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British Journal of Pharmacology, ISSN 0007-1188, 09/2011, Volume 164, Issue 1, pp. 170 - 180
BACKGROUND AND PURPOSE Up‐regulation of thioredoxin interacting protein (TXNIP), an endogenous inhibitor of thioredoxin (Trx), compromises cellular antioxidant... 
peroxynitrite | retina | neuroprotection | verapamil | NMDA | neurodegeneration | TXNIP | apoptosis | retinal ganglion cells | Thioredoxin | DIABETIC-RETINOPATHY | OXIDATIVE STRESS | RAT RETINA | FACTOR-KAPPA-B | CALCIUM-CHANNEL BLOCKERS | NERVE GROWTH-FACTOR | OPEN-ANGLE GLAUCOMA | IN-VIVO | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | UP-REGULATED PROTEIN-1 | Retina - drug effects | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Retina - metabolism | Apoptosis - drug effects | Caspase 3 - metabolism | Male | NF-kappa B - metabolism | Retinal Ganglion Cells - metabolism | Tyrosine - analogs & derivatives | Inflammation - metabolism | MAP Kinase Kinase 4 - metabolism | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | MAP Kinase Kinase 4 - antagonists & inhibitors | Thioredoxins - metabolism | Thioredoxins - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinase 5 - metabolism | MAP Kinase Kinase Kinase 5 - antagonists & inhibitors | Eye Diseases - pathology | Interleukin-1beta - antagonists & inhibitors | NF-kappa B - antagonists & inhibitors | Carrier Proteins - biosynthesis | Carrier Proteins - antagonists & inhibitors | Rats | Eye Diseases - metabolism | Up-Regulation - genetics | Caspase Inhibitors | Poly(ADP-ribose) Polymerase Inhibitors | Rats, Sprague-Dawley | Verapamil - pharmacology | Carrier Proteins - genetics | Poly(ADP-ribose) Polymerases - metabolism | Tyrosine - metabolism | Animals | Carrier Proteins - metabolism | Eye Diseases - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Inflammation - genetics | Neuroglia - metabolism | Oxidative Stress - drug effects | Retinal Ganglion Cells - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | Research Papers
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2012, Volume 26, Issue 7, pp. 1085 - 1094
Highlight ► N -acetylcysteine protects against LPS-induced inhibition of amyloid beta efflux across the blood–brain barrier. 
Psychiatry | Allergy and Immunology | Oxidative stress | Amyloid beta | Alzheimer’s disease | Lipopolysaccharide | Pgp | Neuroinflammation | LRP-1 | N-acetylcysteine | Alzheimer's disease | P-GLYCOPROTEIN FUNCTION | METABOLIC SYNDROME | PSYCHIATRY | ALZHEIMERS-DISEASE | MICROVASCULAR ENDOTHELIAL-CELLS | COGNITIVE IMPAIRMENT | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | NEUROSCIENCES | SYSTEMIC INFLAMMATION | AMYLOID-BETA-PEPTIDE | ACETYL-L-CYSTEINE | Inflammation - chemically induced | Chemokines - blood | Glutathione - metabolism | Antioxidants - metabolism | Cerebral Cortex - pathology | Acetylcysteine - metabolism | Male | Protein Carbonylation - drug effects | Cerebral Cortex - metabolism | Lipopolysaccharides | Inflammation - metabolism | Amyloid beta-Peptides - metabolism | Calcium Channel Blockers - metabolism | Cytokines - blood | Tumor Suppressor Proteins - metabolism | Cytokines - metabolism | Receptors, LDL - metabolism | Hippocampus - pathology | Antioxidants - pharmacology | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | alpha-Macroglobulins - metabolism | Algorithms | Animals | Acetylcysteine - pharmacology | Chemokines - metabolism | Mice | Oxidative Stress - drug effects | Verapamil - metabolism | Inflammation - physiopathology | Serum Albumin - metabolism | Antioxidants | Acetylcysteine | Mitogens | Low density lipoproteins | neuroinflammation | lipopolysaccharide | oxidative stress
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 7/2006, Volume 23, Issue 7, pp. 1543 - 1553
Journal Article
Journal Article
Plant, Cell & Environment, ISSN 0140-7791, 04/2013, Volume 36, Issue 4, pp. 844 - 855
Journal Article
Physiologia Plantarum, ISSN 0031-9317, 11/2017, Volume 161, Issue 3, pp. 322 - 338
Salicylic acid (SA) is a plant hormone involved in a number of physiological responses including both local and systemic resistance of plants to pathogens. In... 
ATP-BINDING CASSETTE | CELL-SUSPENSION CULTURES | TRANSPORT | CARBOXYPEPTIDASE-LIKE PROTEIN | METABOLISM | MEDICAGO-TRUNCATULA | SEED COAT | GLYCOSYLTRANSFERASES | DISEASE RESISTANCE | TOBACCO | PLANT SCIENCES | Salicylic Acid - metabolism | Chromatography, High Pressure Liquid | Vacuolar Proton-Translocating ATPases - metabolism | Vacuoles - drug effects | Arbutin - pharmacology | Salicylic Acid - chemistry | Gramicidin - pharmacology | Protoplasts - metabolism | Time Factors | Adenosine Triphosphate - metabolism | Benzyl Alcohols - pharmacology | ATP-Binding Cassette Transporters - metabolism | Transport Vesicles - drug effects | Glucosides - pharmacology | Arabidopsis - drug effects | Metabolome | Verapamil - pharmacology | Arabidopsis - metabolism | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Quercetin - pharmacology | Transport Vesicles - metabolism | Glucose - metabolism | Vacuoles - metabolism | Carbon Radioisotopes - metabolism | Intracellular Membranes - drug effects | Kinetics | Intracellular Membranes - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Arabidopsis thaliana | Drug resistance in microorganisms | Glucose | Dextrose | Adenosine triphosphatase | Enrichment | H+-transporting ATPase | Efflux | Salicylic acid | Hydrogen | Saturation | Membrane vesicles | Physiological responses | Vanadate | Vesicles | Gramicidin | Inhibitors | Salicin | Acids | Quercetin | Sag | Verapamil | ABC transporters | Inhibition | Transporter | ABC transporter
Journal Article
Biological Psychiatry, ISSN 0006-3223, 01/2018, Volume 83, Issue 1, pp. 29 - 37
Brain-derived neurotrophic factor (BDNF) plays a key role in the pathophysiology and treatment of depression. Recent clinical studies demonstrate that... 
Depression | Muscarinic receptor | Prefrontal cortex | TrkB receptor | Voltage-dependent calcium channel | mTORC1 | ANTAGONIST | VAL66MET POLYMORPHISM | NEUROSCIENCES | KETAMINE | ACETYLCHOLINE-RECEPTOR SUBTYPE | MESSENGER-RNA | BDNF RELEASE | NEURONS | MODULATION | Brain-Derived Neurotrophic Factor - genetics | Neurons - pathology | Synaptosomes - drug effects | Depressive Disorder - pathology | gamma-Aminobutyric Acid - metabolism | Motor Activity - drug effects | Depressive Disorder - drug therapy | Male | Receptor, Muscarinic M1 - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Synaptosomes - metabolism | Brain - metabolism | Scopolamine - pharmacology | Time Factors | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Neurons - drug effects | Disease Models, Animal | Cells, Cultured | Mice, Transgenic | Depressive Disorder - metabolism | Rats, Sprague-Dawley | Verapamil - pharmacology | Brain - drug effects | Animals | Brain - pathology | Calcium Channels, L-Type - metabolism | Receptor, trkB - metabolism | Receptor, Muscarinic M1 - metabolism | Viral antibodies | Medical research | Calcium channels | Scopolamine | Neurons | Antidepressants | Depression, Mental | Medicine, Experimental | Antibodies | Muscle proteins | Glutamate
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 12/2018, Volume 35, Issue 12, pp. 1 - 10
The organic cation transporters (OCTs) and multidrug and toxin extrusions (MATEs) together are regarded as an organic cation transport system critical to the... 
Biochemistry, general | Biomedicine | irinotecan | Pharmacy | Medical Law | organic cation transporters | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | drug and drug interactions | morphine | DRUG | METFORMIN | TOXIN | GENETIC-VARIANTS | CHEMISTRY, MULTIDISCIPLINARY | POLYMORPHISMS | PAIN | PHARMACOKINETICS | MATES | SUBSTRATE | MULTIDRUG | PHARMACOLOGY & PHARMACY | Ondansetron - pharmacology | Humans | Organic Cation Transporter 2 - antagonists & inhibitors | Organic Cation Transporter 2 - metabolism | Organic Cation Transporter 1 - metabolism | Tissue Distribution | Drug Interactions | HEK293 Cells | Ondansetron - metabolism | Irinotecan - pharmacology | Fluoxetine - pharmacology | Organic Cation Transport Proteins - metabolism | Mice, Inbred C57BL | Amitriptyline - metabolism | Morphine - metabolism | Irinotecan - metabolism | Verapamil - pharmacology | Animals | Imipramine - metabolism | Fluoxetine - metabolism | Organic Cation Transporter 1 - antagonists & inhibitors | Narcotics - metabolism | Amitriptyline - pharmacology | Imipramine - pharmacology | Verapamil - metabolism | Antidepressants | Morphine | Drug interactions | Drugs | Organic cation transporter | Amitriptyline | Kidneys | Fluoxetine | Oct-2 protein | Substrates | Irinotecan | Imipramine | Verapamil | Extrusion | Mice | In vivo methods and tests | Drug interaction | Cations | Inhibition | Transporter
Journal Article
The FEBS Journal, ISSN 1742-464X, 05/2017, Volume 284, Issue 9, pp. 1370 - 1387
Verapamil, an L‐type calcium channel blocker, has been used successfully to treat cardiovascular diseases. Interestingly, we have recently shown that treatment... 
cancer | autophagy | cell death | lactate | verapamil | CANCER-CELLS | APOPTOSIS | HYPERTHERMIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUCOSE-TRANSPORT | DEATH | IN-VITRO | INHIBITION | GROWTH | RESISTANCE | STRESS | L-Lactate Dehydrogenase - metabolism | Neoplasms - metabolism | Autophagy-Related Protein 5 - antagonists & inhibitors | Calcium Channel Blockers - adverse effects | Autophagy-Related Protein 7 - metabolism | Humans | Autophagy-Related Protein 5 - genetics | Glycolysis - drug effects | Autophagy - drug effects | Autophagosomes - drug effects | Chloroquine - pharmacology | Antineoplastic Agents - adverse effects | Isoenzymes - metabolism | Verapamil - adverse effects | Cytoprotection - drug effects | Antineoplastic Agents - pharmacology | Autophagy-Related Protein 7 - antagonists & inhibitors | Biomarkers - metabolism | Cell Survival - drug effects | Microscopy, Electron, Transmission | Cells, Cultured | Autophagosomes - metabolism | Neoplasms - ultrastructure | Calcium Channel Blockers - pharmacology | Autophagy-Related Protein 7 - genetics | Verapamil - pharmacology | Antimalarials - pharmacology | Autophagosomes - ultrastructure | Neoplasms - drug therapy | CRISPR-Cas Systems | Autophagy-Related Protein 5 - metabolism | Cell Line, Tumor | L-Lactate Dehydrogenase - antagonists & inhibitors | Cell Line, Transformed | Energy Metabolism - drug effects | Isoenzymes - antagonists & inhibitors | Glucose metabolism | Calcium channels | Chemotherapy | Cell death | Physiological aspects | Verapamil | Cancer | Dehydrogenases | Calcium | Chloroquine | Medical services | Calcium metabolism | Glucose | Dehydrogenase | Autophagy | Inhibition | Heart diseases | CRISPR | Enzymes | Tumor cells | Markers | Lactate dehydrogenase | Pharmacology | Metabolism | L-Lactate dehydrogenase | Inhibitors | Calcium channels (L-type) | Glycolysis | Lactic acid | Cardiovascular diseases | ATP | Prostate | Viability | Phagocytosis | Apoptosis
Journal Article