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1. Full Text Role of the Mmr Efflux Pump in Drug Resistance in Mycobacterium tuberculosis
by Liliana Rodrigues and Cristina Villellas and Rebeca Bailo and Miguel Viveiros and José A. Aínsa
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2013, Volume 57, Issue 2, pp. 751 - 757
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Acriflavine - pharmacology | Isoniazid - pharmacology | Phenazines - pharmacology | Cetrimonium Compounds - pharmacology | Nitriles - pharmacology | Anti-Infective Agents, Local - pharmacology | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Onium Compounds - pharmacology | Gene Knockout Techniques | Mycobacterium tuberculosis - drug effects | Verapamil - pharmacology | Bacterial Proteins | Microbial Sensitivity Tests | Ethidium - pharmacology | Membrane Transport Proteins - genetics | Mycobacterium tuberculosis - enzymology | Drug Resistance, Bacterial - physiology | Organophosphorus Compounds - pharmacology | Membrane Transport Proteins - metabolism | Antineoplastic Agents - pharmacology | Drug Resistance, Bacterial - genetics | Mycobacterium tuberculosis - metabolism | Mycobacterium tuberculosis - genetics | Index Medicus | Cyanide | carbonyls | Drug development | Drug resistance | Acriflavine | Membrane proteins | Ethidium bromide | Tuberculosis | Disinfectants | Verapamil | Cetrimonium bromide | Isoniazid | Cytoplasm | tetraphenylphosphonium | Mechanisms of Resistance
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2. Recent advances in the development of P-gp inhibitors
by Baumert, Christiane and Hilgeroth, Andreas
Anti-cancer agents in medicinal chemistry, ISSN 1871-5206, 2009, Volume 9, Issue 4, pp. 415 - 436
Development | Multidrug resistance | P-gp inhibitor | Pharmacology & Pharmacy | Oncology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Propafenone - pharmacology | Humans | Drug Resistance, Neoplasm | Structure-Activity Relationship | Verapamil - analogs & derivatives | Pyrimidines - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Verapamil - pharmacology | Quinolines - pharmacology | Peptides - pharmacology | Coumarins - pharmacology | Terpenes - pharmacology | Pyrroles - pharmacology | Animals | Drug Design | Tamoxifen - pharmacology | Cell Line, Tumor | Flavonoids - pharmacology | Pyridines - pharmacology | Propanolamines - pharmacology | Quinazolines - pharmacology | Pyrazoles - pharmacology
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3. Full Text A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries
by Wong, P.S and Garle, M.J and Alexander, S.P.H and Randall, M.D and Roberts, R.E
Pharmacological research, ISSN 1043-6618, 12/2014, Volume 90, pp. 25 - 35
Porcine coronary artery | Ca2+-reintroduction | Ouabain-sensitive sodium–potassium pump | KCl relaxation | Rubidium uptake | Hydrogen peroxide (H2O2) relaxation | reintroduction | relaxation | Hydrogen peroxide (H | Ouabain-sensitive sodium-potassium pump | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Catalase - pharmacology | Sodium-Potassium-Exchanging ATPase - physiology | Male | Nitroprusside - pharmacology | Quinoxalines - pharmacology | Oxadiazoles - pharmacology | Swine | Female | Vasodilation - physiology | Bradykinin - pharmacology | Ouabain - pharmacology | Polyethylene Glycols - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Coronary Vessels - drug effects | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Colforsin - pharmacology | Coronary Vessels - physiology | Hydrogen Peroxide - pharmacology | Verapamil - pharmacology | Indomethacin - pharmacology | Peptides - pharmacology | Carbenoxolone - pharmacology | Animals | Vasodilation - drug effects | In Vitro Techniques | Index Medicus
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4. Full Text Evaluation of para-Aminosalicylic Acid as a Substrate of Multiple Solute Carrier Uptake Transporters and Possible Drug Interactions with Nonsteroidal Anti-inflammatory Drugs In Vitro
by Parvez, M. Masud and Shin, Ho Jung and Jung, Jin Ah and Shin, Jae-Gook
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 05/2017, Volume 61, Issue 5
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Octamer Transcription Factor-1 - antagonists & inhibitors | Organic Anion Transport Protein 1 - metabolism | Proton Pump Inhibitors - pharmacology | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Humans | Naproxen - pharmacology | Organic Cation Transporter 2 - antagonists & inhibitors | Organic Cation Transporter 2 - metabolism | Aminosalicylic Acid - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Aminosalicylic Acid - pharmacokinetics | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | ATP-Binding Cassette Transporters - metabolism | Biological Transport - drug effects | Cell Line | Organic Anion Transport Protein 1 - antagonists & inhibitors | Ibuprofen - pharmacology | Antitubercular Agents - pharmacology | Probenecid - pharmacology | Quinidine - pharmacology | Verapamil - pharmacology | Antitubercular Agents - pharmacokinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 - antagonists & inhibitors | Solute Carrier Organic Anion Transporter Family Member 1b1 - metabolism | Drug Interactions - physiology | Cimetidine - pharmacology | Aminosalicylic Acid - pharmacology | Biological Transport - physiology | Rifampin - pharmacology | Antitubercular Agents - metabolism | Octamer Transcription Factor-1 - metabolism | Index Medicus
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5. Full Text Ionotropic glutamate receptor (iGluR)-like channels mediate MAMP-induced calcium influx in Arabidopsis thaliana
by Kwaaitaal, Mark and Huisman, Rik and Maintz, Jens and Reinstad̈ler, Anja and Panstruga, Ralph
Biochemical journal, ISSN 0264-6021, 12/2011, Volume 440, Issue 3, pp. 355 - 365
Ionotropic glutamate receptor channel | Elicitor | Microbe-associated molecular pattern | Calcium channel | Calcium signature | Plant immunity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Calcium Channels - metabolism | Seedlings - genetics | Type C Phospholipases - metabolism | Type C Phospholipases - antagonists & inhibitors | Arabidopsis Proteins - metabolism | Diltiazem - pharmacology | Estrenes - pharmacology | Plants, Genetically Modified | Pyrrolidinones - pharmacology | Gene Expression Regulation, Plant | Neomycin - pharmacology | Transcription, Genetic | Kynurenic Acid - pharmacology | Dideoxyadenosine - pharmacology | Arabidopsis Proteins - genetics | Nifedipine - pharmacology | Arabidopsis - drug effects | Receptors, Ionotropic Glutamate - metabolism | Aequorin - chemistry | Seedlings - drug effects | Calcium Channel Blockers - pharmacology | Chitin - pharmacology | Verapamil - pharmacology | Arabidopsis - metabolism | Arabidopsis - genetics | Receptors, Pattern Recognition | Bacterial Proteins - pharmacology | Calcium Signaling - drug effects | Alloxan - pharmacology | Mitogen-Activated Protein Kinases - genetics | Enzyme Activation | Arabidopsis Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism | Seedlings - metabolism | Index Medicus
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6. Full Text Water-Soluble and Cleavable Quercetin–Amino Acid Conjugates as Safe Modulators for P‑Glycoprotein-Based Multidrug Resistance
by Kim, Mi Kyoung and Choo, Hyunah and Chong, Youhoon
Journal of medicinal chemistry, ISSN 0022-2623, 09/2014, Volume 57, Issue 17, pp. 7216 - 7233
Paclitaxel - pharmacology | Antioxidants - chemistry | Models, Chemical | Antineoplastic Agents - chemical synthesis | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Amino Acids - chemistry | Alanine - chemistry | Amino Acids - pharmacology | Dose-Response Relationship, Drug | Antineoplastic Agents - pharmacology | Molecular Structure | Alanine - pharmacology | Cell Survival - drug effects | Quercetin - chemistry | Glutamic Acid - pharmacology | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Verapamil - pharmacology | Blotting, Western | Microscopy, Confocal | Quercetin - pharmacology | Cell Line, Tumor | Vinblastine - pharmacology | Dactinomycin - pharmacology | Doxorubicin - pharmacology | Glutamic Acid - chemistry | Index Medicus
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7. Full Text Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents
by Gibson, John K and Yue, Yimei and Bronson, Jared and Palmer, Cassie and Numann, Randy
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 11/2014, Volume 70, Issue 3, pp. 255 - 267
Action potentials | APD90 | Patch-clamp method | APD60 | Rate of rise | Resting membrane potential | Human induced stem cell-derived cardiomyocytes | Ventricular-like myocytes | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Terfenadine - pharmacology | Nifedipine - pharmacology | Phenethylamines - pharmacology | Myocytes, Cardiac - cytology | Humans | Cells, Cultured | Terfenadine - analogs & derivatives | Electric Conductivity | Flecainide - pharmacology | Sulfonamides - pharmacology | Verapamil - pharmacology | Dose-Response Relationship, Drug | Myocytes, Cardiac - drug effects | Ion Channels - metabolism | Piperidines - pharmacology | Astemizole - pharmacology | Myocytes, Cardiac - metabolism | Adult | Pyridines - pharmacology | Induced Pluripotent Stem Cells - cytology | Action Potentials - drug effects | Pentamidine - pharmacology | Stem cells | Heart cells | Index Medicus
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8. Full Text In Silico, Ex Vivo and In Vivo Studies of Roflumilast as a Potential Antidiarrheal and Antispasmodic agent: Inhibition of the PDE-4 Enzyme and Voltage-gated Ca++ ion Channels
by Rehman, Najeeb Ur and Ansari, Mohd Nazam and Samad, Abdul
Molecules (Basel, Switzerland), ISSN 1420-3049, 02/2020, Volume 25, Issue 4, p. 1008
Castor Oil - administration & dosage | Benzamides - pharmacokinetics | Diarrhea - physiopathology | Aminopyridines - pharmacokinetics | Diarrhea - prevention & control | Diarrhea - chemically induced | Jejunum - metabolism | Aminopyridines - chemistry | Cyclopropanes - chemistry | Jejunum - drug effects | Antidiarrheals - pharmacology | Benzamides - pharmacology | Protein Interaction Domains and Motifs | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Binding Sites | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Parasympatholytics - chemistry | Benzamides - chemistry | Cyclopropanes - pharmacokinetics | Cyclopropanes - pharmacology | Rabbits | Phosphodiesterase 4 Inhibitors - chemistry | Phosphodiesterase 4 Inhibitors - pharmacokinetics | Protein Structure, Secondary | Antidiarrheals - pharmacokinetics | Papaverine - pharmacology | Calcium Channel Blockers - pharmacology | Phosphodiesterase 4 Inhibitors - pharmacology | Parasympatholytics - pharmacology | Verapamil - pharmacology | Parasympatholytics - pharmacokinetics | Carbachol - pharmacology | Animals | Antidiarrheals - chemistry | Aminopyridines - pharmacology | Isoproterenol - pharmacology | Calcium Channel Blockers - chemistry | Protein Binding | Diarrhea - metabolism | Mice | Molecular Docking Simulation | Calcium Channel Blockers - pharmacokinetics | Motility | Disease | Deflection | Phosphodiesterase IV | Smooth muscle | Tissues | Molecular docking | Proteins | Jejunum | Hydrogen bonds | Castor oil | Ion channels | Inhibition | Drug dosages | Phosphodiesterase | Enzymes | Calcium channels | Pharmacodynamics | Muscle relaxants | Incubation | Calcium channels (voltage-gated) | Contractility | Diarrhea | Pharmacology | Carbachol | Irritable bowel syndrome | Verapamil | In vivo methods and tests | Potassium | Parasympathetic nervous system | Index Medicus | antispasmodic | autodock vina | roflumilast | molecular docking | pde inhibitor | ca++ channel blocker
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9. Full Text Neryl butyrate induces contractile effects on isolated preparations of rat aorta
by de Carvalho, Emanuella Feitosa and Lima Gadelha, Kalinne Kelly and Nogueira de Oliveira, Daniel Maia and Lima-Silva, Karine and Batista-Lima, Francisco Jose and de Brito, Teresinha Silva and Paula, Suliana Mesquita and Bento da Silva, Moises Tolentino and dos Santos, Armenio Aguiar and Caldas Magalhaes, Pedro Jorge
Naunyn-Schmiedeberg's archives of pharmacology, ISSN 0028-1298, 01/2020, Volume 393, Issue 1, pp. 43 - 55
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Amides - pharmacology | Vasoconstrictor Agents - pharmacology | Calcium - pharmacology | Heart Atria - drug effects | Rats, Wistar | Butyrates - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Male | Vasoconstriction - drug effects | Animals | Phenylephrine - pharmacology | Aorta, Thoracic - physiology | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Adrenergic alpha-Agonists - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Aorta, Thoracic - drug effects | In Vitro Techniques | Sympathomimetic agents | Esters | Vasodilators | Nitric oxide | Endothelium | Calcium | Yohimbine | Essential oils | Guanylate cyclase | Kinases | Prostaglandin endoperoxide synthase | Receptors | Aromatic compounds | Phenylephrine | Aorta | Inhibition | Atria | Organic compounds | Atrium | Vasoconstriction | Contractility | Hypotension | Aliphatic compounds | Nitric-oxide synthase | Rho-associated kinase | Phospholipase C | NG-Nitroarginine methyl ester | Organic chemistry | Phospholipase | Prazosin | Bradycardia | Inhibitors | Coronary vessels | Calcium channels (L-type) | Verapamil | Adrenergic receptors | Indomethacin | Receptors (physiology) | Calcium ions | Index Medicus
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10. Full Text Pharmacophore modeling for hERG channel facilitation
by Yamakawa, Yuko and Furutani, Kazuharu and Inanobe, Atsushi and Ohno, Yuko and Kurachi, Yoshihisa
Biochemical and biophysical research communications, ISSN 0006-291X, 02/2012, Volume 418, Issue 1, pp. 161 - 166
Facilitation | Pharmacology | hERG channel | Pharmacophore model | HERG channel | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Nortriptyline - chemistry | Metoprolol - pharmacology | Humans | Sotalol - chemistry | Imipramine - chemistry | ERG1 Potassium Channel | Nortriptyline - pharmacology | Propranolol - pharmacology | Chlorpheniramine - chemistry | Ether-A-Go-Go Potassium Channels - physiology | Metoprolol - chemistry | Haloperidol - pharmacology | Potassium Channel Blockers - pharmacology | Quantitative Structure-Activity Relationship | Atenolol - pharmacology | Terfenadine - pharmacology | Fluoxetine - pharmacology | Promethazine - chemistry | Xenopus laevis | Propranolol - chemistry | Fluoxetine - chemistry | Verapamil - pharmacology | Haloperidol - chemistry | Verapamil - chemistry | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Animals | Sotalol - pharmacology | Atenolol - chemistry | Hydrophobic and Hydrophilic Interactions | Terfenadine - chemistry | Chlorpheniramine - pharmacology | Imipramine - pharmacology | Potassium Channel Blockers - chemistry | Promethazine - pharmacology | Analysis | Models | Universities and colleges | Index Medicus
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11. Full Text Image-based evaluation of contraction–relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: Correlation and complementarity with extracellular electrophysiology
by Hayakawa, Tomohiro and Kunihiro, Takeshi and Ando, Tomoko and Kobayashi, Seiji and Matsui, Eriko and Yada, Hiroaki and Kanda, Yasunari and Kurokawa, Junko and Furukawa, Tetsushi
Journal of molecular and cellular cardiology, ISSN 0022-2828, 2014, Volume 77, pp. 178 - 191
Cardiovascular | Human-induced pluripotent stem cell-derived cardiomyocytes | Ca2 + transient | Multi-electrode arrays | Traction force microscopy | Field potential | Motion vector prediction | transient | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cell Biology | Myocardial Contraction | Induced Pluripotent Stem Cells - physiology | Humans | Cells, Cultured | Adrenergic beta-Agonists - pharmacology | Sodium Channel Blockers - pharmacology | Microscopy, Video | Calcium Channel Blockers - pharmacology | Verapamil - pharmacology | Biomechanical Phenomena | Myocytes, Cardiac - drug effects | Piperidines - pharmacology | Myocytes, Cardiac - physiology | Isoproterenol - pharmacology | Cell Differentiation | Pyridines - pharmacology | Kinetics | Tetrodotoxin - pharmacology | Electrophysiologic Techniques, Cardiac | Calcium Signaling | Analysis | Stem cells | Index Medicus
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