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1. Full Text The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors
by Juul, Kristian Vinter and Bichet, Daniel G and Nielsen, Søren and Nørgaard, Jens Peter
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 05/2014, Volume 306, Issue 9, pp. F931 - F940
The arginine vasopressin (AVP) type 2 receptor (V2R) is unique among AVP receptor subtypes in signaling through cAMP. Its key function is in the kidneys,... 
Arginine vasopressin | Desmopressin | PHYSIOLOGY | COLLECTING DUCT CELLS | arginine vasopressin V-2 receptor | POLYCYSTIC KIDNEY-DISEASE | BREAST-CANCER CELLS | arginine vasopressin | ARGININE-VASOPRESSIN | extrarenal vasopressin V-2 receptor | UROLOGY & NEPHROLOGY | X-CHROMOSOME INACTIVATION | vasopressin V-2 receptor | PERIPHERAL-BLOOD LYMPHOCYTES | ORALLY DISINTEGRATING TABLET | PLACEBO-CONTROLLED TRIAL | NEPHROGENIC DIABETES-INSIPIDUS | desmopressin | THICK ASCENDING LIMB | Kidney - drug effects | Humans | Gene Expression Regulation | Receptors, Vasopressin - metabolism | Genotype | Male | Vasopressins - metabolism | Hormone Antagonists - pharmacology | Kidney - metabolism | Phenotype | Animals | Signal Transduction - drug effects | Receptors, Vasopressin - genetics | Female | Water-Electrolyte Balance | Antidiuretic Hormone Receptor Antagonists | Cyclic AMP - metabolism | Kidney - physiopathology | Physiology, Pathological | Medical research | Arginine | Physiological aspects | Medicine, Experimental | Research | Vasopressin
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2. Vasopressin V2 receptor antagonists
by Verbalis, J.G
Journal of Molecular Endocrinology, ISSN 0952-5041, 08/2002, Volume 29, Issue 1, pp. 1 - 9
Hyponatremia, whether due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or disorders of water retention such as congestive heart... 
Animals | Humans | Receptors, Vasopressin - classification | Antidiuretic Hormone Receptor Antagonists | Arginine Vasopressin - blood | Arginine Vasopressin - secretion | Inappropriate ADH Syndrome - drug therapy
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3. Full Text Vasopressin V2 receptors, ENaC, and sodium reabsorption: A risk factor for hypertension?
by Bankir, Lise and Bichet, Daniel G and Bouby, Nadine
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 11/2010, Volume 299, Issue 5, pp. F917 - F928
Bankir L, Bichet DG, Bouby N. Vasopressin V2 receptors, ENaC, and sodium reabsorption: a risk factor for hypertension? Am J Physiol Renal Physiol 299:... 
Water conservation | Sodium excretion | Collecting duct | Antidiuresis | URINE CONCENTRATION | HEALTHY HUMANS | PHYSIOLOGY | RAT-KIDNEY | EPITHELIAL NA+ CHANNEL | NONCOORDINATE REGULATION | water conservation | DOCA-SALT HYPERTENSION | antidiuresis | ARGININE-VASOPRESSIN | collecting duct | CORTICAL COLLECTING DUCT | UROLOGY & NEPHROLOGY | sodium excretion | BLOOD-PRESSURE VARIATION | SUSTAINED HYPERTENSION | Antihypertensive Agents - pharmacology | Humans | Risk Factors | Water - metabolism | Rats | Sodium - metabolism | Hypertension - physiopathology | Receptors, Vasopressin - drug effects | Hypertension - metabolism | Kidney - metabolism | Animals | Epithelial Sodium Channels - genetics | Epithelial Sodium Channels - drug effects | Sodium - urine | Receptors, Vasopressin - genetics | Blood Pressure - physiology | Hypertension - epidemiology | Vasopressins - physiology
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4. Full Text Vasopressin/V2 receptor stimulates renin synthesis in the collecting duct
by Gonzalez, Alexis A and Cifuentes-Araneda, Flavia and Ibaceta-Gonzalez, Cristobal and Gonzalez-Vergara, Alex and Zamora, Leonardo and Henriquez, Ricardo and Rosales, Carla B and Navar, L. Gabriel and Prieto, Minolfa C
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 02/2016, Volume 310, Issue 4, pp. F284 - F293
Renin is synthesized in the principal cells of the collecting duct (CD), and its production is increased via cAMP in angiotensin (ANG) II-dependent... 
Intrarenal renin-angiotensin system | Collecting duct | Water deprivation | Distal tubular renin | PKA/CREB | Prorenin | PROTEIN-KINASE-C | ANGIOTENSIN-II LEVELS | PHYSIOLOGY | AT RECEPTOR | distal tubular renin | JUXTAGLOMERULAR CELLS | HEART-FAILURE | CAMP ACCUMULATION | CYCLASE TYPE-6 ACTIVATION | water deprivation | intrarenal renin-angiotensin system | collecting duct | MESSENGER-RNA | INFUSED RATS | UROLOGY & NEPHROLOGY | prorenin | HYPERTENSIVE-RATS | Cyclic AMP-Dependent Protein Kinases - metabolism | Kidney Tubules, Collecting - drug effects | Cell Line | RNA, Small Interfering - genetics | Phosphorylation | Renin - biosynthesis | Kidney Medulla - drug effects | Sulfonamides - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Gene Knockdown Techniques | Kidney Tubules, Collecting - metabolism | Animals | Isoquinolines - pharmacology | RNA, Small Interfering - biosynthesis | Receptor, Angiotensin, Type 1 - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Kidney Medulla - metabolism | Renin-Angiotensin System - drug effects | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Deamino Arginine Vasopressin - pharmacology | Receptors, Vasopressin - agonists | Renin | Kidneys | Health aspects | Vasopressin | RNA | Aquaporins | Angiotensin | Protein binding | CREB | PKA
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5. Full Text Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during Biosynthesis
by Terrillon, Sonia and Durroux, Thierry and Mouillac, Bernard and Breit, Andreas and Ayoub, Mohammed A and Taulan, Magali and Jockers, Ralf and Barberis, Claude and Bouvier, Michel
Molecular Endocrinology, ISSN 0888-8809, 04/2003, Volume 17, Issue 4, pp. 677 - 691
G protein-coupled receptor (GPCR) oligomerization is a growing concept that has emerged from several studies suggesting that GPCRs can form both homo- and... 
HETEROMERIC COMPLEXES | RAT-KIDNEY | REVERSE TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | RESONANCE ENERGY-TRANSFER | PROTEIN-COUPLED RECEPTORS | POLYMERASE CHAIN-REACTION | ENDOPLASMIC-RETICULUM | DELTA-OPIOID RECEPTOR | GABA(B) RECEPTOR | LIVING CELLS | Kidney - embryology | Receptors, Oxytocin - genetics | Humans | Receptors, Vasopressin - metabolism | Luminescent Measurements | Recombinant Fusion Proteins - metabolism | Receptors, Oxytocin - biosynthesis | Dimerization | Receptors, Vasopressin - agonists | Kidney - drug effects | Signal Transduction | Cells, Cultured | Morpholines - pharmacology | Receptors, Vasopressin - biosynthesis | Kidney - cytology | Precipitin Tests | Receptors, Oxytocin - metabolism | Receptors, Vasopressin - genetics | Recombinant Fusion Proteins - genetics | Ligands | Luminescent Proteins - genetics | Antidiuretic Hormone Receptor Antagonists | Biophysics - methods | Subcellular Fractions | Spiro Compounds - pharmacology | Luminescent Proteins - metabolism
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6. Full Text Do vasopressin V2 receptor antagonists benefit cirrhotics with refractory ascites?
by Hiroshi Fukui
世界胃肠病学杂志：英文版, ISSN 1007-9327, 2015, Volume 21, Issue 41, pp. 11584 - 11596
Hyponatremia is a frequent complication of advanced cirrhosis with ascites associated with increased morbidity and mortality. It is caused by an impairment in... 
Liver | cirrhosis;Ascites;Hyponatremia;Pathophysiolo | Hyponatremia | V2 receptor antagonist | Pathophysiology | Ascites | Liver cirrhosis | RENAL WATER-EXCRETION | PLASMA ARGININE VASOPRESSIN | HEPATORENAL-SYNDROME | LIVER-CIRRHOSIS PATIENTS | AQUAPORIN-2 URINARY-EXCRETION | EARLY HEPATIC CIRRHOSIS | DOUBLE-BLIND | NITRIC-OXIDE | PLACEBO-CONTROLLED TRIAL | GASTROENTEROLOGY & HEPATOLOGY | INCREASES SERUM SODIUM | Ascites - etiology | Liver Cirrhosis - diagnosis | Protein Precursors - blood | Liver Cirrhosis - complications | Humans | Risk Factors | Receptors, Vasopressin - metabolism | Treatment Outcome | Water-Electrolyte Balance - drug effects | Biomarkers - blood | Receptors, Vasopressin - drug effects | Vasopressins - blood | Antidiuretic Hormone Receptor Antagonists - therapeutic use | Ascites - diagnosis | Ascites - drug therapy | Patient Selection | Antidiuretic Hormone Receptor Antagonists - adverse effects | Aquaporin 2 - metabolism | Animals | Ascites - metabolism | Neurophysins - blood | Topic Highlight
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7. Full Text Acute Hemodynamic Effects of Tolvaptan, a Vasopressin V2 Receptor Blocker, in Patients With Symptomatic Heart Failure and Systolic Dysfunction. An International, Multicenter, Randomized, Placebo-Controlled Trial
by Udelson, James E and Orlandi, Cesare and Ouyang, John and Krasa, Holly and Zimmer, Christopher A and Frivold, Geir and Haught, W. Herbert and Meymandi, Sheiba and Macarie, Cezar and Raef, Dimitar and Wedge, Patricia and Konstam, Marvin A and Gheorghiade, Mihai
Journal of the American College of Cardiology, ISSN 0735-1097, 11/2008, Volume 52, Issue 19, pp. 1540 - 1545
Objectives: This study sought to assess the acute hemodynamic effect of vasopressin V receptor antagonism. Background: In decompensated heart failure (HF),... 
heart failure | vasopressin antagonists | hemodynamics | Multivariate Analysis | Prospective Studies | Follow-Up Studies | Benzazepines - adverse effects | Humans | Middle Aged | Male | Reference Values | Hemodynamics - physiology | Dose-Response Relationship, Drug | Female | Heart Function Tests | Severity of Illness Index | Double-Blind Method | Drug Administration Schedule | Heart Failure, Systolic - drug therapy | Receptors, Vasopressin - administration & dosage | Risk Assessment | Administration, Oral | Heart Failure, Systolic - mortality | Probability | Survival Rate | Treatment Outcome | International Cooperation | Heart Failure, Systolic - diagnosis | Aged | Benzazepines - administration & dosage | Hemodynamics - drug effects | Antidiuretic Hormone Receptor Antagonists | Heart failure | Enzymes | Heart attacks | Statistical analysis | Angioplasty | Pulmonary arteries | Drug therapy | Drug dosages | Veins & arteries | Index Medicus | Abridged Index Medicus
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8. Full Text Determinants of Urine Volume in ADPKD Patients Using the Vasopressin V2 Receptor Antagonist Tolvaptan
by Kramers, Bart J and van Gastel, Maatje D.A and Boertien, Wendy E and Meijer, Esther and Gansevoort, Ron T
American Journal of Kidney Diseases, ISSN 0272-6386, 03/2019, Volume 73, Issue 3, pp. 354 - 362
The vasopressin V2 receptor antagonist (V2RA) tolvaptan is the first drug that has been shown to slow the rate of kidney function decline in patients with... 
tolvaptan | side effect | osmolar load | polyuria | salt | kidney function | aquaresis | urine volume | vasopressin (AVP) | osmoles | sodium | Autosomal dominant polycystic kidney disease (ADPKD) | glomerular filtration rate (GFR) | vasopressin V2 receptor antagonist (V2RA) | total kidney volume (TKV) | GLOMERULAR-FILTRATION-RATE | DIAGNOSIS | SODIUM | PHARMACOKINETICS | POLYCYSTIC KIDNEY-DISEASE | UROLOGY & NEPHROLOGY | WATER-INTAKE | PHARMACODYNAMICS
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9. Full Text A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose
by García-Arroyo, Fernando E and Muñoz-Jiménez, Itzel and Gonzaga, Guillermo and Tapia, Edilia and Osorio-Alonso, Horacio and Roncal-Jiménez, Carlos A and Iroz, Alison and Vecchio, Mariacristina and Reyes-García, Juan G and Johnson, Richard J and Sánchez-Lozada, L Gabriela
International Journal of Molecular Sciences, ISSN 1422-0067, 11/2019, Volume 20, Issue 22, p. 5764
Chronic vasopressin secretion induced by recurrent mild heat stress exposure is significantly enhanced by limited rehydration with a fructose-containing... 
aldose reductase | cortisol | fructokinase | angiotensin ii | vasopressin | sgk1
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10. Full Text Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist
by Harris, Peter C and Wang, Xiaofang and Torres, Vicente E and Gattone, Vincent H
Nature Medicine, ISSN 1078-8956, 10/2003, Volume 9, Issue 10, pp. 1323 - 1326
The polycystic kidney diseases (PKDs) are a group of genetic disorders causing significant renal failure and death in children and adults. There are no... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | MEDULLARY COLLECTING DUCTS | M-1 CELLS | POLYCYSTIC KIDNEY-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEPHRONOPHTHISIS | PROLIFERATION | CELL BIOLOGY | IN-VITRO | CA2 | EXPRESSION | CAMP | Polycystic Kidney Diseases - metabolism | Aquaporin 6 | Kidney - pathology | Humans | Receptors, Vasopressin - metabolism | Rats | Aquaporins - metabolism | Polycystic Kidney Diseases - drug therapy | Rats, Sprague-Dawley | Aquaporins - genetics | Disease Progression | Proteins - genetics | Kidney - metabolism | Animals | Polycystic Kidney Diseases - physiopathology | Proteins - metabolism | Benzazepines - therapeutic use | TRPP Cation Channels | Mice | Benzazepines - metabolism | Antidiuretic Hormone Receptor Antagonists | Cyclic AMP - metabolism | Aquaporin 2 | Disease Models, Animal
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11. Full Text Phosphoproteomic identification of vasopressin V2 receptor-dependent signaling in the renal collecting duct
by Deshpande, V and Kao, A and Raghuram, V and Datta, A and Chou, CL and Knepper, MA
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 10/2019, Volume 317, Issue 4, pp. F789 - F804
Vasopressin controls water balance largely through PKA-dependent effects to regulate the collecting duct water channel aquaporin-2 (AQP2). Although... 
PROTEIN-KINASE-A | PHYSIOLOGY | aquaporin-2 | PHOSPHATASE | TRAFFICKING | WATER CHANNELS | AQP2 | protein kinase | protein phosphatase | UROLOGY & NEPHROLOGY | AQUAPORIN-2 PHOSPHORYLATION | NA+/H+ EXCHANGER | APICAL MEMBRANE | EXPRESSION | CAMP
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12. Full Text Vasopressin V2 receptor antagonists
by Wong, Lisa L and Verbalis, Joseph G
Cardiovascular Research, ISSN 0008-6363, 08/2001, Volume 51, Issue 3, pp. 391 - 402
Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and disorders of water retention such as congestive heart failure and... 
Heart failure | Receptors | Renal function | Hormones | Vasoactive agents | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | receptors | hormones | NONPEPTIDE V-2 ANTAGONIST | vasoactive agents | INAPPROPRIATE SECRETION | HYPONATREMIC ENCEPHALOPATHY | ARGININE-VASOPRESSIN | THERAPEUTIC-EFFICACY | IN-VIVO | renal function | V-2-RECEPTOR ANTAGONIST | PHARMACOLOGICAL PROFILE | CONGESTIVE-HEART-FAILURE | LONG-TERM TREATMENT | Animals | Inappropriate ADH Syndrome - physiopathology | Humans | Water-Electrolyte Imbalance - physiopathology | Water-Electrolyte Imbalance - drug therapy | Clinical Trials as Topic | Antidiuretic Hormone Receptor Antagonists | Inappropriate ADH Syndrome - drug therapy
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13. Full Text Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics
by Hoffert, Jason D and Pisitkun, Trairak and Saeed, Fahad and Song, Jae H and Chou, Chung-Lin and Knepper, Mark A
Molecular and Cellular Proteomics, ISSN 1535-9476, 02/2012, Volume 11, Issue 2, p. M111.014613
G protein-coupled receptors (GPCRs) regulate diverse physiological processes, and many human diseases are due to defects in GPCR signaling. To identify the... 
RENAL PRINCIPAL CELLS | LC-MS/MS | MEDULLARY COLLECTING DUCT | ACTIVATION | KINASE-A | PHOSPHORYLATION | IN-VIVO | BIOCHEMICAL RESEARCH METHODS | AQUAPORIN-2 TRAFFICKING | BETA-CATENIN | IDENTIFICATION | Phosphorylation | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Humans | Receptors, Vasopressin - metabolism | Rats | Proteome - analysis | Kidney Tubules, Collecting - cytology | Phosphoproteins - metabolism | Kidney Tubules, Collecting - metabolism | Animals | Proteomics | Chromatography, Liquid | Phosphopeptides - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Cyclic AMP - metabolism | Research
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14. Full Text Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model
by Wang, Xiaofang and Constans, Megan M and Chebib, Fouad T and Torres, Vicente E and Pellegrini, Lorenzo
American Journal of Nephrology, ISSN 0250-8095, 06/2019, Volume 49, Issue 6, pp. 487 - 493
Background: Vasopressin V2 receptor inhibition is a clinically validated mechanism of action in the treatment of autosomal dominant polycystic kidney disease... 
Patient-Oriented, Translational Research: Research Article | Vasopressin V2 receptor antagonist | TOLVAPTAN | UROLOGY & NEPHROLOGY | PCK rat model | Lixivaptan | NONPEPTIDE | Polycystic kidney disease
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15. Full Text Novel molecular mechanisms in the inhibition of adrenal aldosterone synthesis: Action of tolvaptan via vasopressin V2 receptor‐independent pathway
by Ali, Yusuf and Dohi, Kaoru and Okamoto, Ryuji and Katayama, Kan and Ito, Masaaki
British Journal of Pharmacology, ISSN 0007-1188, 05/2019, Volume 176, Issue 9, pp. 1315 - 1327
Background and Purpose We investigated the inhibitory effect and associated molecular mechanisms of tolvaptan on angiotensin II (AngII)‐induced aldosterone... 
Corticosteroids | RNA | Angiotensin | Cytochrome P-450 | Aldosterone | Vasopressin | Steroids | Diuresis | Phosphorylation | Argipressin | Secretion | Aldosterone synthase | Gene expression | Kinases | Proteins | Molecular modelling | Protein folding | Inhibition | Angiotensin II
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16. Full Text Vasopressin-V2 receptor stimulation reduces sodium excretion in healthy humans
by Bankir, Lise and Fernandes, Sandrine and Bardoux, Pascale and Bouby, Nadine and Bichet, Daniel G
Journal of the American Society of Nephrology, ISSN 1046-6673, 2005, Volume 16, Issue 7, pp. 1920 - 1928
In addition to its effect on water permeability, vasopressin, through its V2 receptors (AVPR2), stimulates Na reabsorption in the collecting duct by increasing... 
UROLOGY & NEPHROLOGY | Diabetes Insipidus - physiopathology | Humans | Male | Renal Agents - pharmacology | Sodium Channels - drug effects | Sodium Channels - physiology | Aquaporins - genetics | Receptors, Vasopressin - drug effects | Diabetes Insipidus - genetics | Adolescent | Receptors, Vasopressin - genetics | Receptors, Vasopressin - physiology | Adult | Female | Child | Sodium - physiology | Aquaporin 2 | Deamino Arginine Vasopressin - pharmacology | Diabetes Insipidus - metabolism
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17. Full Text In Vivo and In Vitro Effects of Vasopressin V2 Receptor Antagonism on Myocardial Fibrosis in Rats
by Zhang, LiangLiang and Joseph, Jacob and Joseph, Lija
The American Journal of the Medical Sciences, ISSN 0002-9629, 02/2019, Volume 357, Issue 2, pp. 151 - 159
Myocardial fibrosis is a major pathophysiologic substrate of heart failure with preserved ejection fraction. Vasopressin is an important therapeutic target in... 
Heart failure with preserved ejection fraction | Animal model | Diastolic dysfunction | Myocardial fibrosis | Vasopressin | HOMOCYSTEINE | HEART-FAILURE | PRESERVED EJECTION FRACTION | FOLIC-ACID | CARDIAC FIBROBLASTS | HYPERTROPHY | MEDICINE, GENERAL & INTERNAL | ARGININE-VASOPRESSIN | HYPERHOMOCYSTEINEMIA LEADS | THERAPIES | DYSFUNCTION
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