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Nutrients, ISSN 2072-6643, 07/2018, Volume 10, Issue 7, p. 921
Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in the regulation of numerous vital biological functions, contributes... 
Hypertension | Obesity | Watermelon | Liver | Cardiovascular disease | Inflammation | Adipocytes | Endothelial function | Supplements | Enterocytes | Mitochondria | Interventions | Arginine | Nitric oxide | Flow mediated dilation | Therapeutics | Aging | Insulin resistance | Muscle | Diabetes | Immune cells | DEPENDENT DIABETES-MELLITUS | therapeutics | NITRIC-OXIDE SYNTHESIS | L-ARGININE SUPPLEMENTATION | PRESERVED EJECTION FRACTION | enterocytes | HUMAN SKELETAL-MUSCLE | NUTRITION & DIETETICS | arginine | inflammation | muscle | CULTURED ENDOTHELIAL-CELLS | MUSCLE PROTEIN ANABOLISM | watermelon | adipocytes | insulin resistance | obesity | endothelial function | cardiovascular disease | nitric oxide | ORAL L-CITRULLINE | liver | SPONTANEOUSLY HYPERTENSIVE-RATS | mitochondria | immune cells | CHAIN AMINO-ACIDS | supplements | interventions | aging | hypertension | diabetes | flow mediated dilation | Vasodilator Agents - therapeutic use | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Humans | Citrulline - metabolism | Metabolic Syndrome - metabolism | Antihypertensive Agents - metabolism | Diabetic Angiopathies - physiopathology | Vasodilator Agents - metabolism | Metabolic Syndrome - physiopathology | Hypertension - prevention & control | Metabolic Syndrome - immunology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Diabetic Angiopathies - prevention & control | Dietary Supplements - adverse effects | Vascular Stiffness | Sarcopenia - metabolism | Endothelium, Vascular - immunology | Hypoglycemic Agents - therapeutic use | Diabetic Angiopathies - metabolism | Sarcopenia - immunology | Endothelium, Vascular - physiopathology | Insulin Resistance | Metabolic Syndrome - therapy | Hypertension - immunology | Citrulline - therapeutic use | Antihypertensive Agents - therapeutic use | Evidence-Based Medicine | Citrulline - adverse effects | Hypertension - physiopathology | Antihypertensive Agents - adverse effects | Hypertension - metabolism | Antioxidants - therapeutic use | Sarcopenia - physiopathology | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Endothelium, Vascular - metabolism | Models, Biological | Sarcopenia - prevention & control | Diabetic Angiopathies - immunology | Antioxidants - adverse effects | Vasodilator Agents - adverse effects | Hypoglycemic Agents - adverse effects | Health | Dietary supplements | Muscles | Amino acids | Gastrointestinal tract | Bioavailability | Citrulline | Metabolism | Nitric-oxide synthase | Substrates | Urea | L-citrulline | Synthesis | Gastrointestinal system | Blood pressure | Adults | Supplementation | Age
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 2016, Volume 23, Issue 35, pp. 4027 - 4036
The enzyme xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism in the highest uricotelic primates. XOR is an enzyme with... 
Anticancer drugs | Antimicrobial drugs | Immunosuppressive drugs | Nitrovasodilators | Purine analogues | Xanthine oxidoreductase | CHEMISTRY, MEDICINAL | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDASE-ACTIVATED PRODRUG | CANCER | DEHYDROGENASE | 6-MERCAPTOPURINE | IN-VITRO | 6-DEOXYACYCLOVIR | REDUCTIVE ACTIVATION | ALDEHYDE OXIDASE | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | Xanthine Dehydrogenase - metabolism | Anti-Infective Agents - metabolism | Purines - metabolism | Humans | Benzoquinones - chemistry | Antineoplastic Agents - chemistry | Antineoplastic Agents - metabolism | Pharmaceutical Preparations - metabolism | Animals | Purines - chemistry | Anti-Infective Agents - chemistry | Vasodilator Agents - metabolism | Pharmaceutical Preparations - chemistry | Immunosuppressive Agents - metabolism | Vasodilator Agents - chemistry | Benzoquinones - metabolism | Immunosuppressive Agents - chemistry | Xanthine Dehydrogenase - chemistry | Drugs | Transcription | Toxicity | Oxidoreductase | Gout | Cytotoxicity | Nucleotides | Immunosuppressive agents | Metabolites | Post-translation | Drug metabolism | Primates | Drug interaction | Antiviral agents | Enzymes | Allopurinol | Quinone | Drug interactions | Tolbutamide | Radioactive half-life | Pharmacology | Bioavailability | Xanthine | Metabolism | Substrates | Inhibitors | Lysis | Catabolism | Nucleoside analogs
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 01/2013, Volume 24, Issue 2, pp. 229 - 242
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2009, Volume 296, Issue 5, pp. 1281 - 1288
The nitrite anion is an endogenous product of mammalian nitric oxide (NO) metabolism, a key intermediate in the nitrogen cycle in plants, and a constituent of... 
Nitrosothiols | Leukocyte adhesion | C-reactive protein | Tetrahydrobiopterin | tetrahydrobiopterin | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | LOW-DENSITY-LIPOPROTEIN | NO HOMEOSTASIS | DEFICIENT MICE | leukocyte adhesion | BLOOD-PRESSURE | nitrosothiols | S-NITROSYLATION | OXIDE SYNTHASE | IN-VIVO | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | Leukocyte Rolling - drug effects | Sodium Nitrite - administration & dosage | Microvessels - metabolism | Endothelium, Vascular - drug effects | Male | Anti-Inflammatory Agents - metabolism | Biopterin - analogs & derivatives | Hypercholesterolemia - drug therapy | Biopterin - metabolism | Inflammation - metabolism | C-Reactive Protein - metabolism | Liver - drug effects | Myocardium - metabolism | Vasodilator Agents - metabolism | Anti-Inflammatory Agents - administration & dosage | Blood Pressure - drug effects | Disease Models, Animal | Liver - metabolism | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Microvessels - drug effects | Inflammation - etiology | Cholesterol, Dietary - blood | Animals | Diet | Endothelium, Vascular - metabolism | Sodium Nitrite - metabolism | Triglycerides - blood | Hypercholesterolemia - complications | Hypercholesterolemia - physiopathology | Inflammation - prevention & control | Mice | Vasodilation - drug effects | Nitric Oxide - metabolism | Hypercholesterolemia - metabolism | Vasodilator Agents - administration & dosage | Inflammation - physiopathology | Genotype & phenotype | Leucocytes | Nitric oxide | Genetics | Nitrogen | Metabolism | Cell adhesion & migration
Journal Article
BioFactors, ISSN 0951-6433, 03/2015, Volume 41, Issue 2, pp. 67 - 77
Low levels of high‐density lipoprotein‐cholesterol (HDL‐C) constitute an independent biomarker of cardiovascular morbi‐mortality. However, recent advances have... 
HDL subpopulations | HDL‐C | functionality | HDL-C | Functionality | CARDIOVASCULAR EVENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RANDOMIZED CONTROLLED-TRIAL | HIGH-DENSITY-LIPOPROTEIN | CELLULAR FREE-CHOLESTEROL | HEART-DISEASE | ANTIINFLAMMATORY PROPERTIES | REVERSE CHOLESTEROL TRANSPORT | ENDOCRINOLOGY & METABOLISM | E-DEFICIENT MICE | CORONARY-ARTERY-DISEASE | APOLIPOPROTEIN-A-I | Fibrinolytic Agents - classification | Antioxidants - metabolism | Humans | Fibrinolytic Agents - metabolism | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | Proto-Oncogene Proteins c-akt - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Apolipoprotein A-I - genetics | Vasodilator Agents - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Cytoprotection | Biomarkers - metabolism | Cholesterol, HDL - pharmacology | Vasodilator Agents - pharmacology | Cardiovascular Diseases - metabolism | Cholesterol, HDL - metabolism | Gene Expression Regulation | Antioxidants - classification | Cardiovascular System - drug effects | Antioxidants - pharmacology | Apolipoprotein A-I - metabolism | Cardiovascular System - pathology | Fibrinolytic Agents - pharmacology | Animals | Cardiovascular System - metabolism | Cholesterol, HDL - classification | Phosphatidylinositol 3-Kinase - genetics | Anti-Inflammatory Agents, Non-Steroidal - classification | Vasodilator Agents - classification
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2008, Volume 46, Issue 3, pp. 309 - 317
Abstract Flavonoids have long been acknowledged for their unique antioxidant properties, and possess other activities that may be relevant to heart... 
Cardiovascular | Antioxidants | Flavonoids | Reactive oxygen species | Phase 2 enzymes | Ischemia–reperfusion | Vasorelaxation | Anti-inflammatory | Ischemia-reperfusion | AORTIC ENDOTHELIAL-CELLS | NADPH OXIDASE | CARDIAC & CARDIOVASCULAR SYSTEMS | ISOLATED RAT HEARTS | VASCULAR SMOOTH-MUSCLE | CELL BIOLOGY | ADHESION MOLECULE EXPRESSION | NITRIC-OXIDE PRODUCTION | RADICAL-SCAVENGING ACTIVITY | GUINEA-PIG HEARTS | RED WINE POLYPHENOLS | GREEN TEA POLYPHENOL | Xanthine Oxidase - metabolism | Reactive Oxygen Species - metabolism | Enzyme Inhibitors - metabolism | Vasodilator Agents - therapeutic use | Antioxidants - metabolism | Humans | Oxidants - metabolism | Enzyme Inhibitors - therapeutic use | Flavonoids - therapeutic use | Gene Expression Regulation - drug effects | Myocardial Reperfusion Injury - metabolism | Antioxidants - therapeutic use | Animals | Ion Channels - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Flavonoids - metabolism | Vasodilator Agents - metabolism | Oxidation-Reduction - drug effects | Platelet Aggregation - drug effects | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Platelet Aggregation Inhibitors - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Myocardial Reperfusion Injury - prevention & control | Xanthine Oxidase - antagonists & inhibitors | Oxidases | Molybdenum compounds | Nitric oxide | Superoxide | Endothelium | Isoflavones | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2004, Volume 24, Issue 41, pp. 8940 - 8949
The role of interneurons in neurovascular coupling was investigated by patch-clamp recordings in acute rat cortical slices, followed by single-cell reverse... 
Neuropeptide Y | Cerebral blood flow | Nitric oxide | Vasoactive intestinal peptide | Brain microcirculation | Somatostatin | Neocortex | nitric oxide | RAT CEREBRAL-CORTEX | NITRIC-OXIDE SYNTHASE | neuropeptide Y | INTESTINAL POLYPEPTIDE VIP | neocortex | NEUROSCIENCES | NEUROPEPTIDE-Y | brain microcirculation | vasoactive intestinal peptide | RECEPTOR SUBTYPES | GABAERGIC CELL SUBTYPES | somatostatin | NEOCORTICAL INTERNEURONS | BLOOD-VESSELS | cerebral blood flow | CENTRAL-NERVOUS-SYSTEM | CHOLINE-ACETYLTRANSFERASE | Interneurons - physiology | Vasoactive Intestinal Peptide - metabolism | Cerebral Cortex - blood supply | Cerebrovascular Circulation - physiology | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Receptors, Neuropeptide - drug effects | Cytoplasm - metabolism | Cerebral Cortex - cytology | Microcirculation - drug effects | Somatostatin - pharmacology | Microcirculation - physiology | Vasoconstriction - physiology | Vasoactive Intestinal Peptide - pharmacology | Vasodilator Agents - metabolism | Nitric Oxide Donors - pharmacology | Vasodilation - physiology | Receptors, Neuropeptide - biosynthesis | Somatostatin - metabolism | Vasoconstrictor Agents - pharmacology | Lysine - analogs & derivatives | Vasodilator Agents - pharmacology | Cerebrovascular Circulation - drug effects | Rats | Receptors, Neuropeptide - genetics | Neuropeptide Y - pharmacology | Muscle, Smooth, Vascular - cytology | Microcirculation - innervation | Rats, Sprague-Dawley | Vasoconstriction - drug effects | Patch-Clamp Techniques | Animals | Interneurons - metabolism | Signal Transduction - drug effects | Vasoconstrictor Agents - metabolism | Cerebral Cortex - physiology | Signal Transduction - physiology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | In Vitro Techniques | Life Sciences | Cognitive Sciences | Neurons and Cognition | Behavioral | Cognitive | Systems
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 1/2012, Volume 69, Issue 2, pp. 247 - 266
Vascular smooth muscle tone is controlled by a balance between the cellular signaling pathways that mediate the generation of force (vasoconstriction) and... 
Biochemistry, general | Calcium sensitivity | PKA | Cyclic AMP | Vascular smooth muscle | Vasorelaxation | PKG | Biomedicine general | Cell Biology | Myosin light chain | Life Sciences | Life Sciences, general | Cyclic GMP | PROTEIN-KINASE-A | SENSITIVE POTASSIUM CHANNELS | SHOCK-RELATED PROTEIN | K-ATP CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRACELLULAR CA2+ STORES | PORCINE CORONARY-ARTERY | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | CELL BIOLOGY | MYOSIN LIGHT-CHAIN | PARTICULATE GUANYLATE CYCLASES | RABBIT PORTAL-VEIN | Nucleotides, Cyclic - metabolism | Calcium-Transporting ATPases - physiology | Calcium - metabolism | Sarcoplasmic Reticulum - drug effects | Humans | Potassium Channels - physiology | Sarcoplasmic Reticulum - physiology | Myosin-Light-Chain Kinase - antagonists & inhibitors | Myosin-Light-Chain Kinase - physiology | Potassium Channels - metabolism | Myosin-Light-Chain Phosphatase - antagonists & inhibitors | Calcium - physiology | Sodium-Calcium Exchanger - metabolism | Myosin-Light-Chain Phosphatase - metabolism | Vasodilator Agents - metabolism | Myosin-Light-Chain Phosphatase - physiology | Calcium-Transporting ATPases - metabolism | Sarcoplasmic Reticulum - metabolism | Vasodilation - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Nucleotides, Cyclic - pharmacology | Vasodilator Agents - pharmacology | Myosin-Light-Chain Kinase - metabolism | Rats | Sodium-Calcium Exchanger - physiology | Nucleotides, Cyclic - physiology | Animals | Muscle Contraction - drug effects | Muscle Contraction - physiology | Potassium Channels - agonists | Mice | Vasodilation - drug effects | Magneto-electric machines | Vasodilators | Myosin | Muscle proteins | Machinery | Cyclic guanylic acid | Phosphotransferases | Proteins | Blood vessels | Signal transduction | Cellular biology | Kinases | Calcium mobilization | Phosphorylation | Calcium (intracellular) | Vasoconstriction | Smooth muscle | Cell membranes | Muscle contraction | Myosin-light-chain kinase | Vasodilation | Calcium signalling | Cyclic nucleotides | Protein kinase | Light chains | Hyperpolarization
Journal Article