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Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 05/2007, Volume 34, Issue 5, pp. 387 - 392
SUMMARY • Astragaloside IV is a component from the widely used traditional Chinese herb Astragalus membranaceus and its effect on rat aortic ring contraction... 
endothelium | nitric oxide | aortic rings | vessel contraction and relaxation | astragaloside IV | Astragaloside IV | Nitric oxide | Vessel contraction and relaxation | Aortic rings | Endothelium | SMOOTH-MUSCLE | PHYSIOLOGY | CONTRACTION | TONE | L-ARGININE | PHARMACOLOGY & PHARMACY | CHANNELS | Triterpenes - pharmacology | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Male | Saponins - chemistry | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Intracellular Fluid - drug effects | Triterpenes - chemistry | Phenylephrine - pharmacology | Oxadiazoles - pharmacology | Aorta, Thoracic - physiology | Potassium Chloride - pharmacology | Molecular Structure | Aorta, Thoracic - drug effects | Cyclic GMP - biosynthesis | Intracellular Fluid - metabolism | Muscle, Smooth, Vascular - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Rats | Vasodilator Agents - isolation & purification | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Indomethacin - pharmacology | Nitroarginine - pharmacology | Aorta, Thoracic - cytology | Calcium Chloride - pharmacology | Animals | Saponins - isolation & purification | Triterpenes - isolation & purification | Vasodilator Agents - chemistry | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | In Vitro Techniques | Saponins - pharmacology | NG-Nitroarginine Methyl Ester, pharmacology | Triterpenes, pharmacology | Calcium, metabolism | Nitric Oxide Synthase, antagonists and inhibitors | Muscle, Smooth, Vascular, metabolism | Vasodilator Agents, chemistry | Quinoxalines, pharmacology | Aorta, Thoracic, drug effects | Triterpenes, chemistry | Vasodilator Agents, pharmacology | Saponins, chemistry | Intracellular Fluid, drug effects | Nitric Oxide Synthase, metabolism | Aorta, Thoracic, cytology | Potassium Chloride, pharmacology | Aorta, Thoracic, physiology | Calcium Chloride, pharmacology | Vasoconstrictor Agents, pharmacology | Muscle, Smooth, Vascular, drug effects | Nitroarginine, pharmacology | Saponins, pharmacology | Vasodilation, drug effects | Triterpenes, isolation and purification | Cyclic GMP, biosynthesis | Vasodilator Agents, isolation and purification | Acetylcholine, pharmacology | Oxadiazoles, pharmacology | Muscle, Smooth, Vascular, cytology | Phenylephrine, pharmacology | Saponins, isolation and purification | Endothelium, Vascular, physiology | Indomethacin, pharmacology | Intracellular Fluid, metabolism
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 01/2008, Volume 35, Issue 1, pp. 29 - 34
SUMMARY • The aim of the present study was to determine whether inhibition of dipeptidyl peptidase IV (DPP IV) elevates arterial blood pressure and whether any... 
3-N-[(2S,3S)-2-amino-3-methylpentanoyl]-1,3-thiazolidine | N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-d-arginine amide | P32/98 | Wistar-Kyoto rat | neuropeptide Y | dipeptidyl peptidase IV | spontaneously hypertensive rat | Y1 receptor | BIBP 3226 | peptide YY | 3‐N‐[(2S,3S)‐2‐amino‐3‐methylpentanoyl]‐1,3‐thiazolidine | Wistar‐Kyoto rat | N2‐(diphenylacetyl)‐N‐[(4‐hydroxyphenyl)methyl]‐d‐arginine amide | BIBP 3226 | Neuropeptide Y | Spontaneously hypertensive rat | N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D- arginine amide | Peptide YY | Dipeptidyl peptidase IV | PHYSIOLOGY | SPONTANEOUSLY HYPERTENSIVE-RATS | NHE3 | NEUROPEPTIDE-Y | N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine amide | PHARMACOLOGY & PHARMACY | RECEPTORS | NORADRENALINE | Y-1 receptor | GLUCOSE-TOLERANCE | VASOCONSTRICTION | Antihypertensive Agents - pharmacology | Dipeptidyl Peptidase 4 - metabolism | Captopril - pharmacology | Hydralazine - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Rats, Inbred WKY | Receptors, Neuropeptide Y - metabolism | Hypertension - drug therapy | Ganglionic Blockers - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Arginine - analogs & derivatives | Dose-Response Relationship, Drug | Drug Interactions | Receptors, Neuropeptide Y - drug effects | Pentanoic Acids - pharmacology | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Hypertension - enzymology | Hypertension - genetics | Thiazolidines - pharmacology | Disease Models, Animal | Chlorisondamine - pharmacology | Rats, Inbred SHR | Vasodilator Agents - pharmacology | Rats | Antihypertensive Agents - therapeutic use | Hypertension - physiopathology | Animals | Arginine - pharmacology | Receptors, Neuropeptide Y, drug effects | Antihypertensive Agents, therapeutic use | Hypertension, enzymology | Arginine, pharmacology | Hypertension, drug therapy | Arginine, analogs and derivatives | Hypertension, genetics | Pentanoic Acids, pharmacology | Captopril, pharmacology | Vasodilator Agents, pharmacology | Ganglionic Blockers, pharmacology | Hypertension, physiopathology | Blood Pressure, drug effects | Dipeptidyl-Peptidase IV Inhibitors, therapeutic use | Angiotensin-Converting Enzyme Inhibitors, pharmacology | Antihypertensive Agents, pharmacology | Chlorisondamine, pharmacology | Receptors, Neuropeptide Y, metabolism | Hydralazine, pharmacology | Dipeptidyl-Peptidase IV Inhibitors, pharmacology | Thiazolidines, pharmacology | Antigens, CD26, metabolism | Antigens, CD26, antagonists and inhibitors | Hypertension | Blood pressure | Captopril | Analysis
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 2008, Volume 8, Issue 6, pp. 538 - 554
Journal Article
Drugs, ISSN 0012-6667, 8/2015, Volume 75, Issue 12, pp. 1349 - 1371
...Drugs (2015) 75:1349–1371 DOI 10.1007/s40265-015-0435-5 REVIEW ARTICLE A Review of Nebivolol Pharmacology and Clinical Evidence Justin Fongemie 1 • Erika Felix... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | BETA-BLOCKER TREATMENT | ARTERIAL-HYPERTENSION | DOUBLE-BLIND | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CENTRAL AORTIC PRESSURE | BLOOD-PRESSURE | HYPERTENSIVE PATIENTS | ERECTILE DYSFUNCTION | LEFT-VENTRICULAR FUNCTION | ELDERLY HEART-FAILURE | Drug Costs | Vasodilator Agents - pharmacokinetics | Vasodilator Agents - therapeutic use | Humans | Heart Failure - physiopathology | Hypertension - drug therapy | Nebivolol - economics | Adrenergic beta-1 Receptor Agonists - pharmacokinetics | Nebivolol - pharmacokinetics | Blood Pressure - drug effects | Heart Failure - diagnosis | Vasodilator Agents - economics | Drug Therapy, Combination | Heart Failure - economics | Hypertension - diagnosis | Hypertension - economics | Antihypertensive Agents - economics | Adrenergic beta-1 Receptor Agonists - therapeutic use | Nebivolol - therapeutic use | Treatment Outcome | Antihypertensive Agents - pharmacokinetics | Adrenergic beta-1 Receptor Agonists - economics | Antihypertensive Agents - therapeutic use | Nebivolol - adverse effects | Hypertension - physiopathology | Antihypertensive Agents - adverse effects | Heart Failure - drug therapy | Animals | Cost-Benefit Analysis | Adrenergic beta-1 Receptor Agonists - adverse effects | Vasodilator Agents - adverse effects
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 0193-1849, 11/2016, Volume 311, Issue 5, pp. E859 - E868
Journal Article
BMC complementary and alternative medicine, ISSN 1472-6882, 02/2014, Volume 14, Issue 1, p. 71
Background: Isodon rugosus is used in folk Pakistan traditional practices to cure ailments related to gastrointestinal, respiratory and cardiovascular... 
Spasmogenic activity | Traditional uses | Spasmolytic activity | Isodon rugosus | Analgesic activity | BRONCHODILATOR | LAVANDULAEFOLIA ESSENTIAL OIL | PAKISTAN | ANTICHOLINESTERASE | SMOOTH-MUSCLE | INTEGRATIVE & COMPLEMENTARY MEDICINE | CALCIUM | DISEASE | RABBIT | ACETYLCHOLINESTERASE INHIBITORS | MEDICINAL-PLANTS | Bronchodilator Agents - therapeutic use | Vasodilator Agents - therapeutic use | Plant Extracts - pharmacology | Calcium Channel Blockers - therapeutic use | Male | Trachea - drug effects | Jejunum - drug effects | Muscle, Smooth - drug effects | Antiemetics - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Female | Parasympatholytics - therapeutic use | Rabbits | Vasodilator Agents - pharmacology | Isodon | Anti-Inflammatory Agents - pharmacology | Antipyretics - therapeutic use | Aorta - drug effects | Lipoxygenase Inhibitors - therapeutic use | Bronchodilator Agents - pharmacology | Antioxidants - pharmacology | Calcium Channel Blockers - pharmacology | Parasympatholytics - pharmacology | Antioxidants - therapeutic use | Ethnopharmacology | Gastrointestinal Agents - pharmacology | Animals | Cholinesterase Inhibitors - pharmacology | Muscle Contraction - drug effects | Gastrointestinal Agents - therapeutic use | Mice | Antipyretics - pharmacology | Cholinesterase Inhibitors - therapeutic use | Lipoxygenase Inhibitors - pharmacology | Plant Extracts - therapeutic use | Antiemetics - pharmacology | Usage | Methanol | Hypertension | Smooth muscle | Experiments | Asthma | Studies | Leaves | Constituents | Pain | Sodium | Analgesics | Rodents | Coronary vessels | Pharmacy | Laboratory animals | Potassium
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 2015, Volume 308, Issue 9, pp. H1020 - H1029
This study addressed the hypothesis that inhibiting the soluble epoxide hydrolase (sEH)-mediated degradation of epoxy-fatty acids, notably epoxyeicosatrienoic... 
Insulin resistance | Cardiac function | Soluble epoxide hydrolase | Endothelium | endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | HEART-FAILURE | RATS | MECHANISMS | soluble epoxide hydrolase | DIABETES-MELLITUS | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | cardiac function | DYSFUNCTION | HYPERTENSION | ARTERY | insulin resistance | EXPRESSION | Obesity - drug therapy | Coronary Vessels - physiopathology | Endothelium, Vascular - drug effects | Heart Diseases - prevention & control | Male | Endothelium, Vascular - enzymology | Obesity - blood | Dose-Response Relationship, Drug | Glyburide - pharmacology | Time Factors | Lipids - blood | Urea - analogs & derivatives | Inflammation Mediators - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Coronary Vessels - enzymology | Vasodilator Agents - pharmacology | Heart Diseases - physiopathology | Obesity - complications | Ventricular Function, Left - drug effects | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Insulin Resistance | Obesity - physiopathology | Heart Diseases - enzymology | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Heart Diseases - etiology | Animals | Eicosanoids - metabolism | Benzoates - pharmacology | Mice | Obesity - enzymology | Epoxide Hydrolases - metabolism | Vasodilation - drug effects | Blood Glucose - metabolism | Nitric Oxide - metabolism | Epoxide Hydrolases - antagonists & inhibitors | Ventricular Remodeling - drug effects | Urea - pharmacology | Prevention | Obesity | Enzymes | Physiological aspects | Hydrolases | Research | Heart diseases | Life Sciences | Call for Papers
Journal Article
Psychopharmacology, ISSN 0033-3158, 1/2017, Volume 234, Issue 2, pp. 211 - 222
Journal Article
Respiratory Research, ISSN 1465-9921, 12/2011, Volume 12, Issue 1, pp. 1 - 8
The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling... 
Medicine & Public Health | Pneumology/Respiratory System | PARENCHYMAL MECHANICS | LUNG | METHACHOLINE-INDUCED BRONCHOCONSTRICTION | AIRWAY | THERAPY | VASOACTIVE-INTESTINAL-PEPTIDE | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | INHALATION | NITRIC-OXIDE | VIP | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Airway Resistance - drug effects | Iloprost - pharmacology | Bronchial Provocation Tests | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Endothelins - metabolism | Sulfones - pharmacology | Lung Volume Measurements | Sildenafil Citrate | Time Factors | Vasoactive Intestinal Peptide - pharmacology | Bronchoconstriction - drug effects | Bronchial Hyperreactivity - physiopathology | Bronchial Hyperreactivity - metabolism | Blood Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Phosphodiesterase 5 Inhibitors - pharmacology | Endothelin Receptor Antagonists | Disease Models, Animal | Bronchial Hyperreactivity - etiology | Prostaglandins I - metabolism | Bronchial Hyperreactivity - therapy | Infusion Pumps, Implantable | Vasodilator Agents - pharmacology | Administration, Oral | Purines - pharmacology | Receptors, Endothelin - metabolism | Infusions, Parenteral | Rats | Hypertension, Pulmonary - metabolism | Lung - physiopathology | Piperazines - pharmacology | Rats, Sprague-Dawley | Animals | Analysis of Variance | Signal Transduction - drug effects | Lung - drug effects | Pyridines - pharmacology | Lung - blood supply | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage | Hypertension, Pulmonary - complications | Bronchi | Physiological aspects | Development and progression | Respiratory agents | Research | Drug therapy | Health aspects | Pulmonary hypertension | Prevention | Nitric oxide
Journal Article
Mini reviews in medicinal chemistry, ISSN 1389-5575, 2014, Volume 14, Issue 4, pp. 355 - 369
In the present article synthesis and medicinal applications of [1, 2, 4] oxadiazoles are reviewed. The oxadiazoles have a wide range of applications such as... 
Heterocycles | Anti-tumor agents | Synthetic methods | Anti-inflammatory | [1,2,4] oxadiazoles | Anaesthetic angent | One pot synthesis | CONVENIENT SYNTHESIS | CHEMISTRY, MEDICINAL | NONQUATERNARY CHOLINESTERASE REACTIVATORS | ONE-POT SYNTHESIS | 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES | MICROWAVE IRRADIATION | ACETYLCHOLINESTERASE INVITRO | anti-tumor agents | one pot synthesis | SOLVENT-FREE | heterocycles | anti-inflammatory | ANTIPROTOZOAL ACTIVITY | synthetic methods | 1,2,4-OXADIAZOLE DERIVATIVES | PHARMACOLOGICAL-PROPERTIES | Fibrinolytic Agents - chemistry | Vasodilator Agents - therapeutic use | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Anesthetics - pharmacology | Hypersensitivity - drug therapy | Antineoplastic Agents - toxicity | Platelet Aggregation Inhibitors - chemical synthesis | Oxadiazoles - pharmacology | Fibrinolytic Agents - therapeutic use | Anesthetics - chemical synthesis | Platelet Aggregation Inhibitors - pharmacology | Vasodilator Agents - chemical synthesis | Fibrinolytic Agents - chemical synthesis | Blood Platelets - drug effects | Oxadiazoles - chemistry | Venous Thrombosis - drug therapy | Anesthetics - chemistry | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Oxadiazoles - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Platelet Aggregation Inhibitors - chemistry | Vasodilator Agents - chemistry | Anti-Inflammatory Agents - chemical synthesis
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2011, Volume 32, Issue 12, pp. 700 - 707
Nicotinic acid (niacin) has been used for decades to prevent and treat atherosclerosis. The well-documented antiatherogenic activity is believed to result from... 
Advanced Basic Science | INTIMA-MEDIA THICKNESS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ESTER TRANSFER PROTEIN | MULTIPLE-SCLEROSIS | MOLECULAR-IDENTIFICATION | CHOLESTEROL EFFLUX | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | PROSTAGLANDIN D-2 | EXTENDED-RELEASE NIACIN | HIGH-DENSITY-LIPOPROTEIN | Flushing - metabolism | Receptors, G-Protein-Coupled - metabolism | Vasodilator Agents - therapeutic use | Humans | Immunosuppressive Agents - therapeutic use | Receptors, G-Protein-Coupled - agonists | Niacin - pharmacology | Niacin - therapeutic use | Niacin - adverse effects | Flushing - chemically induced | Immunosuppressive Agents - pharmacology | Langerhans Cells - drug effects | Neutrophils - metabolism | Macrophages - immunology | Hypolipidemic Agents - adverse effects | Receptors, Nicotinic - metabolism | Atherosclerosis - drug therapy | Atherosclerosis - immunology | Vasodilator Agents - pharmacology | Neutrophils - drug effects | Neutrophils - immunology | Hypolipidemic Agents - pharmacology | Atherosclerosis - metabolism | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Immunosuppressive Agents - adverse effects | Macrophages - drug effects | Hypolipidemic Agents - therapeutic use | Vasodilator Agents - adverse effects | Langerhans Cells - metabolism | Atherosclerosis - prevention & control | Multiple sclerosis | Psoriasis | Health aspects | Niacin | Atherosclerosis
Journal Article