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1. Full Text Weaning from mechanical ventilation
by Boles, J-M and Bion, J and Connors, A and Herridge, M and Marsh, B and Melot, C and Pearl, R and Silverman, H and Stanchina, M and Vieillard-Baron, A and Welte, T
European Respiratory Journal, ISSN 0903-1936, 05/2007, Volume 29, Issue 5, pp. 1033 - 1056
Weaning covers the entire process of liberating the patient from mechanical Support and from the endotracheal tube. Many controversial questions remain... 
Mechanical ventilation | Weaning from mechanical ventilation | mechanical ventilation | ACUTE RESPIRATORY-DISTRESS | ADAPTIVE SUPPORT VENTILATION | CRITICAL ILLNESS POLYNEUROPATHY | PROPORTIONAL ASSIST VENTILATION | OBSTRUCTIVE PULMONARY-DISEASE | END-EXPIRATORY PRESSURE | INTENSIVE-CARE-UNIT | RESPIRATORY SYSTEM | weaning from mechanical ventilation | PROLONGED TRANSLARYNGEAL INTUBATION | QUALITY-OF-LIFE | POSITIVE AIRWAY PRESSURE | Work of Breathing | Respiratory Insufficiency - physiopathology | Respiratory Insufficiency - therapy | Ventilator Weaning - methods | Humans | Treatment Failure
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2. Full Text Influence of weaning methods on the diaphragm after mechanical ventilation in a rat model
by Bruells, Christian S and Breuer, Thomas and Maes, Karen and Bergs, Ingmar and Bleilevens, Christian and Marx, Gernot and Weis, Joachim and Gayan-Ramirez, Ghislaine and Rossaint, Rolf
BMC Pulmonary Medicine, ISSN 1471-2466, 2016, Volume 16, Issue 1, p. 127
Background: Mechanical ventilation (MV) is associated with diaphragm weakness, a phenomenon termed ventilator-induced diaphragmatic dysfunction. Weaning should... 
Pressure support ventilation | Weaning | Mechanical ventilation | Spontaneous breathing trial | Ventilator-induced diaphragmatic dysfunction | OXIDATIVE STRESS | ACTIVATION | ATROPHY | MUSCLE | AKT | PROTEOLYSIS | DISUSE | PROTECTS | RESPIRATORY SYSTEM | MITOCHONDRIAL DYSFUNCTION | Animals | Muscle Contraction | Oxidative Stress | Proteolysis | Biomarkers - analysis | Rats | Male | Ventilator Weaning - methods | Positive-Pressure Respiration | Rats, Sprague-Dawley | Diaphragm - physiopathology | Oxidative stress | Usage | Care and treatment | Analysis | Clinical trials | Homeostasis | Respiratory tract diseases | Protein biosynthesis | Health aspects | Artificial respiration
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3. Full Text Epidemiology of weaning outcome according to a new definition the WIND study
by Beduneau, Gaetan and Pham, Tai and Schortgen, Frederique and Piquilloud, Lise and Zogheib, Elie and Jonas, Maud and Grelon, Fabien and Runge, Isabelle and Terzi, Nicolas and Grange, Steven and Barberet, Guillaume and Guitard, Pierre-Gildas and Frat, Jean-Pierre and Constan, Adrien and Chretien, Jean-Marie and Mancebo, Jordi and Mercat, Alain and Richard, Jean-Christophe M and Brochard, Laurent and WIND Weaning According New and REVA Reseau Europeen Rech and WIND (Weaning according to a New Definition) Study Group and the REVA (Réseau Européen de Recherche en Ventilation Artificielle) Network
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 03/2017, Volume 195, Issue 6, pp. 772 - 783
Rationale: The weaning process concerns all patients receiving mechanical ventilation. A previous classification into simple, prolonged, and difficult weaning... 
Separation attempt | Weaning | Mechanical ventilation | Outcome | mechanical ventilation | RESPIRATORY SYSTEM | TIME | weaning | separation attempt | outcome | DURATION | CRITICAL CARE MEDICINE | Outcome Assessment (Health Care) - methods | Intensive Care Units | Prospective Studies | Humans | Middle Aged | Male | Ventilator Weaning - classification | Switzerland | Spain | Outcome Assessment (Health Care) - statistics & numerical data | Time Factors | Female | France | Ventilator Weaning - methods | Ventilator Weaning - statistics & numerical data | Length of Stay - statistics & numerical data
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4. Full Text Effect of Protocolized Weaning with Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation from Mechanical Ventilation among Patients with Respiratory Failure: The Breathe Randomized Clinical Trial
by Perkins, Gavin D and Mistry, Dipesh and Gates, Simon and Gao, Fang and Snelson, Catherine and Hart, Nicholas and Camporota, Luigi and Varley, James and Carle, Coralie and Paramasivam, Elankumaran and Hoddell, Beverley and McAuley, Daniel F and Walsh, Timothy S and Blackwood, Bronagh and Rose, Louise and Lamb, Sarah E and Petrou, Stavros and Young, Duncan and Lall, Ranjit and Breathe Collaborators and for the Breathe Collaborators
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 11/2018, Volume 320, Issue 18, pp. 1881 - 1888
IMPORTANCE In adults in whom weaning from invasive mechanical ventilation is difficult, noninvasive ventilation may facilitate early liberation, but there is... 
MORTALITY | MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | TUBE | OUTCOMES | PNEUMONIA | Intensive Care Units | Hospital Mortality | Respiratory Insufficiency - mortality | Humans | Middle Aged | Male | Respiratory Insufficiency - therapy | Respiration, Artificial | Noninvasive Ventilation | Time Factors | Female | Aged | Ventilator Weaning - methods | Airway Extubation | Ventilators | Weaning | Clinical trials | Risk analysis | Patients | Survival | Incidence | Intensive care units | Randomization | Hospitals | Respiratory diseases | Ventilation | Tracheostomy | Adults | Breathing | Respiration | Caring for the Critically Ill Patient | Online First | Research | Original Investigation
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5. Full Text Weaning Patients from the Ventilator
by McConville, John F and Kress, John P
The New England Journal of Medicine, ISSN 0028-4793, 12/2012, Volume 367, Issue 23, pp. 2233 - 2239
After the underlying cause of respiratory failure in critically ill patients has been addressed, the priority is to minimize the duration of mechanical... 
PROLONGED MECHANICAL VENTILATION | CONTROLLED-TRIAL | MEDICINE, GENERAL & INTERNAL | EXTUBATION FAILURE | CARDIAC-SURGERY | TRACHEOTOMY | RESPIRATORY-DISTRESS | TRACHEOSTOMY | POSITIVE-PRESSURE VENTILATION | CRITICALLY-ILL PATIENTS | NONINVASIVE VENTILATION | Algorithms | Time Factors | Humans | Respiratory Insufficiency - therapy | Ventilator Weaning - adverse effects | Ventilator Weaning - methods | Positive-Pressure Respiration | Ventilator weaning | Research | Health aspects | Methods | Respiratory therapy | Ventilation | Postoperative period | Respiratory distress syndrome | Weaning | Respiratory diseases
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6. Full Text Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults
by Burns, Karen E. A and Burns, Karen E.A and Lellouche, Francois and Lellouche, Francois and Nisenbaum, Rosane and Nisenbaum, Rosane and Lessard, Martin R and Lessard, Martin R and Friedrich, Jan O and Friedrich, Jan O
The Cochrane database of systematic reviews, ISSN 1469-493X, 2014, Volume 9, Issue 9, p. CD008638
Background Automated systems use closed-loop control to enable ventilators to perform basic and advanced functions while supporting respiration. SmartCare (TM)... 
MORTALITY | CONTROLLED-TRIAL | MEDICINE, GENERAL & INTERNAL | MULTICENTER | EXTUBATION | PRESSURE SUPPORT | MECHANICAL VENTILATION | PROTOCOL | PNEUMONIA | DURATION | CARE | Length of Stay | Intensive Care Units | Ventilator Weaning - instrumentation | Time Factors | Humans | Critical Illness | Work of Breathing | Adult | Ventilators, Mechanical - adverse effects | Ventilator Weaning - methods | Automation - instrumentation | Randomized Controlled Trials as Topic
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7. Full Text Effect of Pressure Support vs Unassisted Breathing Through a Tracheostomy Collar on Weaning Duration in Patients Requiring Prolonged Mechanical Ventilation: A Randomized Trial
by Jubran, Amal and Grant, Brydon J. B and Duffner, Lisa A and Collins, Eileen G and Lanuza, Dorothy M and Hoffman, Leslie A and Tobin, Martin J
JAMA, ISSN 0098-7484, 02/2013, Volume 309, Issue 7, pp. 671 - 677
IMPORTANCE Patients requiring prolonged mechanical ventilation (>21 days) are commonly weaned at long-term acute care hospitals (LTACHs). The most effective... 
MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | FACILITIES | CRITICALLY ILL | OUTCOMES | FAILURE | CARE | Humans | Middle Aged | Male | Treatment Outcome | Long-Term Care | Positive-Pressure Respiration - methods | Time Factors | Survival Analysis | Female | Tracheostomy - instrumentation | Aged | Respiration | Ventilator Weaning - methods | Surgical outcomes | Critical care | Ventilation | Long term health care
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8. Full Text Natriuretic peptide-driven fluid management during ventilator weaning: A randomized controlled trial
by Dessap, Armand Mekontso and Roche-Campo, Ferran and Kouatchet, Achille and Tomicic, Vinko and Beduneau, Gaetan and Sonneville, Romain and Cabello, Belen and Jaber, Samir and Azoulay, Elie and Castanares-Zapatero, Diego and Devaquet, Jerome and Lellouche, François and Katsahian, Sandrine and Brochard, Laurent
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 12/2012, Volume 186, Issue 12, pp. 1256 - 1263
Rationale: Difficult weaning from mechanical ventilation is often associated with fluid overload. B-type natriuretic peptide (BNP) has been proposed as a tool... 
Diuretics | Mechanical ventilation | B-type natriuretic peptide | RISK-FACTORS | mechanical ventilation | HYPOPROTEINEMIC PATIENTS | BALANCE | THERAPY | diuretics | RESPIRATORY SYSTEM | FUROSEMIDE | DYSFUNCTION | ALBUMIN | RESPIRATORY-FAILURE | CRITICAL CARE MEDICINE | Furosemide - administration & dosage | Diuretics - administration & dosage | Water-Electrolyte Balance - physiology | Humans | Middle Aged | Male | Treatment Outcome | Water-Electrolyte Balance - drug effects | Acetazolamide - administration & dosage | Ventricular Dysfunction, Left - therapy | Time Factors | Female | Aged | Ventilator Weaning - methods | Natriuretic Peptide, Brain - blood
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9. Full Text Noninvasive ventilation and weaning in patients with chronic hypercapnic respiratory failure: A randomized multicenter trial
by Girault, Christophe and Bubenheim, Michael and Abroug, Fekri and Diehl, Jean Luc and Elatrous, Souheil and Beuret, Pascal and Richecoeur, Jack and L'Her, Erwan and Hilbert, Gilles and Capellier, Gilles and Rabbat, Antoine and Besbes, Mohamed and Guérin, Claude and Guiot, Philippe and Bénichou, Jacques and Bonmarchand, Guy and VENISE Trial Grp and VENISE Trial Group and for the VENISE Trial Group
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2011, Volume 184, Issue 6, pp. 672 - 679
Rationale: The use of noninvasive ventilation (NIV) as an early weaning/extubation technique from mechanical ventilation remains controversial. Objectives: To... 
Acute respiratory failure | Chronic obstructive pulmonary disease | Noninvasive ventilation | Weaning | Extubation | METAANALYSIS | noninvasive ventilation | MECHANICAL VENTILATION | RISK | weaning | extubation | OBSTRUCTIVE PULMONARY-DISEASE | acute respiratory failure | RESPIRATORY SYSTEM | SUPPORT VENTILATION | POSITIVE-PRESSURE VENTILATION | COPD PATIENTS | chronic obstructive pulmonary disease | CRITICAL CARE MEDICINE | Respiratory Insufficiency - complications | Prospective Studies | Respiration, Artificial - methods | Humans | Middle Aged | Hypercapnia - therapy | Male | Treatment Outcome | Intubation, Intratracheal - methods | Respiratory Insufficiency - therapy | Hypercapnia - complications | Female | Aged | Ventilator Weaning - methods | Chronic Disease
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10. Full Text A randomised, controlled trial of conventional versus automated weaning from mechanical ventilation using SmartCare™/PS
by Rose, Louise and Presneill, Jeffrey J and Johnston, Linda and Cade, John F
Intensive Care Medicine, ISSN 0342-4642, 10/2008, Volume 34, Issue 10, pp. 1788 - 1795
Preliminary assessment of an automated weaning system (SmartCare™/PS) compared to usual management of weaning from mechanical ventilation performed in the... 
Artificial | Pediatrics | Emergency Medicine | Weaning | Intensive / Critical Care Medicine | Pain Medicine | Pneumology/Respiratory System | Medicine & Public Health | Closed-loop ventilation | Automated weaning | Anesthesiology | Respiration | Mechanical ventilation | artificial | MULTICENTER | KNOWLEDGE-BASED SYSTEM | MANAGEMENT | mechanical ventilation | INTENSIVE-CARE-UNIT | respiration | automated weaning | closed-loop ventilation | weaning | CRITICAL CARE MEDICINE | Intensive Care Units | Pilot Projects | Humans | Middle Aged | Adult | Female | Male | Aged | Ventilator Weaning - methods | Therapy, Computer-Assisted | Ventilators | Usage | Ventilator weaning | Health aspects
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11. Full Text Delirium and circadian rhythm of melatonin during weaning from mechanical ventilation an ancillary study of a weaning trial
by Dessap, Armand Mekontso and Roche-Campo, Ferran and Launay, Jean-Marie and Charles-Nelson, Anais and Katsahian, Sandrine and Brun-Buisson, Christian and Brochard, Laurent
Chest, ISSN 0012-3692, 11/2015, Volume 148, Issue 5, pp. 1231 - 1241
BACKGROUND: Delirium is frequent in patients in the ICU, but its association with the outcome of weaning from mechanical ventilation has not been assessed.... 
DISTURBANCES | DISRUPTION | RESPIRATORY SYSTEM | SLEEP-DEPRIVATION | POSTOPERATIVE DELIRIUM | RELIABILITY | URINARY 6-SULFATOXYMELATONIN | MODEL | PREVALENCE | CRITICALLY-ILL PATIENTS | CARE | CRITICAL CARE MEDICINE | Delirium - etiology | Intensive Care Units | Follow-Up Studies | Humans | Middle Aged | Delirium - urine | Male | Circadian Rhythm | Respiration, Artificial | Ancillary Services, Hospital | Melatonin - analogs & derivatives | Melatonin - urine | Time Factors | Female | Aged | Ventilator Weaning - methods | Delirium | Intensive care units | Usage | Care and treatment | Melatonin | Clinical trials | Dosage and administration | Artificial respiration
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12. Full Text Seated-Baduanjin as an adjuvant rehabilitation treatment for dysfunctional ventilatory weaning response: A case report
by Chen, Minggui and Zeng, Rui-Xiang and Liang, Xuefei and Hu, Xiyan and Kong, Lili and Wang, Jingjing and Guo, Liheng and Zhang, Min-Zhou and Zhang, Xiaoxuan
Medicine, ISSN 0025-7974, 08/2018, Volume 97, Issue 34, p. e11854
Rationale: Seated-Baduanjin as adjuvant rehabilitation treatment in a patient with Dysfunctional ventilatory weaning response (DVWR) is extremely rare, and we... 
MEDICINE, GENERAL & INTERNAL | rehabilitation exercise | seated-Baduanjin | dysfunctional ventilatory weaning response | HEART-FAILURE | respiratory failure with ventilation | EXERCISE | Exercise Therapy - methods | Humans | Middle Aged | Respiratory Insufficiency - etiology | Male | Postoperative Complications - therapy | Respiratory Insufficiency - therapy | Respiration | Ventilator Weaning - adverse effects | Ventilator Weaning - methods | Muscle Strength - physiology | Case studies | Qigong | Ventilator weaning | Health aspects | Methods
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13. Full Text Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients
by Blackwood, Bronagh and Blackwood, Bronagh and Burns, Karen E.A and Burns, Karen E. A and Cardwell, Chris R and Cardwell, Chris R and O'Halloran, Peter and O'Halloran, Peter
The Cochrane database of systematic reviews, ISSN 1469-493X, 2014, Volume 11, Issue 11, p. CD006904
Background This is an update of a review last published in Issue 5, 2010, of The Cochrane Library. Reducing weaning time is desirable inminimizing potential... 
Length of Stay | COMPUTERIZED DECISION-SUPPORT | SURGERY | SEDATION PROTOCOL | SURGICAL-PATIENTS | METAANALYSIS | Humans | Critical Illness | RANDOMIZED CONTROLLED-TRIAL | Respiration, Artificial [adverse effects; utilization] | DISCONTINUATION | Randomized Controlled Trials as Topic | MEDICINE, GENERAL & INTERNAL | Time Factors | Ventilator Weaning [methods] | CARE-UNIT | PRESSURE SUPPORT | CLINICAL-TRIALS | Intensive Care Units [utilization] | Adult | Clinical Protocols [standards] | Respiration, Artificial - adverse effects | Respiration, Artificial - statistics & numerical data | Clinical Protocols - standards | Intensive Care Units - statistics & numerical data | Ventilator Weaning - adverse effects | Ventilator Weaning - methods
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14. Full Text Pressure support versus T-tube for weaning from mechanical ventilation in adults
by Ladeira, Magdaline T and Ladeira, Magdaline T and Vital, Flávia M.R and Vital, Flávia M R and Andriolo, Régis B and Andriolo, Régis B and Andriolo, Brenda N. G and Andriolo, Brenda N.G and Atallah, Álvaro N and Atallah, Alvaro N and Peccin, Maria S and Peccin, Maria S
The Cochrane database of systematic reviews, ISSN 1469-493X, 2014, Volume 5, Issue 5, p. CD006056
Background Mechanical ventilation is important in caring for patients with critical illness. Clinical complications, increased mortality, and high costs of... 
CONTROLLED-TRIAL | MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | COMPENSATION | PIECE | BAROTRAUMA | PROTOCOL | CLASSIFICATION | TIME | DURATION | NOSOCOMIAL PNEUMONIA | Respiration, Artificial - methods | Ventilator Weaning - instrumentation | Humans | Adult | Tracheostomy - instrumentation | Respiratory Insufficiency - therapy | Ventilator Weaning - methods | Pressure | Respiration, Artificial - instrumentation | Randomized Controlled Trials as Topic
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