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Journal of translational medicine, ISSN 1479-5876, 2019, Volume 17, Issue 1, pp. 127 - 14
...) especially in those with HF at baseline. These might indicate a potent direct cardioprotective effect, which is currently incompletely understood... 
Sodium-glucose cotransporter-2 inhibitor | Cardioprotection | Canagliflozin | Myocardial ischemia-reperfusion injury | MEDICINE, RESEARCH & EXPERIMENTAL | CARDIOVASCULAR OUTCOMES | SGLT2 INHIBITORS | PHOSPHORYLATION | KINASE | CARDIOMYOCYTES | HEART | PRESSURE | AMPK | ARTERY | Apoptosis - drug effects | Canagliflozin - pharmacology | Myocardial Reperfusion Injury - complications | Systole - drug effects | Male | Aldehydes - metabolism | Liver - physiopathology | Cardiotonic Agents - therapeutic use | Liver - drug effects | Canagliflozin - therapeutic use | Diastole - drug effects | Aorta - physiopathology | Myocardial Reperfusion Injury - drug therapy | Phosphorylation - drug effects | Kidney - physiopathology | Biomarkers - metabolism | Endothelium - pathology | Glycosuria - physiopathology | Kidney - drug effects | Aorta - drug effects | Ventricular Function, Left - drug effects | Cardiotonic Agents - pharmacology | Rats, Sprague-Dawley | Glycosuria - complications | Myocardial Reperfusion Injury - physiopathology | Endothelium - physiopathology | Aorta - pathology | Endothelium - drug effects | Animals | Signal Transduction - drug effects | Oxidative Stress - drug effects | Vasodilation - drug effects | Blood Glucose - metabolism | Myocardial Reperfusion Injury - prevention & control | Nitrosative Stress - drug effects | Heart failure | Diabetics | Rats as laboratory animals | Analysis | Clinical trials | Research | Drug therapy | Health aspects | Occlusion | Myocardial infarction | Heart | Oxidative stress | Phosphorylation | Drug delivery systems | Intravenous administration | Heart attacks | Bax protein | 4-Hydroxynonenal | Bcl-2 protein | AKT protein | Myocardial ischemia | mRNA | Size determination | Kinases | Vasodilation | Proteins | Reperfusion | Ischemia | Rodents | Calcium-binding protein | Aorta | Heart diseases | Injury analysis | Medical research | Adenosine monophosphate | AMP | Diabetes mellitus | Coronary artery | Gene expression | Nitric-oxide synthase | Endothelium | Sodium | Protein kinase | Adenosine kinase | Nitric oxide | Ventricle | Diabetes | Laboratory animals | Apoptosis | Myocardial ischemia–reperfusion injury | Sodium–glucose cotransporter-2 inhibitor
Journal Article
Nature medicine, ISSN 1546-170X, 2011, Volume 17, Issue 7, pp. 822 - 829
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 2015, Volume 308, Issue 9, pp. H1020 - H1029
... beneficial effect on glucose homeostasis. The cardiovascular and metabolic effects of the sEH inhibitor trans-4-[4... 
Insulin resistance | Cardiac function | Soluble epoxide hydrolase | Endothelium | endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | HEART-FAILURE | RATS | MECHANISMS | soluble epoxide hydrolase | DIABETES-MELLITUS | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | cardiac function | DYSFUNCTION | HYPERTENSION | ARTERY | insulin resistance | EXPRESSION | Obesity - drug therapy | Coronary Vessels - physiopathology | Endothelium, Vascular - drug effects | Heart Diseases - prevention & control | Male | Endothelium, Vascular - enzymology | Obesity - blood | Dose-Response Relationship, Drug | Glyburide - pharmacology | Time Factors | Lipids - blood | Urea - analogs & derivatives | Inflammation Mediators - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Coronary Vessels - enzymology | Vasodilator Agents - pharmacology | Heart Diseases - physiopathology | Obesity - complications | Ventricular Function, Left - drug effects | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Insulin Resistance | Obesity - physiopathology | Heart Diseases - enzymology | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Heart Diseases - etiology | Animals | Eicosanoids - metabolism | Benzoates - pharmacology | Mice | Obesity - enzymology | Epoxide Hydrolases - metabolism | Vasodilation - drug effects | Blood Glucose - metabolism | Nitric Oxide - metabolism | Epoxide Hydrolases - antagonists & inhibitors | Ventricular Remodeling - drug effects | Urea - pharmacology | Prevention | Obesity | Enzymes | Physiological aspects | Hydrolases | Research | Heart diseases | Life Sciences | Call for Papers
Journal Article
Circulation research, ISSN 0009-7330, 02/2007, Volume 100, Issue 3, pp. 342 - 353
A large body of evidence has accrued indicating that voltage-gated Ca channel subtypes, including L-, T-, N-, and P/Q-type, are present within renal vascular... 
Renal microcirculation | Mibefradil | channels | Afferent arteriole | channel blockers | Efferent arteriole | Renal disease | Voltage-dependent Ca | Efonidipine | Ca | Ca2+ channel blockers | N-TYPE | CARDIAC & CARDIOVASCULAR SYSTEMS | EFFERENT ARTERIOLES | efonidipine | SPONTANEOUSLY HYPERTENSIVE-RATS | RHO-KINASE INHIBITOR | renal microcirculation | ANGIOTENSIN-II | T-TYPE | renal disease | mibefradil | DEPENDENT CALCIUM-CHANNELS | CARDIAC L-TYPE | RENAL MICROVASCULAR CONSTRICTION | efferent arteriole | voltage-dependent Ca2+ channels | PERIPHERAL VASCULAR DISEASE | afferent arteriole | HEMATOLOGY | IN-VIVO VISUALIZATION | Arterioles - physiology | Kidney - physiology | Protein Subunits | Antihypertensive Agents - pharmacology | Kidney - blood supply | Humans | Calcium Channel Blockers - therapeutic use | Hypertension - drug therapy | Antihypertensive Agents - classification | Calcium Channels - physiology | Calcium Channels, T-Type - chemistry | Neurotransmitter Agents - secretion | Calcium Channels - drug effects | Calcium Channels, N-Type - drug effects | Cardiovascular Diseases - physiopathology | Kidney - drug effects | Calcium Channels - classification | Rats | Calcium Channels, L-Type - physiology | Antihypertensive Agents - therapeutic use | Arterioles - drug effects | Disease Progression | Antihypertensive Agents - adverse effects | Mice, Knockout | Calcium Signaling - drug effects | Diabetes Mellitus - physiopathology | Models, Biological | Calcium Channels - chemistry | Calcium Channels, T-Type - drug effects | Mice | Vasodilation - drug effects | Hydronephrosis - physiopathology | Calcium Channel Blockers - adverse effects | Calcium Signaling - physiology | Cardiovascular Diseases - drug therapy | Renal Circulation - physiology | Microcirculation - drug effects | Microcirculation - physiology | Renal Circulation - drug effects | Blood Pressure - drug effects | Calcium Channels, L-Type - chemistry | Kidney Diseases - metabolism | Calcium Channels, T-Type - physiology | Renin - secretion | Aldosterone - physiology | Kidney Diseases - drug therapy | Renin-Angiotensin System - physiology | Calcium Channel Blockers - pharmacology | Hypertension - physiopathology | Animals | Calcium Channels, L-Type - drug effects | Calcium Channels, N-Type - physiology | Calcium Channels, N-Type - chemistry
Journal Article
European journal of pharmacology, ISSN 0014-2999, 2011, Volume 668, Issue 3, pp. 497 - 506
.... In this study we sought to determine the effect of Ilepatril treatment of high fat fed/low dose streptozotocin-diabetic rats, a model for type 2 diabetes, on vascular and neural complications... 
Diabetic neuropathy | Diabetes | Neutral endopeptidase | Vasopeptidase inhibitor | Angiotensin converting enzyme | Vascular relaxation | IMPROVES INSULIN SENSITIVITY | ENDOTHELIAL DYSFUNCTION | VASOPEPTIDASE INHIBITOR OMAPATRILAT | INCREASED ENERGY-EXPENDITURE | ANGIOTENSIN-CONVERTING-ENZYME | NEUTRAL ENDOPEPTIDASE ACTIVITY | SKELETAL-MUSCLE | NERVE CONDUCTION-VELOCITY | GLUCOSE-TRANSPORT ACTIVITY | PHARMACOLOGY & PHARMACY | ENDONEURIAL BLOOD-FLOW | Blood Vessels - metabolism | Nervous System - metabolism | Thiobarbiturates - metabolism | Body Weight - drug effects | Male | Tyrosine - analogs & derivatives | Nervous System - pathology | Arterioles - physiopathology | Muscle, Skeletal - drug effects | Nociception - drug effects | Diabetes Mellitus, Experimental - complications | Nerve Fibers - pathology | Nerve Fibers - metabolism | Diabetes Complications - physiopathology | Diabetes Complications - metabolism | Enzyme Inhibitors - pharmacology | Lens, Crystalline - metabolism | Rats | Diabetes Complications - drug therapy | Arterioles - drug effects | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Tyrosine - metabolism | Heterocyclic Compounds, 3-Ring - therapeutic use | Vasodilation - drug effects | Blood Glucose - metabolism | Lens, Crystalline - drug effects | Adipose Tissue - drug effects | Carbohydrate Metabolism - drug effects | Glutathione - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Blood Vessels - pathology | Diet, High-Fat - adverse effects | Sciatic Nerve - physiopathology | Insulin - blood | Nervous System - physiopathology | Blood Vessels - physiopathology | Dose-Response Relationship, Drug | Sciatic Nerve - metabolism | Leptin - blood | Superoxides - metabolism | Sciatic Nerve - drug effects | Diabetes Complications - pathology | Glucose Tolerance Test | Nerve Fibers - drug effects | Organ Size - drug effects | Animals | Nervous System - drug effects | Blood Vessels - drug effects | Muscle, Skeletal - pathology | Complications and side effects | Obesity | Insulin resistance | Angiotensin | Animal models | Arterioles | Streptozocin | Diabetes mellitus | Insulin | Fibers | High fat diet | Calcitonin gene-related peptide | Nerve conduction | Peptidyl-dipeptidase A | Acetylcholine | Neprilysin | Sciatic nerve | vasopeptidase inhibitor | vascular relaxation | angiotensin converting enzyme | neutral endopeptidase | diabetic neuropathy | diabetes
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 8, p. e104020
Hypertension is considered as a low-grade inflammatory disease, with adaptive immunity being an important mediator of this pathology. TLR4 may have a role in... 
OXIDATIVE STRESS | ACTIVATION | IMMUNE-SYSTEM | ENDOTHELIAL DYSFUNCTION | RESISTANCE ARTERIES | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | SMOOTH-MUSCLE-CELLS | EXPRESSION | BLOOD-PRESSURE | Reactive Oxygen Species - metabolism | Rats, Wistar | NADPH Oxidases - metabolism | Endothelium, Vascular - drug effects | Male | Heart Rate - drug effects | Phenylephrine - pharmacology | Superoxides - metabolism | Blood Pressure - drug effects | Aorta - physiopathology | Hypertension - genetics | Toll-Like Receptor 4 - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Rats, Inbred SHR | Angiotensin II - pharmacology | Acetylcholine - pharmacology | Aorta - drug effects | Endothelium, Vascular - physiopathology | Toll-Like Receptor 4 - genetics | Antioxidants - pharmacology | Toll-Like Receptor 4 - metabolism | Vasoconstriction - drug effects | Hypertension - pathology | Hypertension - physiopathology | Aorta - pathology | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Cell Movement - drug effects | Muscle, Smooth, Vascular - pathology | Animals | Endothelium, Vascular - pathology | Cell Proliferation - drug effects | Oxidative Stress - drug effects | Vasodilation - drug effects | In Vitro Techniques | Potentiation | Oxidative stress | Reactive oxygen species | Biomedical research | Immunoglobulin G | Smooth muscle | Innate immunity | mRNA | Activation | Biochemistry | Immunity | Experiments | Contraction | NAD(P)H oxidase | Ethics | Renin | Catalase | Rodents | Atherosclerosis | Phenylephrine | Toll-like receptors | Aorta | Physiology | Blood pressure | Angiotensin II | Heart diseases | Hypertension | Heparan sulfate | Oxygen | Muscles | Rats | Superoxide | Inflammation | Adaptive immunity | TLR4 protein | Yang, Cindy | Endothelium | Heart rate | NAD | Pathology | Angiotensin | Acetylcholine | Cardiovascular diseases
Journal Article
Aging cell, ISSN 1474-9718, 2017, Volume 16, Issue 1, pp. 17 - 26
Journal Article
Journal of internal medicine, ISSN 0954-6820, 2016, Volume 279, Issue 4, pp. 315 - 336
Nitric oxide (NO) is generated endogenously by NO synthases to regulate a number of physiological processes including cardiovascular and metabolic functions. A... 
blood pressure | vasodilatation | ischaemia | nitric oxide | beetroot | Beetroot | Ischaemia | Vasodilatation | Blood pressure | Nitric oxide | NADPH OXIDASE | SODIUM-NITRITE | ENDOTHELIAL DYSFUNCTION | PULMONARY-HYPERTENSION | SPONTANEOUSLY HYPERTENSIVE-RAT | MITOCHONDRIAL COMPLEX I | DIETARY NITRATE | REDUCES BLOOD-PRESSURE | ISCHEMIA-REPERFUSION INJURY | MEDICINE, GENERAL & INTERNAL | OXIDE SYNTHASE | Nitric Oxide - biosynthesis | Cardiovascular Diseases - drug therapy | Cardiovascular Diseases - prevention & control | Humans | Reperfusion Injury - drug therapy | Nitrites - metabolism | Biological Availability | Metabolic Diseases - drug therapy | Cardiovascular System - drug effects | Myocardial Infarction - metabolism | Heart Failure - drug therapy | Nitrites - therapeutic use | Nitrates - metabolism | Nitrates - therapeutic use | Animals | Myocardial Infarction - drug therapy | Leukocytes - drug effects | Nitric Oxide Synthase - biosynthesis | Blood Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Metabolic Diseases - prevention & control | Platelet Activation - drug effects | Vasodilation - drug effects | Disease Models, Animal | Hypertension | Analysis | Atherosclerosis | Physiological aspects | Health aspects | Heart attack | Myocardial infarction | Reactive oxygen species | Animal models | Vegetables | Nitrites | Clinical trials | Cardiovascular disease | Nitrates | Vasodilation | Anions | Mitochondria | Reperfusion | Ischemia | Biocompatibility | Oxidation | Medical research | Diabetes mellitus | Lung diseases | Bioavailability | Substrates | Pulmonary artery | Biological activity | Arteriosclerosis | Infarction | Cardiovascular diseases | Metabolic disorders
Journal Article