | Antibodies | Interferon | T cells | Health aspects | Analysis | Hepatitis | Disease | Lymphocytes | T cell receptors | Infections | Genetic engineering | Regression analysis | Gene expression | Viral infections | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 12/2007, Volume 110, Issue 12, pp. 4086 - 4095
Proteinase 3 (PR3), a serine proteinase contained in neutrophil azurophilic granules, is considered a risk factor for vasculitides and rheumatoid arthritis... 
MEMBRANE PROTEINASE-3 | IN-VITRO | TYROSINE PHOSPHORYLATION | SECRETORY VESICLES | DOWN-REGULATION | ANNEXIN-V | ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES | SERINE-PROTEASE | TNF-ALPHA | HEMATOLOGY | PLASMA-MEMBRANE | Neutrophil Activation - genetics | RNA, Small Interfering - genetics | Humans | Apoptosis - genetics | Phospholipid Transfer Proteins - immunology | Phagocytosis - genetics | Myeloblastin - genetics | Antigens, CD - genetics | Antibodies, Antineutrophil Cytoplasmic - immunology | Antigens, CD - metabolism | Pancreatic Elastase - immunology | Protein Transport - immunology | Secretory Vesicles - immunology | Secretory Vesicles - genetics | Vasculitis - genetics | Pancreatic Elastase - genetics | Neutrophils - metabolism | Granulomatosis with Polyangiitis - enzymology | Neutrophil Activation - immunology | Neutrophils - enzymology | Risk Factors | Rats | Arthritis, Rheumatoid - enzymology | Mast Cells - enzymology | Protein Transport - genetics | Macrophages - enzymology | Arthritis, Rheumatoid - genetics | Phospholipid Transfer Proteins - genetics | Cell Membrane - immunology | Antigens, CD - immunology | Cell Membrane - genetics | Mutation - immunology | Phospholipid Transfer Proteins - metabolism | Vasculitis - immunology | Granulomatosis with Polyangiitis - genetics | Antibodies, Antineutrophil Cytoplasmic - metabolism | RNA, Small Interfering - immunology | Granulomatosis with Polyangiitis - immunology | Secretory Vesicles - enzymology | Macrophages - immunology | Myeloblastin - metabolism | Cell Line | Mast Cells - immunology | Peroxidase - immunology | Myeloblastin - immunology | Neutrophils - immunology | Phagocytosis - immunology | Pancreatic Elastase - metabolism | Cell Membrane - enzymology | Animals | Apoptosis - immunology | Vasculitis - enzymology | Peroxidase - genetics | Gene Expression Regulation, Enzymologic - immunology | Arthritis, Rheumatoid - immunology | Peroxidase - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 05/2015, Volume 67, Issue 5, pp. 1353 - 1360
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 11/2009, Volume 9, Issue 11, pp. 2532 - 2541
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2012, Volume 122, Issue 6, pp. 1973 - 1990
EC activation and dysfunction have been linked to a variety of vascular inflammatory disease states. The function of microRNAs (miRNAs) in vascular EC... 
CELL-ADHESION MOLECULE-1 | TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | DEPENDENT INDUCTION | LEUKOCYTE RECRUITMENT | HUMAN-ENDOTHELIAL-CELLS | ACUTE MYELOID-LEUKEMIA | PROGNOSTIC-SIGNIFICANCE | EXPRESSION PROFILES | SIGNAL-TRANSDUCTION PATHWAY | alpha Karyopherins - metabolism | Endotoxemia - therapy | Leukocytes - pathology | Vasculitis - metabolism | Acute Lung Injury - therapy | Endotoxemia - genetics | Humans | NF-kappa B - immunology | Critical Illness | Acute Lung Injury - genetics | MicroRNAs - metabolism | NF-kappa B - metabolism | Endotoxemia - pathology | Vasculitis - immunology | Leukocytes - immunology | Vasculitis - genetics | alpha Karyopherins - immunology | E-Selectin - genetics | Endotoxemia - immunology | Vascular Cell Adhesion Molecule-1 - genetics | Acute Lung Injury - metabolism | Vascular Cell Adhesion Molecule-1 - immunology | Vasculitis - therapy | Lipopolysaccharides - toxicity | Endothelial Cells - metabolism | E-Selectin - metabolism | E-Selectin - immunology | MicroRNAs - immunology | Acute Lung Injury - pathology | Endothelial Cells - immunology | Animals | NF-kappa B - genetics | alpha Karyopherins - genetics | Acute Lung Injury - immunology | Mice | MicroRNAs - genetics | Endothelial Cells - pathology | Endotoxemia - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Leukocytes - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2010, Volume 16, Issue 5, pp. 586 - 591
Journal Article
Circulation, ISSN 0009-7322, 08/2013, Volume 128, Issue 6, pp. 632 - 642
BACKGROUND—The molecular basis for the focal nature of atherosclerotic lesions is poorly understood. Here, we explored whether disturbed flow patterns activate... 
atherosclerosis | shear stress | NLRP3 protein, human | sterol regulatory element binding proteins | endothelial cell | NLRP3 protein | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | CHRONIC GRANULOMATOUS-DISEASE | INTERLEUKIN-1-BETA | RECEPTOR ANTAGONIST | HEART-DISEASE | SHEAR-STRESS | REGIONS | PERIPHERAL VASCULAR DISEASE | MICE | CHOLESTEROL HOMEOSTASIS | human | UP-REGULATION | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Vasculitis - metabolism | Inflammasomes - metabolism | Membrane Glycoproteins - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Stress, Mechanical | Male | MicroRNAs - metabolism | Vasculitis - immunology | Vasculitis - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Membrane Glycoproteins - immunology | Sterol Regulatory Element Binding Protein 2 - metabolism | Carrier Proteins - immunology | Atherosclerosis - immunology | Endothelial Cells - metabolism | Mice, Transgenic | MicroRNAs - immunology | NADPH Oxidase 2 | Atherosclerosis - metabolism | Endothelial Cells - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Carrier Proteins - metabolism | Apolipoproteins E - genetics | Inflammasomes - immunology | Mice | Sterol Regulatory Element Binding Protein 2 - immunology | Hemodynamics - immunology | Sterols | Atherosclerosis | Physiological aspects | Disease susceptibility | Genetic aspects | Research | Hemodynamics | Binding proteins | Endothelium | Index Medicus | Abridged Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2013, Volume 33, Issue 8, pp. 1986 - 1993
Journal Article
Clinical Immunology, ISSN 1521-6616, 2016, Volume 185, pp. 100 - 108
Abstract Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that can affect multiple end organs. Kidney and brain are two of the organs... 
Allergy and Immunology | Lupus nephritis | Neuropsychiatric lupus | Macrophages | SLE | CSF-1R | DEPRESSION | APOPTOSIS | ACTIVATION | MANIFESTATION | IMMUNOLOGY | STIMULATING FACTOR-I | ERYTHEMATOSUS | WEAK INDUCER | NEPHRITIS | CELL | Immunoglobulin G - blood | Kidney - pathology | Antibodies, Antinuclear - immunology | Depression - pathology | Anisoles - pharmacology | Kidney - immunology | Lupus Vasculitis, Central Nervous System - immunology | Complement System Proteins - immunology | Lupus Vasculitis, Central Nervous System - pathology | Lupus Nephritis - drug therapy | Lupus Vasculitis, Central Nervous System - drug therapy | Lupus Vasculitis, Central Nervous System - psychology | Depression - drug therapy | Mice, Inbred MRL lpr | Immunoglobulin G - immunology | Chromatin - immunology | Female | Macrophages - immunology | Cytokines - immunology | Disease Models, Animal | Locomotion - drug effects | Lupus Nephritis - pathology | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Kidney - drug effects | Lupus Nephritis - immunology | Pyrimidines - pharmacology | Lupus Nephritis - psychology | Brain - drug effects | Animals | Spatial Memory - drug effects | Pyrimidines - therapeutic use | Macrophages - drug effects | Anisoles - therapeutic use | Brain - immunology | Depression - immunology | Lupus | Autoimmunity | Autoantibodies | Analysis | Depression, Mental | Kidney diseases | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 05/2008, Volume 19, Issue 5, pp. 973 - 984
Anti-myeloperoxidase (anti-MPO) antibodies have been implicated in the pathogenesis of small-vessel vasculitis, but the molecular mechanisms by which these...