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Publication DateProceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8674 - 8679
Deep vein thrombosis and pulmonary embolism are major health problems associated with high mortality. Recently, DNA-based neutrophil extracellular traps (NETs)...
Chromatin | Pathologic constriction | Neutrophils | Histones | Venous thrombosis | Mice | Leukocytes | Chimeras | Platelets | Thrombosis | Histone citrullination | Inflammation | Programmed cell death | Nuclear swelling | Venous thromboembolism | LOCALIZATION | DNA TRAPS | PAD4 | MULTIDISCIPLINARY SCIENCES | PLATELET-ADHESION | VON-WILLEBRAND-FACTOR | MOUSE MODELS | nuclear swelling | histone citrullination | inflammation | venous thromboembolism | IN-VIVO | programmed cell death | EXTRACELLULAR TRAP FORMATION | INNATE IMMUNITY | Hydrolases - metabolism | Hydrolases - genetics | Venous Thrombosis - enzymology | Neutrophil Activation | Neutrophils - enzymology | Venous Thrombosis - therapy | Chromatin Assembly and Disassembly | Mice, Knockout | Animals | Histones - genetics | Venous Thrombosis - genetics | Histones - metabolism | Venous Thrombosis - pathology | Platelet Aggregation - genetics | Neutrophils - pathology | Pulmonary embolism | Genetic aspects | Models | Properties | Rodents | Mortality | Deoxyribonucleic acid--DNA | Coagulation | Index Medicus | Biological Sciences
Chromatin | Pathologic constriction | Neutrophils | Histones | Venous thrombosis | Mice | Leukocytes | Chimeras | Platelets | Thrombosis | Histone citrullination | Inflammation | Programmed cell death | Nuclear swelling | Venous thromboembolism | LOCALIZATION | DNA TRAPS | PAD4 | MULTIDISCIPLINARY SCIENCES | PLATELET-ADHESION | VON-WILLEBRAND-FACTOR | MOUSE MODELS | nuclear swelling | histone citrullination | inflammation | venous thromboembolism | IN-VIVO | programmed cell death | EXTRACELLULAR TRAP FORMATION | INNATE IMMUNITY | Hydrolases - metabolism | Hydrolases - genetics | Venous Thrombosis - enzymology | Neutrophil Activation | Neutrophils - enzymology | Venous Thrombosis - therapy | Chromatin Assembly and Disassembly | Mice, Knockout | Animals | Histones - genetics | Venous Thrombosis - genetics | Histones - metabolism | Venous Thrombosis - pathology | Platelet Aggregation - genetics | Neutrophils - pathology | Pulmonary embolism | Genetic aspects | Models | Properties | Rodents | Mortality | Deoxyribonucleic acid--DNA | Coagulation | Index Medicus | Biological Sciences
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Loading RightsBlood, ISSN 0006-4971, 11/2016, Volume 128, Issue 20, pp. 2435 - 2449
Deep venous thrombosis (DVT) is one of the most common cardiovascular diseases, but its pathophysiology remains incompletely understood. Although sterile...
NEUTROPHIL EXTRACELLULAR TRAPS | GREEN FLUORESCENT PROTEIN | STERILE INFLAMMATION | IN-VIVO | MOBILITY GROUP BOX-1 | DEEP-VEIN THROMBOSIS | DEPENDENT MECHANISMS | ISCHEMIA-REPERFUSION | HEMATOLOGY | GLYCATION END-PRODUCTS | INNATE IMMUNITY | Blood Platelets - pathology | Disulfides - metabolism | Inflammation - pathology | Toll-Like Receptor 2 - genetics | Mice, Inbred C57BL | Venous Thrombosis - metabolism | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | HMGB1 Protein - genetics | Mice, Knockout | Inflammation - metabolism | Animals | Blood Platelets - metabolism | Disulfides - chemistry | HMGB1 Protein - chemistry | HMGB1 Protein - metabolism | Inflammation - genetics | Mice | Mice, Inbred BALB C | Venous Thrombosis - genetics | Receptor for Advanced Glycation End Products - genetics | Venous Thrombosis - pathology | HMGB1 Protein - physiology | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
NEUTROPHIL EXTRACELLULAR TRAPS | GREEN FLUORESCENT PROTEIN | STERILE INFLAMMATION | IN-VIVO | MOBILITY GROUP BOX-1 | DEEP-VEIN THROMBOSIS | DEPENDENT MECHANISMS | ISCHEMIA-REPERFUSION | HEMATOLOGY | GLYCATION END-PRODUCTS | INNATE IMMUNITY | Blood Platelets - pathology | Disulfides - metabolism | Inflammation - pathology | Toll-Like Receptor 2 - genetics | Mice, Inbred C57BL | Venous Thrombosis - metabolism | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | HMGB1 Protein - genetics | Mice, Knockout | Inflammation - metabolism | Animals | Blood Platelets - metabolism | Disulfides - chemistry | HMGB1 Protein - chemistry | HMGB1 Protein - metabolism | Inflammation - genetics | Mice | Mice, Inbred BALB C | Venous Thrombosis - genetics | Receptor for Advanced Glycation End Products - genetics | Venous Thrombosis - pathology | HMGB1 Protein - physiology | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
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Loading RightsBlood, ISSN 0006-4971, 2012, Volume 120, Issue 3, pp. 656 - 663
There are no risk models available yet that accurately predict a person's risk for developing venous thrombosis. Our aim was therefore to explore whether...
GENETIC SUSCEPTIBILITY | FACTOR-V-LEIDEN | POLYMORPHISMS | REPLICATION | VARIANTS | DISEASE | DEEP-VEIN THROMBOSIS | THROMBOEMBOLISM | HEMATOLOGY | ASSOCIATION | PROSPECTIVE COHORT | Predictive Value of Tests | Venous Thrombosis - diagnosis | Genetic Predisposition to Disease - genetics | Reproducibility of Results | Genetic Testing - standards | Humans | Risk Factors | Male | Models, Statistical | Genetic Testing - methods | Cost-Benefit Analysis | Polymorphism, Single Nucleotide - genetics | Female | ROC Curve | Models, Genetic | Venous Thrombosis - genetics | Genetic Testing - economics | Genetic Predisposition to Disease - epidemiology | Index Medicus | Abridged Index Medicus
GENETIC SUSCEPTIBILITY | FACTOR-V-LEIDEN | POLYMORPHISMS | REPLICATION | VARIANTS | DISEASE | DEEP-VEIN THROMBOSIS | THROMBOEMBOLISM | HEMATOLOGY | ASSOCIATION | PROSPECTIVE COHORT | Predictive Value of Tests | Venous Thrombosis - diagnosis | Genetic Predisposition to Disease - genetics | Reproducibility of Results | Genetic Testing - standards | Humans | Risk Factors | Male | Models, Statistical | Genetic Testing - methods | Cost-Benefit Analysis | Polymorphism, Single Nucleotide - genetics | Female | ROC Curve | Models, Genetic | Venous Thrombosis - genetics | Genetic Testing - economics | Genetic Predisposition to Disease - epidemiology | Index Medicus | Abridged Index Medicus
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Loading RightsPLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, pp. e25581 - e25581
Background: Venous Thrombosis (VT) is a common multifactorial disease associated with a major public health burden. Genetics factors are known to contribute to...
POPULATION | POLYMORPHISMS | VARIANTS | PLASMA-LEVELS | BIOLOGY | DEEP-VEIN THROMBOSIS | RISK | SUSCEPTIBILITY LOCUS | THROMBOEMBOLISM | PROTEIN-C | CORONARY-ARTERY-DISEASE | Haplotypes | Genetic Predisposition to Disease - genetics | Sample Size | Humans | Venous Thrombosis - epidemiology | Computational Biology | Polymorphism, Single Nucleotide - genetics | Aged | Venous Thrombosis - genetics | Genome-Wide Association Study - methods | Case-Control Studies | Analysis | Genes | Genomics | Disease susceptibility | Genetic aspects | Genomes | Thrombosis | Blood clot | Biometrics | Dietary minerals | Principal components analysis | Cardiovascular disease | ABO system | Single-nucleotide polymorphism | Loci | Variance | Vitamins | Studies | Genetic variance | Coronary vessels | Chromosome 20 | Biomarkers | Genetics | Bioindicators | Thromboembolism | Public health | Index Medicus
POPULATION | POLYMORPHISMS | VARIANTS | PLASMA-LEVELS | BIOLOGY | DEEP-VEIN THROMBOSIS | RISK | SUSCEPTIBILITY LOCUS | THROMBOEMBOLISM | PROTEIN-C | CORONARY-ARTERY-DISEASE | Haplotypes | Genetic Predisposition to Disease - genetics | Sample Size | Humans | Venous Thrombosis - epidemiology | Computational Biology | Polymorphism, Single Nucleotide - genetics | Aged | Venous Thrombosis - genetics | Genome-Wide Association Study - methods | Case-Control Studies | Analysis | Genes | Genomics | Disease susceptibility | Genetic aspects | Genomes | Thrombosis | Blood clot | Biometrics | Dietary minerals | Principal components analysis | Cardiovascular disease | ABO system | Single-nucleotide polymorphism | Loci | Variance | Vitamins | Studies | Genetic variance | Coronary vessels | Chromosome 20 | Biomarkers | Genetics | Bioindicators | Thromboembolism | Public health | Index Medicus
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Loading RightsJAMA, ISSN 0098-7484, 03/2008, Volume 299, Issue 11, pp. 1306 - 1314
CONTEXT The genetic causes of deep vein thrombosis (DVT) are not fully understood. OBJECTIVE To identify single-nucleotide polymorphisms (SNPs) associated with...
MEDICINE, GENERAL & INTERNAL | ACTIVATION | MYOCARDIAL-INFARCTION | RISK-FACTOR | FACTOR-XI | INCREASE | SUSCEPTIBILITY | VENOUS THROMBOSIS | MUTATIONS | PROTEIN-C | REGION | Humans | Middle Aged | Risk Factors | Venous Thrombosis - blood | Logistic Models | Male | Venous Thrombosis - epidemiology | Cytochrome P450 Family 4 | Cytochrome P-450 Enzyme System - genetics | Adult | Female | Polymorphism, Single Nucleotide | Venous Thrombosis - genetics | Factor XI - metabolism | Genetic variation | Genes | Causes of | Venous thrombosis | Research | Health aspects | Risk factors | Biological variation | Health risk assessment | Veins & arteries | Blood clots | Polymorphism | Index Medicus | Abridged Index Medicus
MEDICINE, GENERAL & INTERNAL | ACTIVATION | MYOCARDIAL-INFARCTION | RISK-FACTOR | FACTOR-XI | INCREASE | SUSCEPTIBILITY | VENOUS THROMBOSIS | MUTATIONS | PROTEIN-C | REGION | Humans | Middle Aged | Risk Factors | Venous Thrombosis - blood | Logistic Models | Male | Venous Thrombosis - epidemiology | Cytochrome P450 Family 4 | Cytochrome P-450 Enzyme System - genetics | Adult | Female | Polymorphism, Single Nucleotide | Venous Thrombosis - genetics | Factor XI - metabolism | Genetic variation | Genes | Causes of | Venous thrombosis | Research | Health aspects | Risk factors | Biological variation | Health risk assessment | Veins & arteries | Blood clots | Polymorphism | Index Medicus | Abridged Index Medicus
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Loading RightsBlood, ISSN 0006-4971, 01/2011, Volume 117, Issue 4, pp. 1400 - 1407
Deep vein thrombosis (DVT) and its complication, pulmonary embolism, are frequent causes of disability and mortality. Although blood flow disturbance is...
MURINE MODEL | ACTIVATED PROTEIN-C | FACTOR-VIII | IN-VIVO | VENOUS THROMBOSIS | P-SELECTIN | DEFICIENT MICE | GLYCOPROTEIN-IB | VONWILLEBRAND DISEASE | HEMATOLOGY | TISSUE FACTOR | Membrane Glycoproteins - metabolism | Recombinant Fusion Proteins - pharmacology | Humans | Veins - ultrastructure | Platelet Adhesiveness - physiology | Male | von Willebrand Diseases - complications | von Willebrand Factor - genetics | Venous Thrombosis - complications | Recombinant Fusion Proteins - metabolism | Platelet Adhesiveness - genetics | von Willebrand Factor - physiology | Factor VIII - adverse effects | von Willebrand Diseases - genetics | Recombinant Fusion Proteins - administration & dosage | Disease Models, Animal | von Willebrand Factor - metabolism | Mice, Inbred C57BL | Mice, Knockout | Platelet Adhesiveness - drug effects | Veins - drug effects | Animals | Veins - metabolism | Factor VIII - administration & dosage | Mice | Venous Thrombosis - genetics | Infusions, Intravenous | Platelet Glycoprotein GPIb-IX Complex | Venous Thrombosis - pathology | Veins - pathology | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
MURINE MODEL | ACTIVATED PROTEIN-C | FACTOR-VIII | IN-VIVO | VENOUS THROMBOSIS | P-SELECTIN | DEFICIENT MICE | GLYCOPROTEIN-IB | VONWILLEBRAND DISEASE | HEMATOLOGY | TISSUE FACTOR | Membrane Glycoproteins - metabolism | Recombinant Fusion Proteins - pharmacology | Humans | Veins - ultrastructure | Platelet Adhesiveness - physiology | Male | von Willebrand Diseases - complications | von Willebrand Factor - genetics | Venous Thrombosis - complications | Recombinant Fusion Proteins - metabolism | Platelet Adhesiveness - genetics | von Willebrand Factor - physiology | Factor VIII - adverse effects | von Willebrand Diseases - genetics | Recombinant Fusion Proteins - administration & dosage | Disease Models, Animal | von Willebrand Factor - metabolism | Mice, Inbred C57BL | Mice, Knockout | Platelet Adhesiveness - drug effects | Veins - drug effects | Animals | Veins - metabolism | Factor VIII - administration & dosage | Mice | Venous Thrombosis - genetics | Infusions, Intravenous | Platelet Glycoprotein GPIb-IX Complex | Venous Thrombosis - pathology | Veins - pathology | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
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Loading RightsBlood, ISSN 0006-4971, 11/2011, Volume 118, Issue 19, pp. 5302 - 5311
Recent studies indicate that the plasma contact system plays an important role in thrombosis, despite being dispensable for hemostasis. For example, mice...
PLATELET POLYPHOSPHATES | MYOCARDIAL-INFARCTION | BLOOD-COAGULATION | IN-VIVO | VENOUS THROMBOSIS | HAGEMAN-FACTOR | SURFACE-DEPENDENT ACTIVATION | CORONARY-HEART-DISEASE | HEMATOLOGY | ANTIPHOSPHOLIPID SYNDROME | TISSUE FACTOR | Factor XII Deficiency - blood | Hemostasis - physiology | Male | Prekallikrein - deficiency | RNA, Messenger - metabolism | Gene Knockdown Techniques | Hemorrhage - etiology | Factor XII Deficiency - genetics | Prekallikrein - antagonists & inhibitors | Thrombosis - blood | Thrombosis - prevention & control | Disease Models, Animal | Prekallikrein - genetics | Hemorrhage - genetics | Factor XII - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Risk Factors | Hemostasis - genetics | Hemorrhage - blood | Animals | Oligonucleotides, Antisense - genetics | Factor XII - antagonists & inhibitors | Oligonucleotides, Antisense - administration & dosage | Thrombosis - genetics | Mice | Mice, Inbred BALB C | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
PLATELET POLYPHOSPHATES | MYOCARDIAL-INFARCTION | BLOOD-COAGULATION | IN-VIVO | VENOUS THROMBOSIS | HAGEMAN-FACTOR | SURFACE-DEPENDENT ACTIVATION | CORONARY-HEART-DISEASE | HEMATOLOGY | ANTIPHOSPHOLIPID SYNDROME | TISSUE FACTOR | Factor XII Deficiency - blood | Hemostasis - physiology | Male | Prekallikrein - deficiency | RNA, Messenger - metabolism | Gene Knockdown Techniques | Hemorrhage - etiology | Factor XII Deficiency - genetics | Prekallikrein - antagonists & inhibitors | Thrombosis - blood | Thrombosis - prevention & control | Disease Models, Animal | Prekallikrein - genetics | Hemorrhage - genetics | Factor XII - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Risk Factors | Hemostasis - genetics | Hemorrhage - blood | Animals | Oligonucleotides, Antisense - genetics | Factor XII - antagonists & inhibitors | Oligonucleotides, Antisense - administration & dosage | Thrombosis - genetics | Mice | Mice, Inbred BALB C | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
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Loading RightsBlood, ISSN 0006-4971, 12/2005, Volume 106, Issue 13, pp. 4176 - 4183
We investigated the association between haplotypes of fibrinogen alpha (FGA), beta (FGB), and gamma (FGG), total fibrinogen levels, fibrinogen gamma' (gamma...
ANTITHROMBIN-I | AMINO-ACID-SEQUENCE | MESSENGER-RNA | MYOCARDIAL-INFARCTION | THR312ALA POLYMORPHISM | VARIANT GAMMA | FACTOR-VIII | FACTOR-XIII | CROSS-LINKING | LEIDEN THROMBOPHILIA | HEMATOLOGY | Haplotypes | Humans | Middle Aged | Risk Factors | Venous Thrombosis - blood | Fibrinogen - genetics | Base Sequence | Adolescent | Fibrinogen - metabolism | Adult | Aged | Genetic Variation - genetics | Venous Thrombosis - genetics | Venous Thrombosis - pathology | Index Medicus | Abridged Index Medicus
ANTITHROMBIN-I | AMINO-ACID-SEQUENCE | MESSENGER-RNA | MYOCARDIAL-INFARCTION | THR312ALA POLYMORPHISM | VARIANT GAMMA | FACTOR-VIII | FACTOR-XIII | CROSS-LINKING | LEIDEN THROMBOPHILIA | HEMATOLOGY | Haplotypes | Humans | Middle Aged | Risk Factors | Venous Thrombosis - blood | Fibrinogen - genetics | Base Sequence | Adolescent | Fibrinogen - metabolism | Adult | Aged | Genetic Variation - genetics | Venous Thrombosis - genetics | Venous Thrombosis - pathology | Index Medicus | Abridged Index Medicus
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Loading RightsMedicine, ISSN 0025-7974, 03/2019, Volume 98, Issue 12, pp. e14978 - e14978
Background: Tissue factor pathway inhibitor (TFPI) polymorphisms are known to be involved in venous thrombosis; however, any correlation between the TFPI...
tissue factor pathway inhibitor | RISK-FACTORS | GENETIC POLYMORPHISMS | SUSCEPTIBILITY | meta-analysis | FACTOR-PATHWAY-INHIBITOR | polymorphism | LEVEL | MEDICINE, GENERAL & INTERNAL | TISSUE-FACTOR | PLASMA-LEVELS | COAGULATION | THROMBOEMBOLISM | venous thrombosis | EPIDEMIOLOGY | Asian Continental Ancestry Group | Genetic Predisposition to Disease | Lipoproteins - genetics | Humans | Polymorphism, Single Nucleotide | Venous Thrombosis - genetics | Case-Control Studies | Genetic aspects | Venous thrombosis | Polypeptides | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
tissue factor pathway inhibitor | RISK-FACTORS | GENETIC POLYMORPHISMS | SUSCEPTIBILITY | meta-analysis | FACTOR-PATHWAY-INHIBITOR | polymorphism | LEVEL | MEDICINE, GENERAL & INTERNAL | TISSUE-FACTOR | PLASMA-LEVELS | COAGULATION | THROMBOEMBOLISM | venous thrombosis | EPIDEMIOLOGY | Asian Continental Ancestry Group | Genetic Predisposition to Disease | Lipoproteins - genetics | Humans | Polymorphism, Single Nucleotide | Venous Thrombosis - genetics | Case-Control Studies | Genetic aspects | Venous thrombosis | Polypeptides | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
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Loading RightsGene, ISSN 0378-1119, 05/2014, Volume 540, Issue 2, pp. 268 - 269
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Loading RightsBritish Journal of Haematology, ISSN 0007-1048, 03/2018, Volume 180, Issue 6, pp. 892 - 894
colony‐stimulating factor 3 receptor | differential diagnosis | chronic neutrophilic leukaemia | pathogenic mutation | next generation sequencing | colony-stimulating factor 3 receptor | ATYPICAL CML | HEMATOLOGY | Humans | Middle Aged | Repressor Proteins - genetics | STAT5 Transcription Factor - genetics | Infection - genetics | Receptors, Colony-Stimulating Factor - genetics | Infection - pathology | Fever - genetics | Female | Leukemia, Neutrophilic, Chronic - pathology | Venous Thrombosis - genetics | Leukemia, Neutrophilic, Chronic - genetics | Venous Thrombosis - pathology | Neoplasm Proteins - genetics | Leukocytosis - genetics | Fever - pathology | Leukocytosis - pathology | Health aspects | Hyperthermia | Leukemia | Fever | Leukocytes (neutrophilic) | Thromboembolism | Thrombosis | Index Medicus
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Loading RightsBlood, ISSN 0006-4971, 04/2017, Volume 129, Issue 14, pp. 2013 - 2020
Deep vein thrombosis (DVT) with its major complication, pulmonary embolism, is a global health problem. Mechanisms of DVT remain incompletely understood....
VENOUS THROMBOEMBOLISM | MODELS | ENDOTHELIUM | INFLAMMATION | PLATELETS | IN-VIVO | PODOPLANIN | NEUTROPHILS | GLYCOPROTEIN | HEMATOLOGY | FIBROBLASTS | Blood Platelets - pathology | Membrane Glycoproteins - metabolism | Constriction, Pathologic | Venous Thrombosis - metabolism | Gene Expression Regulation | Vena Cava, Inferior - metabolism | Lectins, C-Type - genetics | Membrane Glycoproteins - genetics | Mice, Knockout | Lectins, C-Type - metabolism | Animals | Blood Platelets - metabolism | Vena Cava, Inferior - pathology | Venous Thrombosis - prevention & control | Mice | Venous Thrombosis - genetics | Venous Thrombosis - pathology | Disease Models, Animal | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
VENOUS THROMBOEMBOLISM | MODELS | ENDOTHELIUM | INFLAMMATION | PLATELETS | IN-VIVO | PODOPLANIN | NEUTROPHILS | GLYCOPROTEIN | HEMATOLOGY | FIBROBLASTS | Blood Platelets - pathology | Membrane Glycoproteins - metabolism | Constriction, Pathologic | Venous Thrombosis - metabolism | Gene Expression Regulation | Vena Cava, Inferior - metabolism | Lectins, C-Type - genetics | Membrane Glycoproteins - genetics | Mice, Knockout | Lectins, C-Type - metabolism | Animals | Blood Platelets - metabolism | Vena Cava, Inferior - pathology | Venous Thrombosis - prevention & control | Mice | Venous Thrombosis - genetics | Venous Thrombosis - pathology | Disease Models, Animal | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
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Loading RightsJournal of Clinical Investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3590 - 3600
Venous thrombi, fibrin- and rbc-rich clots triggered by inflammation and blood stasis, underlie devastating, and sometimes fatal, occlusive events. During...
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PLASMA | BLEEDING-TIME | INTEGRIN RECEPTOR | IN-VIVO | FIBRIN STABILIZING FACTOR | COAGULATION FACTOR-XIII | DEEP-VEIN THROMBOSIS | MICE | DEFICIENCY | Factor XIII Deficiency - blood | Humans | Venous Thrombosis - blood | Male | Mice, Mutant Strains | Blood Coagulation | Erythrocytes - pathology | Peptide Fragments - genetics | Disease Models, Animal | Peptide Fragments - metabolism | Mice, Inbred C57BL | Mutant Proteins - genetics | Factor XIII - metabolism | Factor XIIIa - metabolism | Fibrinogen - genetics | Factor XIIIa - genetics | Mice, Knockout | Homozygote | Animals | Erythrocytes - metabolism | Fibrinogen - metabolism | Mice | Venous Thrombosis - genetics | Mutation | Factor XIII Deficiency - genetics | Physiological aspects | Fibrin | Venous thrombosis | Research | Blood coagulation factors | Plasma | Blood platelets | Retention | Thrombosis | Colleges & universities | Blood clots | Index Medicus | Abridged Index Medicus
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PLASMA | BLEEDING-TIME | INTEGRIN RECEPTOR | IN-VIVO | FIBRIN STABILIZING FACTOR | COAGULATION FACTOR-XIII | DEEP-VEIN THROMBOSIS | MICE | DEFICIENCY | Factor XIII Deficiency - blood | Humans | Venous Thrombosis - blood | Male | Mice, Mutant Strains | Blood Coagulation | Erythrocytes - pathology | Peptide Fragments - genetics | Disease Models, Animal | Peptide Fragments - metabolism | Mice, Inbred C57BL | Mutant Proteins - genetics | Factor XIII - metabolism | Factor XIIIa - metabolism | Fibrinogen - genetics | Factor XIIIa - genetics | Mice, Knockout | Homozygote | Animals | Erythrocytes - metabolism | Fibrinogen - metabolism | Mice | Venous Thrombosis - genetics | Mutation | Factor XIII Deficiency - genetics | Physiological aspects | Fibrin | Venous thrombosis | Research | Blood coagulation factors | Plasma | Blood platelets | Retention | Thrombosis | Colleges & universities | Blood clots | Index Medicus | Abridged Index Medicus
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Loading RightsNature Genetics, ISSN 1061-4036, 10/2012, Volume 44, Issue 10, pp. 1117 - 1121
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and shows a propensity to metastasize and infiltrate adjacent and more distant...
LIVER-CANCER | FREQUENT MUTATIONS | HUMAN BREAST | COLORECTAL CANCERS | GENE | GENETICS & HEREDITY | ARISTOLOCHIC ACID | ARID1A | TP53 | CELL CARCINOMA | GENOME | Cell Proliferation | Humans | Middle Aged | Male | Carcinoma, Hepatocellular - secondary | Exome | Hepatitis B - complications | Carcinoma, Hepatocellular - genetics | Venous Thrombosis - virology | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Portal Vein - pathology | Vascular Cell Adhesion Molecule-1 - genetics | Hepatitis B virus | Cyclin-Dependent Kinases - genetics | Nuclear Proteins - genetics | Liver Neoplasms - virology | Chromosomes, Human, X - genetics | Genetic Association Studies | Liver Neoplasms - genetics | Cell Survival | Carcinoma, Hepatocellular - virology | Transcription Factors - genetics | Sequence Analysis, DNA | Cell Line, Tumor | Aged | Polymorphism, Single Nucleotide | Venous Thrombosis - genetics | Usage | Exome sequencing | Causes of | Genetic aspects | Hepatoma |
LIVER-CANCER | FREQUENT MUTATIONS | HUMAN BREAST | COLORECTAL CANCERS | GENE | GENETICS & HEREDITY | ARISTOLOCHIC ACID | ARID1A | TP53 | CELL CARCINOMA | GENOME | Cell Proliferation | Humans | Middle Aged | Male | Carcinoma, Hepatocellular - secondary | Exome | Hepatitis B - complications | Carcinoma, Hepatocellular - genetics | Venous Thrombosis - virology | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Portal Vein - pathology | Vascular Cell Adhesion Molecule-1 - genetics | Hepatitis B virus | Cyclin-Dependent Kinases - genetics | Nuclear Proteins - genetics | Liver Neoplasms - virology | Chromosomes, Human, X - genetics | Genetic Association Studies | Liver Neoplasms - genetics | Cell Survival | Carcinoma, Hepatocellular - virology | Transcription Factors - genetics | Sequence Analysis, DNA | Cell Line, Tumor | Aged | Polymorphism, Single Nucleotide | Venous Thrombosis - genetics | Usage | Exome sequencing | Causes of | Genetic aspects | Hepatoma |