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Cardiovascular Research, ISSN 0008-6363, 07/2018, Volume 114, Issue 8, pp. 1165 - 1177
Abstract Aims Pulmonary arterial hypertension (PAH) is a devastating disease and treatment options are limited. Urocortin-2 (Ucn-2) has shown promising... 
Cardiac hypertrophy | Right ventricular failure | Vascular remodelling | Pulmonary hypertension | Urocortin-2 | DIAGNOSIS | PRESSURE-OVERLOAD | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN-KINASE | REPERFUSION INJURY | ENDOCRINE | INFUSION | HYPERTROPHY | EJECTION FRACTION | EXPERIMENTAL HEART-FAILURE | ECHOCARDIOGRAPHY | Antihypertensive Agents - pharmacology | Receptors, Corticotropin-Releasing Hormone - metabolism | Rats, Wistar | Humans | Hypertension, Pulmonary - physiopathology | Male | Exercise Tolerance - drug effects | Case-Control Studies | Hypertension, Pulmonary - prevention & control | Urocortins - metabolism | Hypertrophy, Right Ventricular - physiopathology | Arterial Pressure - drug effects | Ventricular Dysfunction, Right - physiopathology | Urocortins - pharmacology | Ventricular Function, Right - drug effects | Vascular Remodeling - drug effects | Hypertrophy, Right Ventricular - metabolism | Ventricular Dysfunction, Right - metabolism | Disease Models, Animal | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Corticotropin-Releasing Hormone - metabolism | Corticotropin-Releasing Hormone - pharmacology | Ventricular Dysfunction, Right - prevention & control | Animals | Heart Ventricles - physiopathology | Signal Transduction - drug effects | Hypertrophy, Right Ventricular - prevention & control | Heart Ventricles - metabolism | Vasodilation - drug effects | Ventricular Remodeling - drug effects | Heart Ventricles - drug effects
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 2015, Volume 308, Issue 9, pp. L873 - L890
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2012, Volume 185, Issue 4, pp. 409 - 419
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2014, Volume 307, Issue 3, pp. H273 - H283
Pulmonary arterial hypertension (PAH) results in right ventricular (RV) dysfunction and failure. Paradoxically, women are more frequently diagnosed with PAH... 
Rv catheterization | Cardiopulmonary hemodynamics | Sex difference | Estrogen | Pulmonary artery hypertension | estrogen | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | COLLAGEN | sex difference | rv catheterization | pulmonary artery hypertension | HYDROXYPROLINE | SEX | DECREASES | 17-BETA-ESTRADIOL | HYPERTROPHY | IN-VITRO | VASOREACTIVITY | BIOSYNTHESIS | cardiopulmonary hemodynamics | PERIPHERAL VASCULAR DISEASE | EXPRESSION | Estrogen Replacement Therapy | Hypertension, Pulmonary - diagnosis | Compliance | Pyrroles | Drug Implants | Hypertension, Pulmonary - physiopathology | Myocardial Contraction - drug effects | Time Factors | Arterial Pressure - drug effects | Female | Ventricular Dysfunction, Right - physiopathology | Hypertension, Pulmonary - drug therapy | Ventricular Function, Right - drug effects | Indoles | Vascular Remodeling - drug effects | Heart Ventricles - pathology | Disease Models, Animal | Ovariectomy | Mice, Inbred C57BL | Estradiol - administration & dosage | Stroke Volume - drug effects | Hypoxia - complications | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Ventricular Dysfunction, Right - diagnosis | Ventricular Dysfunction, Right - prevention & control | Animals | Cardiotonic Agents - administration & dosage | Heart Ventricles - physiopathology | Ventricular Dysfunction, Right - etiology | Hypertension, Pulmonary - etiology | Estrogens - administration & dosage | Pulmonary Artery - pathology | Heart Ventricles - drug effects | Women | Physiological aspects | Physiological research | Ventricular function | Research | Pulmonary hypertension | Call for Papers
Journal Article
Circulation: Cardiovascular Imaging, ISSN 1941-9651, 2014, Volume 7, Issue 1, pp. 107 - 114
Journal Article
Circulation: Heart Failure, ISSN 1941-3289, 05/2015, Volume 8, Issue 3, pp. 542 - 550
Background Pulmonary hypertension and right ventricular (RV) dysfunction are common in patients with advanced heart failure with preserved ejection fraction... 
heart failure, diastolic | hypertension, pulmonary | heart failure | ventricular function, right | pulmonary circulation | EUROPEAN-ASSOCIATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ventricular function | GUIDELINES | pulmonary | PLANE SYSTOLIC EXCURSION | EXERCISE CAPACITY | right | diastolic | DISEASE | PHOSPHODIESTERASE-5 INHIBITION | ECHOCARDIOGRAPHY | DYSFUNCTION | hypertension | AMERICAN-SOCIETY | Predictive Value of Tests | Hypertension, Pulmonary - diagnosis | Prospective Studies | Humans | Middle Aged | Heart Failure - physiopathology | Hypertension, Pulmonary - physiopathology | Male | Arterial Pressure - drug effects | Adrenergic beta-1 Receptor Agonists - administration & dosage | Aged, 80 and over | Female | Ventricular Dysfunction, Right - physiopathology | Heart Failure - diagnosis | Hypertension, Pulmonary - drug therapy | Ventricular Function, Right - drug effects | Heart Failure - complications | Ventricular Function, Left - drug effects | Diagnostic Techniques, Cardiovascular | Infusions, Parenteral | Stroke Volume - drug effects | Ventricular Dysfunction, Right - drug therapy | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Ventricular Dysfunction, Right - diagnosis | Dobutamine - administration & dosage | Heart Failure - drug therapy | Ventricular Dysfunction, Right - etiology | Aged | Vasodilation - drug effects | Hypertension, Pulmonary - etiology
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 05/2012, Volume 125, Issue 19, pp. 2353 - 2362
Background-Pressure overload resulting from aortic stenosis causes maladaptive ventricular and vascular remodeling that can lead to pulmonary hypertension,... 
aortic valve stenosis | hypertension, pulmonary | heart failure | hemodynamics | phosphodiesterase inhibitors | MORTALITY | EUROPEAN-ASSOCIATION | CARDIAC & CARDIOVASCULAR SYSTEMS | SILDENAFIL | DIASTOLIC FUNCTION | VALVE-REPLACEMENT | PERIPHERAL VASCULAR DISEASE | INDEX | HYPERTENSION | AMERICAN-SOCIETY | SYSTOLIC HEART-FAILURE | DOPPLER-ECHOCARDIOGRAPHY | Piperazines - administration & dosage | Aortic Valve Stenosis - drug therapy | Phosphodiesterase 5 Inhibitors - adverse effects | Humans | Sulfones - adverse effects | Male | Purines - administration & dosage | Aortic Valve Stenosis - diagnostic imaging | Sildenafil Citrate | Compliance - drug effects | Ultrasonography | Aged, 80 and over | Vascular Resistance - drug effects | Female | Blood Pressure - drug effects | Purines - adverse effects | Ventricular Function, Right - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Severity of Illness Index | Ventricular Function, Left - drug effects | Aortic Valve Stenosis - physiopathology | Phosphodiesterase 5 Inhibitors - administration & dosage | Stroke Volume - drug effects | Treatment Outcome | Piperazines - adverse effects | Aged | Pulmonary Circulation - drug effects | Sulfones - administration & dosage | Hypertension | Care and treatment | Aortic valve stenosis | Causes of | Patients | Pulmonary hypertension | Risk factors | Methods | phosphodiesterase type 5 inhibitors | pulmonary hypertension
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20828
Background: Right ventricular (RV) dysfunction is a complication of pulmonary hypertension and portends a poor prognosis. Pharmacological therapies targeting... 
CONVERTING ENZYME 2 | CHYMASE | PULMONARY-HYPERTENSION | MYOCARDIAL-INFARCTION | MOUSE HEART | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PREVENTION | HEART IN-VIVO | ECHOCARDIOGRAPHY | ANGIOTENSIN-(1-7) | Immunohistochemistry | Humans | Mice, Inbred C57BL | Microvessels - drug effects | Microvessels - pathology | Systole - drug effects | Male | Recombinant Proteins - pharmacology | Pressure | Hypertrophy, Right Ventricular - physiopathology | Animals | Peptidyl-Dipeptidase A - pharmacology | Signal Transduction - drug effects | Fibrosis | Peptidyl-Dipeptidase A - metabolism | Hypertrophy, Right Ventricular - pathology | Peptidyl-Dipeptidase A - administration & dosage | Diastole - drug effects | Hemodynamics - drug effects | Mice | Ventricular Function, Right - drug effects | Ventricular Function, Right - physiology | Disease Models, Animal | Heart failure | Enzymes | Prognosis | Analysis | Pulmonary hypertension | Angiotensin | Cardiac arrhythmia | Intercellular signalling | Phosphorylation | Diastolic pressure | Disease | Critical care | Kinases | Peptidyl-dipeptidase A | Transgenic animals | Blood pressure | Heart diseases | Time constant | Recombinant | Hypertension | Stroke | Pulmonary arteries | Mortality | Cardiomyocytes | Pharmacology | Pulmonary artery | Disease prevention | Medicine | Collagen | Hemodynamics | Ventricle | Hypertrophy | Ejection | Veins & arteries
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2014, Volume 307, Issue 3, pp. H361 - H369
Right ventricular (RV) function is an important determinant of prognosis in congenital heart diseases, pulmonary hypertension, and heart failure. Preventive... 
Pulmonary artery banding | Diastolic dysfunction | Pressure-volume loops | Right ventricular failure | Fibrosis | PRESSURE-OVERLOAD | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | CLINICAL-TRIAL | PULMONARY ARTERIAL-HYPERTENSION | pressure-volume loops | FAILURE | PASSIVE STIFFNESS | pulmonary artery banding | EJECTION FRACTION | CONGENITAL HEART-DISEASE | diastolic dysfunction | PERIPHERAL VASCULAR DISEASE | fibrosis | PHOSPHODIESTERASE-5 INHIBITION | right ventricular failure | LOADING CONDITIONS | REGISTRY | Diastole | Rats, Wistar | Male | Sulfones - pharmacology | Exercise Tolerance - drug effects | Recovery of Function | Sildenafil Citrate | Hypertrophy, Right Ventricular - physiopathology | Time Factors | Hypertrophy, Right Ventricular - pathology | Ventricular Dysfunction, Right - physiopathology | Ventricular Function, Right - drug effects | Heart Ventricles - pathology | Disease Models, Animal | Purines - pharmacology | Ventricular Pressure - drug effects | Stroke Volume - drug effects | Ventricular Dysfunction, Right - drug therapy | Cardiotonic Agents - pharmacology | Piperazines - pharmacology | Animals | Heart Ventricles - physiopathology | Ventricular Dysfunction, Right - pathology | Heart Ventricles - drug effects | Patient outcomes | Abnormalities | Physiological aspects | Dosage and administration | Congenital heart disease | Ventricular function | Sildenafil | Diagnosis | Drug therapy
Journal Article